Gene Dmel\Pxn

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General Information

Symbol

Dmel\Pxn

Species

D. melanogaster

Name

Peroxidasin

Annotation symbol

CG12002

Feature type

protein_coding_gene

FlyBase ID

FBgn0011828

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

62E7-62E7

Sequence location

3L:2,601,450..2,630,072 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Peroxidasin is referred to in FlyBase by the symbol Pxn (CG12002, FBgn0011828). It has the cytological map location 62E7. Its sequence location is 3L:2601450..2630072. Its molecular function is described as: peroxidase activity; protein binding; heme binding; electron donor activity. It is involved in the biological process response to oxidative stress. 4 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62E7-62E7

Limits computationally determined from genome sequence between P{PZ}Spn⁰⁶⁹¹¹ and P{PZ}l(3)06803⁰⁶⁸⁰³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62E8-62F2

(Nelson, 1994.6.20)

Experimentally Determined Recombination Data

Location

(Nelson, 1994.6.20)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Pxn for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Pxn-RA

FBtr0072951

NM_079167

5139

1527

Pxn-RB

FBtr0072950

NM_167957

2498

457

Pxn-RC

FBtr0072952

NM_206255

5197

1527

Pxn-RD

FBtr0072953

NM_206254

5209

1527

Pxn-RE

FBtr0072954

NM_206253

5296

1527

Additional Transcript Data & Comments

Reported size (kB)

4.9 (compiled cDNA)

(Nelson et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Pxn-PA

FBpp0072828

170.5

1527

6.22

NP_523891

AAF47668

Pxn-PB

FBpp0072827

50.6

457

7.09

NP_728759

AAN11518

Pxn-PC

FBpp0089205

170.5

1527

6.22

NP_995977

AAS64946

Pxn-PD

FBpp0089215

170.5

1527

6.22

NP_995976

AAS64947

Pxn-PE

FBpp0089216

170.5

1527

6.22

NP_995975

AAS64948

Additional Polypeptide Data & Comments

Reported size (kD)

1535 (aa); 150 (kD)

(Nelson et al., 1994)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0011828

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Leucine-rich repeat, cysteine-rich flanking region, N-terminal (IPR000372)

von Willebrand factor, type C (IPR001007)

Leucine-rich repeat (IPR001611)

Haem peroxidase, animal (IPR002007)

Leucine-rich repeat, typical subtype (IPR003591)

Immunoglobulin subtype 2 (IPR003598)

Immunoglobulin subtype (IPR003599)

Immunoglobulin-like (IPR007110)

Haem peroxidase (IPR010255)

Immunoglobulin I-set (IPR013098)

Immunoglobulin-like fold (IPR013783)

Haem peroxidase, plant/fungal/bacterial (IPR002016)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VZZ4

Maps to

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

2114

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

larval stage

gastric caecum

(Nelson et al., 1994)

larval stage

embryonic/larval fat body

(Nelson et al., 1994)

embryonic stage

hemocyte

(Nelson et al., 1994)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

embryonic stage

basal lamina

(Nelson et al., 1994)

embryonic stage

hemocyte

(Nelson et al., 1994)

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI534422
AI388144

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011828

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0011828

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0011828

BDGP expression data

•

Show all BDGP original images, annotations and embryonic microarray data for Pxn

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for Pxn

Stage(s) 11-12

Stage(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Pxn^f07229

Sterility

Allele

fertile

Pxn^f07229

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of Pxn	Mutagen	Stocks	Known lesion
Pxn^MB00459		1	--
Pxn^c02616	piggyBac transposase	1	--
Pxn^f07229	piggyBac transposase	2	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Pxn	Class	Mutagen	Stocks	Known lesion
Pxn^GD5987		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)Aprt-156

Useful duplication

Dp(3;3)SMG38

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD5987}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}Pxn^c02616

PBac{WH}Pxn^f07229

insertion of enhancer trap binary system

Mi{ET1}Pxn^MB00459

Related Comments

Please look at the allele reports for the complete phenotype data

Pxn gene product combines peroxidase and extracellular matrix motifs. The properties and expression pattern of Pxn suggest a unique function in extracellular matrix consolidation, phagocytosis and defense.

(Nelson et al., 1994)

Gene Ontology: Function, Process & Cellular Component ( 6 )

Molecular Function

CV term

Evidence

References

electron donor activity

inferred from electronic annotation with InterPro:IPR010255

(FlyBase Curators et al., 2004-)

heme binding

inferred from electronic annotation with InterPro:IPR002007, InterPro:IPR002016, InterPro:IPR010255

(FlyBase Curators et al., 2004-)