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Gene Dmel\wts

General Information
Symbol	Dmel\wts	Species	D. melanogaster
Name	warts	Annotation symbol	CG12072
Feature type	protein_coding_gene	FlyBase ID	FBgn0011739
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100A5-100A5	Sequence location	3R:26,615,379..26,632,341 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene warts is referred to in FlyBase by the symbol wts (CG12072, FBgn0011739). It has the cytological map location 100A5. Its sequence location is 3R:26615379..26632341. Its molecular function is described as: protein serine/threonine kinase activity; protein binding; specific transcriptional repressor activity; ATP binding. It is involved in the biological processes described with 14 unique terms, many of which group under: anatomical structure development; regulation of biological process; regulation of developmental process; cell proliferation; sensory organ development; developmental growth; biopolymer modification; imaginal disc growth; organ development; positive regulation of programmed cell death; response to ionizing radiation; cell cycle; compound eye development; cellular process. 98 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult; imaginal precursor; adult segment; adult mesothoracic segment; larval imaginal precursor; anatomical structure; sense organ. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100A5-100A5   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100A2-100A5   (Justice, 1995.8.3) 100A1-100A5   (Xu et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	ca (Justice et al., 1995)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: anon-100Aa+ zfh1+ wts- anon-100Ab+ anon-100Aa+ (Xu et al., 1995) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\wts for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wts-RA FBtr0085720  NM_170524   5771   1105
Additional Transcript Data & Comments
Reported size (kB)	~6 (northern blot) (Justice et al., 1995) 5.7, 4.7 (northern blot) (Xu et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein wts-PA   FBpp0085082   122.5   1105   9.85     NP_733403   AAF57085
Additional Polypeptide Data & Comments
Reported size (kD)	1099 (aa) (Xu et al., 1995, Justice et al., 1995)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0011739
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, core (IPR000719) Protein kinase, C-terminal (IPR000961) Serine/threonine protein kinase (IPR002290) Serine/threonine protein kinase, active site (IPR008271) Protein kinase-like (IPR011009) Protein kinase ATP binding, conserved site (IPR017441) Serine/threonine protein kinase-related (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003775 AAF57085   AI517339   BI632945   BI637464   BP552812   BP552813   BT004830 AAO45186   CG12072   CO190869   CO268859   CO268947   CO273864   CO311756   CZ468136   CZ468137   CZ473404   CZ483122   EC053975   EC055042   EC055313   EC055356   EC059527   EC068800   EC071138   EC080977   EC218371   EC220893   EC225308   L39837 AAA73959   U29608 AAA70336   Z32153
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24096 Q24590 Q86NM6 Q9VA38
Maps to
Does NOT map to
Identified with	GH28053 SD19495 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References sequence variant wts[100Aa-4] 3R:26,617,931..26,620,211 comment=reported as a 0.3 kb deletion in exon 3 evidence=experimental (Xu et al., 1995) sequence variant wts[100Aa-1] 3R:26,619,620..26,620,065 comment=446 bp deleted in mutants, removing codons 92 to 238 and causing a frame shift from codon 239. evidence=experimental (Xu et al., 1995)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 11400
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage-adult stage   (Xu et al., 1995)  adult stage | male   (Xu et al., 1995)  adult stage | female   (Xu et al., 1995)  embryonic stage | 0-4hr   (Xu et al., 1995)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011739 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0011739 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0011739
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable | recessive wtsGAL4 lethal | recessive wts100Aa-10 wts100Aa-11 wts100Aa-12 wts100Aa-13 wts100Aa-14 wts100Aa-15 wts100Aa-1 wts100Aa-2 wts100Aa-3 wts100Aa-4 wts100Aa-5 wts100Aa-6 wts100Aa-7 wts100Aa-8 wts100Aa-9 wts3-17 wtsE10 wtsE11 wtsE12 wtsE13 wtsE1 wtsE2 wtsE3 wtsE4 wtsE5 wtsE6 wtsE7 wtsE8 wtsE9 wtsMGH1 wtsP10 wtsP11 wtsP12 wtsP13 wtsP14 wtsP15 wtsP16 wtsP17 wtsP18 wtsP19 wtsP1 wtsP20 wtsP21 wtsP22 wtsP23 wtsP24 wtsP25 wtsP26 wtsP27 wtsP28 wtsP29 wtsP30 wtsP31 wtsP32 wtsP3 wtsP4 wtsP5 wtsP6 wtsP7 wtsP8 wtsP9 wtsx1 lethal | partially | pupal stage, with Scer\GAL4ey.PH wtsScer\UAS.L.T:Hsap\MYC lethal | pupal stage | recessive wtsP1X wtsP8 wtse100 wtse119 wtse124 wtse26-1 wtse7-2 wtse78 lethal | pupal stage | somatic clone wtsx1 lethal | pharate adult stage | recessive wtsP2 Other Phenotypes Allele environmental stress response defective | somatic clone wtsx1 cell death decrease | somatic clone wtsx1 hyperplastic wtsP2 wtsP8 wtse26-1 tumorigenic wtsE10 wtsE11 wtsE12 wtsE13 wtsE1 wtsE2 wtsE3 wtsE4 wtsE5 wtsE6 wtsE7 wtsE8 wtsE9 wtsP10 wtsP11 wtsP12 wtsP13 wtsP14 wtsP15 wtsP16 wtsP17 wtsP18 wtsP19 wtsP1 wtsP20 wtsP21 wtsP22 wtsP23 wtsP24 wtsP25 wtsP26 wtsP27 wtsP28 wtsP29 wtsP30 wtsP31 wtsP32 wtsP3 wtsP4 wtsP5 wtsP6 wtsP7 wtsP9 wtsx1 Sterility Allele female sterile wts100Aa-10 wtse53-2 male sterile wts100Aa-10 wtse53-2 Phenotype manifest in Allele ommatidium wts100Aa-10 wtsGMR.PS wtsGMR.PT wtse53-2 head wts100Aa-10 wtse53-2 wing wts100Aa-10 wtse53-2 wing hair | somatic clone wts3-17 eye wtsGMR.PS wtsGMR.PT wtsP8 pigment cell | ectopic | somatic clone wtsMGH1 photoreceptor cell R8 of yellow ommatidium wtsP1 photoreceptor cell R8 of pale ommatidium | supernumerary wtsP1 rhabdomere R8 wtsP1 eye, with Scer\GAL4ey.PH wtsScer\UAS.L.T:Hsap\MYC eye disc, with Scer\GAL4ey.PH wtsScer\UAS.L.T:Hsap\MYC larval central nervous system wtse26-1 dorsal mesothoracic disc & larva wtse26-1 pupa wtse26-1 imaginal disc wtse26-1 cell cycle | somatic clone wtsx1 pigment cell | ectopic wtsx1 photoreceptor cell R8 of yellow ommatidium | supernumerary, with Scer\GAL4GMR.long wtsScer\UAS.X.T:Hsap\MYC photoreceptor cell R8 of pale ommatidium, with Scer\GAL4GMR.long wtsScer\UAS.X.T:Hsap\MYC ommatidium | somatic clone wts5Y2
Classical Alleles ( 86 )
For All Classical Alleles Show
Allele of wts Class Mutagen Stocks Known lesion wts100Aa-10 loss of function ethyl methanesulfonate 0 -- wts100Aa-11 loss of function ethyl methanesulfonate 0 -- wts100Aa-12 loss of function ethyl methanesulfonate 0 -- wts100Aa-13 loss of function ethyl methanesulfonate 0 -- wts100Aa-14 loss of function ethyl methanesulfonate 0 -- wts100Aa-15 loss of function ethyl methanesulfonate 0 -- wts100Aa-1 amorph, loss of function ethyl methanesulfonate 0 Yes wts100Aa-2 loss of function ethyl methanesulfonate 0 -- wts100Aa-3 loss of function ethyl methanesulfonate 0 -- wts100Aa-4 amorph, loss of function ethyl methanesulfonate 0 Yes wts100Aa-5 loss of function ethyl methanesulfonate 0 -- wts100Aa-6 loss of function ethyl methanesulfonate 0 -- wts100Aa-7 loss of function ethyl methanesulfonate 0 -- wts100Aa-8 loss of function ethyl methanesulfonate 0 -- wts100Aa-9 loss of function ethyl methanesulfonate 0 -- wts3-17 ethyl methanesulfonate 1 -- wts5Y2 loss of function 0 Yes wts91 0 -- wtsDG12310 P-element activity 1 -- wtsE10 Δ2-3 0 -- wtsE11 Δ2-3 0 -- wtsE12 Δ2-3 0 -- wtsE13 Δ2-3 0 -- wtsE1 Δ2-3 0 -- wtsE2 Δ2-3 0 -- wtsE3 Δ2-3 0 -- wtsE4 Δ2-3 0 -- wtsE5 Δ2-3 0 -- wtsE6 Δ2-3 0 -- wtsE7 Δ2-3 0 -- wtsE8 Δ2-3 0 -- wtsE9 Δ2-3 0 -- wtsGAL4 P-element activity 0 Yes wtsM72 0 -- wtsMGH1 0 -- wtsP10 Δ2-3 0 Yes wtsP11 Δ2-3 0 Yes wtsP12 Δ2-3 0 Yes wtsP13 Δ2-3 0 Yes wtsP14 Δ2-3 0 Yes wtsP15 Δ2-3 0 Yes wtsP16 Δ2-3 0 Yes wtsP17 Δ2-3 0 Yes wtsP18 Δ2-3 0 Yes wtsP19 Δ2-3 0 Yes wtsP1 hypomorph Δ2-3 0 Yes wtsP1X Δ2-3 0 Yes wtsP20 Δ2-3 0 Yes wtsP21 Δ2-3 0 Yes wtsP22 Δ2-3 0 Yes wtsP23 Δ2-3 0 Yes wtsP24 Δ2-3 0 Yes wtsP25 Δ2-3 0 Yes wtsP26 Δ2-3 0 Yes wtsP27 Δ2-3 0 Yes wtsP28 Δ2-3 0 -- wtsP29 Δ2-3 0 Yes wtsP2 Δ2-3 0 Yes wtsP30 Δ2-3 0 Yes wtsP31 Δ2-3 0 Yes wtsP32 Δ2-3 0 Yes wtsP3 Δ2-3 0 Yes wtsP4 Δ2-3 0 -- wtsP509-19 wild-type allele P-element activity 0 Yes wtsP5 Δ2-3 0 Yes wtsP6 Δ2-3 0 Yes wtsP7 Δ2-3 0 Yes wtsP8 Δ2-3 0 Yes wtsP9 Δ2-3 0 Yes wtsR23 ethyl methanesulfonate 0 -- wtsSH15 ethyl methanesulfonate 0 -- wtsSH16 ethyl methanesulfonate 0 -- wtsXTN33A 0 -- wtsc02680 piggyBac transposase 1 -- wtsd03508 P-element activity 1 -- wtse100 Δ2-3 0 Yes wtse119 Δ2-3 0 Yes wtse124 Δ2-3 0 -- wtse148 Δ2-3 0 -- wtse26-1 Δ2-3 0 Yes wtse53-2 Δ2-3 0 -- wtse7-2 Δ2-3 0 Yes wtse78 Δ2-3 0 Yes wtsf00653 piggyBac transposase 1 -- wtsunspecified 0 -- wtsx1 amorph, loss of function 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wts Class Mutagen Stocks Known lesion wtsAct5C.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wtsAct5C.T:SV5\V5 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wtsAct5C.cHa.T:SV5\V5 in vitro construct | coding region fusion in vitro construct | regulatory fusion 0 Yes wtsGD1563 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes wtsGMR.PS in vitro construct | regulatory fusion 0 Yes wtsGMR.PT in vitro construct | regulatory fusion 0 Yes wtsScer\UAS.L.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wtsScer\UAS.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wtsScer\UAS.X.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes wtsY1098F.hs in vitro construct | site directed mutagenesis 0 Yes wtsdsRNA.0.7 in vitro construct | RNAi 0 Yes wtshs.PX in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3R)20   Df(3R)tll-g
Useful duplication	Dp(3;3)516
Disrupted in	Df(3R)20 (Lai et al., 1993, Xu et al., 1995) Df(3R)A177.X1 (Zilian et al., 1999, Justice et al., 1995) Df(3R)A177.X3 (Zilian et al., 1999) Df(3R)A177der20 (Zilian et al., 1999, Justice et al., 1995) Df(3R)A177der21 (Zilian et al., 1999, Justice et al., 1995) Df(3R)A177der25 (Zilian et al., 1999, Justice et al., 1995) Df(3R)A177der26 (Zilian et al., 1999, Justice et al., 1995) Df(3R)Exel8194 (Ryder, 2004.4.26) Df(3R)P75A.A1 (Justice et al., 1995) Df(3R)PH3 (Zilian et al., 1999) Df(3R)e100 (Xu et al., 1995) Df(3R)e119 (Xu et al., 1995) Df(3R)e78 (Xu et al., 1995) Df(3R)tll-g (Cook, 2006.1.31) Df(3R)tll-pgx (Lai et al., 1993, Xu et al., 1995)
Not disrupted in	Df(3R)A113 (Zilian et al., 1999, Justice et al., 1995) Df(3R)A177der22 (Zilian et al., 1999) Df(3R)PGX8 (Zilian et al., 1999) Df(3R)X3F (Cook, 2006.1.31) Df(3R)tll-e (Cook, 2006.1.31, Lai et al., 1993, Xu et al., 1995, Justice et al., 1995)
Not duplicated in	Ts(YLt;3Rt)A113 (Justice et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1563} NA P{UAS-wts.L.MYC} NA P{UAS-wts.MYC} NA P{UAS-wts.X.MYC} NA characterization construct P{GMR-lats.S} NA P{GMR-wts.T} NA heat-shock construct P{hs-lats.Y1098F} NA