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Gene Dmel\fry

General Information
Symbol	Dmel\fry	Species	D. melanogaster
Name	furry	Annotation symbol	CG32045
Feature type	protein_coding_gene	FlyBase ID	FBgn0016081
Created / Updated	2003-12-01/2006-05-09
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	67C3-67C4	Sequence location	3L:9,624,933..9,672,203 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene furry is referred to in FlyBase by the symbol fry (CG32045, FBgn0016081). It has the cytological map location 67C3-67C4. Its sequence location is 3L:9624933..9672203. Its molecular function is described as: transcription activator activity; protein binding. It is involved in the biological processes: rhabdomere development; bristle morphogenesis; non-sensory hair organization and biogenesis; imaginal disc-derived wing morphogenesis; regulation of dendrite morphogenesis; antennal morphogenesis; Wnt receptor signaling pathway; positive regulation of protein kinase activity; regulation of dendrite development; imaginal disc-derived wing hair organization and biogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: arista; wing hair; triple row; head bristle; rhabdomere; dendrite. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C3-67C4   Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67B-67D   (Cong, 2000.10.2) 67C4-67C5 (determined by in situ hybridisation)   (Spradling et al., 1999) 61-80   (Adler, 1996.4.28) 67C4-67C5   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Neufeld et al., 1998)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: fry+ CG33696- fry+ CG18180- CG18179- CG8329- fry+ (Cong et al., 2001)
Gene Model & Products
Please see the GBrowse view of Dmel\fry for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fry-RB FBtr0076417  NM_168357   10873   3479 fry-RD FBtr0110843  NM_001043133   10790   1629
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein fry-PB   FBpp0076146   384.4   3479   6.47     NP_729520   AAF50228 fry-PD   FBpp0110140   180.4   1629   7.40     NP_001036598   ABI31247
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0016081
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003551 AAF50228   AE003551 AAF50234   AE003551 AAN11950   AF310159 AAG41424   AF351187 AAK37558   AI543616   AW944637   AY069860 AAL40005   BF485747   BF488453   BF489075   BF490802   BF492168   BF501024   BI638306   BI638880   BI641169   CK136020   CK658662   CO314663   CO320834   CO326548   CO330928   CZ484332   EC073956   EC080250   EC200160   EC206312   EC223136   EC234212   EC248646   EC250850   EC253102   EC254425   EC257418   EL884295   EL884426   EL884427   EL884542   EL884543   EL884664   G00700
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VT28
Maps to
Does NOT map to
Identified with	SD10447 (BDGP Project Members, 2000-, Cong et al., 2001) SD20559 (BDGP Project Members, 2000-) Dm0558 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation fry[2] 3L:9,630,011..9,630,011 comment=Position of mutation on reference sequence inferred by FlyBase curator based on author statement evidence=experimental na_change=G9610858T pr_change=Q2244|fry-PC,Q2299|fry-PB reported_pr_change=?2299@ (Cong et al., 2001) sequence variant fry[1] 3L:9,663,652..9,663,654 comment=Position of mutation on reference sequence inferred by FlyBase curator based on author statement. 1bp deletion in exon 3, resulting in a frameshift after amino acid residue 403. evidence=experimental (Cong et al., 2001)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 4627
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI543616
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016081 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0016081 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0016081
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable fryPL00631 viable | poor fry7 lethal | recessive fry02240 lethal | larval stage | recessive fry1 fry2 fry4 Other Phenotypes Allele visible fry02240 visible (with fry02240) fry7 visible (with fry7) fry02240 visible | cell autonomous | recessive | somatic clone fry2 visible | recessive | somatic clone fry1 Sterility Allele fertile fryPL00631 Phenotype manifest in Allele multidendritic neuron & dendrite | supernumerary (with fry1) fry02240 multidendritic neuron & dendrite (with fry1) fry02240 arista (with fry7) fry02240 multidendritic neuron & dendrite | supernumerary fry02240 fry1 multidendritic neuron & dendrite fry02240 fry1 arista fry02240 fry7 wing hair | supernumerary fry02240 adult abdomen & chaeta fry02240 leg & chaeta fry02240 mesothoracic tergum & chaeta fry02240 triple row fry02240 head bristle fry02240 multidendritic neuron & dendrite | supernumerary (with fry02240) fry1 multidendritic neuron & dendrite (with fry02240) fry1 wing hair | somatic clone | supernumerary fry1 dendrite | cell autonomous | somatic clone | supernumerary fry1 multidendritic neuron & dendrite | somatic clone fry1 wing hair | cell autonomous | somatic clone | supernumerary fry2 arista (with fry02240) fry7 rhabdomere | somatic clone frys308 fryunspecified photoreceptor cell & eye disc | somatic clone frys308
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of fry Class Mutagen Stocks Known lesion fry02240 hypomorph P-element activity 1 Yes fry1 ethyl methanesulfonate 0 Yes fry2 ethyl methanesulfonate 0 Yes fry4 hypomorph ethyl methanesulfonate 0 -- fry7 P-element activity 0 -- fryDG23312 P-element activity 1 -- fryEP326 1 Yes fryKY319 0 -- fryMB01915 1 -- fryPL00631 P-element activity 1 Yes fryf01845 piggyBac transposase 1 -- frys308 ethyl methanesulfonate X ray 0 -- fryunspecified ethyl methanesulfonate X ray 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fry Class Mutagen Stocks Known lesion fryGD10439 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes fryN.Scer\UAS.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3L)AC1
Useful duplication	Dp(3;3)M67C+2
Disrupted in	Df(3L)AC1 (Neufeld et al., 1998, Spradling et al., 1999, Cong et al., 2001, BDGP Project Members, 1994-1999) Df(3L)BSC118 (Andrade and Cook, 2005.7.22) Df(3L)BSC391 (Christensen et al., 2007.10.29) Df(3L)Exel6114 (Ryder, 2004.4.26)
Not disrupted in	Df(3L)29A6 (Cong et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10439} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}fryf01845 NA P{wHy}fryDG23312 NA insertion of enhancer trap binary system Mi{ET1}fryMB01915 No PBac{GAL4D,EYFP}fryPL00631 No P{GawB}fryKY319 No insertion of enhancer trap P{PZ}fry02240 Yes insertion of mobile activating element P{EP}fryEP326 NA
Related Comments
	Please look at the allele reports for the complete phenotype data Mutations in fry result in branched arista laterals, branched bristles and a strong multiple wing hair phenotype. (Cong et al., 2001)
Gene Ontology: Function, Process & Cellular Component ( 14 )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with FLYBASE:trc; FB:FBgn0003744 (He et al., 2005)
transcription activator activity inferred from mutant phenotype (Emoto et al., 2004)
Biological Process
CV term Evidence References
NOT Wnt receptor signaling pathway inferred from genetic interaction with FLYBASE:mwh; FB:FBgn0002912 (Cong et al., 2001)
antennal morphogenesis inferred from mutant phenotype (He and Adler, 2002)
bristle morphogenesis inferred from mutant phenotype (Cong et al., 2001)
imaginal disc-derived wing hair organization and biogenesis inferred from genetic interaction with FLYBASE:trc; FB:FBgn0003744 (He et al., 2005)
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Cong et al., 2001)
non-sensory hair organization and biogenesis inferred from mutant phenotype (Cong et al., 2001)
positive regulation of protein kinase activity inferred from mutant phenotype (Emoto et al., 2004)
regulation of dendrite development inferred from mutant phenotype (Emoto et al., 2004)
regulation of dendrite morphogenesis inferred from mutant phenotype (Emoto et al., 2004)
rhabdomere development inferred from mutant phenotype (Neufeld et al., 1998)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (He et al., 2005)
cytoplasm inferred from direct assay (He et al., 2005)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fry allele Gene References fry1 mwh (Cong et al., 2001) frys308 sina (Neufeld et al., 1998) fryunspecified sina (Neufeld et al., 1998) unspecified trc (He et al., 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 64513
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24650 Dere\GG14017 Dgri\GH15141 Dmoj\GI12078 Dpse\GA16635 Dsec\GM24851 Dvir\GJ13348 Dwil\GK17571 Dyak\fry
Curated drosophilid orthologs	Dpse\GA16635   Dyak\fry
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000001136 Anopheles gambiae (Ensembl) ENSBTAP00000008912 Bos taurus (Ensembl) ENSCAFP00000009661 Canis familiaris (Ensembl) ENSCINP00000018857 Ciona intestinalis (Ensembl) NEWSINFRUP00000169810 Takifugu rubripes (Ensembl) ENSGALP00000027526 Gallus gallus (Ensembl) ENSP00000261575 Homo sapiens (Ensembl) ENSMMUP00000009426 Macaca mulatta (Ensembl) ENSMODP00000025818 Monodelphis domestica (Ensembl) ENSPTRP00000009809 Pan troglodytes (Ensembl) ENSRNOP00000034053 Rattus norvegicus (Ensembl) GSTENP00018854001 Tetraodon nigroviridis (Ensembl) ENSXETP00000009575 Xenopus tropicalis (Ensembl) AT5G15680.1 Arabidopsis thaliana (Arabidopsis) WBGene00040127 Caenorhabditis briggsae (Wormbase) WBGene00004728 Caenorhabditis elegans (Wormbase) MGI:2443838 Mus musculus (Informatics) YIL129C Saccharomyces cerevisiae (Yeastgenome) SPBP19A11.04c Schizosaccharomyces pombe (Sanger)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Szeged	- P{EP}fryEP326
Harvard	- PBac{WH}fryf01845
VDRC	v40309 w1118; P{GD10439}v40309 v40308 w1118; P{GD10439}v40308/TM3
Bloomington	23378 y1 w67c23; Mi{ET1}fryMB01915 11558 P{PZ}fry02240 ry506/TM3, ryRK Sb1 Ser1 20460 y1 w67c23; P{wHy}fryDG23312/TM3, Sb1 Ser1 19575 w*; PBac{GAL4D,EYFP}fryPL00631 CG33696PL00631 P{FRT(whs)}2A P{neoFRT}82B
Genomic Clones ( 3 )
	BACR07E07 BACR02B01 BACR12K04
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10447
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD24377 AT29057 AT16216 AT23737 LP15784 SD21280 AT27402 AT19707 AT24774
Other clones	IP15823 EP04123 SD20559 IP15723 EK296450 EK237403 IP15923 EK288401 IP15623