A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Cbp53E

General Information
SymbolDmel\Cbp53ESpeciesD. melanogaster
NameCalbindin 53EAnnotation symbolCG6702
Feature typeprotein_coding_geneFlyBase IDFBgn0004580
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map53E4-53E4Sequence location2R:12,861,465..12,883,566 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Calbindin 53E is referred to in FlyBase by the symbol Cbp53E (CG6702, FBgn0004580). It has the cytological map location 53E4. Its sequence location is 2R:12861465..12883566. Its molecular function is described as calcium ion binding. It is involved in the biological process cellular calcium ion homeostasis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
53E4-53E4  
Limits computationally determined from genome sequence between P{lacW}CG6426k10209&P{lacW}vegk07202 and P{lacW}l(2)k07408k07408  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
53E-53E
(determined by in situ hybridisation)  
(Reifegerste et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Cbp53E for information on other features
detailed view FBtr0087056 FBtr0100251 FBtr0100249 FBtr0100250 FBtr0100252 FBtr0100120 FBtr0100121 FBpp0086204 FBpp0099641 FBpp0099640 FBpp0099638 FBpp0099639 FBpp0100159 FBpp0100158 FBti0041949 FBti0076209 FBti0041146
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Cbp53E-RA
FBtr0087056
 NM_057490
  2676
  310
Additional Transcript Data & Comments
Reported size (kB)
2.8, 1.7 (northern blot)
(Reifegerste et al., 1993)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Cbp53E-PA  
FBpp0086204  
35.7  
310  
4.32  
  NP_476838
  AAF57925
Additional Polypeptide Data & Comments
Reported size (kD)
310 (aa)
(Reifegerste et al., 1993)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Calcium-binding EF-hand (IPR002048)
EF-Hand type (IPR011992)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA567370
 
AA567419
 
AC004335
 
AE003805
AAF57925
 
AI134261
 
AW940422
 
AY058340
AAL13569
 
BI163215
 
BI166678
 
BI213716
 
BI236885
 
BI238532
 
BI239351
 
BI482463
 
BI574978
 
BI575519
 
BI576403
 
BI576701
 
BI585002
 
BI586268
 
BI588304
 
BI588468
 
BI588619
 
BI589331
 
BI589357
 
BI613652
 
BI614161
 
BI614289
 
BI614472
 
BI616380
 
BI618378
 
BI629430
 
BI630417
 
CO264355
 
CO267410
 
CO267498
 
CO269336
 
CO269541
 
CO271149
 
CO273885
 
CO274062
 
CO277150
 
CO287281
 
CO295333
 
CO297517
 
CO303241
 
CO305417
 
CO309819
 
CO310252
 
CO314943
 
CO318123
 
CO322733
 
CO328503
 
CO330546
 
CO339188
 
CZ483352
 
EC056784
 
EC060949
 
EC064558
 
EC067474
 
EC072034
 
EC072246
 
EC072887
 
EC072947
 
EC073044
 
EC075442
 
EC075445
 
EC077359
 
EC082964
 
EC083150
 
EC083544
 
EC084637
 
EC086043
 
EC087519
 
EC199174
 
EC202830
 
EC203342
 
EC203993
 
EC207192
 
EC209401
 
EC212987
 
EC214429
 
EC221274
 
EC229388
 
EC231666
 
EC233666
 
EC234730
 
EC237493
 
EC238761
 
EC243126
 
EC244782
 
EC248802
 
EC251637
 
EC257823
 
S59189
 
S59190
 
S59191
 
S59242
AAA15214
 
X68566
CAA48566
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    (FlyBase, 1992-)
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     adult stage
     ocellar nerve
    (Reifegerste et al., 1993)
     adult stage
     medulla layer M2
    (Reifegerste et al., 1993)
     adult stage
     antenna | restricted
    (Reifegerste et al., 1993)
     larval stage | third instar
     larval central nervous system | restricted
    (Reifegerste et al., 1993)
     adult stage
     adult central nervous system
    (Reifegerste et al., 1993)
     adult stage
     neuron
    (Reifegerste et al., 1993)
     embryonic stage | >12hr
     embryonic central nervous system | restricted
    (Reifegerste et al., 1993)
     embryonic stage | >12hr
     embryonic peripheral nervous system | restricted
    (Reifegerste et al., 1993)
     adult stage
     lamina
    (Reifegerste et al., 1993)
     embryonic stage | >12hr
     neuron
    (Reifegerste et al., 1993)
     adult stage
     thoracic ganglion
    (Reifegerste et al., 1993)
     adult stage
     direct flight muscle
    (Reifegerste et al., 1993)
     embryonic stage | late
     ventral midline
    (Reifegerste et al., 1993)
     adult stage
     adult brain | restricted
    (Reifegerste et al., 1993)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
       embryonic stage | >12hr
       embryonic peripheral nervous system | restricted
      (Reifegerste et al., 1993)
       adult stage
       lamina
      (Reifegerste et al., 1993)
       embryonic stage | > 12hr
       embryonic central nervous system | restricted
      (Reifegerste et al., 1993)
       adult stage
       neuron
      (Reifegerste et al., 1993)
       larval stage | third instar
       larval central nervous system | restricted
      (Reifegerste et al., 1993)
       embryonic stage | late
       ventral midline
      (Reifegerste et al., 1993)
       adult stage
       adult brain | restricted
      (Reifegerste et al., 1993)
       adult stage
       adult central nervous system
      (Reifegerste et al., 1993)
       adult stage
       antenna
      (Reifegerste et al., 1993)
       adult stage
       thoracic ganglion
      (Reifegerste et al., 1993)
       adult stage
       direct flight muscle
      (Reifegerste et al., 1993)
       embryonic stage | >12hr
       neuron
      (Reifegerste et al., 1993)
       adult stage
       medulla layer M2
      (Reifegerste et al., 1993)
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0087056 FBtr0100251 FBtr0100249 FBtr0100250 FBtr0100252 FBtr0100120 FBtr0100121
        AI134261
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        Sterility
        Allele
        fertile
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 2 )
        For All Classical Alleles Show

        Allele of Cbp53EClassMutagenStocksKnown lesion
        Cbp53EMB00150
          		1 --
          Cbp53Ef008762 --
          hide Alleles Carried on Transgenic Constructs ( 1 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of Cbp53EClassMutagenStocksKnown lesion
          Cbp53EGD105842 Yes
          hide Aneuploid Aberrations
          Useful duplication
           
          Disrupted in
          (Ryder, 2004.4.26)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD10584}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          miscellaneous insertions
          PBac{WH}Cbp53Ef00876
          NA
          insertion of enhancer trap binary system
          Mi{ET1}Cbp53EMB00150
          No
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          Cbp53E has been cloned and molecularly characterised.
          (Reifegerste et al., 1993)
          Cbp53E has been cloned and molecularly characterised.
          (Reifegerste et al., 1991)
          hide Gene Ontology: Function, Process & Cellular Component ( 2 )
          hide Molecular Function
          CV term
          Evidence
          References
          calcium ion binding
          inferred from sequence or structural similarity with UniProtKB:P12658
          (FlyBase, 1992-)
          traceable author statement
          (Harteneck, 2003)
          non-traceable author statement
          (Swiss-Prot Project Members, 1995.2.1)
          hide Biological Process
          CV term
          Evidence
          References
          cellular calcium ion homeostasis
          inferred from sequence or structural similarity with UniProtKB:P12658
          (FlyBase, 1992-)
          hide Cellular Component
          CV term
          Evidence
          References
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          Cbp53E allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
           
          Linkouts
          InParanoid orthologs - Eukaryotic orthologs
          •
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 5 )
          Harvard
          -
          PBac{WH}Cbp53Ef00876
          VDRC
          v42535
          w1118; P{GD10584}v42535
          v41812
          w1118; P{GD10584}v41812/CyO
          Bloomington
          18382
          w1118; PBac{WH}Cbp53Ef00876
          22712
          y1 w67c23; Mi{ET1}Cbp53EMB00150
          hide Genomic Clones ( 2 )
          hide cDNA Clones ( 51 )
          Please Note
          This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high