A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\hep

General Information
SymbolDmel\hepSpeciesD. melanogaster
NamehemipterousAnnotation symbolCG4353
Feature typeprotein_coding_geneFlyBase IDFBgn0010303
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map1-
Cytogenetic map 11D10-11D10 Sequence locationX:12,973,240..12,984,466 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene hemipterous is referred to in FlyBase by the symbol hep (CG4353, FBgn0010303). It has the cytological map location 11D10. Its sequence location is X:12973240..12984466. Its molecular function is described as: JUN kinase kinase activity; protein kinase activity; receptor signaling protein serine/threonine kinase activity; protein binding; MAP kinase kinase activity; ATP binding; protein serine/threonine kinase activity. It is involved in the biological processes described with 23 unique terms, many of which group under: anatomical structure development; ovarian follicle cell development; organ morphogenesis; cell projection organization and biogenesis; gamete generation; cell motility; MAPKKK cascade; organ development; eggshell chorion formation; protein kinase cascade; embryonic development via the syncytial blastoderm. 41 alleles are reported. The phenotypes of these alleles are annotated with 39 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; adult; thoracic segment; nervous system; adult mesothoracic segment; imaginal precursor; portion of tissue; integumentary system; egg. It has 3 annotated transcripts and 3 annotated polypeptides.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
11D10-11D10  
Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
11D1-11D4
(determined by in situ hybridisation) 11D (determined by in situ hybridisation)  
(Peter et al., 2002)
11D-11D
(determined by in situ hybridisation)  
(Schaefer et al., 1999.12.2)
11D1-11D4
(determined by in situ hybridisation)  
(Schaefer et al., 1999.12.10)
11D-11D
 
(Noselli, 1994.1.18)
11D1-11D2
 
(Noselli, 1996.4.28)
11D1-11D2
(determined by in situ hybridisation)  
(Glise et al., 1995)
11B12-13F
Determined by complementation mapping, aberrations not specified.  
(Perrimon et al., 1989)
Experimentally Determined Recombination Data
Location
1-
 
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: hep- lic+
(Han, 1998.4.1)
hide Gene Model & Products
Please see the GBrowse view of Dmel\hep for information on other features
detailed view FBtr0073749 FBtr0073748 FBtr0073747 FBtr0073720 FBpp0073580 FBpp0073579 FBpp0073578 FBpp0073551 FBti0050925 FBti0071334 FBti0038228 FBti0041076 FBti0071436 FBti0015538 FBti0015676 FBti0013159 FBti0071274
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
hep-RA
FBtr0073747
 NM_167346
  4908
  1178
hep-RB
FBtr0073749
 NM_167347
  2986
  580
hep-RC
FBtr0073748
 NM_078587
  2724
  492
Additional Transcript Data & Comments
Reported size (kB)
6.0 (northern blot)
(Glise et al., 1995)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
hep-PA  
FBpp0073578  
125.1  
1178  
10.05  
  NP_727661
  AAN09646
hep-PB  
FBpp0073580  
61.9  
580  
10.22  
  NP_727662
  AAG22351
hep-PC  
FBpp0073579  
53.1  
492  
9.19  
  NP_511142
  AAF48222
Additional Polypeptide Data & Comments
Reported size (kD)
487 (aa)
(Glise et al., 1995)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Protein kinase, core (IPR000719)
Serine/threonine protein kinase (IPR002290)
Serine/threonine protein kinase, active site (IPR008271)
Protein kinase-like (IPR011009)
Protein kinase ATP binding, conserved site (IPR017441)
Serine/threonine protein kinase-related (IPR017442)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA202573
 
AA942111
 
AE003491
AAF48222
 
AE003491
AAG22351
 
AE003491
AAN09646
 
AI062601
 
AI296171
 
AI515005
 
AJ426887
 
AJ426888
 
AW943860
 
AY069695
AAL39840
 
AY071210
AAL48832
 
BG636753
 
BG637756
 
BI228126
 
BI363974
 
BI364064
 
BI365530
 
BI366407
 
BI367334
 
BI368106
 
BI368259
 
BI376190
 
BI638067
 
BI642020
 
CK659618
 
CK660969
 
CO154210
 
CO156435
 
CO265915
 
CO271003
 
CO276812
 
CO279004
 
CO295582
 
CO298147
 
CO308665
 
CO338382
 
CO341236
 
CZ485498
 
EC050995
 
EC051985
 
EC054479
 
EC054992
 
EC055875
 
EC072734
 
EC197439
 
EC197700
 
EC198938
 
EC204096
 
EC213066
 
EC215075
 
EC217374
 
EC228883
 
EC235957
 
EC255180
 
EC263496
 
EC263998
 
EC267360
 
LD02714
 
U05240
AAC46944
 
U93032
AAB63449
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage
     
    (Glise et al., 1995)
     embryonic stage-adult stage
     
    (Glise et al., 1995)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0073749 FBtr0073748 FBtr0073747 FBtr0073720
        AI515005
        AA942111
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        viable (with hep1)
        viable (with hep699)
        viable | female
        lethal | recessive
        lethal | recessive | rescuable maternal effect
        lethal | conditional ts, with Scer\GAL4vg.PU
        lethal | embryonic stage | maternal effect | recessive
        lethal | embryonic stage | rescuable maternal effect
        lethal | embryonic stage | recessive
        lethal | embryonic stage, with Scer\GAL4e22c
        lethal | embryonic stage, with Scer\GAL464B
        lethal | pupal stage
        lethal | pupal stage | recessive
        lethal | pharate adult stage
        semi-lethal | recessive
        semi-lethal | male
        semi-lethal | female
        cell lethal | partially | somatic clone, with Scer\GAL4αTub84B.PL
        Other Phenotypes
        Allele
        wild-type
        visible
        visible (with hep1)
        visible (with hepr39)
        visible (with hepr75)
        visible (with hep699)
        visible | recessive
        visible | dominant
        visible, with Scer\GAL4hs.2sev
        visible, with Scer\GAL4pnr-MD237
        visible, with Scer\GAL4GMR.PF
        small body | adult stage, with Scer\GAL4Ilp2.PR
        long lived, with Scer\GAL4elav-C155
        cell death increase
        cell death increase | conditional ts, with Scer\GAL4en-e16E, Scer\GAL80ts.αTub84B
        cell shape defective | embryonic stage, with Scer\GAL4arm.PS
        mitotic | somatic clone
        neuroanatomy defective
        neuroanatomy defective, with Scer\GAL4P2.4.Pdf
        neuroanatomy defective, with Scer\GAL4ato.3.6
        chemical resistant | conditional RU486, with Scer\GAL4elav.Switch.PO
        chemical resistant, with Scer\GAL4arm.PS
        chemical sensitive
        tissue polarity, with Scer\GAL4hs.2sev
        wound healing defective
        Phenotype manifest in
        Allele
        adult thorax (with hepr39)
        chaeta (with hepr39)
        adult thorax (with hepr75)
        chaeta (with hepr75)
        cuticle | dorsal | rescuable maternal effect (with hepr75)
        embryonic leading edge cell | rescuable maternal effect (with hepr75)
        embryonic dorsal epidermis
        eye
        wing
        thorax
        leg
        mesothoracic tergum
        dorsal mesothoracic disc
        adult thorax | dorsal
        dorsal appendage
        embryonic/first instar larval cuticle | dorsal
        embryonic epidermis
        dorsal closure embryo
        embryonic/first instar larval cuticle | dorsal | rescuable maternal effect
        embryonic leading edge cell | rescuable maternal effect
        amnioserosa
        embryonic leading edge cell & actin filament
        adult head | rescuable maternal effect
        wing & adult | rescuable maternal effect
        adult mesothoracic segment | dorsal | rescuable maternal effect
        macrochaeta | maternal effect
        adult thorax | dorsal | maternal effect
        axon & dorsal cluster neuron
        maxillary palpus (with hep699)
        female terminalia (with hep699)
        dorsal closure embryo | germ-line clone
        eye, with Scer\GAL4sev.EP
        embryonic/first instar larval cuticle, with Scer\GAL4arm.PS
        embryonic maxillary segment, with Scer\GAL4arm.PS
        eye, with Scer\GAL4hs.2sev
        eye disc, with Scer\GAL4hs.2sev
        ommatidial cluster, with Scer\GAL4hs.2sev
        lamellocyte, with Scer\GAL4He.PZ
        melanotic mass, with Scer\GAL4He.PZ
        lamellocyte, with Scer\GAL4Hml.PG
        melanotic mass, with Scer\GAL4Hml.PG
        ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf
        eye, with Scer\GAL4GMR.PF
        axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
        wing, with Scer\GAL4vg.PU
        wing vein, with Scer\GAL4vg.PU
        wing margin, with Scer\GAL4vg.PU
        scutellum, with Scer\GAL4pnr-MD237
        adult thorax | dorsal, with Scer\GAL4pnr-MD237
        adult thorax & macrochaeta, with Scer\GAL4pnr-MD237
        ommatidium, with Scer\GAL4hs.2sev
        interommatidial bristle, with Scer\GAL4GMR.PF
        thorax, with Scer\GAL4pnr-MD237
        adult thorax (with hep1)
        chaeta (with hep1)
        imaginal disc
        cuticle | dorsal | rescuable maternal effect (with hep1)
        embryonic leading edge cell | rescuable maternal effect (with hep1)
        adult head
        eye-antennal disc
        ventral thoracic disc
        interommatidial bristle
        pigment cell
        dorsal appendage | maternal effect | somatic clone
        micropyle | maternal effect | somatic clone
        egg chamber | anterior | somatic clone
        embryonic leading edge cell & filopodium
        dorsal mesothoracic disc & cytoskeleton
        cuticle & thorax
        cuticle & abdomen
        cephalopharyngeal skeleton
        cuticle & thorax | germ-line clone
        cuticle & abdomen | germ-line clone
        cephalopharyngeal skeleton | germ-line clone
        peripodial epithelium & dorsal mesothoracic disc & prepupa
        peripodial stalk & dorsal mesothoracic disc & prepupa
        dorsal mesothoracic disc & prepupa
        follicle cell | somatic clone
        maxillary palpus (with hep1)
        female terminalia (with hep1)
        hide Classical Alleles ( 28 )
        For All Classical Alleles Show

        Allele of hepClassMutagenStocksKnown lesion
        hep1hypomorph0 Yes
        hep699
          		0 --
          hep75
            		0 --
            hep7P1
              		0 --
              hepCA0 Yes
              hepG01071 --
              hepG02081 --
              hepG03900 --
              hepG240 Yes
              hepGG017251 --
              hepH490