HomeGene Dmel\neur
| General Information | ||||
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| Symbol | Dmel\neur | Species | D. melanogaster | |
| Name | neuralized | Annotation symbol | CG11988 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0002932 | |
| Created / Updated | 2003-12-01/2003-12-01 | |||
| Genomic Location | ||||
| Chromosome (arm) | 3R | Recombination map | 3-48.5 | |
| Cytogenetic map | 85C2-85C3 | Sequence location | 3R:4,846,068..4,865,189 [-] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene neuralized is referred to in FlyBase by the symbol neur (CG11988, FBgn0002932). It has the cytological map location 85C2-85C3. Its sequence location is 3R:4846068..4865189. Its molecular function is described as: DNA binding; ubiquitin-protein ligase activity; protein binding; zinc ion binding. It is involved in the biological processes described with 16 unique terms, many of which group under: anatomical structure development; sensory organ development; regulation of developmental process; regulation of Notch signaling pathway; nervous system development; regulation of compound eye photoreceptor development; ovarian follicle cell development; protein localization; cell division; response to chemical stimulus; positive regulation of signal transduction. 74 alleles are reported. The phenotypes of these alleles are annotated with 54 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; embryonic nervous system; adult mesothoracic segment; organ system; external sensory organ precursor cell; embryonic glial cell; tormogen cell; portion of tissue. It has 4 annotated transcripts and 4 annotated polypeptides. | |||
| External Summaries | ||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | neu: neuralised (J.C. Hall)
Homozygous lethal, with hyperplasia of neural components at the expense of epidermal components as seen in
other neurogenic lethal mutations (N, bib, mam, etc.); neu
mutations cause especially strong neural hypertrophy; also
aberrant imaginal disc development when expressed in mosaic
clones (Dietrich and Campos-Ortega, 1984, J. Neurogenet.
1: 315-32). N+ duplications reduce the neu neural hypertrophy, while neu+ duplications have no effect on N defects (De
la Concha, Dietrich, Weigel, and Campos-Ortega, 1968, Genetics
118: 499-508).
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 85C2-85C3
Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 85C3-85C4 (determined by in situ hybridisation)
85C9-85C10 (determined by in situ hybridisation)
85C-85C (determined by in situ hybridisation) 85C7--11 (determined by in situ hybridisation) 85C9--10 (determined by in situ hybridisation) 85C9--15 (determined by in situ hybridisation)
85C-85C (determined by in situ hybridisation)
85C9-85C10 (determined by in situ hybridisation) 85C9--15 (determined by in situ hybridisation) 85C (determined by in situ hybridisation)
85C4-85C5 (determined by in situ hybridisation)
68A4-68A5 85D1--27
86C1-86C8 (determined by in situ hybridisation)
85C-85C (determined by in situ hybridisation)
85D-85D (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 3-48.5 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References In direction of increasing cytology: osk+ tgo- neur- anon-85Cc- neur- anon-85Ca+ Nmdmc- Rel- Nmdmc- Mst85C+ pum- Gene Order (overall orientation not stated) References Overall orientation not stated: anon-85Cb? Nmdmc+ anon-85Ca- neur+ Overall orientation not stated: tgo- neur- | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\neur
for information on other features
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| Comments on Gene Model | ||||
Multiple ESTs homologous to non-coding strand of this gene | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 4.2, 4.0 (northern blot) 4.1, 3.7 (northern blot) | |||
| Comments | The 3.7 and 4.1 kb neu transcripts contain an
identical ORF. The size difference is likely to be due to a difference in
polyadenylation sites. The reported cDNA sequence is derived from 3
overlapping clones. | |||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | 754 (aa); 82 (kD predicted) 411 (aa) 753 (aa) | |||
| Comments | last few amino acids differ from neur+P754 | |||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | |||
| UniProtKB/Swiss-Prot | ||||
| UniProtKB/TrEMBL | ||||
| Maps to | ||||
| Does NOT map to | ||||
| Identified with | ||||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation neur[unspecified] 3R:4,848,465..4,848,466 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified) evidence=experimental pr_change=W376|neur-PC,W376|neur-PD,W458|neur-PA, W458 |neur-PB reported_pr_change=?458@ | ||||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | ||||
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Expression Data
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| FlyBase-Curated Data | ||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | |||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
embryonic stage | early
mesectoderm
embryonic stage | 3-9 hr
neuroblast
embryonic stage | 3-9 hr
epidermoblast
embryonic stage | stage 5
mesoderm | presumptive
embryonic stage | early
mesoderm
embryonic stage | early
ectoderm
larval stage | third instar stage 2
inner optic anlagen
embryonic stage-adult stage
larval stage | third instar stage 2
eye-antennal disc | restricted
embryonic stage | early
larval stage | third instar stage 2
outer optic anlagen
embryonic stage | stage 9
neurectoderm
embryonic stage
embryonic stage | 0-12 hr
embryonic stage | stage 10
neuroblast
larval stage | third instar stage 2
sensillum precursor <of> dorsal mesothoracic disc
larval stage | third instar stage 2
adult neuroblast
adult stage | female | ||||
| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
larval stage | third instar
eye disc | ||||
| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele | ||||
Stage(s)
1-3
Stage(s)
4-6
Stage(s)
7-8
Stage(s)
9-10
Stage(s)
11-12
Stage(s)
13-16