HomeGene Dmel\ninaC
| General Information | ||||
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| Symbol | Dmel\ninaC | Species | D. melanogaster | |
| Name | neither inactivation nor afterpotential C | Annotation symbol | CG5125 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0002938 | |
| Created / Updated | 2003-12-01/2003-12-01 | |||
| Genomic Location | ||||
| Chromosome (arm) | 2L | Recombination map | ||
| Cytogenetic map | 27F3-27F3 | Sequence location | 2L:7,377,718..7,384,344 [+] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene neither inactivation nor afterpotential C is referred to in FlyBase by the symbol ninaC (CG5125, FBgn0002938). It has the cytological map location 27F3. Its sequence location is 2L:7377718..7384344. Its molecular function is described as: protein kinase activity; protein serine/threonine kinase activity; calmodulin binding; receptor signaling protein serine/threonine kinase activity; ATPase activity, coupled; phosphoinositide binding; ATP binding; protein-tyrosine kinase activity; motor activity. It is involved in the biological processes: cytoskeleton organization and biogenesis; phototransduction, visible light; protein localization; protein amino acid phosphorylation; adaptation of rhodopsin mediated signaling; intracellular protein transport; phototransduction, UV; deactivation of rhodopsin mediated signaling. 49 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; photoreceptor cell; ommatidium; retina; eye. It has 2 annotated transcripts and 2 annotated polypeptides. | |||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | ninaC (J.C. Hall)
Basic physiological and rhodopsin-depleted phenotypes like those of ninaB or ninaD mutants, except that amplitude of prolonged depolarizing afterpotential and rhodopsin
levels are not so severely depressed, and these phenotypes
cannot be rescued by vitamin A (or other retinoid) feeding.
Decreased rhodopsin content is due to reduction in diameter of
the rhabdomeres; the microvilli are shorter than normal and
have reduced cytoskeletal electron-dense regions (Matsumoto et
al., 1983). In particular, the central axial filament of the
microvillus is absent (ninaC5) or greatly reduced (ninaC2,
ninaC3). Actin immunoreactivity retained in the villi of
flies homozygous for these alleles (Stowe and Davis). The
mutant phenotype can be rescued using P-element mediated germ
line transformation.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 27F3-27F3
Limits computationally determined from genome sequence between P{PZ}wg02657 and P{EP}EP787EP787
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 28A-28A 28A1-28A3 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | ||||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\ninaC
for information on other features
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| Comments on Gene Model | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 5, 4 (northern blot) | |||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | 1501, 1135 (aa); 174, 132 (kD observed) | |||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• IQ calmodulin-binding region (IPR000048)
Protein kinase, core (IPR000719)
Tyrosine protein kinase (IPR001245)
Myosin head, motor region (IPR001609)
Serine/threonine protein kinase (IPR002290)
Tyrosine protein kinase, active site (IPR008266)
Protein kinase-like (IPR011009)
Protein kinase ATP binding, conserved site (IPR017441)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | |||