A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Strn-Mlck

General Information
SymbolDmel\Strn-MlckSpeciesD. melanogaster
NameStretchin-MlckAnnotation symbolCG18255
Feature typeprotein_coding_geneFlyBase IDFBgn0013988
Created / Updated2004-08-31/2004-08-31
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map52D4-52D9Sequence location2R:11,834,430..11,873,458 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Stretchin-Mlck is referred to in FlyBase by the symbol Strn-Mlck (CG18255, FBgn0013988). It has the cytological map location 52D4-52D9. Its sequence location is 2R:11834430..11873458. Its molecular function is described as: myosin light chain kinase activity; structural constituent of cytoskeleton; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; ATP binding; vascular endothelial growth factor receptor activity. It is involved in the biological process protein amino acid phosphorylation. 10 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
52D4-52D9  
Limits computationally determined from genome sequence between P{lacW}l(2)k02205k02205&P{PZ}sli05248 and P{lacW}ATPCLk09217  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D-52D
 
(Champagne, 2000.4.14)
52D2-52D7
 
(Kojima, 1996.12.3)
52D-52D
(determined by in situ hybridisation)  
(Champagne et al., 1995)
52D4-52D15
(determined by in situ hybridisation)  
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Strn-Mlck for information on other features
detailed view FBtr0114558 FBtr0087276 FBtr0087275 FBtr0087201 FBtr0087274 FBtr0087272 FBtr0087273 FBtr0087271 FBtr0087270 FBtr0087269 FBpp0113050 FBpp0086414 FBpp0086413 FBpp0086412 FBpp0086343 FBpp0086411 FBpp0086410 FBpp0086408 FBpp0086409 FBpp0086407 FBti0037888 FBti0067926 FBti0049993 FBti0051721 FBti0041068 FBti0047601 FBti0066745 FBti0047363 FBti0050445
Comments on Gene Model
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Strn-Mlck-RA
FBtr0087270
 NM_166125
  28145
  9270
Strn-Mlck-RB
FBtr0087275
 NM_079030
  3284
  929
Strn-Mlck-RC
FBtr0087272
 NM_166126
  13747
  4463
Strn-Mlck-RD
FBtr0087271
 NM_166129
  22129
  7210
Strn-Mlck-RE
FBtr0087273
 NM_166130
  7731
  2403
Strn-Mlck-RF
FBtr0087274
 NM_166127
  5244
  1506
Strn-Mlck-RG
FBtr0087276
 NM_166128
  3345
  785
Additional Transcript Data & Comments
Reported size (kB)
18, 13, 5.2, 3.6 (northern blot)
(Kojima et al., 1996)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Strn-Mlck-PA  
FBpp0086408  
1036.8  
9270  
4.87  
  NP_725506
  AAM70936
Strn-Mlck-PB  
FBpp0086413  
102.0  
929  
8.54  
  NP_523754
  AAF58089
Strn-Mlck-PC  
FBpp0086410  
497.0  
4463  
6.14  
  NP_725507
  AAM70937
Strn-Mlck-PD  
FBpp0086409  
809.0  
7210  
4.75  
  NP_725510
  AAF58087
Strn-Mlck-PE  
FBpp0086411  
269.2  
2403  
5.84  
  NP_725511
  AAM70939
Strn-Mlck-PF  
FBpp0086412  
166.5  
1506  
6.49  
  NP_725508
  AAF58090
Strn-Mlck-PG  
FBpp0086414  
86.0  
785  
8.37  
  NP_725509
  AAM70938
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Protein kinase, core (IPR000719)
Serine/threonine protein kinase (IPR002290)
Immunoglobulin/major histocompatibility complex, conserved site (IPR003006)
Immunoglobulin subtype 2 (IPR003598)
Immunoglobulin subtype (IPR003599)
Fibronectin, type III (IPR003961)
Fibronectin, type III subdomain (IPR003962)
Immunoglobulin-like (IPR007110)
Serine/threonine protein kinase, active site (IPR008271)
Fibronectin, type III-like fold (IPR008957)
Vascular endothelial growth factor receptor, VEGFR, N-terminal (IPR009134)
Protein kinase-like (IPR011009)
Immunoglobulin I-set (IPR013098)
Immunoglobulin (IPR013151)
Immunoglobulin-like fold (IPR013783)
Protein kinase ATP binding, conserved site (IPR017441)
Serine/threonine protein kinase-related (IPR017442)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA264459
 
AA697372
 
AC004426
 
AC004516
 
AE003808
AAF58087
 
AE003808
AAF58089
 
AE003808
AAF58090
 
AE003808
AAM70936
 
AE003808
AAM70937
 
AE003808
AAM70938
 
AE003808
AAM70939
 
AF254359
AAF90108
 
AF254360
AAF90109
 
AF254361
AAF90110
 
AF254362
AAF90111
 
AF254363
AAF90112
 
AF254364
AAF90113
 
AF254365
AAF90114
 
AF254366
AAF90115
 
AF254368
AAF90116
 
AF254369
AAF90117
 
AF254370
AAF90118
 
AF254371
AAF90119
 
AF254372
AAF90120
 
AF255667
AAG01794
 
AF255668
AAG01795
 
AF255669
AAG01796
 
AF255670
AAG01797
 
AF255671
AAG01798
 
AF255672
AAG01799
 
AF257306
AAF90124
 
AF257307
AAF90125
 
AF257308
AAF90126
 
AF257309
AAF90127
 
AF257310
AAF90128
 
AF257311
AAF90129
 
AF257312
 
AF257313
AAF90131
 
AI238593
 
AI388294
 
AI403054
 
AI403160
 
AI513718
 
AI513859
 
AI517150
 
AW940567
 
AW941074
 
AY061828
AAL27639
 
AY075340
 
AY113646
AAM29651
 
BF490632
 
BG633424
 
BG633438
 
BI215858
 
BI240062
 
BI486865
 
BI576243
 
BI579131
 
BI583213
 
BI592091
 
BI606990
 
BI607592
 
BI621713
 
BI631436
 
CA804508
 
CA804828
 
CA805904
 
CA805992
 
CA806193
 
CA806213
 
CA806274
 
CA806433
 
CA806452
 
CA806902
 
CA806918
 
CA807515
 
CO270820
 
CO271994
 
CO294349
 
CO303789
 
CO311418
 
CO336081
 
CO340862
 
CO343875
 
CZ468267
 
CZ479695
 
CZ479929
 
CZ479930
 
CZ480093
 
CZ480094
 
CZ483954
 
CZ484684
 
CZ484685
 
CZ486864
 
CZ486865
 
D89661
BAA19488
 
D89662
BAA19489
 
D89663
BAA20906
 
DN154272
 
EC051530
 
EC054490
 
EC054513
 
EC054518
 
EC055791
 
EC057531
 
EC072183
 
EC080261
 
EC088093
 
EC202357
 
EC213700
 
EC224645
 
EC255025
 
EC260370
 
EC261399
 
GH26970
 
U51473
AAA96526
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    (BDGP Project Members, 1994-1999)
    Does NOT map to
    Identified with
    (Champagne et al., 2000)
    (BDGP Project Members, 2000-, Champagne et al., 2000, Champagne, 2000.4.14)
    (Champagne et al., 2000, Champagne, 2000.4.14)
    (BDGP Project Members, 2000-, Champagne et al., 2000, Champagne, 2000.4.14, Champagne, 2000.4.14, Zou et al., 2000)
    (Champagne et al., 2000, Champagne, 2000.4.14)
    (Zou et al., 2000)
    (Champagne et al., 2000, Champagne, 2000.4.14)
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage | stage >14
     larval muscle system
    (Kojima et al., 1996)
     adult stage
     
    (Kojima et al., 1996)
     pupal stage | late
     
    (Kojima et al., 1996)
     embryonic stage
     
    (Kojima et al., 1996)
     pupal stage | late
     
    (Kojima et al., 1996)
     embryonic stage
     
    (Kojima et al., 1996)
     embryonic stage-adult stage
     
    (Kojima et al., 1996)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0114558 FBtr0087276 FBtr0087275 FBtr0087201 FBtr0087274 FBtr0087272 FBtr0087273 FBtr0087271 FBtr0087270 FBtr0087269
        AI403160
        AI517150
        AI238593
        AI513859
        AI513718
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 8 )
        For All Classical Alleles Show

        Allele of Strn-MlckClassMutagenStocksKnown lesion
        Strn-MlckC234
          		1 --
          Strn-Mlckc028602 --
          Strn-Mlcke018781 --
          Strn-Mlcke021000 --
          Strn-Mlcke022661 --
          Strn-Mlckf014821 --
          Strn-Mlckf02175