HomeGene Dmel\run
| General Information | ||||
|---|---|---|---|---|
| Symbol | Dmel\run | Species | D. melanogaster | |
| Name | runt | Annotation symbol | CG1849 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0003300 | |
| Created / Updated | 2005-09-09/2005-09-09 | |||
| Genomic Location | ||||
| Chromosome (arm) | X | Recombination map | 1-65 | |
| Cytogenetic map | 19E2-19E2 | Sequence location | X:20,565,468..20,568,353 [+] | |
| Map ( GBrowse ) | 
| |||
Summary Information
| ||||
|
Automatically generated summary
See sections below for more information | The gene runt is referred to in FlyBase by the symbol run (CG1849, FBgn0003300). It has the cytological map location 19E2. Its sequence location is X:20565468..20568353. Its molecular function is described as: specific RNA polymerase II transcription factor activity; transcription regulator activity; RNA polymerase II transcription factor activity; DNA binding; protein binding; ATP binding; transcription factor activity. It is involved in the biological processes described with 11 unique terms, many of which group under: anatomical structure development; regulation of metabolic process; reproductive developmental process; transcription, DNA-dependent; central nervous system development; system development; embryonic development; regulation of biological process; periodic partitioning by pair rule gene; primary sex determination, soma; sex determination; neuroblast fate commitment; organ development. 92 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: anatomical structure; organ system; nervous system; embryonic nervous system; peripheral nervous system; thoracic segment; abdominal ventral denticle belt; embryonic segment; cuticle; larval abdominal segment. It has one annotated transcript and one annotated polypeptide. | |||
| External Summaries | ||||
|
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
| ||||
| Gene/Allele symbols may differ from current usage | run: runt
A pair-rule embryonic lethal; causes deletions of
the dentical belts of the mesothoracic and the first, third,
fifth, and seventh abdominal segments, extending through the
more anterior naked cuticle and into the denticle belts of the
next most anterior segments. Deleted regions appear to be
replaced by mirror image duplications of the remaining more
anterior pattern elements. Deleted regions exceed duplications in size, resulting in shorter embryos. The amount of
material deleted varies among segments, alleles, and among
animals with the same alleles. Hypomorphic alleles do not
remove as much tissue as amorphs, and weak hypomorphic alleles
produce occasional survivors missing methathoracic legs or
halteres or both and are frequently missing one or more abdominal tergites. run31, among the weakest alleles, survives to
adulthood. Deficiencies for run have discernable dominant
effects on embryonic development; extra doses of run+ produce
anti-runt phenotype, i.e., 30% of males with two doses of run+
display deletions of portions of the dentical belts of A6 and
less frequently of A2 and A8; males with three run+ alleles
more severely affected with 70% penetrance. run+ postulated
to repress eve function and positively regulate ftz; run
mutants show expansion of stripes of eve expression and premature disappearance of stripes of ftz expression in the embryo
(Frasch and Levine, 1987, Genes Dev. 1: 981-95). ftz+
expression in cellular blastoderm reduced in four anterior
stripes; A5-A7 expression abnormal, possibly reflecting pattern duplication; nuclear shape abnormal [Carroll and Scott,
1986, Cell 45: 113-26 (fig.)]. For expression pattern later
in development see Kania, Bonner, Duffy, and Gergen (1990,
Genes Dev. 4: 1701-13). run is autonomous in gynandropmorphs
both for missing and for mirror-image duplicated phenotypes,
suggesting that the duplication does not result from proliferation following cell death (Gergen and Wieschaus, 1985,
Dev. Biol. 109: 321-35). Also, the earliest embryonic phenotypes are dosage compensated (Gergen, 1987). run embryos
produced by homozygous ovarian clones not different from those
produced by heterozygous mothers (Wieschaus and Noell, 1986,
Roux's Arch. Dev. Biol. 195: 63-73).
| |||
|
Detailed Mapping Data
| ||||
| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 19E2-19E2
Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
| ||||
| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 19E1-19E2 (determined by in situ hybridisation)
| ||||
| Experimentally Determined Recombination Data | ||||
| Location | 1-65 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | ||||
|
Gene Model & Products
| ||||
Please see the
GBrowse view of
Dmel\run
for information on other features
| ||||
| Comments on Gene Model | ||||
|
Transcript Data
| ||||
| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 2.6 (northern blot) | |||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
|
Polypeptide Data
| ||||
| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
| ||||
| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | 509 (aa); 68 (kD observed); 53 (kD predicted) | |||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
| |||
| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Acute myeloid leukemia 1 protein (AML 1)/Runt (IPR000040)
p53-like transcription factor, DNA-binding (IPR008967)
Acute myeloid leukemia 1 (AML 1)/Runt (IPR013524)
TRANSFAC
- Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles
•
| |||
|
Sequences Consistent with the Gene Model
| ||||
| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | |||