Gene Dmel\sc

General Information
Symbol	Dmel\sc	Species	D. melanogaster
Name	scute	Annotation symbol	CG3827
Feature type	protein_coding_gene	FlyBase ID	FBgn0004170
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.0
Cytogenetic map	1A8-1A8	Sequence location	X:290,093..291,514 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene scute is referred to in FlyBase by the symbol sc (CG3827, FBgn0004170). It has the cytological map location 1A8. Its sequence location is X:290093..291514. Its molecular function is described as: DNA binding; specific RNA polymerase II transcription factor activity; transcription activator activity. It is involved in the biological processes described with 14 unique terms, many of which group under: anatomical structure development; system development; regulation of biological process; regulation of metabolic process; reproductive developmental process; sensory organ development; transcription, DNA-dependent; organ development; central nervous system development; nervous system development. 177 alleles are reported. The phenotypes of these alleles are annotated with 68 unique terms, many of which group under: adult segment; peripheral nervous system; adult mesothoracic segment; nervous system; adult external prothorax; postalar bristle; humeral trabecule; tormogen cell; anterior vertical bristle; embryonic nervous system; anterior orbital bristle; dorsal thoracic disc; antennal segment. It has one annotated transcript and one annotated polypeptide.
External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Hw: Hairy wing Hw: Hairy wing Edith M. Wallace, unpublished. Gain of function alleles of ASC, which lead to the development of supernumerary bristles and hairs in all segments of the fly: in the prefrons, postfrons, postgena, and occipital regions of the head; in the preepisternum, episternum, anepisternum, scutum, scutellum, postnotum, wingblade, legs, humerus, and halteres of the thorax; and in the tergites, pleura, and sternites of the abdomen. Phenotype suppressed by three doses of h+ (Botas, Moscoso del Prado, and Garcia-Bellido, 1982, EMBO J. 1: 307-10) and enhanced by h, emc, and pyd (Neel, 1941, Genetics 26: 52-58; Moscoso del Prado and Garcia-Bellido, 1984, Wilhelm Roux's Arch Dev. Biol. 193: 242-45). Numbers of super numerary bristles reduced in da+ hemizygotes (Dambly-Chaudiere, Ghysen, Jan and Jan, 1988, Roux's Arch Dev. Biol. 97: 419-23). sc: scute Specifies the differentiation of numerous macrochaetae on the head and thorax as well as microchaetae on the tergites: anterior, medial, and posterior orbital, posterior vertical, ocellar, and postvertical bristles on the head plus humeral, presutural, anterior and posterior notopleural, anterior supra-alar, sternopleural, anterior and posterior postalar, and anterior and posterior scutellar bristles on the mesothorax; also participates with ac in specifying the anterior vertical, posterior supra-alar, and anterior dorsocentral bristles; specifies the majority of the campaniform sensilla on the wing blade (Leyns, Dambly-Chaudiere and Ghysen, 1989, Wilhelm Roux's Arch. Dev. Biol. 198: 227-32). Males deficient for sc, i.e., In(1)sc8Lsc4R, are poorly viable and catatonic; homozygous deficient females lethal; males deficient for both ac and sc, i.e., In(1)y3PLsc4R, are lethal (Garcia-Bellido, 1979, Genetics 91: 491-520). sc deficiencies suppress the phenotype of emc; extra doses of ASC enhance the emc phenotype (Moscoso del Prado and Garcia-Bellido, 1984, Wilhelm Roux's Arch. Dev. Biol. 193: 242-51). sc260-25 Variegates for y, ac, and probably l(1)1Ac but not for svr; more extreme than scV1. Homozygous lethal. RK2A. scB57 Embryo displays reduced numbers of CNS and PNS neurons. Hw59g Extra vertical, dorsocentral, and scutellar bristles. Suppression of sc with su(Hw)2 does not suppress Hw59g. HwUa Weak Hw phenotype in heterozygous females. Phenotype only slightly enhanced by suppressing the pre-existing sc1 allele with su(Hw)2 (Garcia-Alonzo and Garcia-Bellido). sc1 Causes loss or marked reduction in number of scutellar, coxal, ocellar, first and second orbital, anterior notopleural, postvertical, tergital, and sternal bristles. Bristle sockets missing; bristle cells absent 19 hr after pupation, when normally present [Lees and Waddington, 1942, DIS 16: 70-70a; 1943, Proc. Roy. Soc. (London), Ser. B 131: 87-110]. Suppressed by su(Hw) and su(Hw)2. RK1. sc3 Most bristles affected, principally ventrals, orbitals, verticals, postverticals, ocellars, humerals, presuturals, notopleurals, supra-alars, postalars, sternopleurals, abdominals, and anterior dorsocentrals; scutellars and postdorsocentrals usually present. Viability of male low; female virtually lethal. RK2. sc3-1 Partial reversion from sc3. Homozygous females show reduced viability; hemizygous females lethal (Garcia-Bellido, 1979, Genetics 91: 491-520). RK2. sc3B: scute-3 of Bridges Like sc but does not affect anterior notopleurals. Suppressed by su(Hw)2 (Lee, 1973, Aust. J. Biol. Sci. 26: 903-09). RK1. sc4 Extreme scute. Bristles of head, except anterior verticals, absent. Only posterior notopleurals and alars remain on sides of mesothorax; abdominals, ventrals, coxals, and scutellars also missing. Slight variegation for Hw. RK1A. sc5 Sternital and scutellar bristles reduced in number; others rarely affected. sc5/sc6 is practically wild type. RK1. sc6 Slight sc; removes coxals, ocellars, first and second orbitals, postverticals, and anterior notopleurals. Scutellars and sternitals not affected. RK1. sc7 Like sc but anterior notopleurals not affected. sc7 tends to suppress expression of h (Steinberg, 1942, DIS 16: 68). RK1A. sc8 Slight sc; supra-alars, sternopleurals, or other bristles sometimes affected. Extra bristles may be present. Shows Hw effect and may be recognized in heterozygote, homozygote, or male by presence of one or more hairs on anterior mesopleural region. The Hw effect interacts strongly with h to produce extremely hairy wings (Steinberg, 1942, DIS 16: 68). sc8/0 male nearly lethal; survivors show variegation for y and ac; lethality suppressed by a Y chromosome, partially suppressed by parts of the Y (Hess, 1962, DIS 36: 74-75; 1963, Verhandl. Deut. Zool. Ges., Zool. Anz. Suppl. 26: 87-92). RK2A. sc9 Like sc but scutellars always absent. Abdomen swollen and wings poorly expanded, like sc2. RK2A. sc10-1 Like sc3 but more extreme; most extreme viable sc allele. Viability low. RK2A. sc12 First and second orbitals reduced or absent; other head bristles, posterior scutellars, and coxals also affected. Also shows achaete effect. Viability of homozygous female low. RK2. sc13 Like sc but scutellars invariably absent and ocellars, postverticals, and first and second orbitals less frequent. Anterior and posterior dorsocentrals also absent, as are thoracic hairs, because of ac4. Viability low. RK2. sc15 Originally allelic to sc and semilethal in male. Subsequently, allelic to y, ac, and sc, and male lethal. Lethal form exaggerates other ac and sc alleles in heterozygote. RK2A. sc19 Scutellar bristles absent and sternitals reduced. RK1A. sc28 Strong scute; not suppressed by su(Hw)2. sc29 Similar to sc7. Viable and fertile. RK2A. sc49c sc52c sc67b5 Strong scute; not suppressed by su(Hw)2. sc260-14 Both sexes viable and fertile. RK2A. sc260-15 Male sterile. Viability reduced. RK2A. sc260-16 sc260-16/sc overlaps wild type. Lethal homozygous and hemizygous. RK2. sc260-17 Male and homozygous female viable and fertile. RK2A. sc260-18 Male sterile. RK2A. sc260-20 Male and homozygous female viable and fertile. RK2A. sc260-22 Both sexes viable and fertile. RK2A. sc260-23 Both sexes viable. RK3A. sc260-26 Viability reduced in male. Male fertile. RK2A. sc260-27 Male viable but sterile. RK2A. sc260-29 Male viable but sterile. RK2A. scA: scute of Agol Similar to sc. Viability low. RK2A. scB1: scute of Brande Similar to sc. Viability good. RK2A. scD1: scute of Dobzhansky Weak sc. RK2. scD2 Slight sc. RK2. scFah: scute of Fahmy Bristles (principally orbitals, verticals, postverticals, and ocellars) missing. Scutellars and postdorsocentrals left nearly intact. Male viable and fertile; female homozygous lethal. scFah/sc has only occasional absence of postvertical or ocellar bristles. RK2A. scH: scute of Hackett Similar to sc but more extreme. RK2A. scJ4 Scute and achaete effects. RK3A. scK: scute of Krivshenko Similar to sc but semilethal in male and lethal in homozygous female. RK2A. scL3: scute of Levy In addition to scute, it has a spoon-like wing caused by a mutation to the right of sc. Viable. Suppressed by su(Hw)2 (Lee, 1973, Aust. J. Biol. Sci. 26: 903-09). RK2. scL6 Moderate scute; suppressed by su(Hw)2 (Lee, 1973, Aust. J. Biol. Sci. 26: 903-09) scL8 Similar to sc4 but more extreme. Homozygous female sterile. RK2A. scS1: scute of Sinitskaya Rather extreme sc allele; slight Hw effect; hairs often removed from abdomen and wings. Homozygous female sterile and low in viability. Male fertile and fairly viable. RK2A. scS2 Similar to sc7. RK1A. *scSo: scute of Sytko Like sc; viability of homozygous female low. RK2. scV1: scute of Valencia Extreme scute and achaete. Viability low. RK2A. scV2 Both achaete and scute variably affected. Some tendency for extra or twin bristles. Abdominal bristles markedly fewer both dorsally and ventrally. Male and homozygous female viable and fertile. RK2A. sis-b: sisterless b (T. W. Cline) Original hypomorphic allele recovered as a reversion of sc3 to nearly wild-type ac and sc phenotype in hemizygote and homozygote; originally designated sc3-1 by Sturtevant, renamed sis-b by Cline. Locus also characterized by dominant effects of deficiencies and duplications of the ASC region, and later by mutant alleles sc10-1 and Hw49c that affect ASC functions more than sis-b functions. sis-b reduces viability of homozygous females and hemizygous females are lethal; yet hemizygous males fully viable. Dominant synergistic female-specific lethal interactions with loss-of-function alleles of Sxl, sis-a, and/or maternal da; magnitude of viability effects depends on genetic background and inversely correlates with background effects on male-lethal effects; interactions temperature dependent, generally more extreme at higher temperatures. Female viability effects suppressed by gain-of-function SxlM1 allele, and by duplications of Sxl+ or sis-a+. Duplication of sis-b+ male-lethal in combination with duplication of Sxl+ and/or sis-a+, more so at lower temperatures. Male lethality of duplication combinations suppressed by Sxl-. Phenotype of 2X;3A intersexes strongly dependent on dose of sis-b+. The dose-dependent interactions of this gene identify it as a positive regulator of Sxl+ and part of the numerator of what is referred to as the X/A balance, the primary sex-determination signal. This is a character it shares with sis-a.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1A8-1A8 Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-0.0 (Fahmy and Fahmy, 1958, Neel, 1942)
Left of (cM)	RpL36 (Garcia-Bellido, 1979)
Right of (cM)	y (Williamson et al., 1970, Garcia-Bellido, 1979) ac (Williamson et al., 1970)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\sc for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sc-RA FBtr0070073 NM_057455 1422 345
Additional Transcript Data & Comments
Reported size (kB)	1.6, 1.3 (northern blot) (Campuzano et al., 1986) 1.4 (northern blot) (Alonso and Cabrera, 1988)
Comments	The pattern of sc transcript accumulation closely resembles the distribution of sc protein. (Cubas et al., 1991)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein sc-PA FBpp0070072 38.2 345 7.13 NP_476803 AAF45499
Additional Polypeptide Data & Comments
Reported size (kD)	42 (kD observed); 39 (kD predicted) (Deshpande et al., 1995)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0004170
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Basic helix-loop-helix dimerisation region bHLH (IPR001092) Helix-loop-helix DNA-binding (IPR011598) Achaete-scute transcription factor related (IPR015660) TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • T00004
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003417 AAF45499 AF060506 AF132808 AL024453 CAA19657 BT022151 EC067213 EC221785 M17119 AAA28313

UniProtKB/Swiss-Prot	P10084
UniProtKB/TrEMBL

Maps to	198A6 (FlyBase, 1992-)
Does NOT map to
Identified with	IP01419 (Hoskins et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References complex substitution sc[sisB-3] X:290,723..290,728 comment=Approximate location of sc[sisB-3] mutation. Five foreign base pairs are substituted for six endogenous residues beginning at Gly172. The mutation introduces an immediate translation termination codon and a frameshift. evidence=experimental pr_change=G172@\|sc-PA reported_pr_change=G172@ (Wrischnik et al., 2003) deletion sc[Hw-49crv5] X:290,548..290,555 comment=8bp deletion that causes a frameshift and a shortened polypeptide. evidence=experimental (Balcells et al., 1988) deletion sc[sisB-2] X:293,614..296,308 comment=Approximate location of sc[sisB-2], a deletion of 2594bp starting 2.15kb downstream of the sc transcription unit. evidence=experimental (Wrischnik et al., 2003) point mutation sc[M6] X:290,549..290,549 evidence=experimental na_change=C290549T pr_change=Q114@\|sc-PA reported_na_change=C1000T reported_pr_change=Q114@ (Gomez-Skarmeta et al., 1995, Jimenez and Ish-Horowicz, 1997, Wrischnik et al., 2003) point mutation sc[sisB-1] X:290,615..290,615 comment=sc[[sisB-1] contains a point mutation and a 12kb tandem duplication containing the sc[sisB-1] allele and the adjacent wild type l(sc) transcription unit. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=A290615T pr_change=K136@\|sc-PA reported_pr_change=K136@ (Wrischnik et al., 2003) point mutation sc[10-1] X:290,696..290,696 evidence=experimental na_change=C290696T pr_change=Q163@\|sc-PA reported_na_change=C1147T reported_pr_change=?163@ (Villares and Cabrera, 1987) protein binding site sc-protein_bind-1 X:289,758..289,762 bound_moiety=ara-XP evidence=experimental (Gomez-Skarmeta et al., 1996, Bergman et al., 2004) protein binding site sc-protein_bind-2 X:287,138..287,178 bound_moiety=E(spl)-XP evidence=experimental (Culi and Modolell, 1998, Bergman et al., 2004) protein binding site sc-protein_bind-3 X:289,746..289,753 bound_moiety=ara-XP evidence=experimental (Bergman et al., 2004, Gomez-Skarmeta et al., 1996) regulatory region sc-reg_element-1 X:286,997..287,352 comment=SMC enhancer, directs expression in sensory organ mother cells (SMCs) evidence=experimental (Culi and Modolell, 1998) rescue fragment sc[+t.XSE] X:287,763..296,879 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=PstI-SalI_rfrag (Wrischnik et al., 2003)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 56
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 16023
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference embryonic stage labral segment (Romani et al., 1987) embryonic stage neuroblast (Ruiz-Gomez and Ghysen, 1993) embryonic stage stomodeum (Romani et al., 1987) proneural cluster (Cubas et al., 1991) larval stage \| third instar dorsal mesothoracic disc \| restricted (Romani et al., 1989) embryonic stage neurogenic region (Ruiz-Gomez and Ghysen, 1993) embryonic stage ectoderm (Romani et al., 1987) larval stage \| third instar stage 2 dorsal mesothoracic disc (Rodriguez et al., 1990) dorsal mesothoracic disc (Cubas et al., 1991) pupal stage (Erickson and Cline, 1993) embryonic stage embryonic peripheral nervous system (Ruiz-Gomez and Ghysen, 1993) embryonic stage sensory organ mother cell (Ruiz-Gomez and Ghysen, 1993) embryonic stage posterior embryonic/larval midgut (Romani et al., 1987) embryonic stage central nervous system (Romani et al., 1987) larval stage \| third instar adult trachea \| precursor (Romani et al., 1989) embryonic stage \| embryonic cycle 9-13 cleavage nuclei (Erickson and Cline, 1993) embryonic stage neuroblast (Cabrera et al., 1987) larval stage \| third instar dorsal mesothoracic disc \| restricted (Cabrera et al., 1994) embryonic stage \| 0-12hr (Erickson and Cline, 1993) larval stage \| third instar sensillum precursor (Romani et al., 1989) embryonic stage ventral midline (Romani et al., 1987) embryonic stage cephalic furrow (Romani et al., 1987) embryonic stage neurogenic region (Cabrera et al., 1987) embryonic stage posterior embryonic/larval midgut (Cabrera et al., 1987) embryonic stage sensory organ cell (Ruiz-Gomez and Ghysen, 1993) larval stage \| third instar sensillum precursor (Cabrera et al., 1994) embryonic stage procephalic neuroblasts (Cabrera et al., 1987) larval stage \| third instar (Erickson and Cline, 1993) embryonic stage procephalic segment (Romani et al., 1987)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference embryonic stage embryonic/larval hindgut \| restricted (Vassin et al., 1994) embryonic stage embryonic peripheral nervous system \| restricted (Vassin et al., 1994) larval stage proneural cluster (Cubas et al., 1991) embryonic stage proneural cluster (Vassin et al., 1994) larval stage \| third instar dorsal mesothoracic disc \| restricted (Cabrera et al., 1994) larval stage \| third instar sensory organ mother cell (Skeath and Carroll, 1991) embryonic stage embryonic central nervous system (Vassin et al., 1994) larval stage \| third instar ectoderm (Skeath and Carroll, 1991) embryonic stage \| stage 10-11 procephalic neuroblast \| subset (Urbach et al., 2003) embryonic stage \| stage 9-11 protocerebral neuroblast \| subset (Urbach and Technau, 2003) embryonic stage \| stage 12-14 embryonic stomatogastric nervous system (Vassin et al., 1994) embryonic stage neurectoderm (Vassin et al., 1994) larval stage \| third instar wing vein L1 (Skeath and Carroll, 1991) embryonic stage neuroblast (Vassin et al., 1994) embryonic stage P cell (Vassin et al., 1994) larval stage \| third instar sensillum precursor (Cabrera et al., 1994) larval stage dorsal mesothoracic disc (Cubas et al., 1991) embryonic stage (Vassin et al., 1994) embryonic stage \| stage 10-11 procephalic neurectoderm \| restricted (Urbach et al., 2003) embryonic stage \| stage 9-11 deuterocerebral neuroblast \| subset (Urbach and Technau, 2003) embryonic stage sensillum precursor (Vassin et al., 1994) embryonic stage-adult stage (Deshpande et al., 1995) larval stage \| third instar proneural cluster (Skeath and Carroll, 1991) larval stage \| third instar dorsal mesothoracic disc (Skeath and Carroll, 1991)
Marker for

Subcellular Localization
CV Term	nucleus (Cubas et al., 1991) cytoplasm nucleus (Deshpande et al., 1995)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004170 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0004170 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0004170 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for sc Stage(s) 7-8 Stage(s) 9-10 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable sc^260-14 sc^260-17 sc^260-18 sc^260-20 sc^260-22 sc^260-23 sc^260-29 sc²⁹ sc⁵ sc⁸ sc^B sc^L3 sc^V2 viable \| male sc^260-17 sc^B22 sc^Fah sc^M6 sc^V2 sc^sisB-2 sc^sisB-3 viable \| male \| reduced sc^260-26 sc^260-27 sc^S1 viable \| female \| recessive sc^260-17 sc^V2 viable \| female \| recessive \| reduced sc¹² viable \| reduced sc¹³ sc^260-15 semi-viable sc^10-1 sc^V1 semi-viable \| male sc³ semi-viable \| female \| recessive sc^So lethal \| recessive sc^19-30D sc^260-16 sc⁴ sc^K sc^SJ lethal \| female limited sc^M6 lethal \| conditional ts, with Scer\GAL4^hs.PB sc^Scer\UAS.cCa lethal \| male sc^B5 sc^hb.PP lethal \| female sc³ sc^hb.PP sc^sisB-1 lethal \| female \| recessive sc^10-1 sc^Fah sc^K sc^sisB-1 lethal \| female \| recessive \| conditional ts sc^M6 sc^sisB-3 lethal \| female \| conditional ts sc^sisB-1 sc^sisB-2 sc^sisB-3 lethal \| embryonic stage sc^sisB-1 lethal \| embryonic stage \| recessive sc^Hw-49crv5 lethal \| embryonic stage \| female sc^10-1 sc^sisB-1 lethal \| pharate adult stage, with Scer\GAL4^ptc-559.1 sc^Scer\UAS.cCa semi-lethal sc^10-1 sc⁸ sc^A semi-lethal \| recessive sc^A semi-lethal \| conditional ts sc^sisB-1 semi-lethal \| male sc^K semi-lethal \| female sc^S1 semi-lethal \| female \| recessive sc^M6 semi-lethal \| female \| recessive \| conditional ts sc^sisB-2 Other Phenotypes Allele wild-type sc^hs.PR visible sc^10-1 sc¹ sc^260-14 sc^260-15 sc^260-17 sc^260-18 sc^260-20 sc^260-22 sc^260-23 sc^260-27 sc^260-29 sc^3B sc⁴¹ⁱ sc⁴ sc⁵ sc⁶ sc⁸ sc^D1 sc^M6 sc^S1 sc^SJ sc^V2 sc^ase-1 sc^eas211 sc^eas41 sc^eas42 sc^eas4 sc^ebs12 sc^hs.PR sc^ls-1 sc^ls-2 sc^ls-3 sc^ls42 sc^ls4 sc^lx1 sc^me sc^mes21 sc^mes26 sc^ms16 sc^ms1 sc^ms212 sc^ms217 sc^ms2 sc^ms sc^sisB-1 visible (with In(1)sc^8Lsc^4R) sc^M6 sc^sisB-1 visible (with Df(1)sc19) sc^M6 sc^sisB-1 sc^sisB-2 sc^sisB-3 visible \| recessive sc^10-1 sc¹ sc⁴ sc⁷ sc⁸ sc⁹ sc^D1 sc^Fah sc^L8 sc^M6 sc^NDC19 sc^ase-1 visible \| conditional ts, with Scer\GAL4^hs.PB sc^Scer\UAS.cCa visible \| adult stage sc^10-1 visible \| adult stage \| dominant sc^M6 visible, with Scer\GAL4^dpp.blk1 sc^Scer\UAS.cHa visible, with Scer\GAL4^hs.PB sc^Scer\UAS.cCa sc^{bHLH.Scer\UAS} visible, with Scer\GAL4^ptc-559.1 sc^Scer\UAS.cCa visible, with Scer\GAL4^C-765 sc^Scer\UAS.cPa visible, with Scer\GAL4^pnr-MD237 sc^Scer\UAS.cPa visible, with Scer\GAL4^ap-md544 sc^Scer\UAS.cHa visible, with Scer\GAL4^sca-C253 sc^Scer\UAS.cHa visible, with Scer\GAL4¹⁰⁹ sc^Scer\UAS.cCa visible, with Scer\GAL4^sr-md710 sc^Scer\UAS.cHa visible, with Scer\GAL4^kni.L2 sc^Scer\UAS.cCa flightless, with Scer\GAL4^sr-md710 sc^Scer\UAS.cHa mitotic sc^10-1 mitotic, with Scer\GAL4^bbg-C96 sc^Scer\UAS.cHa sex-determination defective \| conditional ts sc^sisB-1 Sterility Allele sterile sc^10-1 female sterile sc^L8 sc^NDC19 sc^S1 male sterile sc^260-15 sc^260-18 sc^260-27 sc^260-29 fertile sc^260-20 sc^260-22 sc²⁹ fertile \| male sc^260-26 sc^Fah sc^V2 fertile \| female \| recessive sc^V2 male fertile sc^260-17 sc^Fah sc^S1 female fertile \| recessive sc^260-17 Phenotype manifest in Allele dorsocentral bristle sc^+mDC sc³ sc^Hw-59g wing sc¹ sc⁹ mesothoracic tarsal bristle sc¹ sc^10-1 sc⁴ sc⁷ sc⁹ sc^L8 sc^ase-1 mesothoracic tarsal bristle longitudinal row 6.5 sc¹ sc⁷ mesothoracic tarsal bristle longitudinal row 6 sc¹ sc⁷ scutellar bristle sc¹ sc¹³ sc¹⁹ sc^260-15 sc³ sc^3B sc⁴ sc⁴¹ⁱ sc⁵ sc⁸ sc⁹ sc^D1 sc^Hw-59g sc^S1 sc^SJ sc^V2 sc^ase-1 sc^eas211 sc^eas4 sc^eas41 sc^ebs1 sc^ebs11 sc^me sc^mes21 sc^mes26 sc^ms sc^ms1 sc^ms16 sc^ms2 sc^ms212 sc^ms217 anterior dorsocentral bristle sc¹ sc¹³ sc^3B sc^M6 sc^bald ocellar bristle sc¹ sc¹³ sc^260-15 sc³ sc^3B sc⁴ sc⁶ sc^D1 sc^Fah sc^M6 sc^S1 sc^SJ sc^me sc^mes21 sc^mes26 sc^ms sc^ms1 sc^ms16 sc^ms2 sc^ms212 sc^ms217 anterior orbital bristle sc¹ sc¹² sc¹³ sc^260-15 sc^3B sc⁴ sc⁶ sc^D1 sc^S1 sc^SJ sc^eas211 sc^eas4 sc^eas41 sc^ebs1 sc^ebs11 sc^ls4 sc^ls42 sc^lx1 sc^me sc^mes21 sc^mes26 sc^ms sc^ms1 sc^ms16 sc^ms2 sc^ms212 sc^ms217 sc^sisB-1 middle orbital bristle sc¹ sc¹² sc¹³ sc^3B sc⁶ sc^SJ postvertical bristle