Gene Dmel\dod

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General Information

Symbol

Dmel\dod

Species

D. melanogaster

Name

dodo

Annotation symbol

CG17051

Feature type

protein_coding_gene

FlyBase ID

FBgn0015379

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

19F5-19F5

Sequence location

X:21,216,407..21,218,164 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene dodo is referred to in FlyBase by the symbol dod (CG17051, FBgn0015379). It has the cytological map location 19F5. Its sequence location is X:21216407..21218164. Its molecular function is described as: peptidyl-prolyl cis-trans isomerase activity; protein binding. It is involved in the biological process epidermal growth factor receptor signaling pathway. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

External Summaries

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19F5-19F5

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

19F-19F

(Maleszka, 1995.8.31)

19F-19F

(determined by in situ hybridisation)

(Campbell et al., 1993)

Experimentally Determined Recombination Data

Location

(Maleszka, 1995.8.31)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: tty? fliI+ dod+ pen-

(Campbell et al., 1993)

In direction of increasing cytology: tty- fliI+ dod+ pen- dod+ pen- sol+

(Maleszka et al., 1996)

In direction of increasing cytology: tty? fliI? dod+ pen- dod+ pen- sol? Sep1? waw? bbx? slgA? Hlc? mst? lcs?

(Maleszka et al., 1998)

Gene Order (overall orientation not stated)

References

Overall orientation not stated: tty- fliI+ dod+ pen- sol+ Sep1+ waw+ bbx+ slgA+ Hlc- mst+ lcs-

(Miklos, 1997.8.4)

Gene Model & Products

Please see the GBrowse view of Dmel\dod for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

dod-RA

FBtr0077193

NM_078704

1278

166

Additional Transcript Data & Comments

Reported size (kB)

1.0 (longest cDNA)

(Maleszka et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

dod-PA

FBpp0076894

18.4

166

7.57

NP_523428

AAF50829

Additional Polypeptide Data & Comments

Reported size (kD)

166 (aa)

(Maleszka et al., 1996, Maleszka et al., 1998)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0015379

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Peptidyl-prolyl cis-trans isomerase, PpiC-type (IPR000297)

WW/Rsp5/WWP (IPR001202)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P54353

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

GH25582

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5202

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0015379

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0015379

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0015379

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of dod	Class	Mutagen	Stocks	Known lesion
dod^EY03779		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of dod	Mutagen	Stocks	Known lesion
dod^Act5C.PH	in vitro construct \| regulatory fusion	0	Yes
dod^GD9274	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
dod^T2	in vitro construct \| genomic fragment	0	Yes
dod^hs.PH	in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)GA104

Useful duplication

Dp(1;Y)y⁺mal¹⁷¹

Disrupted in

Df(1)16-129

(Maleszka et al., 1996)

Df(1)17-257

(Maleszka et al., 1996)

Df(1)GA104

(Maleszka et al., 1996)

Not disrupted in

Df(1)2/19B

(Maleszka et al., 1996)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD9274}

characterization construct

P{pen^T2}

heat-shock construct

P{hs-dod.H}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}dod^EY03779

Related Comments

Please look at the allele reports for the complete phenotype data

Defined as a transcription unit during the molecular analysis of the nearby fliI gene.

(Campbell et al., 1993)

Transgenic flies (containing the vital gene fliI) carrying overlapping deficiencies that totally delete dod are viable and can fly. Loss of dod function is compensated for by a duplicate copy, by other unrelated proteins or by protein complexes that perform similar functions.

(Maleszka et al., 1996)

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

peptidyl-prolyl cis-trans isomerase activity

inferred from sequence or structural similarity with HGNC_gene:PIN1; HGNC:8988; OMIM:601052 AND inferred from sequence or structural similarity with SGD_LOCUS:ESS1; SGD:S0003778

(Maleszka et al., 1996)

inferred from sequence or structural similarity

(Hanes et al., 1996)

inferred from sequence or structural similarity with NCBI_gi:5453898

(FlyBase, 1992-)

non-traceable author statement

(Swiss-Prot Project Members, 1996.10.1)

protein binding

inferred from electronic annotation with InterPro:IPR001202

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Hsu et al., 2001)

Cellular Component

CV term

Evidence

References

nucleus

inferred from direct assay

(Hsu et al., 2001)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

dod allele

Gene

References

External Data

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

59389

Orthologs

Genome-wide drosophilid orthologs

Dana\GF22548

Dere\GG19723

Dgri\GH24043

Dmoj\GI15719

Dper\GL14862

Dpse\GA14299

Dsec\GM23077

Dsim\GD17528

Dvir\GJ15247

Dwil\GK10078

Dyak\GE17920

Curated drosophilid orthologs

Dpse\GA14299

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000013455
Anopheles gambiae (Ensembl)
ENSBTAP00000022592
Bos taurus (Ensembl)
ENSCAFP00000026537
Canis familiaris (Ensembl)
NEWSINFRUP00000134102
Takifugu rubripes (Ensembl)
ENSP00000247970
Homo sapiens (Ensembl)
ENSMMUP00000010805
Macaca mulatta (Ensembl)
ENSMODP00000005818
Monodelphis domestica (Ensembl)
ENSPTRP00000017779
Pan troglodytes (Ensembl)
ENSRNOP00000027819
Rattus norvegicus (Ensembl)
GSTENP00015744001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000012882
Xenopus tropicalis (Ensembl)
Q7XTK0
Oryza sativa (Gramene)
AT2G18040.1
Arabidopsis thaliana (Arabidopsis)
WBGene00038800
Caenorhabditis briggsae (Wormbase)
WBGene00022448
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-040425-2654
Danio rerio (Zfin)
ZDB-GENE-040426-1714
Danio rerio (Zfin)
DDB0191263
Dictyostelium discoideum (Dictybase)
MGI:1346036
Mus musculus (Informatics)
YJR017C
Saccharomyces cerevisiae (Yeastgenome)
NP_418223.1
Escherichia coliK12 (NCBI)
SPCC16C4.03
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Functionally complements

Scer\ess1

(Maleszka et al., 1996)

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v25210

w¹¹¹⁸; P{GD9274}v25210

v25209

w¹¹¹⁸; P{GD9274}v25209/CyO

Bloomington

15677

y¹ w^67c23 P{EPgy2}dod^EY03779

Genomic Clones ( 2 )

cDNA Clones ( 27 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones