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Gene Dmel\mmy

General Information
Symbol	Dmel\mmy	Species	D. melanogaster
Name	mummy	Annotation symbol	CG9535
Feature type	protein_coding_gene	FlyBase ID	FBgn0259749
Created / Updated	2008-06-26/2008-06-26
Genomic Location
Chromosome (arm)	2L	Recombination map	2-16
Cytogenetic map	26D7-26D7	Sequence location	2L:6,468,538..6,473,919 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	[an error occurred while processing this directive]
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	mmy: mummy Embryonic lethal; mouth parts and denticles poorly differentiated.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26D7-26D7   Limits computationally determined from genome sequence between P{lacW}l(2)k09923k09923&P{lacW}CG9523k07502b and P{EP}Sec61αEP2180
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26D7-26E1   (Araujo et al., 2005)
Experimentally Determined Recombination Data
Location	2-20 (Hummel et al., 1999) 2-16 (Tearle and Nusslein-Volhard, 1987) 2- (Beitel and Krasnow, 2000)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\mmy for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mmy-RA FBtr0079268  NM_135188   2098   520 mmy-RB FBtr0079269  NM_164690   1919   483
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein mmy-PA   FBpp0078898   58.2   520   7.22     NP_609032   AAF52387 mmy-PB   FBpp0078899   54.2   483   6.47     NP_723183   AAN10586
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • UTP--glucose-1-phosphate uridylyltransferase (IPR002618)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA820763   AE003613 AAF52387   AE003613 AAN10586   AF145686 AAD38661   AI135900   AI238186   AI238867   AI259203   AI259783   AI294295   AI404776   AI455511   AI512397   AI532928   AI542879   AQ074028   AX154893   BE976564   BF490459   BF496023   BG632783   BH759449   BI171639   BI173158   BI213949   BI235752   BI243336   BI367488   BI369690   BI370779   BI373615   BI374669   BI375170   BI575683   BI576757   BI583212   BI585494   BI585833   BI585988   BI586972   BI593583   BI605036   BI619231   BI625477   BI625623   BI629038   BI629432   BI629569   BI631446   BI631897   BI634149   BI634214   BI635800   BI638675   BT001608 AAN71363   BZ665626   CK132100   CK132349   CK132460   CK657401   CO195271   CO278153   EC072567   EC199031   EC201236   EC248146   GH13818
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9Y0Z0 Q8IPJ6 Q8IGT8
Maps to
Does NOT map to
Identified with	LD24639 (BDGP Project Members, 2000-) RE31673 (BDGP Project Members, 2000-, Devine et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation mmy[LM51] 2L:6,471,405..6,471,405 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6471405A pr_change=L124|mmy-PA,L87|mmy-PB reported_pr_change=L124@ (Devine et al., 2005) point mutation mmy[LM24] 2L:6,471,334..6,471,334 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G6471334A pr_change=G148R|mmy-PA,G111R|mmy-PB reported_pr_change=G148R (Devine et al., 2005) point mutation mmy[LM16] 2L:6,471,328..6,471,328 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G6471328A pr_change=G150S|mmy-PA,G113S|mmy-PB reported_pr_change=G150S (Devine et al., 2005) point mutation mmy[LM55] 2L:6,469,956..6,469,956 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6469956T pr_change=T151I|mmy-PA,T114I|mmy-PB reported_pr_change=T151I (Devine et al., 2005) point mutation mmy[LM21] 2L:6,469,866..6,469,866 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6469866C pr_change=L181P|mmy-PA,L144P|mmy-PB reported_pr_change=181P (Devine et al., 2005) point mutation mmy[IL07] 2L:6,469,818..6,469,818 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6469818A pr_change=I197N|mmy-PA,I160N|mmy-PB reported_pr_change=I197N (Tonning et al., 2006) point mutation mmy[H053] 2L:6,469,811..6,469,812 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=W199|mmy-PA,W162|mmy-PB reported_pr_change=W199@ (Araujo et al., 2005) point mutation mmy[LM1] 2L:6,469,797..6,469,797 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6469797T pr_change=S204L|mmy-PA,S167L|mmy-PB reported_pr_change=S204L (Devine et al., 2005) point mutation mmy[LM32] 2L:6,469,680..6,469,680 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G6469680A pr_change=G243E|mmy-PA,G206E|mmy-PB reported_pr_change=G243E (Devine et al., 2005) point mutation mmy[IK63] 2L:6,469,626..6,469,626 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G6469626T pr_change=G261V|mmy-PA,G224V|mmy-PB reported_pr_change=G261V (Tonning et al., 2006) point mutation mmy[LM47] 2L:6,469,600..6,469,600 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C6469600T pr_change=Q270|mmy-PA,Q233|mmy-PB reported_pr_change=Q270@ (Devine et al., 2005) point mutation mmy[GA74] 2L:6,469,152..6,469,152 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6469152A pr_change=V419D|mmy-PA,V382D|mmy-PB reported_pr_change=V419D (Araujo et al., 2005) point mutation mmy[LM35] 2L:6,469,107..6,469,107 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6469107A pr_change=V434E|mmy-PA,V397E|mmy-PB reported_pr_change=V434E (Devine et al., 2005) point mutation mmy[LM42] 2L:6,469,080..6,469,080 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T6469080G pr_change=L443R|mmy-PA,L406R|mmy-PB reported_pr_change=L443R (Devine et al., 2005)
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mmyEP2016 lethal mmyIK63 mmyIL07 lethal | embryonic stage | recessive mmy1 mmyunspecified Other Phenotypes Allele neuroanatomy defective | embryonic stage 16 mmyG131 mmyJ1201 Sterility Allele sterile (with mmyKG04349) mmyIK63 mmyIL07 sterile (with mmyIL07) mmyKG04349 sterile (with mmyIK63) mmyKG04349 Phenotype manifest in Allele embryonic/larval dorsal trunk mmyunspecified mmyIK63 mmyIL07 mmyk13717b taenidial fold mmyunspecified mestracheon mmyunspecified embryonic/first instar larval cuticle mmyunspecified mmyJ1201 mmyΔ2016-3 denticle belt mmyunspecified mmy1 mmyIK63 mmyKG08617 cephalopharyngeal skeleton mmyunspecified mmy1 larval hindgut & embryo mmy1 embryonic Malpighian tubule mmy1 embryonic central nervous system mmyGA74 mmyGA760 commissure & embryo mmyGA74 mmyGA760 connective & embryo mmyGA74 mmyGA760 intermediate longitudinal fascicle mmyGA74 mmyGA760 lateral longitudinal fascicle mmyGA74 mmyGA760 medial longitudinal fascicle mmyGA74 mmyGA760 embryonic/larval tracheal system mmyH053 mmyk13717b larval cuticle mmyIK63 mmyIL07 mmyKG08617 larval head mmyIK63 mmyIL07 mmyKG08617 larval salivary gland mmyIK63 mmyKG08617 procuticle mmyIK63 mmyIL07 epicuticle mmyIK63 mmyIL07 mmyLM1 mmyLM42 exocuticle mmyIK63 larval epidermis mmyIK63 septate junction mmyIK63 adherens junction mmyIK63 embryonic ganglionic branch mmyIK63 embryonic dorsal branch mmyIK63 larval cuticle (with Df(2L)BSC6) mmyIK63 denticle belt (with Df(2L)BSC6) mmyIK63 larval head (with Df(2L)BSC6) mmyIK63 larval salivary gland (with Df(2L)BSC6) mmyIK63 embryonic/larval trachea (with mmyk13717b) mmyLM1 embryonic/larval trachea mmyLM1 mmyLM16 mmyLM21 mmyLM23 mmyLM24 mmyLM29 mmyLM32 mmyLM33 mmyLM35 mmyLM42 mmyLM44 mmyLM45 mmyLM47 mmyLM49 mmyLM51 mmyLM55 mmyLM59 taenidia mmyLM1 mmyLM42 embryonic/larval trachea (with mmyLM1) mmyk13717b embryonic/larval transverse connective mmyk13717b ventral nerve cord commissure & stage 16 embryo mmyJ1201 longitudinal connective & stage 16 embryo mmyJ1201 chordotonal organ & stage 16 embryo mmyJ1201 mmyG131 embryonic leading edge cell mmyJ1201 eye | somatic clone mmyJ1201 ommatidium | somatic clone mmyJ1201 eye photoreceptor cell | somatic clone mmyJ1201
Classical Alleles ( 38 )
For All Classical Alleles Show
Allele of mmy Class Mutagen Stocks Known lesion mmy03851 P-element activity 0 Yes mmy1 ethyl methanesulfonate 1 -- mmy2 ethyl methanesulfonate 0 -- mmyDG19612 P-element activity 1 -- mmyEP2016 P-element activity 1 -- mmyG131 hypomorph 0 -- mmyGA74 ethyl methanesulfonate 0 Yes mmyGA760 ethyl methanesulfonate 0 -- mmyH053 ethyl methanesulfonate 0 Yes mmyH120 amorph 0 -- mmyIK63 ethyl methanesulfonate 0 Yes mmyIL07 ethyl methanesulfonate 0 Yes mmyJ1201 amorph 0 -- mmyKG04349 P-element activity 1 -- mmyKG08617 P-element activity 1 -- mmyLM16 loss of function ethyl methanesulfonate 0 Yes mmyLM1 loss of function ethyl methanesulfonate 0 Yes mmyLM21 ethyl methanesulfonate 0 Yes mmyLM23 loss of function ethyl methanesulfonate 0 -- mmyLM24 loss of function ethyl methanesulfonate 0 Yes mmyLM29 loss of function ethyl methanesulfonate 0 -- mmyLM32 ethyl methanesulfonate 0 Yes mmyLM33 loss of function ethyl methanesulfonate 0 -- mmyLM35 loss of function ethyl methanesulfonate 0 Yes mmyLM42 loss of function ethyl methanesulfonate 0 Yes mmyLM44 loss of function ethyl methanesulfonate 0 -- mmyLM45 loss of function ethyl methanesulfonate 0 -- mmyLM47 loss of function ethyl methanesulfonate 0 Yes mmyLM49 loss of function ethyl methanesulfonate 0 -- mmyLM51 loss of function ethyl methanesulfonate 0 Yes mmyLM55 loss of function ethyl methanesulfonate 0 Yes mmyLM59 loss of function ethyl methanesulfonate 0 -- mmyQ180 amorph 0 -- mmyZ234 0 -- mmyZ237 0 -- mmyk13717b 0 -- mmyunspecified 0 -- mmyΔ2016-3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mmy Class Mutagen Stocks Known lesion mmyGD14242 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes
Aneuploid Aberrations
Useful deficiency	In(2L)C263
Useful duplication	Dp(2;2)C619
Disrupted in	Df(2L)BSC6 (Araujo et al., 2005, Tonning et al., 2006)
Not disrupted in	Df(2L)BSC7 (Araujo et al., 2005) Df(2L)ED380 (Araujo et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14242} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}mmyKG04349 NA P{SUPor-P}mmyKG08617 NA P{wHy}mmyDG19612 NA insertion of enhancer trap P{lacW}l(2)SH0155SH0155 No insertion of mobile activating element P{EP}mmyEP2016 NA
Related Comments
	Please look at the allele reports for the complete phenotype data Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Mutation in mmy alters tracheal tube size in embryos without affecting other aspects of tracheal development including primary branch budding and outgrowth or branch fusion. (Beitel and Krasnow, 2000)
Gene Ontology: Function, Process & Cellular Component ( 11 )
Molecular Function
CV term Evidence References
UDP-N-acetylglucosamine diphosphorylase activity inferred from mutant phenotype (Schimmelpfeng et al., 2006) inferred from sequence or structural similarity (Araujo et al., 2005) inferred from sequence or structural similarity (Tonning et al., 2006) inferred from sequence or structural similarity with SGD_LOCUS:QRI1; SGD:S0002261 (FlyBase, 1992-)
Biological Process
CV term Evidence References
axonal fasciculation inferred from mutant phenotype (Schimmelpfeng et al., 2006)
central nervous system development inferred from mutant phenotype (Hummel et al., 1999) inferred from mutant phenotype (Araujo et al., 2005)
chitin-based embryonic cuticle biosynthetic process inferred from mutant phenotype (Araujo et al., 2005)
cuticle chitin biosynthetic process inferred from mutant phenotype (Devine et al., 2005) inferred from mutant phenotype (Araujo et al., 2005) inferred from mutant phenotype (Tonning et al., 2006)
dorsal closure inferred from mutant phenotype (Schimmelpfeng et al., 2006)
embryonic epithelial tube formation inferred from mutant phenotype (Devine et al., 2005)
extracellular matrix organization and biogenesis inferred from mutant phenotype (Tonning et al., 2006)