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Gene Dmel\dpld

General Information
Symbol	Dmel\dpld	Species	D. melanogaster
Name	dappled	Annotation symbol	CG1624
Feature type	protein_coding_gene	FlyBase ID	FBgn0015930
Created / Updated	2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	43C5-43C5	Sequence location	2R:3,369,375..3,377,368 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dappled is referred to in FlyBase by the symbol dpld (CG1624, FBgn0015930). It has the cytological map location 43C5. Its sequence location is 2R:3369375..3377368. Its molecular function is described as zinc ion binding. It is involved in the biological processes: instar larval development; regulation of cell cycle. 11 alleles are reported. The phenotypes of these alleles are annotated with: melanotic mass; larval digestive system. It has 3 annotated transcripts and 3 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43C5-43C5   Limits computationally determined from genome sequence between P{lacW}cosk16101 and P{EP}CG1600EP398
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43D1-43D4 (determined by in situ hybridisation)   (Spradling et al., 1999) 43C-43C (determined by in situ hybridisation)   (Rodriguez et al., 1996) 43C-43C   (Wu et al., 1996) 43D1-43D4 43D3--7   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Wu et al., 1996)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\dpld for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dpld-RA FBtr0088986  NM_165533   4516   832 dpld-RB FBtr0088987  NM_165534   4591   832 dpld-RC FBtr0088985  NM_080033   4367   832
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein dpld-PA   FBpp0088059   90.6   832   6.46     NP_724567   AAF59246 dpld-PB   FBpp0088060   90.6   832   6.46     NP_724568   AAF59245 dpld-PC   FBpp0088058   90.6   832   6.46     NP_524772   AAM68901
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0015930
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, B-box (IPR000315) NHL repeat (IPR001258) NHL repeat, subgroup (IPR013017) Six-bladed beta-propeller, TolB-like (IPR011042)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201331   AA202306   AA202838   AA246441   AA264909   AA390768   AA390872   AA392381   AA439470   AA440877   AA441395   AA536449   AA538710   AA539312   AA540436   AA817077   AA820075   AA979504   AE003841 AAF59245   AE003841 AAF59246   AE003841 AAM68901   AI514564   AI514570   AI519540   AI945209   AQ025018   AQ025871   AQ073465   AW941507   AW943456   AY060421 AAL25460   AZ300912   AZ300951   BG637924   BH900975   BI162212   BI165838   BI167689   BI169871   BI171309   BI172329   BI212699   BI213133   BI215532   BI228201   BI231258   BI234017   BI236940   BI237903   BI239623   BI240581   BI240974   BI242540   BI356910   BI357412   BI363429   BI364391   BI364423   BI364436   BI365568   BI365978   BI369467   BI372448   BI375353   BI375449   BI573457   BI578061   BI578102   BI580315   BI581227   BP546018   BT010087 AAQ22556   BT030403   CO263375   CO276315   CO276835   CO281617   CO299281   CO302587   CO303098   CO315691   CO316511   CO319695   CO339475   CO342531   CZ469601   DN154255   EC060007   EC060193   EC065599   EC070777   EC070778   EC072542   EC074350   EC077862   EC077976   EC080403   EC080560   EC087659   EC194773   EC203072   EC213537   EC215887   EC215888   EC216238   EC223295   EC224327   EC225842   EC236397   EC240140   EC245318   EC250780   EC256063   EC257285
UniProtKB/Swiss-Prot	Q9V4M2
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	bs10c01 LD41117 (Oliver, 2001.8.16) LD19006 (Spradling et al., 1999) LD02463 LD39167 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 13535
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI519540
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015930 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0015930 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0015930 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for dpld FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dpld Stage(s) 1-3 Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable dpldk09716 dpldk09716 lethal | recessive dpldk08815a dpldk08815a dpldk14202 dpldk14202 lethal | larval stage | recessive dpldk14202 Phenotype manifest in Allele melanotic mass dpldk08815a larval digestive system dpldk08815a melanotic mass (with Df(2R)ST1) dpldk08815a larval digestive system (with Df(2R)ST1) dpldk08815a
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of dpld Class Mutagen Stocks Known lesion dpldEP1050 P-element activity 1 -- dpldEP2291 P-element activity 1 -- dpldEP2594 P-element activity 1 -- dpldEP813 P-element activity 2 -- dpldGS14358 0 -- dpldKG07955 P-element activity 1 -- dpldc04907 piggyBac transposase 1 -- dpldk08815a P-element activity 2 -- dpldk09716 P-element activity 0 -- dpldk14202 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dpld Class Mutagen Stocks Known lesion dpldGD9167 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)Drlrv22
Disrupted in	Df(2R)ST1 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Kimbrell, 1996.4.28, Rodriguez et al., 1996) Df(2R)cn83c (Kimbrell, 1996.4.28, Rodriguez et al., 1996) Df(2R)nap16 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)pk78k (Spradling et al., 1999, BDGP Project Members, 1994-1999, Rodriguez et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9167} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}dpldEP1050 NA P{EP}dpldEP2291 NA P{EP}dpldEP2594 NA P{EP}dpldEP813 NA P{GSV6}dpldGS14358 NA miscellaneous insertions PBac{PB}dpldc04907 NA P{SUPor-P}dpldKG07955 NA insertion of enhancer trap P{lacW}dpldk08815a No P{lacW}dpldk09716 Yes P{lacW}dpldk14202 Yes P{lacW}l(2)SH0217SH0217 No
Related Comments
	Please look at the allele reports for the complete phenotype data Mutant alleles show formation of melanotic pseudotumors. (Wu et al., 1996) Cg25C is a member of the fat body enhancer detector strains. (Rodriguez et al., 1996)
Gene Ontology: Function, Process & Cellular Component ( 4 )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR000315 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
instar larval development inferred from mutant phenotype (Rodriguez et al., 1996)
regulation of cell cycle inferred from mutant phenotype (Rodriguez et al., 1996)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000315 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dpld allele Gene References dpldEP1050 pnr (Pena-Rangel et al., 2002) unspecified Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 69183 Drosophila PIMRider - The Drosophila Protein Interaction map • 522654
Orthologs
Genome-wide drosophilid orthologs	Dpse\GA14054 Dana\GF13678 Dere\GG10744 Dgri\GH20597 Dmoj\GI19797 Dper\GL20119 Dsec\GM20790 Dsim\GD10251 Dvir\G