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Gene Dmel\C15

General Information
Symbol	Dmel\C15	Species	D. melanogaster
Name	C15	Annotation symbol	CG7937
Feature type	protein_coding_gene	FlyBase ID	FBgn0004863
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93E3-93E3	Sequence location	3R:17,325,977..17,338,054 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol C15 (CG7937, FBgn0004863). It has the cytological map location 93E3. Its sequence location is 3R:17325977..17338054. Its molecular function is described as: transcription factor activity; sequence-specific DNA binding. It is involved in the biological processes: regulation of transcription, DNA-dependent; elongation of arista core; leg disc development; positive regulation of Notch signaling pathway; mesodermal cell fate specification. 6 alleles are reported. The phenotypes of these alleles are annotated with: unguis; arista; mesothoracic bristle; ocellar bristle; tarsal segment 4; tarsal segment 5; pulvillus; empodium. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93E3-93E3   Limits computationally determined from genome sequence between P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101 and P{PZ}InR05545
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93E1-93F8   (Kojima et al., 2005) 93C3-93F Location based on deficiency mapping.   (Campbell, 2005) 93E-93E   (Dear, 1993.6.4) 93E-93E (determined by in situ hybridisation)   (Dear and Rabbitts, 1994) 93E1-93E2   (Dessain and McGinnis, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: slou? C15? (Frasch, 1995.3.24) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\C15 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) C15-RA FBtr0084111  NM_057525   1105   339
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Dear and Rabbitts, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein C15-PA   FBpp0083510   37.4   339   6.87     NP_476873   AAF55898
Additional Polypeptide Data & Comments
Reported size (kD)	307 (aa); 34 (kD predicted) (Dear and Rabbitts, 1994)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0004863
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AC016132   AE003735 AAF55898   BT022127   BT025203   CO299733   EC234209   EL879116   EL879117   EL879175   EL879176   L08620 AAA28614   Z22959 CAA80535
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JQ85 Q7KS72 Q9VD99
Maps to	FBcl0298118 (FlyBase, 1992-)
Does NOT map to
Identified with	IP08859 (Hoskins et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation C15[3] 3R:17,328,310..17,328,310 comment=Resulting protein is truncated before the homeodomain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C17328310T pr_change=Q170@|C15-PA reported_pr_change=?137@ (Campbell, 2005) point mutation C15[2] 3R:17,332,870..17,332,870 comment=Resulting protein is truncated before the homeodomain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C17332870T pr_change=R203@|C15-PA reported_pr_change=?170@ (Campbell, 2005) point mutation C15[1] 3R:17,332,884..17,332,884 comment=The mutation is N-terminal to the homeodomain. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T17332884R pr_change=H207Q|C15-PA reported_pr_change=H175Q (Campbell, 2005) point mutation C15[cll-dl92] 3R:17,333,078..17,333,079 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). This results in the deletion of the 68 C-terminal amino acid residues, which include the 5 C-terminal residues of the homeodomain. evidence=experimental na_change=G17333078.11391A pr_change=W272@|C15-PA reported_pr_change=W240@ (Kojima et al., 2005)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 10228
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  larval stage | late   (Dear and Rabbitts, 1994)  pupal stage | early   (Dear and Rabbitts, 1994)  embryonic stage | cellular blastoderm  dorsal ectoderm anlage | restricted (Stathopoulos et al., 2002)  embryonic stage | 4-24hr   (Dear and Rabbitts, 1994)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004863 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0004863 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0004863
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable C151 lethal | adult stage C152 C153 lethal | adult stage | partially | recessive C15cll-dl92 Phenotype manifest in Allele arista C151 C152 C153 C15cll-dl92 unguis C152 C153 C15cll-dl92 tarsal segment 4 C152 C153 tarsal segment 5 C152 C153 pulvillus C152 C153 empodium C152 C153 mesothoracic bristle C15cll-dl92 ocellar bristle C15cll-dl92
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of C15 Class Mutagen Stocks Known lesion C151 ethyl methanesulfonate 0 Yes C152 ethyl methanesulfonate 0 Yes C153 ethyl methanesulfonate 0 Yes C15cll-dl92 loss of function 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of C15 Class Mutagen Stocks Known lesion C15Scer\UAS.cKa in vitro construct | regulatory fusion 0 Yes C15dsRNA.Scer\UAS in vitro construct | regulatory fusion in vitro construct | RNAi 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3R)e-H4
Useful duplication	Dp(3;3)M95A+13
Partially disrupted in	Df(3R)lb (De Graeve et al., 2004)
Disrupted in	Df(3R)e-19 (Campbell, 2005) Df(3R)e-BS2 (Campbell, 2005) Df(3R)e-GC3 (Kojima et al., 2005) Df(3R)e-H4 (Kojima et al., 2005)
Not disrupted in	Df(3R)e-F1 (Kojima et al., 2005) Df(3R)e-R1 (Kojima et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{C15.350-1.hs43-lacZ} No P{C15.350-2.hs43-lacZ} No P{C15.650-1.hs43-lacZ} No P{C15.650-3.hs43-lacZ} No P{C15.I-2-1.hs43-lacZ} No P{C15.I-2-2.hs43-lacZ} No P{C15.I-2-3.hs43-lacZ} No P{C15.I-2-4.hs43-lacZ} No P{C15.I-2-5.hs43-lacZ} No P{C15.I-2.hs43-lacZ} No P{C15.M2,5,Z2m.hs43-lacZ} No P{C15.M2,5m.hs43-lacZ} No P{C15.M2m.hs43-lacZ} No P{C15.M5,6,7m.hs43-lacZ} No P{C15.M5,7m.hs43-lacZ} No P{C15.M5,Z2m.hs43-lacZ} No P{C15.M5m.hs43-lacZ} No P{C15.M7m.hs43-lacZ} No P{C15.Z1,2,3m.hs43-lacZ} No P{C15.Z1m.hs43-lacZ} No P{C15.Z2m.hs43-lacZ} No P{C15.Z3m.hs43-lacZ} No UAS construct P{UAS-C15.K} NA P{UAS.C15.dsRNA} NA
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data C15 has been cloned and sequenced. (Dear and Rabbitts, 1994)
Gene Ontology: Function, Process & Cellular Component ( 8 )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356 (FlyBase Curators et al., 2004-)
transcription factor activity inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Biological Process
CV term Evidence References
elongation of arista core inferred from mutant phenotype (Campbell, 2005)
leg disc development inferred from mutant phenotype (Campbell, 2005)
mesodermal cell fate specification non-traceable author statement (Jagla et al., 2001)
positive regulation of Notch signaling pathway inferred from expression pattern (Campbell, 2005)
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions C15 allele Gene References C152 al (Campbell, 2005)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 67510
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18604 Dere\GG24664 Dgri\GH22054 Dper\GL23122 Dpse\GA27150 Dsec\GM10429 Dsim\GD19430 Dvir\GJ14312 Dwil\GK12060 Dyak\GE25740
Curated drosophilid orthologs	Dpse\GA20702
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000019636 Anopheles gambiae (Ensembl) ENSBTAP00000013194 Bos taurus (Ensembl) ENSCAFP00000014447 Canis familiaris (Ensembl) NEWSINFRUP00000131598 Takifugu rubripes (Ensembl) ENSGALP00000012693 Gallus gallus (Ensembl) ENSP00000296921 Homo sapiens (Ensembl) ENSMMUP00000023350 Macaca mulatta (Ensembl) ENSMODP00000014916 Monodelphis domestica (Ensembl) ENSPTRP00000005043 Pan troglodytes (Ensembl) ENSPTRP00000020756 Pan troglodytes (Ensembl) ENSRNOP00000006676 Rattus norvegicus (Ensembl) GSTENP00024580001 Tetraodon nigroviridis (Ensembl) ENSXETP00000039652 Xenopus tropicalis (Ensembl) ZDB-GENE-021021-1 Danio rerio (Zfin) MGI:1351209 Mus musculus (Informatics)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 2 )
	BACR48I01 BACR34E13
cDNA Clones ( 2 )
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP08859
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EK176427
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0004863 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0004863
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
	In situ and antibody staining show that C15 is expressed in amnioserosa cells, from cellularized blastoderm until the amnioserosa degenerates in late embryogenesis. From stage 11 on, there is also expression in small, segmentally repeated clusters of neurons of the CNS and in sensory cells of the Keilin's organs and of the antenno-maxillary complex. (Frasch, 1995.3.24)
Comments About Molecular Function
	Location based on deficiency mapping. Overall orientation not stated: lbe- CG7922+ C15+ CG7056+ (Kojima et al., 2005)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057525 RefSeq (Proteins) • NP_476873 DDBJ / EMBL / GenBank • AC016132 AE003735 AAF55898 L08620 AAA28614 Z22959 CAA80535 UniProtKB/TrEMBL • Q7JQ85 Q7KS72 Q9VD99
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 67510 DEDB - Drosophila exon database: splicing graphs • 10228 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0004863 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004863 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0004863 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004863 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0004863 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0004863 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000019636 Anopheles gambiae (Ensembl) ENSBTAP00000013194 Bos taurus (Ensembl) ENSCAFP00000014447 Canis familiaris (Ensembl) NEWSINFRUP00000131598 Takifugu rubripes (Ensembl) ENSGALP00000012693 Gallus gallus (Ensembl) ENSP00000296921 Homo sapiens (Ensembl) ENSMMUP00000023350 Macaca mulatta (Ensembl) ENSMODP00000014916 Monodelphis domestica (Ensembl) ENSPTRP00000005043 Pan troglodytes (Ensembl) ENSPTRP00000020756 Pan troglodytes (Ensembl) ENSRNOP00000006676 Rattus norvegicus (Ensembl) GSTENP00024580001 Tetraodon nigroviridis (Ensembl) ENSXETP00000039652 Xenopus tropicalis (Ensembl) ZDB-GENE-021021-1 Danio rerio (Zfin) MGI:1351209 Mus musculus (Informatics) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/c15clawless1.htm PANTHER - Protein classification by function, families, and pathways • FBgn0004863
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	93Bal   311 (Dear and Rabbitts, 1994) C15 (Lin et al., 2006, Yasunaga et al., 2006, Liang et al., 2007, Hoskins et al., 2005) CG7937   cll (Yasunaga et al., 2006, Kojima et al., 2005) Cll (Takahashi et al., 2005) Ect5 (Stathopoulos et al., 2002) Hox11-311
Name Synonym	C15   clawless (Yasunaga et al., 2006, Kojima et al., 2005)
Secondary FlyBase IDs
	FBgn0002943 FBgn0008640 FBgn0010393
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 1 ) Review  ( 2 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Lin et al., 2006, Development 133(24): 4805--4813 Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues. [FBrf0194560] Yasunaga et al., 2006, Mech. Dev. 123(12): 893--906 Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. [FBrf0194566] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...