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Gene Dmel\dom

General Information
Symbol	Dmel\dom	Species	D. melanogaster
Name	domino	Annotation symbol	CG9696
Feature type	protein_coding_gene	FlyBase ID	FBgn0020306
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57D11-57D12	Sequence location	2R:17,210,949..17,229,346 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene domino is referred to in FlyBase by the symbol dom (CG9696, FBgn0020306). It has the cytological map location 57D11-57D12. Its sequence location is 2R:17210949..17229346. Its molecular function is described as: helicase activity; DNA-dependent ATPase activity; general RNA polymerase II transcription factor activity; ATP binding; DNA topoisomerase (ATP-hydrolyzing) activity. It is involved in the biological processes: cell proliferation; establishment and/or maintenance of chromatin architecture; gene silencing; instar larval or pupal development; hemopoiesis; negative regulation of hemocyte proliferation; regulation of alternative nuclear mRNA splicing, via spliceosome; oogenesis; DNA topological change. 26 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: anatomical structure; organ system; imaginal precursor; hemocyte; embryonic/larval hemocoel; larval imaginal precursor; developing anatomical structure; circulatory system; organism; adult. It has 3 annotated transcripts and 3 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57D11-57D12   Limits computationally determined from genome sequence between P{EP}CG30394EP962&P{lacW}domk08108 and P{PZ}tmx1&P{EP}MESK2EP2347
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57E1-57E2   (Ruhf, 1998.7.6) 57D11-57D12 (determined by in situ hybridisation)   (Spradling et al., 1999) 57E1-57E2 (determined by in situ hybridisation)   (Braun et al., 1997) 57E1-57E2 (determined by in situ hybridisation)   (Braun et al., 1997) 57D11-57D12   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\dom for information on other features
Comments on Gene Model
	DGC clone LD46784 appears problematic: incomplete CDS DGC clone LD322234 appears problematic: incomplete CDS DGC clone LD35434 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dom-RA FBtr0071603  NM_080094   10501   3198 dom-RD FBtr0071602  NM_166446   10158   3183 dom-RE FBtr0071604  NM_176244   8567   2497
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein dom-PA   FBpp0071529   350.2   3198   9.37     NP_524833   AAM70871 dom-PD   FBpp0071528   348.4   3183   9.26     NP_726065   AAM70870 dom-PE   FBpp0071530   274.6   2497   6.32     NP_788424   AAM70872
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0020306
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) SANT, DNA-binding (IPR001005) DNA topoisomerase, type IIA, subunit B or N-terminal (IPR001241) DNA/RNA helicase, C-terminal (IPR001650) HSA (IPR006562) HAS subgroup (IPR013999) DEAD-like helicase, N-terminal (IPR014001) Helicase/SANT-associated, DNA binding (IPR014012) Helicase, superfamily 1 and 2, ATP-binding (IPR014021)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141627   AA141628   AA142157   AA246962   AA264923   AA391109   AA735911   AA817080   AA941231   AA942594   AA950529   AA950695   AA950956   AA951610   AA952085   AA978564   AE003453 AAM70870   AE003453 AAM70871   AE003453 AAM70872   AF076776 AAF82185   AF254373 AAK53539   AI061953   AI134600   AI259725   AI259838   AI455755   AI456803   AI515235   AI541846   AI542108   AI544026   AI945330   AQ034011   AW943124   AW943287   AX260228   AY051813 AAK93237   AY058653 AAL13882   AY118307 AAM48336   BF489961   BF497693   BF501973   BF504862   BG637952   BG638663   BG638751   BP553674   BP553675   BT024932   BT031261   BT032837   BZ748811   CK657241   CK658567   CO153381   CO179197   CO265214   CO266250   CO278188   CO278940   CO281964   CO292601   CO296182   CO296695   CO307579   CO307914   CO311383   CO312220   CO319635   CO330013   CO331278   CO333925   CO339018   CO340621   CZ483424   CZ483425   CZ486761   EC057487   EC058975   EC066108   EC066171   EC072620   EC072820   EC078511   EC078512   EC079431   EC087219   EC199538   EC201135   EC202219   EC203922   EC210392   EC215537   EC216255   EC220604   EC232632   EC232904   EC243056   EC243880   EC244088   EC247346   EC248165   EC252094   EC255325   EC258870   EC267278   EL885374   FF579039   LD35056
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLW2 Q8MT92 Q960W1 Q9NDJ2
Maps to
Does NOT map to
Identified with	bs11e09 (Oliver, 2001.8.16) GH12111 LD35434 (BDGP Project Members, 2000-) GM10082 Dm4306 (Spradling et al., 1999) LD32234 (BDGP Project Members, 2000-, Eisberg, 2001.7.11)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 1186
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA978564 AI061953 AI134600 AI455755 AI455874
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0020306 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0020306 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0020306
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable domf04230 semi-viable | somatic clone dom9 lethal | recessive dom16 dom17 domk00904 domk02704 domk07921 domk08108 lethal | germ-line clone | maternal effect dom9 lethal | larval stage | recessive dom14 lethal | pupal stage domk08108 lethal | pupal stage | recessive dom11 dom13 dom15 dom2 dom3 dom6 domk08108 semi-lethal | recessive dom10 dom12 dom18 dom7 dom9 cell lethal | somatic clone dom14 dom3 domk08108 Other Phenotypes Allele suppressor of variegation | dominant, with In(1)wm4h dom14 dom2 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-4 dom14 dom2 Sterility Allele female sterile | recessive dom10 dom12 dom18 dom7 dom9 female sterile | germ-line clone | recessive dom14 dom3 domk08108 fertile domf04230 male fertile dom10 dom12 dom18 dom7 dom9 Phenotype manifest in Allele wing dom10 dom12 dom18 dom7 dom9 imaginal disc dom11 dom13 dom14 dom15 dom2 dom3 dom6 domk02704 domk08108 lymph gland dom11 dom13 dom14 dom15 dom16 dom17 dom2 dom3 dom6 domk08108 hemocyte dom11 dom2 dom6 domk08108 adult neuroblast dom11 dom2 dom6 domk08108 follicle stem cell | somatic clone dom3 domk08108 prohemocyte domk08108 imaginal ring domk08108 midgut imaginal island domk08108 embryonic/larval hemocyte domk08108 plasmatocyte domk08108
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of dom Class Mutagen Stocks Known lesion dom10 Δ2-3 0 Yes dom11 Δ2-3 0 Yes dom12 Δ2-3 0 Yes dom13 Δ2-3 0 Yes dom14 amorph Δ2-3 0 Yes dom15 Δ2-3 0 Yes dom16 Δ2-3 0 Yes dom17 Δ2-3 0 Yes dom18 Δ2-3 0 Yes dom2 Δ2-3 0 Yes dom3 Δ2-3 1 Yes dom6 Δ2-3 0 Yes dom7 Δ2-3 0 Yes dom9 hypomorph Δ2-3 1 Yes domBA00164 piggyBac transposase 0 Yes domC281 0 -- domEY01281 P-element activity 1 -- domMB02981