A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Gtp-bp

General Information
SymbolDmel\Gtp-bpSpeciesD. melanogaster
NameGTP-binding proteinAnnotation symbolCG2522
Feature typeprotein_coding_geneFlyBase IDFBgn0010391
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map10A6-10A6Sequence locationX:11,020,908..11,023,136 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene GTP-binding protein is referred to in FlyBase by the symbol Gtp-bp (CG2522, FBgn0010391). It has the cytological map location 10A6. Its sequence location is X:11020908..11023136. Its molecular function is described as: GTP binding; mRNA binding; signal recognition particle binding; GTPase activity; 7S RNA binding. It is involved in the biological processes: axonogenesis; regulation of protein secretion; SRP-dependent cotranslational protein targeting to membrane. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
10A6-10A6  
Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
11C-11D
 
(Fredieu, 1993.12.20)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Gtp-bp for information on other features
detailed view FBtr0073436 FBtr0073480 FBtr0073479 FBtr0073478 FBtr0073477 FBtr0073475 FBtr0073476 FBpp0073292 FBpp0073336 FBpp0073335 FBpp0073334 FBpp0073333 FBpp0073331 FBpp0073332 FBti0012833
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Gtp-bp-RA
FBtr0073480
 NM_080148
  2074
  614
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Gtp-bp-PA  
FBpp0073336  
67.8  
614  
6.80  
  NP_524887
  AAF48002
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Signal recognition particle, SRP54 subunit, GTPase (IPR000897)
AAA+ ATPase, core (IPR003593)
Signal recognition particle receptor, alpha subunit, N-terminal (IPR007222)
Signal recognition particle, SRP54 subunit, helical bundle (IPR013822)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA142160
 
AA142161
 
AA391187
 
AA695501
 
AA696867
 
AA802475
 
AA817477
 
AA941487
 
AE003485
AAF48002
 
AI107591
 
AI109038
 
AI238528
 
AI257388
 
AI294171
 
AI295141
 
AI297065
 
AI389419
 
AI405887
 
AI518715
 
AI534216
 
AI544140
 
AI546398
 
AW942807
 
AY061329
AAL28877
 
BF494497
 
BF502193
 
BG636399
 
BG636751
 
BG637223
 
BI162904
 
BI168403
 
BI230995
 
BI234996
 
BI236850
 
BI239788
 
BI241996
 
BI353216
 
BI354586
 
BI356287
 
BI370479
 
BI373556
 
BI626876
 
BI639338
 
BI639443
 
BI639675
 
BI641862
 
CK604661
 
CK605273
 
CK660355
 
CK660896
 
CO186088
 
EC053442
 
EC053923
 
EC053948
 
EC053949
 
EC054398
 
EC054960
 
EC061639
 
EC069520
 
EC083664
 
EC084569
 
EC206675
 
EC229672
 
ES690329
 
ES690357
 
ES690378
 
ES690381
 
S65640
AAB27926
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Kopczynski et al., 1998)
    (BDGP Project Members, 2000-, Abrams and Andrew, 2005)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0073436 FBtr0073480 FBtr0073479 FBtr0073478 FBtr0073477 FBtr0073475 FBtr0073476
        AA941487
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for Gtp-bp
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for Gtp-bp
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of Gtp-bpClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Gtp-bpClassMutagenStocksKnown lesion
        Gtp-bpGD64821 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        reporter construct
        P{Gtp-bp-lacZ}
        No
        UAS construct
        P{GD6482}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 12 )
        hide Molecular Function
        CV term
        Evidence
        References
        7S RNA binding
        inferred from electronic annotation with InterPro:IPR000897, InterPro:IPR013822
        (FlyBase Curators et al., 2004-)
        GTP binding
        non-traceable author statement
        (Fredieu, 1993.12.20)
        inferred from electronic annotation with InterPro:IPR000897, InterPro:IPR007222, InterPro:IPR013822
        (FlyBase Curators et al., 2004-)
        GTPase activity
        inferred from electronic annotation with InterPro:IPR007222
        (FlyBase Curators et al., 2004-)
        mRNA binding
        non-traceable author statement
        (Fredieu and Mahowald, 1993)
        signal recognition particle binding
        inferred from sequence or structural similarity with NCBI_gi:4507223
        (FlyBase, 1992-)
        hide Biological Process
        CV term
        Evidence
        References
        SRP-dependent cotranslational protein targeting to membrane
        inferred from electronic annotation with InterPro:IPR000897, InterPro:IPR013822
        (FlyBase Curators et al., 2004-)
        axonogenesis
        inferred from expression pattern
        (Fredieu and Mahowald, 1993)
        regulation of protein secretion
        inferred from expression pattern
        (Fredieu and Mahowald, 1993)
        hide Cellular Component
        CV term
        Evidence
        References
        endoplasmic reticulum membrane
        inferred from direct assay
        (Fredieu and Mahowald, 1993)
        lipid particle
        inferred from direct assay
        (Cermelli et al., 2006)
        signal recognition particle
        inferred from electronic annotation with InterPro:IPR013822
        (FlyBase Curators et al., 2004-)
        signal recognition particle receptor complex
        inferred from sequence or structural similarity with NCBI_gi:4507223
        (FlyBase, 1992-)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Gtp-bp allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 1 )
        VDRC
        v14877
        w1118; P{GD6482}v14877/TM3
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 57 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Source for merge of: Gtp-bp CG2522
        (Bayraktaroglu, 2000.4.7)
        Source for merge of: Gtp-bp BEST:CK00309 Source for merge of Gtp-bp BEST:CK00309 was sequence comparison (date:030820).
        (FlyBase, 1996-)
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
        (Kopczynski et al., 1998)
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/Swiss-Prot
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Signal recognition particle, SRP54 subunit, GTPase (IPR000897)
        AAA+ ATPase, core (IPR003593)
        Signal recognition particle receptor, alpha subunit, N-terminal (IPR007222)
        Signal recognition particle, SRP54 subunit, helical bundle (IPR013822)
        Linkouts
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for Gtp-bp
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyExpress - Embryonic expression images (BDGP data)
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        REDfly</