A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\gypsy\env

General Information
SymbolDmel\gypsy\envSpeciesD. melanogaster
Namegypsy\envelopeAnnotation symbol
Feature typetransposable_element_geneFlyBase IDFBgn0014964
Created / Updated2006-05-31/2007-09-12
Genomic Location
Chromosome (arm)Recombination map
Cytogenetic mapSequence location
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Automatically generated summary

See sections below for more information
The gene gypsy\envelope is referred to in FlyBase by the symbol gypsy\env (FBgn0014964). It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has no annotated transcripts.

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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
2.1 (northern blot)
(Pelisson et al., 1994)
2.072 (northern blot, sequence analysis)
(Avedisov and Ilyin, 1994)
Comments
A subgenomic RNA.
(Pelisson et al., 1994)
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
483 (aa)
(Pelisson et al., 1994, Avedisov and Ilyin, 1994)
66, 54, 28 (kD observed)
(Song et al., 1994)
Comments
The gypsy env-like protein is glycosylated and processed, like all retroviral envelope proteins. It is found primarily in viral particles.
(Song et al., 1994)
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Gypsy (IPR009882)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AF033821
AAC82605
 
M12927
AAA70220
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
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Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
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FlyBase-Curated Data
Transcript and
Protein data 		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
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Stage
Tissue/Position
Reference
 oogenesis stage,adult stage
 follicle cell
(Pelisson et al., 1994)
Marker for
    Subcellular Localization
    CV Term
    hide Summary of Polypeptide Expression
    Stage
    Tissue/Position
    Reference
     oogenesis stage,adult stage
     follicle cell
    (Pelisson et al., 1994)
    Marker for
      Subcellular Localization
      CV Term
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      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      hide Alleles & Phenotypes
      hide Summary of Allele Phenotypes
      Phenotype manifest in
      Allele
      hide Classical Alleles ( 1 )
      For All Classical Alleles Show

      Allele of gypsy\envClassMutagenStocksKnown lesion
      gypsy\envSS0 --
      hide Alleles Carried on Transgenic Constructs ( 6 )
      For All Alleles Carried on Transgenic Constructs Show

      Allele of gypsy\envClassMutagenStocksKnown lesion
      gypsy\env111fs30 Yes
      gypsy\env6Kfs10 Yes
      gypsy\env6Kfs30 Yes
      gypsy\envAct5C.PC0 Yes
      gypsy\envCMV.cTa0 Yes
      gypsy\envScer\UAS.hs0 Yes
      hide Aneuploid Aberrations
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      Transgenic Constructs
      Type of construct
      Name
      Expression data
      Insertions
      Type of insertions
      Name
      Expression data
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      Please look at the allele reports for the complete phenotype data
      Production of the gypsy\env message and corresponding protein is strongly repressed by one copy of the non-permissive allele of flam, flamN. A less dramatic reduction in the accumulation of other transcripts and retrotranscripts is also observed. These effects correlate with the inhibition of gypsy transposition in the progeny of these females and is likely to be responsible for this phenomenon. The effects of flam on gypsy\env expression are restricted to the somatic follicle cells that surround the maternal germline.
      (Pelisson et al., 1994)
      The gypsy\env RNA is generated by splicing of the full length gypsy transcript.
      (Avedisov and Ilyin, 1994)
      The protein encoded by gypsy\env is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels and found in viral particles in strains in which gypsy elements are active. Introduction of these particles into strains carrying inactive gypsy elements causes a high level of gypsy insertion activity in the progeny.
      (Song et al., 1994)
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      CV term
      Evidence
      References
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      CV term
      Evidence
      References
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      CV term
      Evidence
      References
      hide Sequence Ontology: Class of Gene
      transposable_element_gene
       
      hide Interactions & Pathways
      hide Summary of Genetic Interactions
      Interacts with
      Please look at the allele data for full details of the genetic interactions
      gypsy\env allele
      Gene
      References
      hide External Data
      Linkouts
      hide Orthologs
      Genome-wide drosophilid orthologs
      Curated drosophilid orthologs
      (Vazquez-Manrique et al., 2000)
      (Vazquez-Manrique et al., 2000)
      (Vazquez-Manrique et al., 2000)
       
      (Vazquez-Manrique et al., 2000)
      (Vazquez-Manrique et al., 2000)
      (Vazquez-Manrique et al., 2000)
      (Mejlumian et al., 2002)
      (Vazquez-Manrique et al., 2000)
      (Vazquez-Manrique et al., 2000)
       
       
       
       
      (Mejlumian et al., 2002)
      Linkouts
      hide Functional Complementation between Species
      hide Inter-Species Misexpression Data
      Produces phenotype in
      Produces NO phenotype in
      hide Stocks & Reagents
      hide Stocks Listed in FlyBase ( 0 )
      hide Genomic Clones ( 0 )
      hide cDNA Clones ( 0 )
      cDNA Clones, Fully Sequenced
      BDGP DGC clones
      Other clones
      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      hide RNAi & Array Information
      Affy Oligo
      Linkouts
      hide Antibody Information
      monoclonal
      (Song et al., 1994)
      hide Other Information
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      hide Etymology
      hide Identification
      hide Position Effect Variegation Data
      hide Relationship to Other Genes
      Source for database identity of
      Source for database merge of
      Encoded by
      gypsy
       
      Additional comments
      hide Comments About Role
      The expression of gypsy encoded proteins is analysed to explore how gypsy is transmitted between generations. gypsy\env expression is observed in ovaries of flam females and levels of expression are shown to increase as a consequence of a flam mutation. Monoclonal antibodies raised against specific domains of the gypsy\env protein suggests that gypsy\env is processed into surface and trans-membrane proteins.
      (Song et al., 1997)
      hide Comments About Molecular Function
      hide Other Comments
      The infectious properties of gypsy\env are studied by packaging a Moloney murine-leukemia (MoMLV) virus-based retroviral vector pseudotyped in the gypsy\env protein. Results suggest the infectious property of gypsy is due to its gypsy\env product.
      (Teysset et al., 1998)
      hide External Crossreferences & Linkouts
      Sequence Crossreferences
      DDBJ / EMBL / GenBank
      •
      UniProtKB/Swiss-Prot
      •
      UniProtKB/TrEMBL
      •
      Other Crossreferences
      InterPro domains - A database of protein families, domains, and functional sites
      •
      Gypsy (IPR009882)
      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      hide Synonyms & Secondary IDs ( 7 )
      Reported As
      Symbol Synonym
      DmeGypV env
      (Mejlumian et al., 2002)
      ENV
      (Labrador and Corces, 1999)
      env
      (Gabus et al., 2006)
      gypsy\env
       
      ORF3
      (Smith and Cronmiller, 2001, Lyubomirskaya et al., 2001, Song et al., 1997, Alberola and de Frutos, 1996, Avedisov and Ilyin, 1994, )
      Name Synonym
      gypsy\envelope
      (Song et al., 1994, )
      gypsy ENV-like ORF3
      (Teysset et al., 1998)
      Secondary FlyBase IDs
        hide References ( 24 )
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        hide Recent research papers ( 1 )
        Gabus et al., 2006, Nucleic Acids Res. 34(20): 5764--5777
        Characterization of a nucleocapsid-like region and of two distinct primer tRNALys,2 binding sites in the endogenous retrovirus Gypsy. [FBrf0194191]
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