Gene Dmel\y

General Information
Symbol	Dmel\y	Species	D. melanogaster
Name	yellow	Annotation symbol	CG3757
Feature type	protein_coding_gene	FlyBase ID	FBgn0004034
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.0
Cytogenetic map	1A5-1A5	Sequence location	X:250,542..255,278 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene yellow is referred to in FlyBase by the symbol y (CG3757, FBgn0004034). It has the cytological map location 1A5. Its sequence location is X:250542..255278. Its molecular function is unknown. It is involved in the biological processes: cuticle pigmentation; melanin biosynthetic process; pigmentation during development; male courtship behavior, veined wing extension; mating behavior; pigmentation; adult chitin-based cuticle development; instar larval or pupal development; courtship behavior; melanin biosynthetic process from tyrosine. 943 alleles are reported. The phenotypes of these alleles are annotated with 39 unique terms, many of which group under: adult segment; peripheral nervous system; nervous system; adult mesothoracic segment; appendage segment; metatarsus; organ system; cephalopharyngeal skeleton; antennal segment; embryonic head. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1A5-1A5 Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452
Experimentally Determined Cytological Location
Cytogenetic map Notes References 1B-1B (determined by in situ hybridisation) (Vieira et al., 1997) 1B1-1B1 (determined by in situ hybridisation) (Lozovskaya et al., 1993) 1A8-1B1 (determined by in situ hybridisation) (Geyer et al., 1990) 1B1-1B1 (determined by in situ hybridisation) (Biessmann and Mason, 1988) 1B1-1B2 (determined by in situ hybridisation) (Biessmann and Green, 1986) 1A8-1B1 (determined by in situ hybridisation) (Geyer et al., 1986) 1B1-1B2 (determined by in situ hybridisation) (Biessmann, 1985)
Experimentally Determined Recombination Data
Location	1-0.0 (John Innes Laboratory, 1941, Meyer, 1963, Mickey, 1963, Neel, 1942, Fernandez Gianotti, 1950, University of Buenos Aires, 1951) 1- (Kiil, 1946)
Left of (cM)	sc (Williamson et al., 1970, Garcia-Bellido, 1979) ph-d (Dura et al., 1985) l(1)adl8 l(1)adl9 l(1)adl13 l(1)adl7 l(1)adl15 l(1)adl6 l(1)adl10 l(1)adl12 l(1)adl14 l(1)adl11 l(1)adl3 (Homyk et al., 1986) ung (Aguado Rodriguez et al., 1991) l(1)CP9 (Perez-Chiesa et al., 1987)
Right of (cM)	cin (Padilla and Nash, 1977)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: y? anon-1Be? ac? (Chia et al., 1986)
Gene Model & Products
Please see the GBrowse view of Dmel\y for information on other features
Comments on Gene Model
	Replace with wild type sequence from GenBank accession NG_000211 Translation start was set at the CTG codon (->Leu) preceding the second codon (TTC). Compare with GB:CAA28024, compare with SWISSPROT:P09957 Known mutation in sequenced strain A single nucleotide (C) inserted into translation start codon (ATG -> ACTG). Compare with GB:X04427.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) y-RA FBtr0070071 NM_057444 2038 541
Additional Transcript Data & Comments
Reported size (kB)	1.9 (unknown) (Martin et al., 1989) 2.0 (northern blot) (Biessmann, 1985) 1.990 (northern blot, sequence analysis) (Geyer et al., 1986) 1.9 (northern blot) (Geyer et al., 1990)
Comments	Expression levels of y transcript were analyzed in potential y regulatory mutants. (Geyer et al., 1990)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein y-PA FBpp0070070 60.5 541 5.57 NP_476792 AAF45497
Additional Polypeptide Data & Comments
Reported size (kD)	541 (aa); 57 (kD) (Kornezos and Chia, 1992) 541 (aa); 60.752 (kD predicted) (Geyer et al., 1986) 60 (kD) (Walter et al., 1991)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0004034
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Major royal jelly protein (IPR003534)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003417 AAF45497 AF074338 AF074339 AF345767 AF345768 AF345769 AF345770 AF345771 AF345772 AF345773 AF345774 AF345775 AF345776 AF345777 AF345778 AF516513 AL023873 CAA19640 CO266754 DQ099804 DQ099805 DQ099806 DQ099807 DQ099812 DQ099813 DQ099814 DQ099815 DQ099816 DQ099817 DQ099818 DQ099819 DQ099820 DQ099821 DQ099822 DQ099823 DQ099824 DQ099825 DQ099826 DQ099827 DQ099828 DQ099829 DQ099830 DQ099831 DQ099832 DQ099833 DQ099834 DQ099835 DQ099836 DQ099837 DQ099838 DQ099839 DQ099840 DQ099841 DQ099842 DQ099843 DQ099844 DQ099845 DQ099846 DQ099847 DQ099848 DQ099849 DQ099850 DQ099851 DQ099852 DQ099853 DQ099854 DQ099855 DQ099856 DQ099857 DQ099858 DQ099859 DQ099860 DQ099861 DQ099862 DQ099863 DQ099864 DQ099865 DQ099866 DQ099867 DQ099868 DQ099869 DQ099870 DQ099871 DQ099872 DQ099873 DQ099874 DQ099875 DQ099876 DQ099877 DQ099878 DQ099879 DQ099880 DQ099881 DQ099882 DQ099883 DQ099884 DQ099885 DQ099886 DQ099887 DQ099888 DQ099889 DQ099890 DQ099891 DQ099892 DQ099893 EC073082 S57430 X04427 CAA28024 X04703 X06481 X07529

UniProtKB/Swiss-Prot	P09957
UniProtKB/TrEMBL

Maps to	125H10 (FlyBase, 1992-)
Does NOT map to
Identified with	D1071 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References protein binding site y-protein_bind-1 X:255,594..255,604 bound_moiety=Su(Hw)-XP comment=putative Su(Hw) binding site evidence=experimental (Golovnin et al., 2003) protein binding site y-protein_bind-2 X:255,643..255,653 bound_moiety=Su(Hw)-XP comment=putative Su(Hw) binding site evidence=experimental (Golovnin et al., 2003) regulatory region y-reg_element-1 X:247,683..248,690 comment=Tissue-specific enhancer; location from GB:X06481. evidence=experimental (Geyer and Corces, 1987) regulatory region y-reg_element-2 X:248,691..249,860 comment=Tissue-specific enhancer; location from GB:X06481. evidence=experimental (Geyer and Corces, 1987) regulatory region y-reg_element-3 X:255,328..255,746 comment=Su(Hw) insulator that contains two putative Su(Hw) binding sites and has full insulator activity. evidence=experimental (Golovnin et al., 2003) rescue fragment y[+t7.7] X:247,683..255,363 comment=Position of rescue fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=SalI-BglII_rfrag rescue fragment y[+t12] X:247,683..259,288 comment=Position of rescue fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=SalI-EcoRI_rfrag (Chia et al., 1986) transposable element target site duplication gypsy{}y[2] X:249,853..249,856 comment=Insertion site location from GB:X04427. evidence=experimental (Geyer et al., 1986)
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 15022
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference larval stage (Biessmann, 1985) pupal stage (Geyer et al., 1990) embryonic stage \| stage 15 (Biessmann, 1985) embryonic stage \| stage 17 anal plate (Martin et al., 1989) embryonic stage \| stage 17 embryonic/larval oesophagus (Martin et al., 1989) adult stage (Geyer et al., 1986) pupal stage (Geyer et al., 1986) embryonic stage \| stage 17 cephalopharyngeal skeleton (Martin et al., 1989) embryonic stage \| stage 16 (Biessmann, 1985)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference pupal stage epidermis (Walter et al., 1991) adult stage cuticle (Walter et al., 1991) embryonic stage \| stage 16 embryonic/larval pharynx \| anterior (Kornezos and Chia, 1992) embryonic stage \| stage 16 Keilin\\\'s organ (Kornezos and Chia, 1992) embryonic stage \| stage 16 abdominal segment 1..8 \| anterior (Kornezos and Chia, 1992) embryonic stage \| stage 16 cephalopharyngeal skeleton (Kornezos and Chia, 1992) embryonic stage \| stage 16 microchaetae (Kornezos and Chia, 1992) embryonic stage \| stage 16 epidermis (Kornezos and Chia, 1992) embryonic stage epidermis (Walter et al., 1991) embryonic stage \| stage 16 denticle belt (Kornezos and Chia, 1992)
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004034 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0004034 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0004034
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable y^260-11 y^260-12 y^260-13 y^260-24 y^260-30 y^260-4 y^RU viable \| male y^67k5 y^Ee13 y^Ee14 y^Ee15 y^Ee16 y^Ee4 y^Ee5 y^Ee6 y^Ee7 y^Ee8 y^R1 y^R10 y^R11 y^R12 y^R17 y^R19 y^R2 y^R21 y^R22 y^R26 y^R29 y^R3 y^R30 y^R5 y^R6 y^R7 Other Phenotypes Allele wild-type y^Δ0-101 y^Δ0-53 y^Δ25-67 y^Δ25-70 y⁺²⁰⁸³ y^+mDCla y^+ovo y^+s11 y^+s12 y^+s2 y^+s22 y^+s23 y^+s3 y^+s6 y^+s7 y^+s8 y^3B y^D-527 y^D-527 y^D-643 y^gc y^+t7.7 y^+t7.7 y^+t7.7 visible y^γ1028 y^γ1144 y^γ12 y^γ199 y^+mDint2 y¹ y² y² y^2U1-1 y^2U1-2 y^2U1-3 y^2U1-4 y^2U1-5 y^2U1-6 y^2U1-7 y^A66c y^A71k1 y^A71l2 y^A72a y^A72d1 y^A72d3 y^A72d4 y^A74b121 y^A74b46 y^A74b51 y^A74c166 y^A74c40 y^A74d1 y^A74e y^A74e3 y^A75l2 y^A76a110 y^A76a123 y^A76b37 y^A76b94 y^A77d y^A77f y^A78j y^A79b18 y^A79b21 y^A79d y^A79d2 y^A79d3 y^A79dsd y^A79g y^A79h1 y^A81c1 y^A81c2 y^A81c3 y^A81k29 y^A82c1 y^A82c2 y^A82c3 y^A83f12 y^A83f26 y^A83f58 y^A83fXL y^A84dS y^A84e61S y^A84eS y^D-786 y^D-CTLR y^D0.8HIII y^D0.8R1.3HIII y^D1868 y^cu y^v2 visible (with y¹) y^{P1\loxP.gypsy\su(Hw)BR-350.-300} y^{P1\loxP.gypsy\su(Hw)BR-350.-600} y^{P1\loxP.gypsy\su(Hw)BR-350.-900} visible (with y^{P1\loxP.gypsy\su(Hw)BR-350.-900}) y¹ visible (with y^{P1\loxP.gypsy\su(Hw)BR-350.-600}) y¹ visible (with y^{P1\loxP.gypsy\su(Hw)BR-350.-300}) y¹ visible \| recessive y^Δ25-120 y^Δ375-25 y^Δ375-39 y^Δ493-41 y^Δ493-42 y^Δ493-47 y^γ1028 y^γ1144 y^γ12 y^γ199 y^+13-11 y⁺¹³¹⁰ y⁺⁶⁶⁰ y⁺⁶⁶⁰ y^+660R y^-1868 y^-700 y^-700R y^-800 y^-800 y^-800R y^1h y² y² y² y² y² y^2bs1 y^2bs2 y^2bs3 y^2h115 y^2h12 y^2h131 y^2h15 y^2h16 y^2h25 y^2h29 y^2ns1 y^2ns2 y^2ns3 y^2ns4 y^2ns5 y^2s.2s7 y^P59 y^dh1 y^dh12 y^dh19 y^dh21 y^dh24 y^ds1 y^ds2 y^ds3 y^lh11 y^lh13 y^lh14 y^lh15 y^lh17 y^mh32 y^mws1 y^mws2 y^mws3 y^mws4 y^mws5 y^rh1 y^rh2 y^rh3 y^rh7 y^rh9 y^vs1 y^vs2 y^vs3 y^vs4 y^vs5 y^vs6 y^vs7 visible, with y¹ y^{P1\loxP.su(Hw)BR-y-AS-C.-900} visible, with y^{P1\loxP.su(Hw)BR-y-AS-C.-900} y¹ eye color defective y^2-717 y^2-717a1 y^2-717a2 y^2-717a4 y^2-717a5 y^2-717a6 y^2-717a7 y^2-717a8 body color defective y^γ1028 y^γ1144 y^γ12 y^γ199 y^+13-11 y^+Ds y^+ews1 y^+ews2 y^+mDint y^+mDint2 y^+mDint2 y^+ms y^-294 y^-495 y^-700 y^-700R y^-800 y^-800 y^-800 y^-800R y^-92 y¹ y¹ y¹ y¹ y¹ y¹¹ y¹⁶ y^18CH1 y^1s y^1s16 y^2#1 y^2#4 y² y² y² y² y² y² y² y² y² y² y²³⁷⁴ y²³⁷⁴ y²⁵ y^260-11 y^260-11 y^260-12 y^260-12 y^260-13 y^260-13 y^260-24 y^260-24 y^260-28 y^260-28 y^260-30 y^260-30 y^260-31 y^260-4 y^260-4 y^2PR1 y^2PR2 y^2S y^2S y^2S y^2U1-1 y^2U1-2 y^2U1-3 y^2U1-4 y^2U1-5 y^2U1-6 y^2U1-7 y^2bs y^2ns y^2s y^2s10-2 y^2s11 y^2s11 y^2s14 y^2s14 y^2s2 y^2s20 y^2s25 y^2s26 y^2s34 y^2s42 y^2s7 y^2s7 y^2sA3 y³ y^31b y^31c y^31d y^31d y^34c y^34c y^35a y^39e y^39e y^3M y^3d y^3d y^3d y⁴ y^4.5:2.9 y^40a y^50a y^50b25