Gene Dmel\tsr

General Information
Symbol	Dmel\tsr	Species	D. melanogaster
Name	twinstar	Annotation symbol	CG4254
Feature type	protein_coding_gene	FlyBase ID	FBgn0011726
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60B5-60B5	Sequence location	2R:19,931,971..19,934,359 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene twinstar is referred to in FlyBase by the symbol tsr (CG4254, FBgn0011726). It has the cytological map location 60B5. Its sequence location is 2R:19931971..19934359. Its molecular function is described as actin binding. It is involved in the biological processes described with 13 unique terms, many of which group under: anatomical structure development; actin filament-based process; establishment of planar polarity; cellular macromolecule metabolic process; organelle organization and biogenesis; cell division; organ development; cell motility; cell cycle; cell projection organization and biogenesis. 41 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; adult segment; cytoplasmic part; cell cycle; follicle cell; M phase of meiotic cell cycle; actin cytoskeleton; adult cuticle. It has one annotated transcript and one annotated polypeptide.
External Summaries

Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B5-60B5 Limits computationally determined from genome sequence between P{lacW}Phm^k07623&P{lacW}tsr^k05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A-60B (Edwards, 1994.3.30) 60B4-60B5 (determined by in situ hybridisation) (Spradling et al., 1999) 60A-60D (Chen, 1998.3.12) 60B4-60B5 (Beaton, 1997.12.27) 60A10-60B1 (determined by in situ hybridisation) (Gunsalus et al., 1995) 60B3-60B5 60B4--5 (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)	sp (Chen et al., 2001)
Right of (cM)	px (Chen et al., 2001)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\tsr for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tsr-RA FBtr0072188 NM_057686 771 148
Additional Transcript Data & Comments
Reported size (kB)	0.8-0.9 (northern blot) (Gunsalus et al., 1995) 0.7 (longest cDNA) (Edwards et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein tsr-PA FBpp0072097 17.2 148 7.24 NP_477034 AAF47146
Additional Polypeptide Data & Comments
Reported size (kD)	17 (aa); 148 (kD) (Gunsalus et al., 1995) 148 (aa) (Edwards et al., 1994)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0011726
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263578 AA441478 AA567190 AA696258 AA736147 AA803668 AA820621 AA950590 AC004642 AE003462 AAF47146 AI062940 AI134359 AI257183 AI258047 AI258758 AI296681 AI388171 AI515146 AI532163 AQ025765 BE975668 BG635436 BG636345 BG637061 BG639642 BG640305 BG640922 BG640963 BG641023 BI163684 BI163855 BI163979 BI164557 BI165896 BI167550 BI168201 BI168542 BI168742 BI169605 BI169777 BI173013 BI173748 BI212464 BI212838 BI213140 BI213748 BI214384 BI228990 BI229923 BI230093 BI231082 BI234998 BI235736 BI235807 BI235872 BI237462 BI239669 BI240987 BI241714 BI242007 BI243593 BI243862 BI352062 BI353433 BI353442 BI354007 BI357222 BI358216 BI361453 BI361515 BI361765 BI362767 BI364447 BI366616 BI367543 BI367862 BI373675 BI374178 BI481678 BI481873 BI482368 BI482884 BI483138 BI483933 BI486288 BI486440 BI577775 BI579843 BI580702 BI632401 BI635774 BI636103 BI636258 BI637314 BI638401 BI638488 BI638498 BI638616 BI641712 BI641970 BP541076 BP541335 BP541507 BP541988 BP542128 BP542517 BP542734 BP543329 BP543330 BP543461 BP543462 BP543652 BP543653 BP543867 BP543868 BP544163 BP544164 BP545037 BP545038 BP545591 BP545592 BP545748 BP545804 BP545840 BP545855 BP546081 BP546090 BP546363 BP546970 BP547072 BP547249 BP547748 BP547950 BP548057 BP548192 BP548549 BP549390 BP549391 BP551162 BP551163 BP551554 BP551555 BP551865 BP551866 BP553963 BP553964 BP554111 BP554112 BP555555 BP555556 BP555588 BP556464 BP556465 BT022688 CK660618 CL868481 CO152691 CO152730 CO152962 CO153217 CO153336 CO153376 CO153498 CO153834 CO154303 CO154574 CO154708 CO155612 CO155927 CO156378 CO156540 CO156932 CO179886 CO180062 CO180458 CO180478 CO180889 CO181316 CO181666 CO181855 CO182172 CO182565 CO184367 CO185555 CO186986 CO191197 CO191239 CO191396 CO192678 CO195009 CO195619 CO284037 CO305108 CO329407 CO335475 CO335888 CO336218 CO336269 CZ469867 CZ474596 CZ489582 EC056966 EC057023 EC206371 EC249103 EC250660 EC260837 EC260849 EC262685 EC262849 EC262945 EC262981 EC263037 EC263063 EC263242 EC264588 EC265020 EC265361 EC265371 EC265469 EC265979 EC266749 EC267202 EC267221 EC267375 U08217