Gene Dmel\Su(H)

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General Information

Symbol

Dmel\Su(H)

Species

D. melanogaster

Name

Suppressor of Hairless

Annotation symbol

CG3497

Feature type

protein_coding_gene

FlyBase ID

FBgn0004837

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

2-50.5

Cytogenetic map

35B8-35B8

Sequence location

2L:15,039,496..15,043,335 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Suppressor of Hairless is referred to in FlyBase by the symbol Su(H) (CG3497, FBgn0004837). It has the cytological map location 35B8. Its sequence location is 2L:15039496..15043335. Its molecular function is described as: DNA binding; RNA polymerase II transcription factor activity; transcription activator activity; protein binding; transcription repressor activity; specific transcriptional repressor activity; sequence-specific DNA binding; transporter activity; transcription factor activity. It is involved in the biological processes described with 15 unique terms, many of which group under: anatomical structure development; regulation of metabolic process; positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; transcription, DNA-dependent; organ development; transport; cell division; regulation of developmental process; cell communication; cell-cell signaling; sensory organ development; Notch signaling pathway. 83 alleles are reported. The phenotypes of these alleles are annotated with 60 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; nervous system; adult mesothoracic segment; thoracic segment; embryonic nervous system; embryonic neuron; imaginal precursor; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide.

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

Su(H): Suppressor of Hairless

Homozygous lethal; hemizygotes die in the pupal stage, between head eversion and the beginning of eye pigmentation. Heterozygotes in the absence of H are wild type in phenotype. Suppresses H; Su(H)/+; H/+ have 7-10 more bristles that H/+ alone; besides affecting the bristle phenotype of H, all alleles tend to enhance its wing-vein phenotype of shortening L4 and L5. Su(H) is without effect on the lethal phenotype of homozygous H. One homozygous-lethal allele acts as a dominant enhancer of H. Most alleles are amorphic or hypomorphic; heterozygous deficiencies for the locus also suppress, and duplications enhance H (Nash, 1970). Enhanced genotypes have 10-15 fewer bristles and a far more extreme loss of microchaetae on the thorax than their unenhanced counterparts. The number of bristles in H/+ flies is inversely related to the dose of Su(H)+, with the number of bristles varying from fewer than ten with four doses to approximately 35 with one dose. Some combinations of hypomorphic alleles produce occasional escapers; survivors have distinctive phenotypes, which are described under entries for specific alleles.

Su(H)3

A leaky allele; trans heterozygotes with Su(H)1 show 20% survival; almost viable with Su(H)7; semilethal with Su(H)2, Su(H)4, Su(H)6, and Su(H)8; lethal in combination with Su(H)16. Survivors have vestigial wings and halteres and eyes somewhat reduced and rough; bristles normal.

Su(H)7

Homozygous lethal; in trans heterozygotes with other alleles produces rare escapers, which have an extreme mutant phenotype; wings and halteres similar to those of an extreme vestigial allele; eyes, although large, have rough glazed appearance and the flies are almost achaetous, having fewer than ten macrochaetae per fly; acrostichal hairs and other microchaetae reduced in number and disturbed in arrangement; tarsal claws also much reduced.