Gene Dmel\Crz

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General Information

Symbol

Dmel\Crz

Species

D. melanogaster

Name

Corazonin

Annotation symbol

CG3302

Feature type

protein_coding_gene

FlyBase ID

FBgn0013767

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

88B3-88B3

Sequence location

3R:10,140,658..10,141,439 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Corazonin is referred to in FlyBase by the symbol Crz (CG3302, FBgn0013767). It has the cytological map location 88B3. Its sequence location is 3R:10140658..10141439. Its molecular function is described as neuropeptide hormone activity. It is involved in the biological process neuropeptide signaling pathway. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88B3-88B3

Limits computationally determined from genome sequence between P{lacW}trx^j14A6&P{PZ}trx⁰⁰³⁴⁷ and P{PZ}cv-c⁰⁶⁹⁵¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Crz for information on other features

Comments on Gene Model

<new comment>GB:S74038 for Crz lists a peptide CDS of 72 amino acids. A single EST shows a splice in the Crz mRNA that eliminates a stop codon and predicts an ORF of 154aa.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Crz-RA

FBtr0082927

NM_079626

573

154

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Crz-PA

FBpp0082386

17.2

154

7.56

NP_524350

AAF55046

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q26377

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

LP11439

(Hewes and Taghert, 2001)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

9416

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

embryonic stage | stage 17

EW3 neuron

(Lundell et al., 2003)

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0013767

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0013767

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0013767

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Crz	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Crz	Class	Mutagen	Stocks	Known lesion
Crz^GD4673		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)red-P93

Disrupted in

Df(3R)Exel6267

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4673}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Isolation and characterisation of Crz.

(Veenstra, 1994)

Gene Ontology: Function, Process & Cellular Component ( 2 )

Molecular Function

CV term

Evidence

References

neuropeptide hormone activity

traceable author statement

(vanden Broeck, 2001)

traceable author statement

(Baggerman et al., 2002)

non-traceable author statement

(Swiss-Prot Project Members, 2001.8.20)

Biological Process

CV term

Evidence

References

neuropeptide signaling pathway

traceable author statement

(vanden Broeck, 2001)

traceable author statement

(Baggerman et al., 2002)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Crz allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

66818

Orthologs

Genome-wide drosophilid orthologs

Dana\GF16166

Dere\Crz

Dgri\GH18707

Dmoj\GI10817

Dper\GL23272

Dpse\GA17242

Dsec\GM24160

Dsim\Crz

Dvir\Crz

Dwil\GK11346

Dyak\GE24230

Curated drosophilid orthologs

Dere\Crz

(Choi et al., 2003)

Dpse\GA17242

Dsim\Crz

(Choi et al., 2003)

Dvir\Crz

(Choi et al., 2003)

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v30670

w¹¹¹⁸; P{GD4673}v30670

v30669

w¹¹¹⁸; P{GD4673}v30669/CyO

Genomic Clones ( 1 )

BACR26A02

cDNA Clones ( 4 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0013767

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0013767

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

The EcR-A isoform is not a signal transducer for programmed cell death in Crz-expressing ventral nerve cord neurons. EcR-B isoforms play significant roles in Crz-expressing ventral nerve cord neuron cell death.

(Choi et al., 2006)

Comments About Molecular Function

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

(McDonald and Rosbash, 2001)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_079626

RefSeq (Proteins)

•

NP_524350

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

Q26377

Other Crossreferences

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

66818

DEDB - Drosophila exon database: splicing graphs

•

9416

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0013767

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0013767

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0013767

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0013767

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0013767

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0013767

Synonyms & Secondary IDs ( 10 )

Reported As

Symbol Synonym

CG3302

COR

(Johnson et al., 2003)

Cora

(Lundell et al., 2003)

Crz

(Choi et al., 2006, Kadener et al., 2006)

crz

(Melcher and Pankratz, 2005)

Dm-Crz

(Choi et al., 2003)

Drm-COR

(Baggerman et al., 2002, vanden Broeck, 2001)

Name Synonym

corazonin

(Hewes et al., 2003, Veenstra, 2000, Veenstra, 1994, Kadener et al., 2006)

Corazonin

(Choi et al., 2006)

preprocorazonin

(Veenstra, 1995.4.12)

Secondary FlyBase IDs

References ( 35 )

Generate a list of

All references relating to this gene ( 35 )

List References by type

Recent research papers ( 2 )

Choi et al., 2006, Development 133(11): 2223--2232: Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. [FBrf0190281]
Kadener et al., 2006, Proc. Natl. Acad. Sci. USA 103(36): 13537--13542: Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. [FBrf0194527]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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