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Gene Dmel\Su(var)3-3

General Information
Symbol	Dmel\Su(var)3-3	Species	D. melanogaster
Name	Suppressor of variegation 3-3	Annotation symbol	CG17147
Feature type	protein_coding_gene	FlyBase ID	FBgn0259698
Created / Updated	2008-05-29/2008-05-29
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46.6
Cytogenetic map	77A2-77A2	Sequence location	3L:20,216,989..20,218,393 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Suppressor of variegation 3-3 is referred to in FlyBase by the symbol Su(var)3-3 (CG17147, FBgn0259698). It has the cytological map location 77A2. Its sequence location is 3L:20216989..20218393. Its molecular function is described as: structural constituent of peritrophic membrane; chitin binding. It is involved in the biological process chitin metabolic process. 28 alleles are reported. The phenotype of these alleles is annotated with wing. It has one annotated transcript and one annotated polypeptide.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Su(var)3-3 Homozygotes strongly semilethal in males; weakly so in females; homozygous females sterile; produce no eggs. Homozygous males have spread-wing phenotype and reduced fertility. Survival sensitive to the presence of the Y chromosome as well as to the presence of 0.1 M butyrate in the medium.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77A2-77A2   Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-46.7 +/- 2.3 (Reuter et al., 1983) 3-46.6 +/- 0.2 (Reuter et al., 1986) 3-46.6
Left of (cM)	Ki (Reuter et al., 1986)
Right of (cM)	kni (Reuter et al., 1986)
Notes	Mapping on 3L based on its absence from induced C(3R)RM derivatives of Su(var)3-3-bearing chromosomes. (Reuter et al., 1986)
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Su(var)3-3 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(var)3-3-RA FBtr0074824  NM_140936   1017   338
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(var)3-3-PA   FBpp0074593   37.7   338   4.82     NP_649193   AAF49053
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chitin binding protein, peritrophin-A (IPR002557)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003514 AAF49053
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VW96
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially | recessive Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-31 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 lethal | embryonic stage | recessive Su(var)3-31 Other Phenotypes Allele visible | male | recessive Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-31 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 suppressor of variegation | dominant, with In(1)wm4h Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-31 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-326 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-3unspecified Sterility Allele female sterile | recessive Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-31 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-3unspecified male sterile | partially | recessive Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-31 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Phenotype manifest in Allele wing Su(var)3-31 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-32 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Su(var)3-3 Class Mutagen Stocks Known lesion Su(var)3-310 ethyl methanesulfonate 0 -- Su(var)3-311 ethyl methanesulfonate 0 -- Su(var)3-312 ethyl methanesulfonate 0 -- Su(var)3-313 X ray 0 -- Su(var)3-314 ethyl methanesulfonate 0 -- Su(var)3-315 ethyl methanesulfonate 0 -- Su(var)3-316 ethyl methanesulfonate 0 -- Su(var)3-317 ethyl methanesulfonate 0 -- Su(var)3-318 X ray 0 -- Su(var)3-319 X ray 0 -- Su(var)3-31 ethyl methanesulfonate 0 -- Su(var)3-320 ethyl methanesulfonate 0 -- Su(var)3-321 ethyl methanesulfonate 0 -- Su(var)3-322 ethyl methanesulfonate 0 -- Su(var)3-323 ethyl methanesulfonate 0 -- Su(var)3-324 ethyl methanesulfonate 0 -- Su(var)3-325 ethyl methanesulfonate 0 -- Su(var)3-326 PM hybrid dysgenesis 0 -- Su(var)3-32 ethyl methanesulfonate 0 -- Su(var)3-33 ethyl methanesulfonate 0 -- Su(var)3-34 ethyl methanesulfonate 0 -- Su(var)3-35 ethyl methanesulfonate 0 -- Su(var)3-36 ethyl methanesulfonate 0 -- Su(var)3-37 ethyl methanesulfonate 0 -- Su(var)3-38 ethyl methanesulfonate 0 -- Su(var)3-39 ethyl methanesulfonate 0 Yes Su(var)3-3unspecified 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(var)3-3 Class Mutagen Stocks Known lesion Su(var)3-3GD9295 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes
Aneuploid Aberrations
Useful deficiency	Df(3L)XS533
Useful duplication	Dp(3;3)M72
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Su(var)3-326 NA
Related Comments
	Please look at the allele reports for the complete phenotype data Homozygotes strongly semi-lethal in males; weakly so in females; homozygous females sterile; produce no eggs. Homozygous males have spread-wing phenotype and reduced fertility. Survival sensitive to the presence of the Y chromosome as well as to the presence of 0.1 M butyrate in the medium.   Suppression of In(1)wm4 position effect variegation by Su(var)3-3 was reversed by a supernumerary copy of Su(var)3-7. (Reuter et al., 1990) No additive effect of mutant alleles with mod alleles on suppression of position effect variegation at In(1)wm4. (Garzino et al., 1992)
Gene Ontology: Function, Process & Cellular Component ( 4 )
Molecular Function
CV term Evidence References
chitin binding inferred from electronic annotation with InterPro:IPR002557 (FlyBase Curators et al., 2004-)
structural constituent of peritrophic membrane inferred from sequence or structural similarity with EMBL:L25106 (FlyBase, 1992-)
Biological Process
CV term Evidence References
chitin metabolic process inferred from electronic annotation with InterPro:IPR002557 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
extracellular region inferred from electronic annotation with InterPro:IPR002557 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(var)3-3 allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25314 Dere\GG16088 Dgri\GH16338 Dmoj\GI11529 Dper\GL25120 Dpse\GA23689 Dsec\GM22261 Dsim\GD14860 Dvir\GJ11548 Dwil\GK16942 Dyak\GE19650
Curated drosophilid orthologs	Dpse\GA14348
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v32864 w1118; P{GD9295}v32864 v32865 w1118; P{GD9295}v32865
Genomic Clones ( 2 )
	BACR16G09 BACR31C03
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Su(var)3-3 CG17147 (Rudolph et al., 2007)
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
	Su(var)3-3 and Wow represent different complementation groups based on their effects on w mutations and fertility/viability. (Birchler et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140936 RefSeq (Proteins) • NP_649193 DDBJ / EMBL / GenBank • AE003514 AAF49053 UniProtKB/TrEMBL • Q9VW96
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chitin binding protein, peritrophin-A (IPR002557)
Linkouts
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG17147   SU(VAR)3-3 (Rudolph et al., 2007) Su(var)3-3 (Joanis and Lloyd, 2002, Curtis et al., 2008) Suvar(3)3 (Bashaw and Baker, 1996, Reuter and Spierer, 1992, ) Su-var(3)3 (Wustmann et al., 1989, Reuter et al., 1986)
Name Synonym	CG17147   Suppressor of variegation 3-3
Secondary FlyBase IDs
	FBgn0003594 FBgn0036954
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 13 ) Review  ( 3 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Book  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Rudolph et al., 2007, Molec. Cell 26(1): 103--115 Heterochromatin Formation in Drosophila Is Initiated through Active Removal of H3K4 Methylation by the LSD1 Homolog SU(VAR)3-3. [FBrf0204799] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...