Gene Dmel\Vha68

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General Information

Symbol

Dmel\Vha68

Species

D. melanogaster

Name

Vacuolar H⁺-ATPase 68kD A subunit

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0013355

Created / Updated

2006-05-31/2006-05-31

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

34B-34B

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Vacuolar H⁺-ATPase 68kD A subunit is referred to in FlyBase by the symbol Vha68 (FBgn0013355). It has the cytological map location 34B. It has not been localized to the genome sequence. Its molecular function is described as hydrogen-exporting ATPase activity, phosphorylative mechanism. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has no annotated transcripts.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34B-34B

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34B-34B

(Dow, 1999)

34B-34B

(Dow et al., 1997)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0013355

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0013355

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of Vha68	Class	Mutagen	Stocks	Known lesion
Vha68⁵⁷			0	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Vha68	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful duplication

Dp(2;2)GYL

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{PT1}Vha68⁵⁷

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 2 )

Molecular Function

CV term

Evidence

References

hydrogen-exporting ATPase activity, phosphorylative mechanism

inferred from sequence or structural similarity with SGD_LOCUS:TFP1; SGD:S0002344

(Dow, 1999)

inferred from sequence or structural similarity with SGD_LOCUS:TFP1; SGD:S0002344

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

vacuolar proton-transporting V-type ATPase, V1 domain

inferred from sequence or structural similarity with SGD_LOCUS:TFP1; SGD:S0002344

(Dow, 1999)

inferred from sequence or structural similarity with SGD_LOCUS:TFP1; SGD:S0002344

(FlyBase, 1992-)

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Vha68 allele

Gene

References

External Data

Linkouts

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

•

Other Crossreferences

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0013355

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0013355

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0013355

Synonyms & Secondary IDs ( 9 )

Reported As

Symbol Synonym

V-ATPase

(Dow and Davies, 2000)

Vha8

(Guo et al., 1996)

vha67-1

(Dow, 1999)

Vha68

(Larsen et al., 2006)

VhaA

Name Synonym

A subunit

(Dow et al., 1997)

vacuolar ATPase subunit A

(Yoon, 1995.1.10)

Vacuolar H⁺-ATPase 68kD A subunit

Vacuolar H⁺-ATPase A subunit

Secondary FlyBase IDs

FBgn0013354

References ( 10 )

Research paper

Andolfatto and Przeworski, 2001, Genetics 158(2): 657--665: Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster. [FBrf0178973]
Araki et al., 2001, Genetics 157(2): 667--677: Molecular evolution of duplicated Amylase gene regions in Drosophila melanogaster. Evidence of positive selection in the coding regions and selective constraints in the cis-regulatory regions. [FBrf0132339]
Dow, 1999, J. Bioenerg. Biomembranes 31(1): 75--83: The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. [FBrf0108722]
Dow et al., 1997, J. exp. Biol. 200(2): 237--245: Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. [FBrf0092512]

Supplementary material

Larsen et al., 2006, Proc. Natl. Acad. Sci. USA 103(47):: Supporting Table 2. [FBrf0202556]

Abstract

Dow and Davies, 2000, Comp. Biochem. Physiol. A. Molec. Integrative Physiol. 126A(Suppl. 1): S44: Integrative physiology of the V-ATPase in Drosophila melanogaster. [FBrf0129790]
Guo et al., 1996, A. Dros. Res. Conf. 37: 91: Molecular characterization and inactivation of the 68 kDa A-subunit of V-ATPase in Drosophila. [FBrf0085150]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

DNA/RNA sequence record

Yoon, 1995.1.10, GenBank/EMBL/DDBJ: U19742: Drosophila melanogaster vacuolar ATPase subunit A gene, complete cds. [FBrf0122304]

Computer file

BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]