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A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008

Gene Dmel\dap

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General Information

Symbol

Dmel\dap

Species

D. melanogaster

Name

dacapo

Annotation symbol

CG1772

Feature type

protein_coding_gene

FlyBase ID

FBgn0010316

Created / Updated

2004-08-09/2004-08-09

Genomic Location

Chromosome (arm)

2R

Recombination map

2-

Cytogenetic map

46B1-46B1

Sequence location

2R:5,599,828..5,603,768 [+]

Map ( GBrowse )

detailed view

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Summary Information

Automatically generated summary

See sections below for more information

The gene dacapo is referred to in FlyBase by the symbol dap (CG1772, FBgn0010316). It has the cytological map location 46B1. Its sequence location is 2R:5599828..5603768. Its molecular function is described as cyclin-dependent protein kinase inhibitor activity. It is involved in the biological processes described with 13 unique terms, many of which group under: anatomical structure development; cell cycle; cell cycle process; regulation of kinase activity; sensory organ development; organ development; regulation of molecular function; regulation of cyclin-dependent protein kinase activity; negative regulation of phosphate metabolic process; system development. 31 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; nervous system; adult mesothoracic segment; imaginal precursor; embryonic/larval tracheal system; embryonic nervous system; egg; anatomical structure. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

46B1-46B1

Limits computationally determined from genome sequence between P{lacW}l(2)k09221^k09221&P{PZ}dap⁰⁴⁴⁵⁴ and P{lacW}l(2)k05420^k05420

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

46B1-46B2

(determined by in situ hybridisation)

(Abdelilah-Seyfried et al., 2000)

46B1-46B14

(de Nooij, 1996.11.12)

46B1-46B2

(determined by in situ hybridisation)

(Spradling et al., 1999)

46B-46B

(determined by in situ hybridisation)

(de Nooij et al., 1996)

46B-46B

(determined by in situ hybridisation)

(Lane et al., 1996)

46B1-46B2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-

(de Nooij, 1996.11.12)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

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Gene Model & Products

Please see the GBrowse view of Dmel\dap for information on other features

detailed view

Comments on Gene Model

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Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

FBtr0088469

2535

245

FBtr0088470

2502

234

Additional Transcript Data & Comments

Reported size (kB)

2.5 (northern blot)

(de Nooij et al., 1996)

Comments

External Data

Crossreferences

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Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

dap-PA

FBpp0087553

27.1

245

10.27

NP_476948

AAF58907

dap-PB

FBpp0087554

25.8

234

10.42

NP_724820

AAM68790

Additional Polypeptide Data & Comments

Reported size (kD)

245 (aa); 27 (kD predicted)

(de Nooij et al., 1996)

245 (aa)

(Lane et al., 1996)

Comments

External Data

PANTHER - Protein classification by function, families, and pathways

•

FBgn0010316

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Cyclin-dependent kinase inhibitor (IPR003175)

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Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

LD11071

(Spradling et al., 1999)

Dm2302

(BDGP Project Members, 1994-1999, Spradling et al., 1999)

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Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

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External Data

DEDB - Drosophila exon database: splicing graphs

•

13161

Crossreferences

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Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

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Summary of Transcript Expression

Stage

Tissue/Position

Reference

embryonic stage | stage 6

cephalic furrow

(de Nooij et al., 1996)

embryonic stage

ventral nerve cord | restricted

(de Nooij et al., 1996)

embryonic stage

ectoderm

(Lane et al., 1996)

embryonic stage | early

(de Nooij et al., 1996)

larval stage

morphogenetic furrow

(de Nooij et al., 1996)

embryonic stage

posterior midgut primordium

(Lane et al., 1996)

embryonic stage

embryonic central nervous system

(de Nooij et al., 1996)

embryonic stage | early

(Lane et al., 1996)

embryonic stage

mesoderm

(Lane et al., 1996)

embryonic stage | stage 6

amnioserosa

(de Nooij et al., 1996)

larval stage

eye-antennal disc

(de Nooij et al., 1996)

embryonic stage | stage 6

ventral furrow

(de Nooij et al., 1996)

embryonic stage

amnioserosa

(Lane et al., 1996)

embryonic stage

epidermis

(de Nooij et al., 1996)

larval stage

morphogenetic furrow | posterior to

(Lane et al., 1996)

embryonic stage

supraoesophageal ganglion

(de Nooij et al., 1996)

embryonic stage

peripheral nervous system

(de Nooij et al., 1996)

embryonic stage

anterior midgut primordium

(Lane et al., 1996)

Marker for

Subcellular Localization

CV Term

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Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

embryonic stage | stage 6

amnioserosa

(de Nooij et al., 1996)

embryonic stage | early

pole cell

(de Nooij et al., 1996)

embryonic stage | early

yolk nuclei

(de Nooij et al., 1996)

embryonic stage

epidermis

(de Nooij et al., 1996)

embryonic stage

peripheral nervous system

(de Nooij et al., 1996)

embryonic stage

ventral nerve cord | restricted

(de Nooij et al., 1996)

embryonic stage

embryonic central nervous system

(de Nooij et al., 1996)

Marker for

Subcellular Localization

CV Term

nucleus

(de Nooij et al., 1996)

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External Data & Images

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0010316

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0010316

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0010316

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Alleles & Phenotypes

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Summary of Allele Phenotypes

Lethality

Allele

dap⁹

dap^CB05233

lethal | recessive

lethal | partially

dap¹

dap²

Other Phenotypes

Allele

dap^GMR.PdN

visible, with Scer\GAL4^sca-537.4

dap^EP2584

visible, with Scer\GAL4^ptc-559.1

dap^Scer\UAS.cLa

visible, with Scer\GAL4^en-e16E

dap^{Scer\UAS.cdNa}

visible, with Scer\GAL4^vg.int2.1

dap^Scer\UAS.cLa

visible, with Scer\GAL4^ey.PH

dap^{Scer\UAS.cdNa}

cell death decrease | embryonic stage, with Scer\GAL4^en-e16E

dap^{Scer\UAS.cdNa}

mitotic cell cycle defective

mitotic cell cycle defective | somatic clone, with Scer\GAL4^Act5C.PP

dap^{Scer\UAS.cdNa}

mitotic cell cycle defective | embryonic stage, with Scer\GAL4^en-e16E

dap^{Scer\UAS.cdNa}

mitotic cell cycle defective, with Scer\GAL4^unspecified

dap^{Scer\UAS.cdNa}

mitotic cell cycle defective, with Scer\GAL4^Act5C.PP

dap^{Scer\UAS.cdNa}

mitotic cell cycle defective, with Scer\GAL4^neur-P72

dap^Scer\UAS.cLa

neuroanatomy defective

dap⁰⁴⁴⁵⁴

neuroanatomy defective, with Scer\GAL4^sca-537.4

dap^Scer\UAS.cLa

Sterility

Allele

female sterile, with Scer\GAL4^c323

dap^Scer\UAS.cLa

Phenotype manifest in

Allele

embryonic/larval transverse connective

embryonic/larval dorsal trunk

interface glial cell

dap⁰⁴⁴⁵⁴

dap⁰⁴⁴⁵⁴

embryonic abdomen & glial cell | ectopic

dap⁰⁴⁴⁵⁴

embryonic epidermis

mitotic cell cycle | ectopic

dap⁴

external sensory organ precursor cell IIIb & S phase

dap⁴

PNS glial cell & S phase

dap⁴

oocyte | germ-line clone

dap⁴

karyosome | germ-line clone

dap⁴

macrochaeta | ectopic

dap⁹

dorsocentral bristle, with Scer\GAL4^sca-537.4

dap^EP2584

trichogen cell, with Scer\GAL4^sca-537.4

dap^EP2584

tormogen cell, with Scer\GAL4^sca-537.4

dap^EP2584

scutellar bristle, with Scer\GAL4^sca-537.4

dap^EP2584

dap^GMR.PdN

dap^GMR.PdN

neuroblast NB6-4 of thorax, with Scer\GAL4^sca-537.4

dap^Scer\UAS.cLa

neuron & embryonic thorax, with Scer\GAL4^sca-537.4

dap^Scer\UAS.cLa

dorsal appendage, with Scer\GAL4^c323

dap^Scer\UAS.cLa

egg, with Scer\GAL4^c323

dap^Scer\UAS.cLa

chorion, with Scer\GAL4^c323

dap^Scer\UAS.cLa

G1 phase & external sensory organ precursor cell IIb, with Scer\GAL4^neur-P72

dap^Scer\UAS.cLa

G1 phase & external sensory organ precursor cell IIa, with Scer\GAL4^neur-P72

dap^Scer\UAS.cLa

embryonic pericardial cell, with Scer\GAL4^twi.PG

dap^Scer\UAS.cLa

cardioblast, with Scer\GAL4^twi.PG

dap^Scer\UAS.cLa

embryonic pericardial cell, with Scer\GAL4^eve.eme

dap^Scer\UAS.cLa

wing margin, with Scer\GAL4^ptc-559.1

dap^Scer\UAS.cLa

dorsal mesothoracic disc, with Scer\GAL4^ptc-559.1

dap^Scer\UAS.cLa

wing, with Scer\GAL4^vg.int2.1

dap^Scer\UAS.cLa

histoblast | somatic clone, with Scer\GAL4^Act5C.PI

dap^Scer\UAS.cLa

larval epidermis | somatic clone, with Scer\GAL4^Act5C.PI

dap^Scer\UAS.cLa

adult abdomen | somatic clone, with Scer\GAL4^Act5C.PI

dap^Scer\UAS.cLa

follicle cell & nucleus | somatic clone, with Scer\GAL4^Act5C.PP

dap^{Scer\UAS.cdNa}

mitotic cell cycle, with Scer\GAL4^Act5C.PP

dap^{Scer\UAS.cdNa}

eye disc, with Scer\GAL4^ey.PH

dap^{Scer\UAS.cdNa}

eye, with Scer\GAL4^ey.PH

dap^{Scer\UAS.cdNa}

wing | posterior compartment, with Scer\GAL4^en-e16E

dap^{Scer\UAS.cdNa}

embryonic segment | posterior compartment, with Scer\GAL4^en-e16E

dap^{Scer\UAS.cdNa}

mitotic cell cycle, with Scer\GAL4^unspecified

dap^{Scer\UAS.cdNa}

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Classical Alleles ( 19 )

For All Classical Alleles Show

Allele of dap	Class	Mutagen	Stocks	Known lesion
dap⁰⁴⁴⁵⁴	loss of function	P-element activity	1	Yes
dap¹		P-element activity	0	Yes
dap²		Δ2-3	0	Yes
dap^2X10	loss of function	Δ2-3	0	Yes
dap³		Δ2-3	0	Yes
dap^3x41		P-element activity	0	Yes
dap⁴	amorph	P-element activity	1	Yes
dap⁹		P-element activity	0	Yes
dap^B13-2-10		P-element activity	0	--
dap^BG01387		P-element activity	0	Yes
dap^BG02785		P-element activity	0	Yes
dap^CB05233		P-element activity	0	Yes
dap^EP2584		P-element activity	1	Yes
dap^G36		ethyl methanesulfonate	0	--
dap^c02041		piggyBac transposase	1	--
dap^d01128		P-element activity	1	--
dap^k07309		P-element activity	2	--
dap^rQ447		P-element activity	0	--
dap^unspecified			0	--

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Alleles Carried on Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show