Gene Dmel\heph

General Information
Symbol	Dmel\heph	Species	D. melanogaster
Name	hephaestus	Annotation symbol	CG31000
Feature type	protein_coding_gene	FlyBase ID	FBgn0011224
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D3-100E1	Sequence location	3R:27,676,731..27,819,000 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene hephaestus is referred to in FlyBase by the symbol heph (CG31000, FBgn0011224). It has the cytological map location 100D3-100E1. Its sequence location is 3R:27676731..27819000. Its molecular function is described as: poly-pyrimidine tract binding; mRNA binding; nucleotide binding. It is involved in the biological processes: spermatid development; nuclear mRNA splicing, via spliceosome; Notch signaling pathway; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis. 74 alleles are reported. The phenotypes of these alleles are annotated with: wing vein; wing margin; wing; testis; spermatozoon; late spermatid; macrochaeta; germ cell. It has 14 annotated transcripts and 14 annotated polypeptides.
External Summaries

Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D3-100E1 Limits computationally determined from genome sequence between P{EP}pygo^EP1076 and P{PZ}ttk⁰²⁶⁶⁷&P{lacW}ttk^j6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100F-100F (determined by in situ hybridisation) (Weber, 2005) 100F-100F (Standiford, 1999.12.3) 100F1-100F5 (determined by in situ hybridisation) 100E1--3 (determined by in situ hybridisation) (Spradling et al., 1999) 100F1-100F5 74D3--5 100E1--3 (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\heph for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) heph-RA FBtr0085879 NM_170582 3341 608 heph-RB FBtr0085878 NM_170581 2880 608 heph-RC FBtr0085880 NM_079964 2990 581 heph-RD FBtr0085882 NM_176596 2923 608 heph-RE FBtr0085883 NM_176597 3797 608 heph-RF FBtr0085888 NM_176598 3406 608 heph-RG FBtr0085887 NM_176599 2997 615 heph-RH FBtr0085881 NM_176603 3466 789 heph-RI FBtr0085884 NM_176600 3033 608 heph-RJ FBtr0085885 NM_176601 3092 608 heph-RK FBtr0085886 NM_176602 2854 608 heph-RL FBtr0112864 NM_001104522 3075 622 heph-RM FBtr0112865 NM_001104523 3175 568 heph-RN FBtr0112866 NM_001104524 3046 608
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein heph-PA FBpp0085238 65.5 608 9.25 NP_733461 AAN14297 heph-PB FBpp0085237 65.5 608 9.25 NP_733460 AAF57208 heph-PC FBpp0085239 62.6 581 9.36 NP_524703 AAN14296 heph-PD FBpp0085241 65.5 608 9.25 NP_788773 AAO41620 heph-PE FBpp0085242 65.5 608 9.25 NP_788774 AAO41621 heph-PF FBpp0085247 65.5 608 9.25 NP_788775 AAO41622 heph-PG FBpp0085246 66.3 615 9.25 NP_788776 AAO41623 heph-PH FBpp0085240 84.6 789 9.32 NP_788780 AAO41627 heph-PI FBpp0085243 65.5 608 9.25 NP_788777 AAO41624 heph-PJ FBpp0085244 65.5 608 9.25 NP_788778 AAO41625 heph-PK FBpp0085245 65.5 608 9.25 NP_788779 AAO41626 heph-PL FBpp0111777 67.3 622 9.21 NP_001097992 ABW08816 heph-PM FBpp0111778 61.2 568 9.47 NP_001097993 ABW08817 heph-PN FBpp0111779 65.5 608 9.25 NP_001097994 ABW08818
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0011224
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif, RNP-1 (IPR000504) HnRNP-L/PTB/hephaestus splicing factor (IPR006536) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142302 AA201355 AA202345 AA202411 AA202699 AA246357 AA264373 AA392237 AA438701 AA540904 AA698868 AA735919 AA948855 AE003780 AAF57208 AE003780 AAN14296 AE003780 AAN14297 AE003780 AAO41620 AE003780 AAO41621 AE003780 AAO41622 AE003780 AAO41623 AE003780 AAO41624 AE003780 AAO41625 AE003780 AAO41626 AE003780 AAO41627 AF211191 AAF22979 AF373596 AF436844 AAL27010 AF455053 AAL57860 AI387029 AI388789 AI512776 AI520203 AQ026438 AW942041 AY052367 AAL14775 AY069318 AAL39463 AY118448 AAM48477 AY628765 AAT72299 BF485596 BF504718 BI163823 BI164745 BI169271 BI212513 BI230813 BI240537 BI242229 BI357878 BI362798 BI363479 BI363535 BI363838 BI370291 BI374153 BI482383 BI579247 BI640181 BP541217 BP541218 BT025074 BT030984 BT032832 CL943562 CO176919 CO176970 CO178194 CO181728 CO186354 CO190945 CO263356 CO263824 CO264447 CO265341 CO265814 CO269597 CO270670 CO271022 CO273696 CO276510 CO276794 CO277741 CO282395 CO287655 CO287859 CO289699 CO290755 CO292428 CO292565 CO296547 CO298846 CO301945 CO304294 CO307591 CO310246 CO310899 CO313091 CO314026 CO314405 CO316085 CO318556 CO319292 CO320327 CO320638 CO321684 CO323549 CO323649 CO326952 CO332498 CO339598 CO341401 CO344802 CZ466145 CZ466200 CZ466226 CZ466234 CZ466280 CZ466302 CZ466308 CZ466309 CZ466574 CZ466679 CZ466758 CZ466759 CZ466774 CZ466799 CZ466876 CZ467131 CZ467223 CZ467244<