A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\Ror

General Information
SymbolDmel\RorSpeciesD. melanogaster
NameRorAnnotation symbolCG4926
Feature typeprotein_coding_geneFlyBase IDFBgn0010407
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map 31B1-31B1 Sequence location2L:10,251,838..10,254,686 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol Ror (CG4926, FBgn0010407). It has the cytological map location 31B1. Its sequence location is 2L:10251838..10254686. Its molecular function is described as: transmembrane receptor protein tyrosine kinase activity; protein-tyrosine kinase activity; neurotrophin receptor activity; ATP binding; calcium ion binding. It is involved in the biological processes: central nervous system development; protein amino acid phosphorylation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
31B1-31B1  
Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
31B-31B
 
(Wilson, 1993.9.21)
31B-31C
(determined by in situ hybridisation)  
(Wilson et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: me31B+ chico- bsk- Ror+
(Riesgo-Escovar et al., 1996)
In direction of increasing cytology: Ror? Pten?
(Wilson, 1999.3.4)
In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+
(Huang et al., 1999)
In direction of increasing cytology: chico- bsk- Ror+ Pten-
(Goberdhan et al., 1999)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Ror for information on other features
detailed view FBtr0080087 FBtr0079977 FBtr0079978 FBtr0080086 FBtr0089902 FBtr0089901 FBtr0089900 FBtr0089903 FBtr0089904 FBtr0089905 FBpp0079567 FBpp0079568 FBpp0079675 FBpp0088843 FBpp0088841 FBpp0088839 FBti0040036 FBti0065551 FBti0024141 FBti0018137
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Ror-RA
FBtr0079978
 NM_057614
  2276
  685
Additional Transcript Data & Comments
Reported size (kB)
2.272 (longest cDNA)
(Wilson et al., 1993)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Ror-PA  
FBpp0079568  
78.1  
685  
7.89  
  NP_476962
  AAF52885
Additional Polypeptide Data & Comments
Reported size (kD)
685 (aa)
(Wilson et al., 1993)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Kringle (IPR000001)
Frizzled cysteine-rich domain (IPR000024)
Protein kinase, core (IPR000719)
Tyrosine protein kinase (IPR001245)
Receptor tyrosine kinase, class II, conserved site (IPR002011)
Calcium-binding EF-hand (IPR002048)
Tyrosine protein kinase, active site (IPR008266)
Protein kinase-like (IPR011009)
Kringle-like fold (IPR013806)
Protein kinase ATP binding, conserved site (IPR017441)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AC009849
 
AC092237
 
AE003628
AAF52885
 
AJ002908
CAA05743
 
CO277353
 
EC051026
 
EC053510
 
EC054525
 
EC055360
 
EC055789
 
EC220617
 
L20297
AAA28860
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    (FlyBase, 1992-)
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    aberration junction
    Df(2L)41C.bk2
    2L:10,251,707..10,253,900
    comment=A deficiency generated by imprecise P excision, extending from chico into Ror. Aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator
    evidence=experimental
    linked_to=HindIII-EcoRI_rfrag
    (Goberdhan et al., 1999)
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage | stage >=11
     central nervous system
    (Wilson et al., 1993)
     embryonic stage
     embryonic peripheral nervous system | restricted
    (Wilson et al., 1993)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of RorClassMutagenStocksKnown lesion
        Ror41C
          		0 Yes
          hide Alleles Carried on Transgenic Constructs ( 3 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of RorClassMutagenStocksKnown lesion
          RorGD143771 Yes
          RorGD25360 Yes
          RorGD402 Yes
          hide Aneuploid Aberrations
          Useful deficiency
           
          Useful duplication
           
          Disrupted in
          (Goberdhan et al., 1999)
          (Ryder, 2004.4.26)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD14377}
          NA
          P{GD2536}
          NA
          P{GD40}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          cDNA encoding Ror identified by screening a late-third-instar larval brain library with a PCR-based approach designed to identify receptor tyrosine kinase-encoding genes: from its DNA sequence and neural-specific expression pattern authors conclude ror protein related to vertebrate neurotrophin receptors.
          (Wilson et al., 1993)
          hide Gene Ontology: Function, Process & Cellular Component ( 12 )
          hide Molecular Function
          CV term
          Evidence
          References
          ATP binding
          inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR002011, InterPro:IPR008266, InterPro:IPR017441
          (FlyBase Curators et al., 2004-)
          calcium ion binding
          inferred from electronic annotation with InterPro:IPR002048
          (FlyBase Curators et al., 2004-)
          neurotrophin receptor activity
          non-traceable author statement
          (Wilson, 1993.9.21)
          protein tyrosine kinase activity
          non-traceable author statement
          (Oates, 1997.11.10)
          non-traceable author statement
          (Morrison et al., 2000)
          transmembrane receptor protein tyrosine kinase activity
          inferred from sequence or structural similarity
          (Wilson et al., 1993)
          inferred from sequence or structural similarity with EMBL:AB010384; protein_id:BAA75481.1
          (FlyBase, 1992-)
          non-traceable author statement
          (Wilson, 1993.9.21)
          hide Biological Process
          CV term
          Evidence
          References
          central nervous system development
          inferred from expression pattern
          (Wilson et al., 1993)
          protein amino acid phosphorylation
          inferred from sequence or structural similarity
          (Wilson et al., 1993)
          non-traceable author statement
          (Morrison et al., 2000)
          inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR002011, InterPro:IPR008266, InterPro:IPR017441
          (FlyBase Curators et al., 2004-)
          signal transduction
          inferred from sequence or structural similarity
          (Wilson et al., 1993)
          transmembrane receptor protein tyrosine kinase signaling pathway
          inferred from electronic annotation with InterPro:IPR002011
          (FlyBase Curators et al., 2004-)
          hide Cellular Component
          CV term
          Evidence
          References
          integral to membrane
          non-traceable author statement
          (Wilson et al., 1993)
          membrane
          inferred from electronic annotation with InterPro:IPR002011
          (FlyBase Curators et al., 2004-)
          plasma membrane
          inferred from sequence or structural similarity
          (Wilson et al., 1993)
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          Ror allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
           
          Linkouts
          InParanoid orthologs - Eukaryotic orthologs
          •
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 3 )
          VDRC
          v932
          w1118; P{GD40}v932
          v935
          w1118; P{GD40}v935
          v29930
          w1118 P{GD14377}v29930
          hide Genomic Clones ( 2 )
          hide cDNA Clones ( 6 )
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          hide Antibody Information
          hide Other Information
          hide Discoverer
          hide Etymology
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for database merge of
          Additional comments
          Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
           
          Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
          (Oates, 1997.11.10)
          hide Comments About Role
          hide Comments About Molecular Function
          hide Other Comments
          Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS-induced alleles of bsk.
          (Goberdhan et al., 1995)
          Phylogenetic analysis of the PTK family.
          (Suga et al., 1997)
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          (Kiger et al., 2003)
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          RefSeq (Transcripts)
          •
          RefSeq (Proteins)
          •
          DDBJ / EMBL / GenBank
          •
          UniProtKB/Swiss-Prot
          •
          Other Crossreferences
          InterPro domains - A database of protein families, domains, and functional sites
          •
          Kringle (IPR000001)
          Frizzled cysteine-rich domain (IPR000024)
          Protein kinase, core (IPR000719)
          Tyrosine protein kinase (IPR001245)
          Receptor tyrosine kinase, class II, conserved site (IPR002011)
          Calcium-binding EF-hand (IPR002048)
          Tyrosine protein kinase, active site (IPR008266)
          Protein kinase-like (IPR011009)
          Kringle-like fold (IPR013806)
          Protein kinase ATP binding, conserved site (IPR017441)
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          DEDB - Drosophila exon database: splicing graphs
          •
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          •
          FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
          •
          GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          InParanoid orthologs - Eukaryotic orthologs
          •
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          •
          PANTHER - Protein classification by function, families, and pathways
          •
          hide Synonyms & Secondary IDs ( 7 )
          Reported As
          Symbol Synonym
          CG4926
          (Morrison et al., 2000, )
          DmHD-2
          (Oates, 1997.11.10, Oates et al., 1998, )
          Dror
          (Hidalgo, 2002, Jaaro et al., 2001, Goberdhan and Wilson, 2002, Goberdhan et al., 1999, Wilson, 1993.9.21, Huang et al., 1999, Wilson, 1999.3.4, Oates et al., 1998, Suga et al., 1997, Goberdhan et al., 1997, Wilson et al., 1997, Wilson et al., 1995, Steller and Grether, 1994, Wilson et al., 1993, )
          DRor
          (Bai and Montell, 1998)
          HD-2
           
          ROR
          (Rehn et al., 1998)
          Ror
          (Reeves and Posakony, 2005)
          Name Synonym
          Ror
           
          Secondary FlyBase IDs
          • FBgn0022797
          hide References ( 34 )
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