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Gene Dmel\futsch

General Information
Symbol	Dmel\futsch	Species	D. melanogaster
Name	futsch	Annotation symbol	CG34387
Feature type	protein_coding_gene	FlyBase ID	FBgn0259108
Created / Updated	2008-03-27/2008-03-27
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2A3-2A3 2A2-2A2	Sequence location	X:1,308,295..1,343,049 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol futsch (CG34387, FBgn0259108). It has the cytological map location 2A3. Its sequence location is X:1308295..1343049. Its molecular function is described as: microtubule binding; protein binding. It is involved in the biological processes described with 12 unique terms, many of which group under: anatomical structure development; organelle organization and biogenesis; regulation of developmental process; cell projection organization and biogenesis; microtubule-based process; olfactory learning; regulation of apoptosis; neuron differentiation; intermediate filament-based process; microtubule cytoskeleton organization and biogenesis; learning; sensory organ development; axon cargo transport; dendrite morphogenesis. 13 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: nervous system; organ system; anatomical structure; peripheral nervous system; adult segment; adult brain; embryonic nervous system; synapse; axon; antennal segment; neuromuscular junction. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2A3-2A3   Limits computationally determined from genome sequence between P{EP}futschEP1419 and P{EP}brEP1515
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1F-2A   (Hummel et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\futsch for information on other features
Comments on Gene Model
	Gene merge based on protein alignment (BLASTX) data. DGC SD17959 clone appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) futsch-RC FBtr0112628  NM_001103394   16488   5495
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein futsch-PC   FBpp0111540   592.1   5495   4.61     NP_001096864   ABW09325
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1213 (IPR009603)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003420 AAF45620   AE003420 AAF45622   AI389853   AI514120   AL031128 CAA20006   AQ025455   BG632155   BG633447   BI636317   BT030436   BT030858   CK135981   CO282580   CO305713   CO307383   CO309066   EC080691   EC080725   EC088985   EC089780   EC198926   EC210930   EC248369   EC249630   EL887343   EL887383   EL887421   EW712977   GH27181
UniProtKB/Swiss-Prot	Q9W596
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	GH21135 (Benos et al., 2001) SD17959 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
	neuron <of> peripheral nervous system
Subcellular Localization
CV Term
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable futschK68 lethal futschP158 lethal | recessive futschPG97 Other Phenotypes Allele learning defective | adult stage futscholk1 futscholk3 olfaction defective | adult stage futscholk1 cell death increase | adult stage futscholk1 neurophysiology defective futschN94 neurophysiology defective, with Scer\GAL4elav-C155 futschEP1419 neuroanatomy defective futschN94 neuroanatomy defective | recessive futschK68 futschN94 neuroanatomy defective | larval stage futschK68 neuroanatomy defective, with Scer\GAL4elav-C155 futschEP1419 Sterility Allele male fertile futschN94 Phenotype manifest in Allele bouton, with Scer\GAL4elav-C155 futschEP1419 synapse, with Scer\GAL4elav-C155 futschEP1419 neuromuscular junction, with Scer\GAL4elav-C155 futschEP1419 photoreceptor cell, with Scer\GAL4elav-C155 futschEP1419 axon, with Scer\GAL4sim.PS futschEP1419 synapse futschK68 futschN94 bouton futschK68 futschN94 synapse & microtubule futschK68 futschN94 neuromuscular junction futschN94 photoreceptor cell futschN94 sensory nerve & dendrite futschP158 axon futschP158 longitudinal connective futschP158 abdominal posterior fascicle neuron futschP158 motor neuron futschP158 calyx futscholk1 antennal lobe futscholk1 neuropil futscholk1 protocerebrum futscholk1 microtubule & antennal lobe futscholk1 mitochondrion & neuron futscholk1
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of futsch Class Mutagen Stocks Known lesion futschEP1419 P-element activity 2 Yes futschK68 hypomorph 1 -- futschM455 0 -- futschN94 hypomorph 1 -- futschP158 amorph 0 -- futschP28 0 -- futschPG97 Δ2-3 0 -- futscholk1 0 Yes futscholk2 hypomorph 0 -- futscholk3 hypomorph 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of futsch Class Mutagen Stocks Known lesion futschGD1263 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes futschGD8438 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes futschNterm.Scer\UAS in vitro construct | deletion in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)S39
Disrupted in	Df(1)A94 (Hummel et al., 2000) Df(1)AC7 (Hummel et al., 2000) Df(1)Exel6227 (Ryder, 2004.4.26) Df(1)RH4 (Hummel et al., 2000) Df(1)S39 (Hummel et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1263} NA P{GD8438} NA P{UAS-Nterm.futsch} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}futschEP1419 NA miscellaneous insertions P{SUPor-P}KG03606 NA insertion of enhancer trap binary system P{GawB}futschPG97 No
Related Comments
	Please look at the allele reports for the complete phenotype data Either loss or overexpression of Fmr1 or futsch have identical effects on synaptic transmission - elevation at the NMJ and suppression in photoreceptor cells. (Zhang et al., 2001)
Gene Ontology: Function, Process & Cellular Component ( 16 )
Molecular Function
CV term Evidence References
microtubule binding inferred from direct assay AND inferred from sequence or structural similarity with UniProt:P46821 (Hummel et al., 2000) inferred from direct assay (Roos et al., 2000) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity (EDGP Project Members, 1994-)
protein binding inferred from physical interaction with FLYBASE:Fmr1; FB:FBgn0028734 (Zhang et al., 2001)
Biological Process
CV term Evidence References
axon cargo transport inferred from mutant phenotype (da Cruz et al., 2005)
axonogenesis inferred from mutant phenotype (Hummel et al., 2000)
compound eye development non-traceable author statement (Oostra, 2002)
dendrite morphogenesis inferred from mutant phenotype (Hummel et al., 2000)
microtubule cytoskeleton organization and biogenesis inferred from mutant phenotype (Roos et al., 2000)
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
negative regulation of neuron apoptosis inferred from mutant phenotype (da Cruz et al., 2005)
nervous system development non-traceable author statement (Oostra, 2002)
neurofilament cytoskeleton organization and biogenesis inferred from mutant phenotype (da Cruz et al., 2005)
neuromuscular junction development non-traceable author statement (Oostra, 2002)
olfactory learning inferred from mutant phenotype (da Cruz et al., 2005)
regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Franco et al., 2004) inferred from mutant phenotype (Roos et al., 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hummel et al., 2000) inferred from direct assay (Roos et al., 2000) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity (EDGP Project Members, 1994-)
microtubule cytoskeleton inferred from direct assay (Hummel et al., 2000)
Sequence Ontology: Class of Gene
	protein_coding_gene (da Cruz et al., 2005) nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions futsch allele Gene References futschN94 Fmr1 (Zhang et al., 2001) unspecified Fmr1 (da Cruz et al., 2005) tau (da Cruz et al., 2005) flexin (Roos et al., 2000)
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dere\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dore\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dpse\GA13235   Dpse\GA15901   Dsim\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dtei\futsch (Ko et al., 2006, Ko et al., 2005.8.29) Dyak\futsch (Ko et al., 2006)
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Szeged	- P{EP}futschEP1419
Bloomington	13249 y1 P{SUPor-P}KG03606 8794 y1 futschK68 8805 y1 futschN94 10751 P{EP}futschEP1419 w1118
VDRC	v6972 w1118; P{GD1263}v6972 v6973 w1118; P{GD1263}v6973
Genomic Clones ( 2 )
	BACR30G24 BACR09H15
cDNA Clones ( 7 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH21135 GH04292
Other clones	EK254456 EK249304 EK160750 GH27181 EK260044
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
	Etymology: futsch is German for "gone". (Hummel et al., 2000)
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: EG:49E4.1 CG3064 (Bayraktaroglu, 2000.4.7) Source for merge of: futsch EG:49E4.1 (Gatt, 2000.11.14) Source for merge of: futsch CG14772 (FlyBase Genome Annotators, 2007) Source for merge of: futsch olk (da Cruz et al., 2005)
Additional comments	Annotations CG3064 and CG14772 merged as CG34387 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
Comments About Role
	futsch is necessary for dendritic and axonal growth. (Hummel et al., 2000) futsch may control synaptic growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. (Roos et al., 2000)
Comments About Molecular Function
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103394 RefSeq (Proteins) • NP_001096864 DDBJ / EMBL / GenBank • AAF45620 BI636317 AL031128 CAA20006 AE003420 AI389853 AQ025455 AAF45622 UniProtKB/Swiss-Prot • Q9W596
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF1213 (IPR009603)
Linkouts
	Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/futsch1.htm
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	22C10 (Ashley et al., 2005, Fischler et al., 2007, Dutta et al., 2005, Singh et al., 2006, Sweeney et al., 2006, Sanchez, 2006, Sanchez et al., 2006, Beronja et al., 2005, Yamamoto, 2006, Rogers et al., 2005, Acar et al., 2006, Wheeler et al., 2006, Ataman, 2006, Park et al., 2006, Sengupta, 2006, Chu-LaGraff et al., 2007, Fernandes and Krishan, 2007, Sterling et al., 2007, Bessa and Casares, 2005, Sanchez-Soriano et al., 2005, Wildonger and Mann, 2005, Monier et al., 2005, Schubiger et al., 2005, Coulson et al., 2005, Read et al., 2005, Yano et al., 2005, Singh et al., 2005, Mizutani et al., 2005, Bhalerao et al., 2005, Escudero et al., 2005, Mace and Tugores, 2004, Gong et al., 2004, Usui-Ishihara and Simpson, 2005, Pielage et al., 2004, Read et al., 2004, Kinrade and Hidalgo, 2004, Bhat, 2005, Lee et al., 2005, Grabbe et al., 2004, Niwa et al., 2004, Islam et al., 2004, Mellerick and Modica, 2002, Andrenacci et al., 2004, Schmid et al., 2002, Domingos et al., 2004, Langlais et al., 2004, Koh et al., 2004, Beck et al., 2004, Singh and Choi, 2003, Artero et al., 2003, Han et al., 2003, Yamada et al., 2003, Schenck et al., 2003, Yang et al., 2003, Sepp and Auld, 2003, Weng et al., 2003, Reim et al., 2003, Villa-Cuesta et al., 2003, Inbal et al., 2003, Koelzer and Klein, 2003, Shandala et al., 2003, Xu et al., 2002, Kambris et al., 2002, Grueber et al., 2003, Song et al., 2002, Moore et al., 2002, Song et al., 2002, Dubruille et al., 2002, Wang et al., 2002, Packard et al., 2002, Uhler et al., 2002, Dumstrei et al., 2002, Rusten et al., 2002, Soustelle et al., 2002, Terman et al., 2002, Eaton et al., 2002, Schenkel et al., 2002, Hardiman et al., 2002, Goberdhan and Wilson, 2002, Sweeney et al., 2002, Umesono et al., 2002, Tekotte et al., 2002, Marques et al., 2002, Ozon et al., 2002, Jhaveri and Rodrigues, 2002, Bulgheresi et al., 2001, Murawsky et al., 2001, Kumar et al., 2001, Ramain et al., 2001, Inbal et al., 2001, Sepp et al., 2001, Quinn et al., 2001, Badenhorst, 2001, Mehta and Bhat, 2001, Jones, 2001, Alonso et al., 2001, Schimmelpfeng et al., 2001, Adachi et al., 2001, Kammermeier et al., 2001, Vandaele et al., 2001, Kataoka et al., 2001, Koizumi et al., 2001, Plaza et al., 2001, Rusten et al., 2001, Ben-Yaacov et al., 2001, Quinn et al., 2000, Geng et al., 2000, Yeh et al., 2000, Usui-Ishihara et al., 2000, Nolo et al., 2000, Hiramoto et al., 2000, Chen and Rebay, 2000, Brown and Castelli-Gair Hombria, 2000, Connell-Crowley, 2000, Schmucker et al., 2000, Ishimoto et al., 2000, Bour et al., 2000, Aguilera et al., 2000, White and Jarman, 2000, Hoyle et al., 2000, Kuang et al., 2000, Eberl et al., 2000, Kurant and Salzberg, 2000, Schubiger and Truman, 2000, Lai et al., 2000, Justice et al., 1999, Irion and Leptin, 1999, Bhat et al., 2000, Lilly et al., 1999, Lear et al., 1999, Helms et al., 1999, Gao et al., 1999, Byars et al., 1999, Auld, 1999, Ashraf et al., 1999, Madden et al., 1999, Merianda et al., 2005, Layalle et al., 2005, Melcher and Pankratz, 2005, With et al., 2003, Grillenzoni et al., 2007, Holohan et al., 2006, Guntur and Lundell, 2008, Liu et al., 2007) 22c10 (Griffiths and Hidalgo, 2004, Ragone et al., 2003, Yeh et al., 2001, Durand et al., 2001, Taniguchi et al., 2000, Hidalgo and Booth, 2000, Booth et al., 2000) 22C10/FUTSCH (Sedaghat et al., 2002) CG3064 (Benos, 2000.12.13, Goldstein and Gunawardena, 2000, ) CG14772   CG34387 (FlyBase Genome Annotators, 2007) EG:49E4.1 (Bolshakov et al., 2002, Benos et al., 2001, Benos, 2000.12.13, Gatt, 2000.11.14, Hummel et al., 2000, ) Futsch (Elliott et al., 2005, Kracklauer et al., 2007, Gao and Bogert, 2003) futsch (Sweeney et al., 2006, Bossing and Brand, 2006, Denman, 2006, Wheeler et al., 2006, Ko et al., 2006, Wiggin et al., 2005, Ashley et al., 2005, da Cruz et al., 2005, Franco et al., 2004, Monzo et al., 2006) mAb22C10 (Yasunaga et al., 2006, Harris and Whitington, 2001, Kraut and Zinn, 2004, Sen et al., 2004, Parsons et al., 2003, Jang et al., 2003, Sen et al., 2003, Suh et al., 2002, Chang et al., 2001, Kaminker et al., 2001, Takizawa and Hotta, 2001, Lukacsovich et al., 2001, Usui-Aoki et al., 2000, Jhaveri et al., 2000<