Gene Dmel\syt

General Information
Symbol	Dmel\syt	Species	D. melanogaster
Name	synaptotagmin	Annotation symbol	CG3139
Feature type	protein_coding_gene	FlyBase ID	FBgn0004242
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23A6-23B1	Sequence location	2L:2,780,741..2,799,970 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene synaptotagmin is referred to in FlyBase by the symbol syt (CG3139, FBgn0004242). It has the cytological map location 23A6-23B1. Its sequence location is 2L:2780741..2799970. Its molecular function is described as: calcium ion binding; protein binding; calcium-dependent phospholipid binding; transporter activity. It is involved in the biological processes: neurotransmitter secretion; vesicle-mediated transport; larval locomotory behavior; exocytosis; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle transport; regulation of pole plasm oskar mRNA localization; regulation of synapse structure and activity. 43 alleles are reported. The phenotypes of these alleles are annotated with: neuromuscular junction; synaptic vesicle; larval neuromuscular junction; eye; bouton; synapse; neuron; crystal cell; egg; wing. It has 4 annotated transcripts and 4 annotated polypeptides.
External Summaries

Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23A6-23B1 Limits computationally determined from genome sequence between P{EP}EP832 and P{PZ}oho23B⁰³⁵⁷⁵
Experimentally Determined Cytological Location
Cytogenetic map Notes References 23B-23B Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones. (Lloyd et al., 2000) 23B1-23B2 (determined by in situ hybridisation) (Spradling et al., 1999) 23B1-23B2 (BDGP Project Members, 1994-1999) 23B-23B (determined by in situ hybridisation) (DiAntonio et al., 1993) 23B-23B (determined by in situ hybridisation) (Perin et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: anon-23Ab+ anon-23Aa- colt- syt? (Hartenstein et al., 1997)
Gene Model & Products
Please see the GBrowse view of Dmel\syt for information on other features
Comments on Gene Model
	EST data support existence of multiple transcripts.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) syt-RA FBtr0077726 NM_078736 3984 474 syt-RB FBtr0077727 NM_164501 3978 472 syt-RC FBtr0077728 NM_164502 3627 472 syt-RD FBtr0077729 NM_205897 3547 251
Additional Transcript Data & Comments
Reported size (kB)	7.0, 4.5, 2.18 (longest cDNA) (Perin et al., 1991) 6.5, 4.0 (northern blot) (DiAntonio et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein syt-PA FBpp0077410 53.3 474 5.64 NP_523460 AAF51205 syt-PB FBpp0077411 53.0 472 5.64 NP_722838 AAF51206 syt-PC FBpp0077412 53.0 472 5.64 NP_722839 AAN10415 syt-PD FBpp0089345 28.6 251 8.75 NP_995619 AAS64625
Additional Polypeptide Data & Comments
Reported size (kD)	474 (aa) (Perin et al., 1991) 69 (kD) (Littleton et al., 1993)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0004242
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium-dependent membrane targeting (IPR000008) Synaptotagmin (IPR001565) C2 calcium/lipid-binding region, CaLB (IPR008973)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140679 AA567822 AA567865 AA697281 AE003582 AAF51205 AE003582 AAF51206 AE003582 AAN10415 AE003582 AAS64625 AI062148 AI063013 AI238814 AI292449 AI297169 AI387168 AI388431 AI513807 AQ025774 AW940031 AW940571 AY119455 AAM50109 BH854537 BH854692 BI173031 BI239409 BI356305 BI366697 BI373613 BI374159 BI374427 BI565040 BI574200 BI584705 BI588556 BI592737 BI609085 BI610277 BI613228 BI619050 BI621436 BT004498 AAO42662 CO178730 CO178892 CO179269 CO179865 CO180029 CO185665 CO186789 CO187010 CO189102 CO189379 CO189477 CO190003 CO190507 CO190849 CO262256 CO264724 CO266585 CO267179 CO267453 CO267750 CO267967 CO268993 CO269000 CO269003 CO269575 CO269744 CO270037 CO270319 CO272080 CO276097 CO277672 CO278393 CO279297 CO280296 CO281032 CO284203 CO285777 CO285978 CO287716 CO288024 CO288398 CO288931 CO289295 CO292494 CO293151 CO293814 CO294756 CO295849 CO297707 CO297718 CO299324 CO300874 CO300946 CO301693 CO302318 CO303740 CO303887 CO304685 CO304841 CO305239 CO307163 CO307202 CO307905 CO308260 CO308853 CO309100 CO310855 CO311765 CO312168 CO313850 CO314515 CO317389 CO318813 CO319766 CO324156 CO324297 CO326659 CO327534 CO328233 CO330061 CO330474 CO331998 CO332162 CO333600 CO333958 CO341519 CO342262 CZ467306 CZ474280 CZ474281 CZ484588 CZ484589 EC052820 EC056932 EC057099 EC059041 EC059593 EC061657 EC064151 EC064876 EC067021 EC067478 EC067760 EC069884 EC070013 EC070158 EC071273 EC072740 EC073187 EC074768 EC075202 EC075326 EC076132 EC076449 EC077147 EC077595 EC077738 EC078493 EC079440 EC079606 EC081015 EC081327 EC082544 EC082710 EC082810 EC082917 EC085327 EC085683 EC086581 EC088701 EC089478 EC089874 EC090297 EC195537 EC197003 EC197196 EC198535 EC198669 EC200068 EC200852 EC201341 EC202222 EC202768 EC202940 EC202988 EC203232 EC203740 EC203858 EC207015 EC207319 EC207330 EC207381 EC208913 EC209638 EC211628 EC212878 EC213012 EC213707 EC216732 EC219984 EC221177 EC222047 EC222934 EC223684 EC227051 EC229834 EC229871 EC233162 EC233822 EC234609 EC235398 EC236113 EC236723 EC238036 EC238937 EC238979