A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\AttA

General Information
SymbolDmel\AttASpeciesD. melanogaster
NameAttacin-AAnnotation symbolCG10146
Feature typeprotein_coding_geneFlyBase IDFBgn0012042
Created / Updated2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map51C1-51C1Sequence location2R:10,634,864..10,635,726 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Attacin-A is referred to in FlyBase by the symbol AttA (CG10146, FBgn0012042). It has the cytological map location 51C1. Its sequence location is 2R:10634864..10635726. Its molecular function is unknown. It is involved in the biological processes: defense response to Gram-negative bacterium; defense response to bacterium; antibacterial humoral response. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
51C1-51C1  
Limits computationally determined from genome sequence between P{lacW}ttvk03617&P{EP}ttvEP765 and P{lacW}Rpn6k00103  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
51A-51B
 
(Dushay, 2000.1.3)
51A-51B
(determined by in situ hybridisation)  
(Asling et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: AttA+ AttB?
(Eldon, 2000.3.4)
Overall orientation not stated: AttA+ AttB+
(Lazzaro, 2000.3.9, Dushay et al., 2000)
Overall orientation not stated: Dro+ AttA+ AttB+
(Hedengren et al., 2000)
hide Gene Model & Products
Please see the GBrowse view of Dmel\AttA for information on other features
detailed view FBtr0087436 FBtr0087437 FBtr0087438 FBtr0087475 FBtr0087474 FBpp0086566 FBpp0086567 FBpp0086568 FBti0023134
Comments on Gene Model
DGC clone appears problematic: unspliced intron
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
AttA-RA
FBtr0087437
 NM_079021
  799
  221
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
AttA-PA  
FBpp0086567  
22.9  
221  
10.54  
  NP_523745
  AAF58215
Additional Polypeptide Data & Comments
Reported size (kD)
224 (aa)
(Dushay et al., 2000)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Attacin, N-terminal region (IPR005520)
Attacin, C-terminal region (IPR005521)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AC007580
 
AE003813
AAF58215
 
AF220544
AAF70455
 
AI257408
 
AW944054
 
AX154656
 
AY056855
AAL23641
 
AY056856
AAL23642
 
AY056857
AAL23643
 
AY056858
AAL23644
 
AY056859
 
AY056860
AAL23645
 
AY056861
AAL23646
 
AY056862
AAL23647
 
AY056863
AAL23648
 
AY056864
AAL23649
 
AY056865
AAL23650
 
AY056866
AAL23651
 
AY056891
 
AY056892
 
AY056893
 
AY056894
 
AY056895
 
AY056896
 
AY056897
 
AY056898
 
AY056899
 
AY056900
 
AY056901
 
AY056902
 
AY060448
AAL25487
 
AY060448
AAO24989
 
CA805407
 
CG10146
 
CO152844
 
CO154227
 
CO155160
 
CO155698
 
CO336447
 
CO336730
 
CO337510
 
CO337784
 
CO338144
 
CO338708
 
EC261144
 
EC262372
 
EC262592
 
EC264474
 
EC265079
 
EC267084
 
EC267362
 
Z46893
CAA86995
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
(FlyBase, 1992-)
Does NOT map to
Identified with
(BDGP Project Members, 2000-)
hide Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
DEDB - Drosophila exon database: splicing graphs
•
Crossreferences
hide Expression Data
FlyBase-Curated Data
Transcript and
Protein data 		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
hide Summary of Transcript Expression
Stage
Tissue/Position
Reference
Marker for
    Subcellular Localization
    CV Term
    hide Summary of Polypeptide Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Microarray Data
      Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
      Untitled Document detailed view FBtr0087436 FBtr0087437 FBtr0087438 FBtr0087475 FBtr0087474
      AI257408
      hide External Data & Images
      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      •
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      •
      hide Alleles & Phenotypes
      hide Summary of Allele Phenotypes
      Lethality
      Allele
      viable, with Scer\GAL4da.G32
      Phenotype manifest in
      Allele
      hide Classical Alleles ( 0 )
      For All Classical Alleles Show

      Allele of AttAClassMutagenStocksKnown lesion
      hide Alleles Carried on Transgenic Constructs ( 2 )
      For All Alleles Carried on Transgenic Constructs Show

      Allele of AttAClassMutagenStocksKnown lesion
      AttAGD16492 Yes
      AttAScer\UAS.cTa0 Yes
      hide Aneuploid Aberrations
      Useful deficiency
       
      Useful duplication
       
      Disrupted in
      (Ryder, 2004.4.26)
      hide Transgenic Constructs & Insertions
      Transgenic Constructs
      Type of construct
      Name
      Expression data
      reporter construct
      P{AttA-lacZ.497}
      No
      P{AttA-lacZ.780}
      No
      UAS construct
      P{GD1255}
      NA
      P{GD1649}
      NA
      P{GD17307}
      NA
      P{UAS-AttA.T}
      NA
      Insertions
      Type of insertions
      Name
      Expression data
      hide Related Comments
      Please look at the allele reports for the complete phenotype data
      Differential display can be applied to a whole organism to identify induced immune genes, the technique has been used to isolate and characterise AttA.
      (Asling et al., 1995)
      Genes encoding antibacterial peptides are regulated in a manner distinct from that of Drs, encoding the antifungal peptide.
      (Lemaitre et al., 1996)
      hide Gene Ontology: Function, Process & Cellular Component ( 5 )
      hide Molecular Function
      CV term
      Evidence
      References
      hide Biological Process
      CV term
      Evidence
      References
      antibacterial humoral response
      inferred from expression pattern
      (Lemaitre et al., 1997)
      non-traceable author statement
      (Swiss-Prot Project Members, 1995.9.1)
      defense response to Gram-negative bacterium
      inferred from expression pattern
      (Lemaitre et al., 1997)
      non-traceable author statement
      (Dushay et al., 2000)
      defense response to bacterium
      traceable author statement
      (Meister et al., 2000)
      hide Cellular Component
      CV term
      Evidence
      References
      extracellular region
      inferred from electronic annotation with InterPro:IPR005520, InterPro:IPR005521
      (FlyBase Curators et al., 2004-)
      extracellular space
      inferred from direct assay
      (Liu et al., 2006)
      hide Sequence Ontology: Class of Gene
      protein_coding_gene
       
      nuclear_gene
       
      hide Interactions & Pathways
      hide Summary of Genetic Interactions
      Interacts with
      Please look at the allele data for full details of the genetic interactions
      AttA allele
      Gene
      References
      hide External Data
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      hide Orthologs
      Genome-wide drosophilid orthologs
      Curated drosophilid orthologs
      (Lazzaro and Clark, 2001)
       
      (Lazzaro and Clark, 2001)
      (Lazzaro and Clark, 2001)
       
      Linkouts
      hide Functional Complementation between Species
      hide Inter-Species Misexpression Data
      Produces phenotype in
      Produces NO phenotype in
      hide Stocks & Reagents
      hide Stocks Listed in FlyBase ( 2 )
      VDRC
      v9288
      w1118 P{GD1649}v9288
      v9287
      w1118; P{GD1649}v9287
      hide Genomic Clones ( 2 )
      hide cDNA Clones ( 12 )
      Please Note
      This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
      cDNA Clones, Fully Sequenced
      BDGP DGC clones
      Other clones
      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      hide RNAi & Array Information
      Affy Oligo
      Linkouts
      DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
      •
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      hide Antibody Information
      hide Other Information
      hide Discoverer
      hide Etymology
      hide Identification
      hide Position Effect Variegation Data
      hide Relationship to Other Genes
      Source for database identity of
      Source for database merge of
      Source for merge of: AttA BcDNA:LP05763
      (BDGP Project Members, 2000-)
      Source for merge of: AttA anon-WO0140519.5 Source for merge of AttA anon-WO0140519.5 was sequence comparison (date:051113).
      (FlyBase, 1996-)
      Additional comments
      hide Comments About Role
      hide Comments About Molecular Function
      Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
      (McDonald and Rosbash, 2001)
      hide Other Comments
      Ecol\lacZDpt.PR adults are pricked with a sterile needle dipped in culture pellets of various living microorganisms (distinct bacterial strains, fungal spores or hyphae). Pricking results in a low but clearly detectable expression of all antimicrobial genes and these genes are induced above the background level by specific classes of microorganism.
      (Lemaitre et al., 1997)
      hide External Crossreferences & Linkouts
      Sequence Crossreferences
      RefSeq (Transcripts)
      •
      RefSeq (Proteins)
      •
      DDBJ / EMBL / GenBank
      •
      UniProtKB/Swiss-Prot
      •
      UniProtKB/TrEMBL
      •
      Other Crossreferences
      InterPro domains - A database of protein families, domains, and functional sites
      •
      Attacin, N-terminal region (IPR005520)
      Attacin, C-terminal region (IPR005521)
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      DEDB - Drosophila exon database: splicing graphs
      •
      DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
      •
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      •
      FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
      •
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      •
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      PANTHER - Protein classification by function, families, and pathways
      •
      REDfly - Regulatory element database for Drosophila
      •
      University of Chicago Dev. Expression
      •
      hide Synonyms & Secondary IDs ( 16 )
      Reported As
      Symbol Synonym
      anon-WO0140519.5
       
      Att
      (Zambon et al., 2005, Takehana et al., 2002, Gottar et al., 2002, Lemaitre et al., 1997, Lemaitre et al., 1996)
      ATT
      (Tzou et al., 2000)
      att
      (De Gregorio et al., 2002, Leulier et al., 2000, Williams et al., 1997, Georgel et al., 2001)
      attA
      (Boutros et al., 2002, Wu et al., 2001)
      Att A
      (Tzou et al., 2002)
      att A
      (Lemaitre, 2000.12.20)
      AttA
      (Kocks et al., 2005, Ramos et al., 2006, Zraly et al., 2006, Waterhouse et al., 2007, Lazzaro et al., 2004)
      BcDNA:LP05763
       
      CG10146
      (Irving et al., 2001, De Gregorio et al., 2001, Wang et al., 2006, Liu et al., 2006)
      Name Synonym
      attacin
      (Delaney et al., 2005, Steiner, 2004, Leclerc and Reichhart, 2004, Mellroth et al., 2003, Cooper et al., 2002, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Aderem and Ulevitch, 2000, Meister et al., 2000, Basset et al., 2000, Dushay et al., 1998, Park et al., 2004, Georgel et al., 2001, Zelinger and Heifetz, 2006, Delaney et al., 2006, Brennan et al., 2007)
      Attacin
      (Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Kimbrell and Beutler, 2001, Vidal et al., 2001, Rutschmann et al., 2000, Silverman et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Elrod-Erickson et al., 2000, Govind, 1999, Hultmark, 1994.12.5, Han et al., 1998, Mathey-Prevot and Perrimon, 1998, Hoffmann and Reichhart, 1997, Silverman et al., 2003, Tanji et al., 2006, Zhou et al., 2005, Rutschmann et al., 2000, Huh et al., 2007, Avila et al., 2002)
      attacin A
      (Mukae et al., 2002)
      Attacin A
      (Lazzaro and Clark, 2001, Tzou et al., 2002, Wang et al., 2006, Kim and Lis, 2005, Lazzaro et al., 2006, Lazzaro et al., 2004)
      Attacin-A
      (Sano et al., 2005)
      Attackin
      (Pletcher et al., 2002)
      Secondary FlyBase IDs
      • FBgn0044580
      • FBgn0064916
      hide References ( 120 )
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      hide Recent research papers ( 8 )
      Brennan et al., 2007, Curr. Biol. 17(1): 67--72
      Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. [FBrf0193493]
      Huh et al., 2007, J. Biol. Chem. 282(3): 2056--2068
      The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim fam