A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\CG5861

General Information
SymbolDmel\CG5861SpeciesD. melanogaster
NameCG5861Annotation symbolCG5861
Feature typeprotein_coding_geneFlyBase IDFBgn0015338
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map35F1-35F1Sequence location2L:16,305,786..16,307,275 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol CG5861 (FBgn0015338). It has the cytological map location 35F1. Its sequence location is 2L:16305786..16307275. Its molecular function is unknown. It is involved in the biological process phagocytosis, engulfment. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
35F1-35F1  
Limits computationally determined from genome sequence between P{lacW}heixk11403&P{lacW}heixk12401 and P{EP}fzyEP1028&P{lacW}mRpL4k14608  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
35F-35F
 
(Dawson et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: CG5861- Syx5+ cni- fzy+ cact-
(Dawson et al., 1995)
In direction of increasing cytology: CG5861- Syx5+ cni-
(Roth et al., 1995)
In direction of increasing cytology: CG5869- CG5861- c(2)M+
(Ashburner et al., 1999)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG5861 for information on other features
detailed view FBtr0080830 FBtr0080850 FBtr0080831 FBtr0080832 FBpp0080388 FBpp0080407 FBpp0080390 FBpp0080389 FBti0010861 FBti0057577 FBti0011029 FBti0047805 FBti0038780
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG5861-RA
FBtr0080850
 NM_135945
  1118
  227
Additional Transcript Data & Comments
Reported size (kB)
1.0 (northern blot)
(Roth et al., 1995)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG5861-PA  
FBpp0080407  
25.1  
227  
8.69  
  NP_609789
  AAF53519
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA803126
 
AA803560
 
AE003650
AAF53519
 
AI061692
 
AY071295
AAL48917
 
BI171506
 
BI216222
 
BI236553
 
BI483372
 
BI485272
 
CO182174
 
CO182440
 
CO295163
 
CZ479380
 
CZ479381
 
EC075619
 
EC221444
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    (Ashburner et al., 1999.10.12)
    Does NOT map to
    Identified with
    (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
    (Ashburner et al., 1999.10.12)
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     adult stage
     
    (Roth et al., 1995)
     embryonic stage
     
    (Roth et al., 1995)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of CG5861ClassMutagenStocksKnown lesion
        CG5861e015690 --
        hide Alleles Carried on Transgenic Constructs ( 3 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of CG5861ClassMutagenStocksKnown lesion
        CG5861GD171341 Yes
        CG5861GD17421 Yes
        CG5861t14.20 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
         
        Useful duplication
         
        Not disrupted in
        (Roth et al., 1995)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD17134}
        NA
        P{GD1742}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        miscellaneous insertions
        PBac{RB}CG5861e01569
        NA
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
        (Stroschein-Stevenson et al., 2006)
        hide Gene Ontology: Function, Process & Cellular Component ( 1 )
        hide Molecular Function
        CV term
        Evidence
        References
        hide Biological Process
        CV term
        Evidence
        References
        phagocytosis, engulfment
        inferred from mutant phenotype
        (Stroschein-Stevenson et al., 2006)
        hide Cellular Component
        CV term
        Evidence
        References
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        CG5861 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 2 )
        VDRC
        v47665
        w1118; P{GD17134}v47665
        v6360
        w1118; P{GD1742}v6360/TM3
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 11 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Source for merge of: anon-35Fc anon-35Fa
        (Dawson et al., 1995)
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 6 )
        Reported As
        Symbol Synonym
        anon-35Fa
        (Reese et al., 2000, Reese et al., 2000, )
        anon-35Fc
         
        BG:DS02740.11
        (Ashburner et al., 1999.10.12, Ashburner et al., 1999)
        CG5861
        (Stroschein-Stevenson et al., 2006)
        III
        (Dawson et al., 1995)
        unnamed
        (Ashburner et al., 1999, Roth et al., 1995)
        Name Synonym
        CG5861
         
        Secondary FlyBase IDs
        • FBgn0020603
        hide References ( 14 )
        Research paper
        Stroschein-Stevenson et al., 2006, PLoS Biol. 4(1): 87--99
        Identification of Drosophila gene products required for phagocytosis of Candida albicans. [FBrf0191376]
        Willingham and Keil, 2004, Mech. Dev. 121(10): 1289--1297
        A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. [FBrf0179737]
        Bolshakov et al., 2002, Genome Res. 12(1): 57--66
        A comparative genomic analysis of two distant Diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. [FBrf0141561]
        Reese et al., 2000, Genome Res. 10(4): 483--501
        Genome annotation assessment in Drosophila melanogaster. [FBrf0127290]
        Reese et al., 2000, Genome Res. 10(4): 529--538
        Genie - Gene finding in Drosophila melanogaster. [FBrf0127289]
        Ashburner et al., 1999, Genetics 153(1): 179--219
        An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326]
        Dawson et al., 1995, J. Cell Biol. 129(3): 725--737
        The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. [FBrf0081900]
        Roth et al., 1995, Cell 81(6): 967--978
        cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. [FBrf0082538]
        Supplementary material
        Ashburner et al., 1999, Genetics 153(1):
        Table S2. Genes, known and predicted, that have been determined on the sequence of the Adh region. All genes are protein coding, unless indicated tscan in the prediction column, these are tRNAs. [FBrf0112151]
        Personal communication to FlyBase
        Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
        RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
        Ashburner et al., 1999.10.12, Adh.
        Adh. [FBrf0112153]
        Computer file
        Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection.
        Genomic mapping of Exelixis insertion collection. [FBrf0184340]
        Gene Disruption Project members, 2001-, [title not yet available]
        [title not yet available] [FBrf0132177]
        BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
        Berkeley Drosophila Genome Project. [FBrf0125078]