Gene Dmel\αTub84D

General Information
Symbol	Dmel\αTub84D	Species	D. melanogaster
Name	α-Tubulin at 84D	Annotation symbol	CG2512
Feature type	protein_coding_gene	FlyBase ID	FBgn0003885
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84D9-84D9	Sequence location	3R:3,356,377..3,358,873 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene α-Tubulin at 84D is referred to in FlyBase by the symbol αTub84D (CG2512, FBgn0003885). It has the cytological map location 84D9. Its sequence location is 3R:3356377..3358873. Its molecular function is described as: structural constituent of cytoskeleton; GTP binding; protein binding; structural molecule activity; GTPase activity. It is involved in the biological processes: microtubule-based process; cytokinesis; cellular process; microtubule-based movement; protein polymerization. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	αTub84D (α3t) A structural gene for α-Tubulin. Coordinately expressed with αTub84B at most developmental stages with the exception of the adult stage where no 84D mRNA can be detected in males (Matthews et al., 1989).
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84D9-84D9 Limits computationally determined from genome sequence between P{EP}EP3060^EP3060 and P{PZ}grn⁰⁵⁹³⁰
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84D-84D (determined by in situ hybridisation) (Drosopoulou and Scouras, 1998) 84D4-84D8 (determined by in situ hybridisation) (Natzle and McCarthy, 1984) 84D4-84D8 (determined by in situ hybridisation) (Mischke and Pardue, 1982) 84D4-84D8 (determined by in situ hybridisation) (Kalfayan and Wensink, 1981) 84D4-84D8 (determined by in situ hybridisation) (Sanchez et al., 1980)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\αTub84D for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) alphaTub84D-RA FBtr0081538 NM_079540 2497 450 alphaTub84D-RB FBtr0081539 NM_169189 2291 450
Additional Transcript Data & Comments
Reported size (kB)	1.95 (northern blot) (Matthews et al., 1989) 1.3 (unknown) (Baum et al., 1983) 2.0 (northern blot) (Kalfayan and Wensink, 1982, Natzle and McCarthy, 1984) 1.996 (sequence analysis) (Theurkauf et al., 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein alphaTub84D-PA FBpp0081062 49.9 450 4.78 NP_524264 AAF54007 alphaTub84D-PB FBpp0081063 49.9 450 4.78 NP_731169 AAN13341
Additional Polypeptide Data & Comments
Reported size (kD)	450 (aa); 55 (kD predicted) (Theurkauf et al., 1986)
Comments	The location of maternal and constitutive α-tubulins is indistinguishable until ~8 hrs of development as determined by staining with maternal α-tubulin-specific and general α-tubulin antibodies. Studies with mutant embryos lacking zygotic α-tubulin show that the constitutive form is more stable than the maternal form. (Theurkauf, 1992)
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0003885
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tubulin (IPR000217) Alpha tubulin (IPR002452) Tubulin/FtsZ, GTPase (IPR003008) Tubulin/FtsZ, C-terminal (IPR008280)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201947 AA263232 AA263699 AA264140 AA264188 AA392675 AA440020 AA440259 AA536307 AA536474 AA695821 AA696109 AA698086 AA698493 AA735353 AA735843 AA803139 AA803455 AA816629 AA816787 AA817230 AA820472 AA820923 AA941636 AA942494 AA949094 AA949515 AA950068 AA951567 AA951781 AA978933 AA979239 AE003671 AAF54007 AE003671 AAN13341 AI063036 AI063045 AI110049 AI113963 AI133823 AI134889 AI387221 AI403612 AI456067 AI457076 AI512029 AI512542 AI514512 AI514581 AI514895 AI515256 AI516285 AI516469 AI516498 AI516914 AI518440 AI518723 AI520339 AI532013 AI541872 AI542641 AI543464 AI944783 AI944810 AI946369 AI947084 AT01053 AT01285 AT01783 BF486126 BF486145 BF486525 BF486764 BF486846 BF487196 BF487541 BF487624 BF487880 BF488089 BF488114 BF488195 BF488318 BF488962 BF489643 BF489875 BF489945 BF490260 BF491391 BF491421 BF491429 BF491506 BF491752 BF491817 BF492404 BF492550 BF492551 BF492931 BF493172 BF493491 BF493492 BF493738 BF493743 BF494691 BF494817 BF494852 BF495351 BF495717 BF495902 BF495977 BF496597 BF496718 BF496724 BF496770 BF497046 BF497100 BF498159 BF498302 BF498659 BF499502 BF500994 BF501263 BF502132 BF502222 BF502243 BF502817 BF503017 BF503544 BF504341 BF504361 BF504387 BF504750 BF504898 BF505033 BF505134 BF505902 BF506140 BF506178 BF506188 BF506391 BF506668 BG631933 BG633429 BG633883 BG634111 BG634210 BG634232 BG634537 BG634897 BG635122 BG635220 BG635396 BG636883 BG639346 BI141939 BI163632 BI215358 BI216250 BI227949 BI230220 BI236668 BI352880 BI353482 BI354618 BI354976 BI355150 BI355395 BI355559 BI355786 BI373564 BI484284 BI565190 BI567042 BI567308 BI576812 BI591965 BI592133 BI611269 BI617791 BI619390 BI620596 BI622588 BI625278 BI625404 BI631533 BI633422 BI637261 BQ103744 BT003630 AAO39634 BT003630 AAO39634 BT016118 CK131310 CK132066 CK132090 CK604467 CK604526 CK604527 CK658957 CO193817 CO280059 CO307881 CO329239 CO335602 CZ482993 CZ485918 CZ485919 CZ487980 EC073250 EC089050 EC205120 EC227730 EC264097 EL873915 EL880764 EL880765 M14645 AAA28987

UniProtKB/Swiss-Prot	P06605
UniProtKB/TrEMBL

Maps to
Does NOT map to
Identified with	bs24d09 bs34h03 LD10355 LD33142 LD28345 bs05d10.y1 bs05g01.y1 (Oliver, 2001.8.16) LD07757 (BDGP Project Members, 2000-)
Mapped Features & Mutations