Gene Dmel\Dms

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General Information

Symbol

Dmel\Dms

Species

D. melanogaster

Name

Dromyosuppressin

Annotation symbol

CG6440

Feature type

protein_coding_gene

FlyBase ID

FBgn0011581

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

95F14-95F14

Sequence location

3R:20,167,275..20,169,407 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Dromyosuppressin is referred to in FlyBase by the symbol Dms (CG6440, FBgn0011581). It has the cytological map location 95F14. Its sequence location is 3R:20167275..20169407. Its molecular function is described as neuropeptide hormone activity. It is involved in the biological processes: neuropeptide signaling pathway; negative regulation of heart contraction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95F14-95F14

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

96A1-96A1

(Nichols et al., 1995)

96A-96A

(determined by in situ hybridisation)

(Nichols, 1995)

Experimentally Determined Recombination Data

Location

(Nichols et al., 1995)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Dms for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Dms-RA

FBtr0084607

NM_080511

923

100

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Dms-PA

FBpp0083991

11.1

100

8.33

NP_536772

AAF56283

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P61849

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

GH10451

(BDGP Project Members, 2000-, Hewes and Taghert, 2001)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

10602

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI113930

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011581

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0011581

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0011581

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Dms	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Dms	Class	Mutagen	Stocks	Known lesion
Dms^GD4874		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes
Dms^TDVDHVFLRF		in vitro construct \| other	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)crb87-4

Useful duplication

Dp(3;3)M95A⁺13

Disrupted in

Df(3R)Exel6199

(Ryder, 2004.4.26)

Df(3R)Exel8178

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4874}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

neuropeptide hormone activity

traceable author statement

(vanden Broeck, 2001)

non-traceable author statement

(Hewes and Taghert, 2001)

traceable author statement

(Baggerman et al., 2002)

inferred from sequence or structural similarity with EMBL:U50341

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

negative regulation of heart contraction

inferred from direct assay

(Johnson et al., 2000)

neuropeptide signaling pathway

traceable author statement

(vanden Broeck, 2001)

traceable author statement

(Baggerman et al., 2002)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Dms allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68977

Orthologs

Genome-wide drosophilid orthologs

Dana\GF20742

Dere\GG11282

Dgri\GH18813

Dmoj\GI10071

Dper\GL21855

Dpse\GA19595

Dsec\GM26590

Dsim\GD21092

Dvir\GJ23807

Dwil\GK22333

Dyak\GE23474

Curated drosophilid orthologs

Dpse\GA19595

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011771
Anopheles gambiae (Ensembl)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

VDRC

v12975

w¹¹¹⁸; P{GD4874}v12975/TM3

Genomic Clones ( 1 )

BACR04E17

cDNA Clones ( 19 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

GH10451

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0011581

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0011581

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Dms CG6440

(Hewes and Taghert, 2001)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

The pattern of Dms protein expression during development has been analysed.

(McCormick and Nichols, 1993)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_080511

RefSeq (Proteins)

•

NP_536772

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

P61849

Other Crossreferences

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68977

DEDB - Drosophila exon database: splicing graphs

•

10602

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0011581

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011581

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0011581

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0011581

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0011581

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0011581

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011771
Anopheles gambiae (Ensembl)

Synonyms & Secondary IDs ( 15 )

Reported As

Symbol Synonym

CG6440

(Hewes and Taghert, 2001, )

cg6440

(Kadener et al., 2006)

DMS

(Johnson et al., 2003, vanden Broeck, 2001)

Dms

dms

(Melcher and Pankratz, 2005)

Drm-MS

(Baggerman et al., 2002, Meeusen et al., 2002, Cazzamali and Grimmelikhuijzen, 2002, vanden Broeck, 2001)

Drome-MS

(Egerod et al., 2003)

FLRFa

(vanden Broeck, 2001)

(Yapici et al., 2008)

Nems

(Whitfield, 2000.10.30, )

Name Synonym

dromyosuppressin

(Veenstra, 2000, Hewes and Taghert, 2001)

Dromyosuppressin

myosuppressin

(Feng et al., 2003, Egerod et al., 2003, Cazzamali et al., 2003, Rosenkilde et al., 2003, Egerod et al., 2003, Yapici et al., 2008)

Neomyosuppressin

TDVDHVFLRFamide

(Nichols, 1992)

Secondary FlyBase IDs

FBgn0013996
FBgn0039185

References ( 38 )

Generate a list of

All references relating to this gene ( 38 )

List References by type

Recent research papers ( 2 )

Yapici et al., 2008, Nature 451(7174): 33--37: A receptor that mediates the post-mating switch in Drosophila reproductive behaviour. [FBrf0202765]
Kadener et al., 2006, Proc. Natl. Acad. Sci. USA 103(36): 13537--13542: Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. [FBrf0194527]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2006

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