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Gene Dmel\comm

General Information
Symbol	Dmel\comm	Species	D. melanogaster
Name	commissureless	Annotation symbol	CG17943
Feature type	protein_coding_gene	FlyBase ID	FBgn0010105
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	71F2-71F2	Sequence location	3L:15,715,424..15,721,523 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene commissureless is referred to in FlyBase by the symbol comm (CG17943, FBgn0010105). It has the cytological map location 71F2. Its sequence location is 3L:15715424..15721523. Its molecular function is described as protein binding. It is involved in the biological processes: axon midline choice point recognition; axon guidance; endocytosis; synaptogenesis; nervous system development; neuron recognition; dendrite morphogenesis. 68 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: nervous system; embryonic nervous system; organ system; embryonic neuron; commissure; embryonic/larval tracheal system; antennal segment; peripheral nervous system; adult brain; adult segment. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71F2-71F2   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References 71E3-71E5 (determined by in situ hybridisation)   (Seeger, 1995.7.6)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\comm for information on other features
Comments on Gene Model
	EST data suggest additional 5' exon(s)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) comm-RA FBtr0075579  NM_079371   1675   370
Additional Transcript Data & Comments
Reported size (kB)	1.7, 1.0 (northern blot) (Tear et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein comm-PA   FBpp0075332   40.3   370   5.04     NP_524095   AAF49584
Additional Polypeptide Data & Comments
Reported size (kD)	370 (aa); 40 (kD predicted) (Tear et al., 1996)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0010105
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003530 AAF49584   BI162781   BI163774   BI212266   BI214069   BI215013   BI234643   BI239188   BI240408   BI357364   BI357649   BI358525   BI362351   BI368790   BI369612   BI484996   BI570071   BI589963   BI612564   BI624989   BT031163   CK135751   CO185333   CO284089   CO293396   CO294981   CO297600   CO304112   CO306683   CO311963   CO326160   CO331047   CZ473966   DN154364   EC057707   EC064838   EC069134   EC076413   EC079046   EC085312   EC086595   EC087696   EC087740   EC088201   EC194402   EC200532   EC205045   EC222195   EC224626   EC237161   EC246262   U35854 AAC47019
UniProtKB/Swiss-Prot	Q24139
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	RH64772 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References aberration junction Tp(3;3)comm[3].bk2 3L:15,714,120..15,717,859 comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator evidence=experimental linked_to=PstI-SalI_rfrag (Tear et al., 1996) sequence variant comm[5] 3L:15,721,557..15,722,456 comment=900bp deletion of 5' untranslated and transcription start site. Isolated during mobilization of P-elements from a Birm2 ammo chromosome. evidence=experimental (Tear et al., 1996) sequence variant comm[1] 3L:15,716,223..15,716,231 comment=comm[1] is a deletion of 9bp with an insertion of 2bp, causing a frameshift at amino acid 217. This leads to premature translation termination after 26 amino acids of novel reading frame. Annotated deletion endpoints are approximate. evidence=experimental (Tear et al., 1996)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 4029
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage | stage 12-16  midline | restricted (Tear et al., 1996)  embryonic stage | stage 10  ganglion mother cell (Tear et al., 1996)  embryonic stage | stage 6-10   (Tear et al., 1996)  embryonic stage | stage 12-16  midline glial cell (Tear et al., 1996)  embryonic stage | stage 10  neuroblast (Tear et al., 1996)  embryonic stage | stage 12  visceral mesoderm (Tear et al., 1996)  embryonic stage | cellular blastoderm   (Tear et al., 1996)  embryonic stage | stage 10  epidermis (Tear et al., 1996)  embryonic stage | stage >=10  embryonic central nervous system | presumptive | segmentally repeated pattern (Tear et al., 1996)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage | stage 10  neuroblast (Tear et al., 1996)  embryonic stage | stage 12-16  midline | restricted (Tear et al., 1996)  embryonic stage  ventral nerve cord commissure (Tear et al., 1996)  embryonic stage | stage 6-10   (Tear et al., 1996)  embryonic stage | stage 12-16  midline glial cell (Tear et al., 1996)  embryonic stage  axon (Tear et al., 1996)  embryonic stage | stage 12-16  visceral mesoderm (Tear et al., 1996)  embryonic stage | stage >=10  embryonic central nervous system | presumptive | segmentally repeated pattern (Tear et al., 1996)  embryonic stage | cellular blastoderm   (Tear et al., 1996)  embryonic stage | stage 10  epidermis | longitudinal stripes (Tear et al., 1996)  embryonic stage | stage 10  ganglion mother cell (Tear et al., 1996)
Marker for
Subcellular Localization
CV Term	Golgi apparatus endosome plasma membrane (Tear et al., 1996)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0010105 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0010105 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for comm Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive comm1 comm2 comm4 comm6 comm7 comm8 lethal | larval stage comm3 comm5 Other Phenotypes Allele uncoordinated comm1 comm2 comm4 comm6 comm7 comm8 neuroanatomy defective comm1 commE39 commdsRNA.cIa communspecified neuroanatomy defective (with comm1) comm5 neuroanatomy defective (with comm5) comm1 neuroanatomy defective | cell autonomous comm5 neuroanatomy defective | recessive comm1 comm5 neuroanatomy defective, with Scer\GAL4elav.PLu commHP.dsRNA.Scer\UAS commL229A.Scer\UAS.T:Hsap\MYC commP230A.Scer\UAS.T:Hsap\MYC commS231A.Scer\UAS.T:Hsap\MYC commS231A.Y232A.Scer\UAS.T:Hsap\MYC commScer\UAS.T:Hsap\MYC commY232A.Scer\UAS.T:Hsap\MYC commΔ176-370.Scer\UAS.T:Hsap\MYC neuroanatomy defective, with Scer\GAL4elav-C155 commScer\UAS.cWa commΔPSY.Scer\UAS.T:Hsap\MYC neuroanatomy defective, with Scer\GAL4unspecified commHP.dsRNA.Scer\UAS commScer\UAS.T:Avic\GFP-m6 commΔ1.Scer\UAS.T:Avic\GFP-m6 commΔ2.Scer\UAS.T:Avic\GFP-m6 neuroanatomy defective, with Scer\GAL4eg-Mz360 commHP.dsRNA.Scer\UAS neuroanatomy defective, with Scer\GAL4A307 commScer\UAS.cKa neuroanatomy defective, with Scer\GAL448Y commEP neuroanatomy defective, with Scer\GAL4ap-md52 commScer\UAS.cKa Phenotype manifest in Allele embryonic central nervous system, with Scer\GAL4unspecified commΔ1.Scer\UAS.T:Avic\GFP-m6 commΔ2.Scer\UAS.T:Avic\GFP-m6 commScer\UAS.T:Avic\GFP-m6 anterior fascicle, with Scer\GAL4how-24B commΔC.Scer\UAS abdominal posterior fascicle, with Scer\GAL4how-24B commΔC.Scer\UAS ventral nerve cord, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa anterior commissure, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa posterior commissure, with Scer\GAL4elav-C155 commΔPSY.Scer\UAS.T:Hsap\MYC commScer\UAS.cWa ventral nerve cord commissure commΔe39 comm1 comm5 comm8 commE39 commdsRNA.cIa midline glial cell commΔe39 comm1 embryonic central nervous system commΔe39 commB204 commissure comm1 comm3 comm4 comm5 comm7 comm8 commB204 commE39 communspecified ventral nerve cord commissure & larval brain | somatic clone comm1 comm5 tritocerebral commissure comm1 ventral anastomosis 0 comm1 ventral anastomosis 1 comm1 ventral anastomosis 2 comm1 ventral nerve cord comm1 anterior commissure comm1 posterior commissure comm1 anterior fascicle comm1 comm5 abdominal posterior fascicle comm1 comm5 axon | cell autonomous comm5 neuroblast NB3-1 | cell autonomous comm5 neuroblast NB5-6 | cell autonomous comm5 RP3 neuron comm5 RP2 neuron comm5 aCC neuron comm5 V neuron comm5 longitudinal connective comm8 mesothoracic dorsal triscolopidial chordotonal organ dch3, with Scer\GAL448Y commEP metathoracic dorsal triscolopidial chordotonal organ dch3, with Scer\GAL448Y commEP commissure, with Scer\GAL4unspecified commHP.dsRNA.Scer\UAS longitudinal connective, with Scer\GAL4unspecified commHP.dsRNA.Scer\UAS commissure, with Scer\GAL4elav.PLu commHP.dsRNA.Scer\UAS longitudinal connective, with Scer\GAL4elav.PLu commHP.dsRNA.Scer\UAS commL229A.Scer\UAS.T:Hsap\MYC commP230A.Scer\UAS.T:Hsap\MYC commS231A.Y232A.Scer\UAS.T:Hsap\MYC embryonic neuron, with Scer\GAL4eg-Mz360 commHP.dsRNA.Scer\UAS embryonic ventral nervous system, with Scer\GAL4ap-md52 commScer\UAS.cKa giant fibers, with Scer\GAL4A307 commScer\UAS.cKa embryonic ganglionic branch, with Scer\GAL4btl.PS commScer\UAS.cKa antennal glomerulus, with Scer\GAL4SG18.1 commScer\UAS.cKa antennal commissure, with Scer\GAL4SG18.1 commScer\UAS.cKa chordotonal organ & embryo & nerve terminal, with Scer\GAL412.1 commScer\UAS.cKa embryonic neuron, with Scer\GAL4sca-537.4 commScer\UAS.cKa pCC neuron, with Scer\GAL4sca-537.4 commScer\UAS.cKa embryonic central nervous system, with Scer\GAL4sca-537.4 commScer\UAS.cKa embryonic neuron communspecified commissure & embryo communspecified embryonic ganglionic branch communspecified
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of comm Class Mutagen Stocks Known lesion comm072 0 -- comm1 hypomorph ethyl methanesulfonate 0 Yes comm2 hypomorph ethyl methanesulfonate 0 -- comm3 amorph X ray 0 Yes comm4 hypomorph X ray 0 Yes comm5 amorph P-element activity 0 Yes comm6 hypomorph P-element activity 0 Yes comm7 hypomorph P-element activity 0 -- comm8 hypomorph ethyl methanesulfonate 0 -- commB204 ethyl methanesulfonate 0 -- commE39 loss of function 0 Yes commEP 0 -- commd04506 P-element activity 1 -- communspecified loss of function 0 -- commΔe39 loss of function 0 --
Alleles Carried on Transgenic Constructs ( 53 )
For All Alleles Carried on Transgenic Constructs Show
Allele of comm Class Mutagen Stocks Known lesion comm2PY.AY.MtnA.T:Hsap\MYC in vitro construct | amino acid replacement in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commAct5C.PT in vitro construct | regulatory fusion 0 Yes commAct5C.T:Zzzz\HPC4 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commDEAL-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commGD2477 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes commHP.dsRNA.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes commIC.MtnA.T:Mmus\Cd8a,T:Avic\GFP-m6 in vitro construct | coding region fusion 0 Yes commIC.MtnA.T:Uuuu\Myr5,T:Avic\GFP-m6 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commIC.Scer\UAS.T:Mmus\Cd8a,T:Avic\GFP-m6 in vitro construct | coding region fusion 0 Yes commIC.Scer\UAS.T:Uuuu\Myr5,T:Avic\GFP-m6 in vitro construct | coding region fusion in vitro construct | regulatory fusion 0 Yes commKR.MtnA.T:Hsap\MYC in vitro construct | amino acid replacement in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commL229A.P230A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commL229A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commMtnA.T:Avic\GFP-m6 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commP230A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commPCYT-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commS231A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commS231A.Y232A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commScer\UAS.T:Avic\GFP-m6 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commScer\UAS.T:Hsap\MYC in vitro construct | regulatory fusion 0 Yes commScer\UAS.cKa in vitro construct | regulatory fusion 0 Yes commScer\UAS.cRa in vitro construct | regulatory fusion 0 Yes commScer\UAS.cWa in vitro construct | regulatory fusion 0 Yes commT:Avic\GFP-S65T in vitro construct | coding region fusion 0 Yes commT:Hsap\MYC in vitro construct | coding region fusion 0 Yes commY232A.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commYPSL-AAAA.Scer\UAS.T:Hsap\MYC in vitro construct | amino acid replacement 0 Yes commdsRNA.cIa in vitro construct | RNAi 0 Yes commΔ1.MtnA.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔ1.Scer\UAS.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔ176-199.245-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-199.258-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-199.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-219.245-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-219.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-244.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-257.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ176-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ2.MtnA.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔ2.Scer\UAS.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔ220-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ245-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ258-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ266-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ293-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔ2PY.MtnA.T:Hsap\MYC in vitro construct | deletion in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commΔ2PY.Scer\UAS.T:Hsap\MYC in vitro construct | deletion in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commΔ319-370.Scer\UAS.T:Hsap\MYC in vitro construct | deletion 0 Yes commΔC.Scer\UAS in vitro construct | regulatory fusion in vitro construct | deletion 0 Yes commΔEC.MtnA.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔEC.Scer\UAS.T:Avic\GFP-m6 in vitro construct | deletion 0 Yes commΔPSY.MtnA.T:Hsap\MYC in vitro construct | deletion in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes commΔPSY.Scer\UAS.T:Hsap\MYC in vitro construct | deletion in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes