A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\rpr

General Information
SymbolDmel\rprSpeciesD. melanogaster
NamereaperAnnotation symbolCG4319
Feature typeprotein_coding_geneFlyBase IDFBgn0011706
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map75C6-75C6Sequence location3L:18,390,653..18,391,503 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene reaper is referred to in FlyBase by the symbol rpr (CG4319, FBgn0011706). It has the cytological map location 75C6. Its sequence location is 3L:18390653..18391503. Its molecular function is described as phospholipid binding. It is involved in the biological processes described with 17 unique terms, many of which group under: programmed cell death; cell death; positive regulation of programmed cell death; anatomical structure development; regulation of metabolic process; cellular macromolecule metabolic process; regulation of developmental process; regulation of apoptosis; response to DNA damage stimulus; biopolymer modification; negative regulation of cellular biosynthetic process; embryonic development via the syncytial blastoderm; catabolic process; ovarian nurse cell to oocyte transport. 61 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; adult segment; adult mesothoracic segment; thoracic segment; adult; embryonic nervous system; embryonic neuron; follicle cell. It has one annotated transcript and one annotated polypeptide.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
75C6-75C6  
Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
75C1-75C2
 
(White, 1994.6.13)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: W- CG7320? CheA75a? CG5103? CG13700? grim- rpr- skl-
(Wing et al., 2002)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\rpr for information on other features
detailed view FBtr0075120 FBpp0074886 FBti0033630 FBti0023609 FBti0028181 FBti0033700 FBti0057213
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
rpr-RA
FBtr0075120
 NM_079414
  851
  65
Additional Transcript Data & Comments
Reported size (kB)
1.3 (northern blot)
(White et al., 1994)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
rpr-PA  
FBpp0074886  
7.7  
65  
10.53  
  NP_524138
  AAF49264
Additional Polypeptide Data & Comments
Reported size (kD)
65 (aa)
(White et al., 1994)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003520
AAF49264
 
AX230475
 
BT023284
 
BT029413
 
CO153479
 
EC266358
 
EL870444
 
EL870445
 
EL870446
 
EL870447
 
L31631
AAA18983
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     pupal stage
     salivary gland
    (Lee et al., 2003)
     embryonic stage | stage 12
     segmentally repeated
    (Namba et al., 1997)
    Marker for
    Subcellular Localization
    CV Term
    hide Summary of Polypeptide Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide External Data & Images
      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      •
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      •
      hide Alleles & Phenotypes
      hide Summary of Allele Phenotypes
      Lethality
      Allele
      viable, with Scer\GAL4GMR.PF
      viable, with Scer\GAL4Ilp2.PR
      viable, with Scer\GAL4Akh.PL
      viable, with Scer\GAL4rdgC.PK
      viable, with Scer\GAL4sal.BO, Scer\GAL80svp.3kb
      viable, with Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL
      viable, with Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      viable, with Scer\GAL4AD.Ccap.T:Zzzz\ZipEERRL,T:SV40\nls2
      viable, with Hsim\VP16AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2
      lethal
      lethal | dominant | conditional - heat sensitive
      lethal | embryonic stage, with Scer\GAL4elav.PLu
      lethal | embryonic stage, with Scer\GAL4en-e16E
      lethal | larval stage | polyphasic, with Scer\GAL4sal.BO
      lethal | larval stage, with Scer\GAL4puc-GAL4E69
      lethal | pupal stage, with Scer\GAL4GMR.PF
      lethal | pupal stage, with Scer\GAL4unspecified
      lethal | pupal stage, with Scer\GAL4Ccap.PP
      lethal | pupal stage, with Scer\GAL4sal.BO, Scer\GAL80ts.αTub84B
      lethal | pupal stage, with Hsim\VP16AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2, Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      lethal, with Scer\GAL4GMR.PF
      lethal, with Scer\GAL4ato.3.6
      semi-lethal | larval stage, with Scer\GAL4Eh.2.4
      Other Phenotypes
      Allele
      visible
      visible | dominant
      visible | somatic clone
      visible, with Scer\GAL4GMR.PF
      visible, with sd213-440.hs.T:Scer\GAL4
      small body, with Scer\GAL4Ilp2.PR
      small body, with Scer\GAL4Ilp2.215-3
      reduced cell number, with Scer\GAL4Ilp2.PR
      reduced cell size, with Scer\GAL4Ilp2.PR
      aging defective, with Scer\GAL4Ilp2.PR
      long lived, with Scer\GAL4Ilp2.215-3
      behavior defective | larval stage | recessive
      locomotor rhythm defective | male, with Scer\GAL4npf.1
      locomotor rhythm defective, with Scer\GAL4P2.4.Pdf
      eclosion rhythm defective, with Scer\GAL4Eh.2.4
      eclosion rhythm defective, with Scer\GAL4Ccap.PP
      courtship defective | male, with Scer\GAL4npf.1
      chemosensitive behavior defective, with Scer\GAL4Ilp2.215-3
      chemosensitive behavior defective, with Scer\GAL4Or35a
      heat stress response defective, with Scer\GAL4Ilp2.215-3
      feeding behavior defective | second instar larval stage, with Scer\GAL4sal.BO
      cell death defective
      cell death defective | somatic clone, with Scer\GAL4Act5C.PP
      cell death defective, with Scer\GAL4Eh.2.4
      cell death increase
      cell death increase | conditional - heat sensitive
      cell death increase, with Scer\GAL4en-e16E
      cell death increase, with Scer\GAL4GMR.PF
      cell death increase, with Scer\GAL4179Y
      cell death increase, with Scer\GAL4Eh.2.4
      cell death increase, with Scer\GAL4slbo.2.6
      cell death increase, with Scer\GAL4Appl.G1a
      cell death increase, with Scer\GAL4Act5C.PHb
      cell death increase, with Scer\GAL4P2.4.Pdf
      cell death increase, with Scer\GAL4P2.4.Pdf, Scer\GAL4Rh5.PT
      cell death increase, with Scer\GAL4Ccap.PP
      cell death decrease
      cell death decrease (with Df(3L)H99)
      neurophysiology defective, with Scer\GAL4Or22b.10287
      neurophysiology defective, with Scer\GAL4Or22a.8197
      neurophysiology defective, with Scer\GAL4Or33c.PG
      neurophysiology defective, with Scer\GAL4Or46a.PG
      neurophysiology defective, with Scer\GAL4Or42a.PG
      neurophysiology defective, with Scer\GAL4Or71a.PG
      neurophysiology defective, with Scer\GAL4Or85e.PG
      neurophysiology defective, with Scer\GAL4Or35a
      neuroanatomy defective, with Scer\GAL4Or33c.PG
      neuroanatomy defective, with Scer\GAL4Or46a.PG
      neuroanatomy defective, with Scer\GAL4Or42a.PG
      neuroanatomy defective, with Scer\GAL4Or71a.PG
      neuroanatomy defective, with Scer\GAL4Or85e.PG
      developmental rate defective, with Scer\GAL4ato.3.6
      developmental rate defective, with Scer\GAL4Ilp2.PR
      developmental rate defective, with Scer\GAL4Ilp2.215-3
      Sterility
      Allele
      fertile | reduced, with Scer\GAL4Ilp2.215-3
      fertile, with Scer\GAL4Akh.PL
      female fertile | reduced, with Scer\GAL4Ilp2.215-3
      Phenotype manifest in
      Allele
      eye
      eye, with Scer\GAL4GMR.PF
      ommatidium, with Scer\GAL4GMR.PF
      interommatidial bristle, with Scer\GAL4GMR.PF
      ommatidium
      eye | somatic clone
      interommatidial bristle
      eye disc
      eye photoreceptor cell
      dMP2 neuron & stage 17 embryo (with Df(3L)H99)
      MP1 neuron & stage 17 embryo (with Df(3L)H99)
      wing, with Scer\GAL4Ilp2.PR
      follicle cell, with Scer\GAL4Ilp2.PR
      corpus cardiacum, with Scer\GAL4Akh.PG
      dorsomedial neurosecretory cell, with Scer\GAL4Ilp2.215-3
      oocyte, with Scer\GAL4Ilp2.215-3
      wing, with Scer\GAL4Ilp2.215-3
      abdominal lateral pentascolopidial chordotonal organ lch5 & scolopidial ligament cell & stage 16 embryo, with Scer\GAL4repo
      lch5 ligament attachment cell & stage 16 embryo, with Scer\GAL4repo
      larval oenocyte, with Scer\GAL4sal.BO
      lipid droplet & larval fat body, with Scer\GAL4sal.BO
      wing, with Scer\GAL4Ccap.PP
      neuron, with Scer\GAL4Ccap.PP
      wing, with Scer\GAL4AD.Ccap.T:Zzzz\ZipEERRL,T:SV40\nls2, Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL
      neuron, with Scer\GAL4AD.Ccap.T:Zzzz\ZipEERRL,T:SV40\nls2, Scer\GAL4DBD.elav.T:Zzzz\ZipRREEL
      subesophageal ganglion neuron, with Hsim\VP16N4, Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      thoracic ganglion, with Hsim\VP16N4, Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      wing, with Hsim\VP16N4, Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      neuron, with Hsim\VP16N6, Scer\GAL4DBD.Ccap.T:Zzzz\ZipRREEL
      follicle cell | somatic clone, with Scer\GAL4Act5C.PP
      nurse cell | somatic clone, with Scer\GAL4Act5C.PP
      follicle cell & nucleus | somatic clone, with Scer\GAL4Act5C.PP
      nurse cell & nucleus | somatic clone, with Scer\GAL4Act5C.PP
      nurse cell ring canal | somatic clone, with Scer\GAL4Act5C.PP
      nurse cell & cytoskeleton | somatic clone, with Scer\GAL4Act5C.PP
      wing, with Scer\GAL4vg.PM
      macrochaeta & scutellum, with Scer\GAL4sca-537.4
      macrochaeta & mesothoracic tergum, with Scer\GAL4sca-537.4
      macrochaeta & tergum, with Scer\GAL4sca-537.4
      border follicle cell, with Scer\GAL4slbo.2.6
      larval hindgut & ectoderm, with Scer\GAL4455.2
      hindgut visceral muscle primordium, with Scer\GAL4455.2
      U neuron, with Scer\GAL4eve.CQ2
      pCC neuron, with Scer\GAL4eve.RN2
      RP2 neuron, with Scer\GAL4eve.RN2
      aCC neuron, with Scer\GAL4eve.RN2
      U neuron, with Scer\GAL4eve.CQ2, Scer\GAL4eve.RN2
      pCC neuron, with Scer\GAL4eve.CQ2, Scer\GAL4eve.RN2
      RP2 neuron, with Scer\GAL4eve.CQ2, Scer\GAL4eve.RN2
      aCC neuron, with Scer\GAL4eve.CQ2, Scer\GAL4eve.RN2
      wing, with sd213-440.hs.T:Scer\GAL4
      wing vein | ectopic, with sd213-440.hs.T:Scer\GAL4
      wing vein L2, with sd213-440.hs.T:Scer\GAL4
      wing vein L4, with sd213-440.hs.T:Scer\GAL4
      wing vein L5, with sd213-440.hs.T:Scer\GAL4
      large sensillum basiconicum of antennal segment 3 & olfactory neuron, with Scer\GAL4Or22a.8197
      large sensillum basiconicum of antennal segment 3 & olfactory neuron, with Scer\GAL4Or22b.10287
      olfactory neuron & maxillary palp sense organ, with Scer\GAL4Or42a.PG
      olfactory neuron & maxillary palp sense organ, with Scer\GAL4Or71a.PG
      olfactory neuron & maxillary palp sense organ, with Scer\GAL4Or85e.PG
      olfactory neuron & maxillary palp sense organ, with Scer\GAL4Or33c.PG
      olfactory neuron & maxillary palp sense organ, with Scer\GAL4Or46a.PG
      olfactory sensory organ, with Scer\GAL4Or35a
      neuron & larva, with Scer\GAL4Ccap.PP
      adult head, with Scer\GAL4Ccap.PP
      leg, with Scer\GAL4Ccap.PP
      abdominal dorsal/lateral multidendritic neuron, with Scer\GAL4Ccap.PP
      ventral adult lateral neuron, with Scer\GAL4P2.4.Pdf
      ventral midline glia, with Scer\GAL4Gp150-52A
      centripetally migrating follicle cell, with Scer\GAL4slbo.2.6
      follicle cell, with Scer\GAL4slbo.2.6
      photoreceptor cell R5, with Scer\GAL4Rh5.PT
      embryonic/larval trachea | dorsal, with Scer\GAL4Eh.2.4
      neuron & larva, with Scer\GAL4Eh.2.4
      adult cuticle, with Scer\GAL4Eh.2.4
      wing, with Scer\GAL4Eh.2.4
      EH neurosecretory neuron, with Scer\GAL4Eh.2.4
      larval mouth, with Scer\GAL4Eh.2.4
      Tv neuron, with Scer\GAL4Fmrf.PS
      larval mouth, with Scer\GAL4Ccap.PP, Scer\GAL4Eh.2.4
      embryo
      hide Classical Alleles ( 1 )
      For All Classical Alleles Show

      Allele of rprClassMutagenStocksKnown lesion
      rprNP0520
        		1 Yes
        hide Alleles Carried on Transgenic Constructs ( 60 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of rprClassMutagenStocksKnown lesion
        rpr1-15.T:Avic\GFP0 Yes
        rprAKP.Ub.GMR0 Yes
        rprAKP.Ub.MtnA0 Yes
        rprAVA.Ub.GMR0 Yes
        rprAVA.Ub.MtnA0 Yes
        rprAla1.MtnA.T:Scer\Ubi40 Yes
        rprC.Scer\UAS0 Yes
        rprE29A.MtnA.T:Ivir\HA10 Yes
        rprGD46981 Yes
        rprGH3.MtnA.T:Avic\GFP-EGFP0 Yes
        rprGMR.PA0 Yes
        rprGMR.PH1 Yes
        rprGMR.PW0 Yes
        rprGMR.PY
          		0 --
          rprIE1.PJ0 Yes
          rprKP.Ub.GMR0 Yes
          rprKP.Ub.MtnA0 Yes
          rprKR.MtnA0 Yes
          rprKR.ΔGH3.MtnA0 Yes
          rprL35Q.A36R.MtnA0 Yes
          rprLys-.GMR0 Yes
          rprMtnA.PD0 Yes
          rprMtnA.PF0 Yes
          rprMtnA.PK0 Yes
          rprMtnA.PO0 Yes
          rprMtnA.PP0 Yes
          rprMtnA.T:Avic\GFP-EGFP0 Yes
          rprMtnA.T:Ivir\HA10 Yes
          rprMtnA.T:SV5\V50 Yes
          rprMtnA.T:Scer\Ubi40 Yes
          rprMtnA.T:Zzzz\TAP0 Yes
          rprNT1B10 Yes
          rprScer\UAS.C2 Yes
          rprScer\UAS.cCa0 Yes
          rprScer\UAS.cIa0 Yes
          rprScer\UAS.cJa0 Yes
          rprScer\UAS.cMa0 Yes
          rprScer\UAS.cVa0 Yes
          rprScer\UAS.cYa0