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Gene Dmel\mub

General Information
Symbol	Dmel\mub	Species	D. melanogaster
Name	mushroom-body expressed	Annotation symbol	CG7437
Feature type	protein_coding_gene	FlyBase ID	FBgn0014362
Created / Updated	2003-12-01/2006-05-09
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	79A2-79A3	Sequence location	3L:21,872,710..21,919,801 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mushroom-body expressed is referred to in FlyBase by the symbol mub (CG7437, FBgn0014362). It has the cytological map location 79A2-79A3. Its sequence location is 3L:21872710..21919801. Its molecular function is described as poly(rC) binding. It is involved in the biological process regulation of alternative nuclear mRNA splicing, via spliceosome. 26 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79A2-79A3   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 79B1-79B2 (determined by in situ hybridisation)   (Lukacsovich et al., 2001) 79B1-79B3   (Grams, 1996.7.15) 79B1-79B2 (determined by in situ hybridisation)   (Spradling et al., 1999) 79B-79B (determined by in situ hybridisation)   (Grams and Korge, 1998) 66A1-66A2   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Grams, 1996.7.15)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\mub for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mub-RA FBtr0078468  NM_079484   3406   386 mub-RB FBtr0078469  NM_168946   3401   386 mub-RC FBtr0078470  NM_206423   2865   364 mub-RD FBtr0111017  NM_001043154   2953   539
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein mub-PA   FBpp0078122   40.7   386   8.32     NP_524208   AAF51792 mub-PB   FBpp0078123   40.7   386   8.32     NP_730700   AAN12194 mub-PC   FBpp0089422   38.5   364   8.56     NP_996145   AAS65095 mub-PD   FBpp0110316   54.5   539   8.89     NP_001036619   ABI31266
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0014362
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • K Homology (IPR004087) K Homology, type 1 (IPR004088)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202544   AA540851   AA802077   AA951799   AE003596 AAF51792   AE003596 AAN12194   AE003596 AAS65095   AI544150   AQ025286   AQ034062   AQ073067   AQ254634   AW943137   AX260071   AX260073   AX260074   AX260075   AY060403 AAL25442   BI216536   BI235972   BI363946   BI365502   BI375350   BI565954   BI574370   BI583775   BI585284   BI587109   BI587508   BI606992   BI626681   BI639256   BT030140   BT030417   CO179207   CO179645   CO181223   CO189093   CO263572   CO263887   CO264180   CO267559   CO267803   CO268426   CO269057   CO269317   CO272571   CO273903   CO274409   CO277781   CO282332   CO284189   CO288883   CO294428   CO296031   CO297723   CO303766   CO305535   CO305630   CO311817   CO311823   CO314264   CO342214   CZ466979   CZ466980   CZ472236   CZ472762   CZ473213   CZ476750   CZ478244   CZ479779   CZ479895   CZ481319   CZ486110   CZ486111   CZ486425   CZ486426   CZ487986   CZ487987   EC061025   EC061686   EC065962   EC069621   EC069816   EC073535   EC075390   EC076364   EC080432   EC082063   EC086891   EC194540   EC196511   EC198415   EC200210   EC200757   EC202412   EC203200   EC203810   EC207650   EC207952   EC208591   EC209235   EC209469   EC213020   EC213689   EC218945   EC221497   EC223103   EC223245   EC226500   EC228721   EC231594   EC233295   EC233721   EC234122   EC236921   EC242435   EC243060   EC247075   EC249265   EC250393   EC250394   EC251970   EC252274   EC252280   EC253533   EC255654   EL885891   EL885892   X99340 CAA67719
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	P91632 Q95SZ9
Maps to
Does NOT map to
Identified with	LD20678 Dm3997 (Spradling et al., 1999) LD32520 (BDGP Project Members, 2000-, Levis, 2001.2.27)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 6091
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA951799
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014362 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0014362 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0014362 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for mub FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mub Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mubCC01995 lethal | recessive mub04093 mubGTD7-11 mubj6B10 mubj8B3 semi-lethal | recessive mubGTDZ-1 Phenotype manifest in Allele
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of mub Class Mutagen Stocks Known lesion mub04093 P-element activity 1 -- mubBG00074 P-element activity 1 -- mubCC01995 P-element activity 0 Yes mubDG14808 P-element activity 1 -- mubEP3108 P-element activity 1 Yes mubEP3623 P-element activity 1 Yes mubEP783 P-element activity 1 -- mubGTD7-11 P-element activity 0 Yes mubGTDZ-1 P-element activity 0 Yes mubc01204 piggyBac transposase 0 -- mubd01447 P-element activity 0 -- mubd02339 P-element activity 0 -- mubd03166 P-element activity 1 -- mubd09454 P-element activity 1 -- mube00354 piggyBac transposase 1 -- mube01971 piggyBac transposase 1 -- mube02071 piggyBac transposase 0 -- mube03562 piggyBac transposase 1 -- mubf03532 piggyBac transposase 1 -- mubf03831 piggyBac transposase 1 -- mubf05421 piggyBac transposase 1 -- mubj6B10 P-element activity 0 -- mubj8B3 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mub Class Mutagen Stocks Known lesion mub816.i in vitro construct | other 2 Yes mubGD12242 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes muba.hs in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3L)78E2-3;79E
Not disrupted in	Df(3L)Pc (BDGP Project Members, 1994-1999) Df(3L)Pc-MK (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3L)BSC284 (Christensen et al., 2007.5.8) Df(3L)Exel6137 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12242} NA heat-shock construct P{hs-mub.a} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}mubc01204 NA PBac{RB}mube00354 NA PBac{RB}mube01971 NA PBac{RB}mube02071 NA PBac{RB}mube03562 NA P