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Gene Dmel\na

General Information
Symbol	Dmel\na	Species	D. melanogaster
Name	narrow abdomen	Annotation symbol	CG1517
Feature type	protein_coding_gene	FlyBase ID	FBgn0002917
Created / Updated	2004-08-09/2004-08-09
Genomic Location
Chromosome (arm)	X	Recombination map	1-46.9
Cytogenetic map	12E6-12E7	Sequence location	X:14,161,686..14,170,664 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene narrow abdomen is referred to in FlyBase by the symbol na (CG1517, FBgn0002917). It has the cytological map location 12E6-12E7. Its sequence location is X:14161686..14170664. Its molecular function is described as: cation channel activity; voltage-gated calcium channel activity; ion channel activity; structural constituent of ribosome. It is involved in the biological processes: circadian rhythm; adult locomotory behavior; regulation of circadian rhythm; translation; ion transport. 13 alleles are reported. The phenotypes of these alleles are annotated with: adult abdomen; adult head; wing; thorax. It has one annotated transcript and one annotated polypeptide.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	na: narrow abdomen Abdomen long and cylindrical in both sexes. Viability low; female fertility low. Ovaries in juvenile condition (Brehme). RK2. *na2 Like na. RK2.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12E6-12E7   Limits computationally determined from genome sequence between P{EP}l(1)G0007EP764 and P{EP}EP1599
Experimentally Determined Cytological Location
Cytogenetic map Notes References 12E-12F (determined by in situ hybridisation)   (Mir et al., 1997) 12E2-12E5   (Mir and Krishnan, 1995)
Experimentally Determined Recombination Data
Location	1-46.9 (Hardy et al., 1984) 1-45.2 (Edmondson, 1952)
Left of (cM)	rut (Krishnan and Nash, 1990)
Right of (cM)	g (Krishnan and Nash, 1990)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\na for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) na-RD FBtr0112815  NM_001103511   6699   2232
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein na-PD   FBpp0111727   247.0   2232   9.49     NP_001096981   ABW09413
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0002917
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S7 (IPR000235) Ion transport (IPR005821)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801575   AE003495 AAF48365   AE003495 AAN09585   AI517244   AY160083 AAN77520   BT029686   CO330929   CZ482143   EC052356   EC055204   EC250843   EL886319   EL886320   EW712810   EY198932
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I877
Maps to
Does NOT map to
Identified with	GH27920 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 2794
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  adult stage  supraesophageal ganglion (Nash et al., 2002)  adult stage  optic lobe (Nash et al., 2002)  adult stage  ellipsoid body (Nash et al., 2002)
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002917 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0002917 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0002917
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable nae04385 lethal, with Scer\GAL4Mef2.PR naGD1172 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH naGD1172 lethal, with Scer\GAL4Act5C naGD1172 semi-lethal, with Scer\GAL4pnr-MD237 naGD1172 Other Phenotypes Allele wild-type naPex3 naPex4 visible | recessive na1 nahar38 nahar85 behavior defective naunspecified geotaxis behavior defective naPex1 naPex2 nahar85 locomotor rhythm defective na1 nahar38 nahar85 locomotor behavior defective nae04385 locomotor behavior defective | recessive na1 naP890 naPex1 naPex2 nahar38 nahar85 locomotor behavior defective, with Scer\GAL4elav.PLu naGD1172 locomotor behavior defective, with Scer\GAL4Mef2.PR naGD1172 flight behavior defective, with Scer\GAL4elav.PLu naGD1172 flight behavior defective, with Scer\GAL4Mef2.PR naGD1172 chemical resistant | recessive na1 naP890 nahar38 nahar85 chemical sensitive nae04385 nahar38 chemical sensitive | recessive naPex1 naPex2 Sterility Allele fertile nae04385 Phenotype manifest in Allele adult abdomen na1 nae04385 nahar38 nahar85 adult head nahar38 nahar85 wing, with Scer\GAL4Bx-MS1096 naGD1172 thorax, with Scer\GAL4pnr-MD237 naGD1172
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of na Class Mutagen Stocks Known lesion na+ 4 -- na1 hypomorph X ray 3 -- na2 U.V. 0 -- naP890 hypomorph Δ2-3 0 Yes naPex1 hypomorph Δ2-3 0 -- naPex2 hypomorph Δ2-3 0 -- naPex3 wild-type allele Δ2-3 0 -- naPex4 wild-type allele Δ2-3 0 -- nae04385 piggyBac transposase 2 -- nahar38 chemical 0 -- nahar85 chemical 0 -- naunspecified 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of na Class Mutagen Stocks Known lesion naGD1172 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)KA9
Duplicated in	Dp(1;Y)y+na+   Dp(1;f)LJ4 (Hardy et al., 1984, Livingstone, 1985) Dp(1;f)LJ8 (Hardy et al., 1984) Dp(1;f)LJ9 (Hardy et al., 1984)
Disrupted in	Df(1)CO-1 (Mir et al., 1997) Df(1)CO-2 (Mir et al., 1997) Df(1)KA9 (Craymer and Roy, 1980, Hardy et al., 1984, Krishnan and Nash, 1990) Df(1)RK2 (Krishnan and Nash, 1990, Mir et al., 1997)
Not disrupted in	Df(1)AR10 (Muralidhar and Thomas, 1993) Df(1)AR2 (Muralidhar and Thomas, 1993) Df(1)HA92 (Craymer and Roy, 1980, Krishnan and Nash, 1990) Df(1)RK5 (Krishnan and Nash, 1990)
Not duplicated in	Dp(1;3)v+74c (Schalet, 1986) Dp(1;4)r+l (Schalet, 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1172} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}nae04385 NA P{ry+un2}P890 NA
Related Comments
	Please look at the allele reports for the complete phenotype data Mutations of na display variable resistance and sensitivity to volatile anaesthetics, this demonstrates that the potency of an anaesthetic is influenced by its chemical structure. (Campbell and Nash, 1994)
Gene Ontology: Function, Process & Cellular Component ( 13 )
Molecular Function
CV term Evidence References
cation channel activity inferred from mutant phenotype (Nash et al., 2002)
ion channel activity inferred from mutant phenotype (Lear et al., 2005)
structural constituent of ribosome inferred from electronic annotation with InterPro:IPR000235 (FlyBase Curators et al., 2004-)
voltage-gated calcium channel activity inferred from sequence or structural similarity with UniProtKB:Q01815 (FlyBase, 1992-)
Biological Process
CV term Evidence References
adult locomotory behavior inferred from mutant phenotype (Nash et al., 2002)
circadian rhythm inferred from mutant phenotype (Nash et al., 2002)
ion transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
regulation of circadian rhythm inferred from mutant phenotype (Lear et al., 2005)
translation inferred from electronic annotation with InterPro:IPR000235 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cell soma inferred from direct assay (Lear et al., 2005)
membrane inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
nerve terminal inferred from direct assay (Lear et al., 2005)
ribosome inferred from electronic annotation with InterPro:IPR000235 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions na allele Gene References nahar38 w (Campbell and Nash, 2001)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 69603
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22557 Dere\GG17841 Dgri\GH12930 Dmoj\GI15440 Dper\GL14928 Dpse\GA13546 Dsec\GM17671 Dsim\GD17167 Dvir\GJ19065 Dwil\GK20157 Dyak\GE17135
Curated drosophilid orthologs	Dmir\CG1517 (Thornton, 2005.12.20) Dpse\GA13546
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000024607 Anopheles gambiae (Ensembl) ENSBTAP00000019696 Bos taurus (Ensembl) ENSCAFP00000008853 Canis familiaris (Ensembl) ENSCINP00000018120 Ciona intestinalis (Ensembl) NEWSINFRUP00000134627 Takifugu rubripes (Ensembl) ENSGALP00000027197 Gallus gallus (Ensembl) ENSP00000342900 Homo sapiens (Ensembl) ENSMMUP00000020852 Macaca mulatta (Ensembl) ENSMODP00000009131 Monodelphis domestica (Ensembl) ENSPTRP00000010208 Pan troglodytes (Ensembl) ENSRNOP00000006624 Rattus norvegicus (Ensembl) GSTENP00027904001 Tetraodon nigroviridis (Ensembl) ENSXETP00000044673 Xenopus tropicalis (Ensembl) WBGene00037668 Caenorhabditis briggsae (Wormbase) WBGene00003558 Caenorhabditis elegans (Wormbase) ZDB-CDNA-050410-13 Danio rerio (Zfin) ZDB-GENE-050410-12 Danio rerio (Zfin) MGI:2444306 Mus musculus (Informatics) SPAC6F6.01 Schizosaccharomyces pombe (Sanger)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Harvard	- PBac{RB}nae04385
VDRC	v3306 w1118; P{GD1172}v3306 v3307 w1118; P{GD1172}v3307
Bloomington	18255 w1118 PBac{RB}nae04385 74 na1/C(1)DX, y1 f1 2870 C(1;Y)1, y1 g2 na1/FM3/Dp(1;f)LJ8, y+ g+ na+ Ste+ 3219 C(1;Y)1, Df(1)g, y1 f1 B1/C(1)A, y1/Dp(1;f)LJ9, y+ g+ na+ Ste+
Kyoto	107483 C(1;Y)1, y1 g2 na1/FM3/Dp(1;f)LJ8, y+ g+ na+ Ste+ 106925 C(1;Y)1, Df(1)g, y1 f1 B1/C(1)A, y1/Dp(1;f)LJ9, y+ g+ na+ Ste+
Genomic Clones ( 1 )
	BACR12J05
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP17383
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL02319
Other clones	EK296453 DMG1-chrX.15.028.a 5' EC055204 IP17583 DMG2-chrX.15.027.a.1 EC052356
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0002917 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0002917
Antibody Information
	polyclonal (Nash et al., 2002)
Other Information
Discoverer
	Miller, March 1934.
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: na CG1517 Source for identity of: α1U CG1517 na (Nash, 2002.3.23)
Additional comments
Comments About Role
	Mosaic analysis suggests that the entire head is the focus for the anesthesia and behavioural phenotypes of na mutant alleles. (Mir et al., 1997) na is an important modulator of neural function. (Nash et al., 2002)
Comments About Molecular Function
Other Comments
	The relationship between the determinant on the X chromosome involved in resistance to halothane anesthesia described in FBrf0038409 and na is unclear. (Gamo et al., 1982) "1-46.9" was stated as revision. (Hardy et al., 1984) Shows genomic imprinting on Dp(1;f)LJ9. (Lloyd et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103511 RefSeq (Proteins) • NP_001096981 DDBJ / EMBL / GenBank • AE003495 AAF48365 AAN09585 AI517244 AY160083 AAN77520 CZ482143 UniProtKB/TrEMBL • Q8I877
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S7 (IPR000235) Ion transport (IPR005821)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 69603 DEDB - Drosophila exon database: splicing graphs • 2794 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0002917 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002917 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0002917 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002917 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0002917 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0002917 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000024607 Anopheles gambiae (Ensembl) ENSBTAP00000019696 Bos taurus (Ensembl) ENSCAFP00000008853 Canis familiaris (Ensembl) ENSCINP00000018120 Ciona intestinalis (Ensembl) NEWSINFRUP00000134627 Takifugu rubripes (Ensembl) ENSGALP00000027197 Gallus gallus (Ensembl) ENSP00000342900 Homo sapiens (Ensembl) ENSMMUP00000020852 Macaca mulatta (Ensembl) ENSMODP00000009131 Monodelphis domestica (Ensembl) ENSPTRP00000010208 Pan troglodytes (Ensembl) ENSRNOP00000006624 Rattus norvegicus (Ensembl) GSTENP00027904001 Tetraodon nigroviridis (Ensembl) ENSXETP00000044673 Xenopus tropicalis (Ensembl) WBGene00037668 Caenorhabditis briggsae (Wormbase) WBGene00003558 Caenorhabditis elegans (Wormbase) ZDB-CDNA-050410-13 Danio rerio (Zfin) ZDB-GENE-050410-12 Danio rerio (Zfin) MGI:2444306 Mus musculus (Informatics) SPAC6F6.01 Schizosaccharomyces pombe (Sanger) PANTHER - Protein classification by function, families, and pathways • FBgn0002917
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG1517 (Nash et al., 2002, Lear et al., 2003, ) Dma1U (Lear et al., 2003) Dmα1U (Nash et al., 2002) han (Lear et al., 2005) har (Guan and Nash, 1997, Leibovitch et al., 1995, ) har38 (Campbell and Nash, 2001, Shaw and Franken, 2003, Rajaram and Nash, 2001, Mir and Krishnan, 1995, ) har85 (Mir and Krishnan, 1995, ) harA (Nash et al., 1997) na (Lear et al., 2005, Humphrey et al., 2007, Dietzl et al., 2007) α1U (Nash et al., 2002)
Name Synonym	halothane-resistant   narrow abdomen (Lear et al., 2005, Humphrey et al., 2007)
Secondary FlyBase IDs
	FBgn0004144 FBgn0030560
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper