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Gene Dmel\oc

General Information
Symbol	Dmel\oc	Species	D. melanogaster
Name	ocelliless	Annotation symbol	CG12154
Feature type	protein_coding_gene	FlyBase ID	FBgn0004102
Created / Updated	2005-01-10/2005-01-10
Genomic Location
Chromosome (arm)	X	Recombination map	1-23.1
Cytogenetic map	7F10-8A1	Sequence location	X:8,525,373..8,544,683 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ocelliless is referred to in FlyBase by the symbol oc (CG12154, FBgn0004102). It has the cytological map location 7F10-8A1. Its sequence location is X:8525373..8544683. Its molecular function is described as: transcription factor activity; sequence-specific DNA binding; cysteine-type endopeptidase activity. It is involved in the biological processes described with 14 unique terms, many of which group under: anatomical structure development; organ development; central nervous system development; organ morphogenesis; compound eye photoreceptor development; sensory organ development; embryonic pattern specification; regionalization; cellular macromolecule metabolic process; regulation of metabolic process; anterior/posterior axis specification; head segmentation; embryonic development via the syncytial blastoderm; locomotory behavior. 36 alleles are reported. The phenotypes of these alleles are annotated with 85 unique terms, many of which group under: peripheral nervous system; embryonic nervous system; embryonic neuron; nervous system; abdominal ventral denticle belt; VUM1 neuron; adult; VUM2 neuron; larval abdominal segment 5; commissure; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7F10-8A1   Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8A1-8A2 (determined by in situ hybridisation)   (Finkelstein et al., 1990)
Experimentally Determined Recombination Data
Location	1-23.1   1-26 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\oc for information on other features
Comments on Gene Model
	Due to frame shift mutation in sequenced strain and variable numbers of repetitive sequences, protein sequence differs from that of Genbank Accession number CAA41732 corresponding to Swissprot protein Accession number P22810
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) oc-RA FBtr0089650  NM_078536   3755   671 oc-RB FBtr0100341  NM_001014727   3737   665
Additional Transcript Data & Comments
Reported size (kB)	4.7 (northern blot) (Finkelstein et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein oc-PA   FBpp0088593   69.7   671   12.02     NP_511091   AAF46400 oc-PB   FBpp0099746   69.0   665   12.14     NP_001014727   AAX52481
Additional Polypeptide Data & Comments
Reported size (kD)	671 (aa) (Finkelstein et al., 1990)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0004102
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase, cysteine peptidase active site (IPR000169) Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287) TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • T02078
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003444 AAF46400   BI169182   BI361349   BI484013   BI612123   BT011185   CG12154   CO189025   CO280771   CO288322   CO295640   CO309419   CO323516   CO327177   CO345112   EC054172   EC054681   EC054682   EC058668   EC061912   EC064071   EC064484   EC235097   EC253987   EC254306   X58983 CAA41732
UniProtKB/Swiss-Prot	P22810
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	RE10280 (BDGP Project Members, 2000-) D1038 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage | 5-13 hr  ventral midline (Finkelstein et al., 1990)  embryonic stage | cellular blastoderm   (Rudolph et al., 1997)  embryonic stage | stage 5   (Gao et al., 1996)  embryonic stage | stage 5  dorsal (Gao et al., 1996)  embryonic stage | stage 3   (Gao et al., 1996)  embryonic stage | cellular blastoderm   (Finkelstein et al., 1990)  embryonic stage | stage 3-5   (Gao et al., 1996)  embryonic stage | stage 7  procephalic segment (Gao et al., 1996)  embryonic stage | stage 4   (Ronchi et al., 1993)  embryonic stage | stage >=6  procephalic neurectoderm | restricted (Rudolph et al., 1997)  embryonic stage | stage 4   (Gao et al., 1996)  embryonic stage | stage 8  procephalic mesoderm (Gao et al., 1996)  embryonic stage  head (Finkelstein et al., 1990)  embryonic stage | stage 8  ventral midline (Gao et al., 1996)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage | stage 9-11  procephalic neurectoderm & embryonic intercalary segment | restricted & ventral (Urbach and Technau, 2003)  embryonic stage | stage 9-11  tritocerebral neuroblast | subset (Urbach and Technau, 2003)  embryonic stage | stage 9-11  procephalic neuroectoderm & embryonic acron (Urbach and Technau, 2003)  embryonic stage | stage 9-11  protocerebral neuroblast | subset (Urbach and Technau, 2003)  embryonic stage | stage 9-11  deuterocerebral neuroblast | subset (Urbach and Technau, 2003)  embryonic stage | stage 9-11  procephalic neurectoderm & embryonic head | restricted & dorsal & middle (Urbach and Technau, 2003)  embryonic stage | stage 9-11  procephalic neurectoderm & embryonic antennal segment (Urbach and Technau, 2003)
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004102 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0004102 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0004102
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable oc10 lethal oc2 oc3 oc4 oc5 oc6 oc7 ocotd-XC86 ocotd-YH13 lethal | embryonic stage | recessive oc2 ocotd-EH630 ocotd-EH768 ocotd-XC86 ocotd-XD87 ocotd-YH13 ocotd-YH13 lethal | embryonic stage | recessive, with Scer\GAL4nos.bcd3'UTR.T:Scer\GCN4 ocScer\UAS.cWa Other Phenotypes Allele visible ocγa1 oc1 oc10 oc2 ocYM ocdb ocotd-XD87 ocotd-YH13 visible | recessive oc1 oc1 visual behavior defective | recessive ocuvi locomotor behavior defective oc1 Sterility Allele female sterile ocγa1 oc1 Phenotype manifest in Allele frons & macrochaeta ocγa1 oc1 macrochaeta | ectopic ocγa1 oc1 ocellus ocγa1 oc1 ocdb ocotd-YH13 ocunspecified frons ocγa1 oc1 ocotd-XC86 ocotd-YH13 female accessory gland ocγa1 oc1 protocerebral bridge ocγa1 oc1 postvertical bristle ocγa1 oc1 oc2 ocdb ocotd-XD87 ocotd-YH13 ocellar bristle ocγa1 oc1 oc2 ocdb ocotd-XD87 ocotd-YH13 interocellar bristle ocγa1 oc1 oc2 ocdb ocotd-XD87 ocotd-YH13 lateral ocellus ocγa1 oc2 ocotd-XD87 ocotd-YH13 medial ocellus ocγa1 oc2 ocotd-XD87 ocotd-YH13 ocellus pigment granule oc1 ocellus lens oc1 ocunspecified ocellus & macrochaeta oc10 protocerebral neuromere oc2 oc9 ocotd-XD87 ocotd-YH13 embryonic protocerebral neuromere oc2 embryonic brain & commissure oc2 embryonic head oc2 ocotd-EH630 ocotd-EH768 ocotd-NP162 ocotd-XC86 ocotd-XD87 ocotd-YH13 embryonic segment oc2 ocotd-EH630 ocotd-EH768 ocotd-NP162 ocotd-XC86 ocotd-XD87 ocotd-YH13 neuropil & embryo oc2 ocotd-EH630 ocotd-EH768 ocotd-NP162 ocotd-XC86 ocotd-XD87 ocotd-YH13 commissure & embryo oc2 ocotd-EH630 ocotd-EH768 ocotd-NP162 ocotd-XC86 ocotd-XD87 ocotd-YH13 embryonic central nervous system oc2 ochs.PR ocotd-EH630 ocotd-EH768 ocotd-NP162 ocotd-XC86 ocotd-XD87 ocotd-YH13 embryonic ventral epidermis oc2 embryonic brain oc2 oc76 ochs.PR longitudinal connective oc2 commissure oc2 embryonic antennal segment oc2 ocotd-XD87 ocotd-YH13 embryonic protocerebrum oc76 growth cone oc9 anterior commissure oc9 posterior commissure oc9 ocunspecified midline glial cell oc9 abdominal 1 VUM1 neuron oc9 abdominal 2 VUM1 neuron oc9 abdominal 3 VUM1 neuron oc9 abdominal 4 VUM1 neuron oc9 abdominal 5 VUM1 neuron oc9 abdominal 6 VUM1 neuron oc9 abdominal 7 VUM1 neuron oc9 abdominal 1 VUM2 neuron oc9 abdominal 2 VUM2 neuron oc9 abdominal 3 VUM2 neuron oc9 abdominal 4 VUM2 neuron oc9 abdominal 5 VUM2 neuron oc9 abdominal 6 VUM2 neuron oc9 abdominal 7 VUM2 neuron oc9 abdominal 1 VUM3 neuron oc9 abdominal 2 VUM3 neuron oc9 abdominal 3 VUM3 neuron oc9 abdominal 4 VUM3 neuron oc9 abdominal 5 VUM3 neuron oc9 abdominal 6 VUM3 neuron oc9 abdominal 7 VUM3 neuron oc9 neuroblast MNB oc9 deutocerebral neuromere oc9 ventral midline oc9 abdominal neuromere oc9 larval pharynx & embryo, with Scer\GAL4nos.bcd3'UTR.T:Scer\GCN4 ocScer\UAS.cWa mouth hooks, with Scer\GAL4nos.bcd3'UTR.T:Scer\GCN4 ocScer\UAS.cWa precursor cell of the stomatogastric nervous system, with Scer\GAL4nos.bcd3'UTR.T:Scer\GCN4 ocScer\UAS.cWa antennal primordium ocYM antennal segment ocYM ganglion & embryo | ectopic ochs.PR larval ventral ganglion & embryo ochs.PR embryonic head & ganglion ochs.PR ventral nerve cord | posterior ochs.PR embryonic peripheral nervous system | posterior ochs.PR dorsomedial papilla | ectopic ochs.PR dorsomedial papilla ochs.PR antennal sense organ ochs.PR dorsolateral papilla ochs.PR larval maxillary sense organ ochs.PR cephalopharyngeal skeleton ochs.PR rostral hairs ochs.PR female gonopod ocotd-YH13 denticle belt ocotd-YH13 abdominal 1 ventral denticle belt ocotd-YH13 abdominal 2 ventral denticle belt ocotd-YH13 abdominal 3 ventral denticle belt ocotd-YH13 abdominal 4 ventral denticle belt ocotd-YH13 abdominal 5 ventral denticle belt ocotd-YH13 abdominal 6 ventral denticle belt ocotd-YH13 abdominal 7 ventral denticle belt ocotd-YH13 abdominal 8 ventral denticle belt ocotd-YH13 photoreceptor cell ocuvi rhabdomere ocuvi cone cell ocuvi rhabdomere R1 ocuvi rhabdomere R2 ocuvi rhabdomere R3 ocuvi rhabdomere R4 ocuvi rhabdomere R5 ocuvi rhabdomere R6 ocuvi rhabdomere R7 ocuvi rhabdomere R8 ocuvi
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of oc Class Mutagen Stocks Known lesion oc10 ethyl methanesulfonate 0 -- oc1 X ray 55 -- oc2 amorph X ray 1 Yes oc3 X ray 0 -- oc4 X ray 0 -- oc5 ethyl methanesulfonate 0 -- oc6 ethyl methanesulfonate 0 -- oc76 0 -- oc7 ethyl methanesulfonate 0 -- oc8 ethyl methanesulfonate 0 -- oc9 loss of function ethyl methanesulfonate 5 -- ocP P-element activity 0 -- ocR3.2 2 -- ocYHB 0 -- ocYM 0 -- ocdb spontaneous 0 -- ocmoda1 0 -- ocotd-EH630 ethyl methanesulfonate 0 -- ocotd-EH768 ethyl methanesulfonate 0 -- ocotd-NP162 ethyl methanesulfonate 0 -- ocotd-XC86 ethyl methanesulfonate 2 -- ocotd-XD87 ethyl methanesulfonate 0 -- ocotd-YH13 ethyl methanesulfonate 3 -- ocunspecified 0 -- ocuvi hypomorph X ray 0 Yes ocγa1 γ ray 2 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of oc Class Mutagen Stocks Known lesion ocAct5C.PM in vitro construct | regulatory fusion 0 Yes ocGD15003 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes ocGD1500 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes ocIK28.Act5C in vitro construct | site directed mutagenesis in vitro construct | amino acid replacement 0 Yes ocSR43.Act5C in vitro construct | site directed mutagenesis in vitro construct | amino acid replacement 0 Yes ocScer\UAS.cFa in vitro construct | regulatory fusion 2 Yes ocScer\UAS.cWa in vitro construct | regulatory fusion 0 Yes ocdsRNA.cKa in vitro construct | RNAi 0 Yes ochs.PF in vitro construct | regulatory fusion 0 -- ochs.PR in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)RA2
Useful duplication	Dp(1;1)L72.2
Duplicated in	Dp(1;2)sn+72d (Eberl and Hilliker, 1988) Dp(1;3)sn13a1 (Lefevre, 1981) Dp(1;Y)578 (Lilly and Botas, 1999) Dp(1;Y)619 (Lilly and Botas, 1999) Dp(1;Y)850 (Lilly and Botas, 1999) Dp(1;Y)867 (Lilly and Botas, 1999) Dp(1;Y)921 (Lilly and Botas, 1999) Tp(1;2)sn+72d (Lefevre, 1981)
Not disrupted in	Df(1)Sp8A (Schalet, 1986) Dp(1;f)A12 (Mackensen, 1935)
Disrupted in	Df(1)KA14 (Craymer and Roy, 1980, Tearle and Nusslein-Volhard, 1987, Cohen and Jurgens, 1990, Schmidt-Ott et al., 1994, Harbecke and Lengyel, 1995, Wimmer et al., 1995, van den Dries et al., 1996, Luer et al., 1997) Df(1)RA2 (Craymer and Roy, 1980, Tearle and Nusslein-Volhard, 1987, Harbecke and Lengyel, 1995, van den Dries et al., 1996)
Not duplicated in	Dp(1;2)rb+71g (Eberl and Hilliker, 1988) Dp(1;2)w+64b (Eberl and Hilliker, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hsp70-otd.F} NA P{hsp70-otd.R} NA reporter construct P{HZ50PL-1.1} Yes P{HZ50PL-1.5} Yes P{HZ50PL-2.6} Yes P{oc-lacZ.+7} No P{oc-lacZ.1.8} No P{oc-lacZ.186mut} No P{oc-lacZ.186} No P{oc-lacZ.526} No P{oc-lacZ.7.6} No P{oc-lacZ.900} No P{oc-lacZ.Δ10} No P{oc-lacZ.Δ3'4} No P{oc-lacZ.Δ3'5} No P{oc-lacZ.Δ3'6} No P{oc-lacZ.Δ3'7} No P{oc-lacZ.Δ3'8} No P{oc-lacZ.Δ3'AvrII} No P{oc-lacZ.Δ3'SpeI} No P{oc-lacZ.Δ5'1} No P{oc-lacZ.Δ5'2} No P{oc-lacZ.Δ5'3} No P{oc-lacZ.Δ5'BglII} No P{oc-lacZ.Δ5'ClaI} No P{oc-lacZ.Δ5'EcoRV} No P{oc-lacZ.Δ5'HincII} No P{oc-lacZ.Δ5'KpnI} No P{oc-lacZ.Δ5'SpeI} No UAS construct P{GD15003} NA P{GD1500} NA P{UAS-oc.F} NA P{UAS-oc.W} NA
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data Ocelli completely absent. Bristles in ocellar area and on top of head irregular and more numerous; postverticals usually absent. Eyes somewhat reduced and body size dwarfed. Phototaxis normal (Benzer, 1967). Viability about 90% wild type. oc and deficiencies for oc show partial dominance to oc+; ocelli placed somewhat far back on head and slight indentation apparent between postvertical bristles (Craymer and Roy, 1980). Ubl/+ enhances dominance of oc; Df(1)RA2/+ exhibit delayed hatch and an oc phenotype; oc2/+ display strong oc phenotype and oc1/oc1 are lethal in combination with Ubl/+ (Mortin and Lefevre, 1981). Lethal alleles (recovered as otd: orthodenticle) die as embryos; all denticles in anterior abdom