Home

A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008

Gene Dmel\mα

Close All Open All

General Information

Symbol

Dmel\mα

Species

D. melanogaster

Name

E(spl) region transcript mα

Annotation symbol

CG8337

Feature type

protein_coding_gene

FlyBase ID

FBgn0002732

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

3R

Recombination map

3-89.1

Cytogenetic map

96F10-96F10

Sequence location

3R:21,836,685..21,837,101 [+]

Map ( GBrowse )

hide

Summary Information

Automatically generated summary

See sections below for more information

The gene E(spl) region transcript mα is referred to in FlyBase by the symbol mα (CG8337, FBgn0002732). It has the cytological map location 96F10. Its sequence location is 3R:21836685..21837101. Its molecular function is unknown. It is involved in the biological processes: Notch signaling pathway; cell fate specification; sensory organ development. 5 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult segment; anatomical structure; adult mesothoracic segment; tormogen cell; embryonic nervous system; embryonic peripheral nervous system; trichogen cell; sensory nerve; sensillum campaniformium. It has one annotated transcript and one annotated polypeptide.

hide

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96F10-96F10

Limits computationally determined from genome sequence between P{PZ}l(3)rQ197^rQ197 and P{lacW}scrib^j7B3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

96F11-96F14

(Wurmbach, 1998.8.16)

96F11-96F14

(Nellesen, 1998.12.18)

Experimentally Determined Recombination Data

Location

3-89.1

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: HLHmδ+ HLHmγ- HLHmβ- mα+ m1? m2? HLHm3+ m4- HLHm5- m6+ HLHm7+ E(spl)+ gro+

(Ligoxygakis et al., 1998)

In direction of increasing cytology: HLHmβ- mα+ m1+ m2- HLHm3+ m4- HLHm5- m6+ HLHm7+

(Wurmbach et al., 1999)

Gene Order (overall orientation not stated)

References

Overall orientation not stated: HLHmδ+ HLHmγ+ HLHmβ- mα+ m1+ m2- HLHm3+ m4- HLHm5- m6+ HLHm7+ E(spl)+ gro+

(Lai et al., 2000)

hide

Gene Model & Products

Please see the GBrowse view of Dmel\mα for information on other features

detailed view

Comments on Gene Model

hide

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

FBtr0084956

417

138

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

hide

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

mα-PA

FBpp0084330

15.9

138

4.43

NP_524506

AAF56547

Additional Polypeptide Data & Comments

Reported size (kD)

138 (aa)

(Wurmbach et al., 1999, Lai et al., 2000)

Comments

External Data

PANTHER - Protein classification by function, families, and pathways

•

FBgn0002732

Crossreferences

hide

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

O97178

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

hide

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

hide

External Data

DEDB - Drosophila exon database: splicing graphs

•

10875

Crossreferences

hide

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

hide

Summary of Transcript Expression

Stage

Tissue/Position

Reference

embryonic stage | stage >7

neurectoderm

(Wurmbach et al., 1999)

larval stage | third instar

wing vein

(Lai et al., 2000)

embryonic stage | stage >7

mesoderm

(Wurmbach et al., 1999)

pupal stage | 8hr APF

sensillum campaniformium <of> wing

(Lai et al., 2000)

larval stage | third instar

morphogenetic furrow

(Lai et al., 2000)

pupal stage | 8-30hr APF

wing | restricted

(Lai et al., 2000)

embryonic stage | stage 6,7

mesectoderm

(Wurmbach et al., 1999)

pupal stage | 30hr APF

wing blade

(Lai et al., 2000)

larval stage | third instar

morphogenetic furrow | posterior to

(Lai et al., 2000)

larval stage | third instar

proneural cluster <of> dorsal mesothoracic disc

(Lai et al., 2000)

larval stage | third instar

proneural cluster <of> ventral thoracic disc

(Wurmbach et al., 1999)

larval stage | third instar

wing cell

(Wurmbach et al., 1999)

larval stage | third instar

wing margin

(Wurmbach et al., 1999)

pupal stage | 30hr APF

wing vein

(Lai et al., 2000)

larval stage | third instar

dorsal mesothoracic disc | restricted

(Lai et al., 2000)

larval stage | third instar

proneural cluster

(Wurmbach et al., 1999)

larval stage | third instar

eye disc

(Lai et al., 2000)

larval stage | third instar

ventral thoracic disc

(Wurmbach et al., 1999)

Marker for

Subcellular Localization

CV Term

hide

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

hide

External Data & Images

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0002732

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0002732

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0002732

hide

Alleles & Phenotypes

hide

Summary of Allele Phenotypes

Other Phenotypes

Allele

visible, with Scer\GAL4^455.2

mα^Scer\UAS.cAa

visible, with Scer\GAL4^sca-537.4

mα^Scer\UAS.cLa

visible, with Scer\GAL4^69B

mα^Scer\UAS.cLa

visible, with Scer\GAL4^Bx-MS1096

mα^Scer\UAS.cLa

visible, with Scer\GAL4^ptc-559.1

mα^Scer\UAS.cAa

visible, with Scer\GAL4^sca-T3

mα^Scer\UAS.cAa

visible, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

visible, with Scer\GAL4^ap-md544

mα^Scer\UAS.cAa

Phenotype manifest in

Allele

sensory mother cell | ectopic, with Scer\GAL4^bi-omb-Gal4

mα^Scer\UAS.cAa

sensillum campaniformium, with Scer\GAL4^455.2

mα^Scer\UAS.cAa

macrochaeta, with Scer\GAL4^455.2

mα^Scer\UAS.cAa

microchaeta, with Scer\GAL4^455.2

mα^Scer\UAS.cAa

scutellar bristle, with Scer\GAL4^455.2

mα^Scer\UAS.cAa

dorsocentral bristle, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

macrochaeta & scutum, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

microchaeta & scutum, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

sensillum campaniformium, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

macrochaeta, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

microchaeta, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

trichogen cell, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

tormogen cell, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

thecogen cell, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

eo neuron, with Scer\GAL4^pnr-MD237

mα^Scer\UAS.cAa

sensillum campaniformium, with Scer\GAL4^ptc-559.1

mα^Scer\UAS.cAa

macrochaeta, with Scer\GAL4^ptc-559.1

mα^Scer\UAS.cAa

microchaeta, with Scer\GAL4^ptc-559.1

mα^Scer\UAS.cAa

sensillum campaniformium, with Scer\GAL4^sca-T3

mα^Scer\UAS.cAa

macrochaeta, with Scer\GAL4^sca-T3

mα^Scer\UAS.cAa

microchaeta, with Scer\GAL4^sca-T3

mα^Scer\UAS.cAa

sensillum campaniformium, with Scer\GAL4^ap-md544

mα^Scer\UAS.cAa

macrochaeta, with Scer\GAL4^ap-md544

mα^Scer\UAS.cAa

microchaeta, with Scer\GAL4^ap-md544

mα^Scer\UAS.cAa

dorsal row & sensory mother cell, with Scer\GAL4^ap-md544

mα^Scer\UAS.cAa

adult sense organ, with Scer\GAL4^sca-537.4

mα^Scer\UAS.cLa

wing sensillum & wing vein, with Scer\GAL4^Bx-MS1096

mα^Scer\UAS.cLa

wing margin bristle, with Scer\GAL4^Bx-MS1096

mα^Scer\UAS.cLa

wing sensillum & wing vein, with Scer\GAL4^69B

mα^Scer\UAS.cLa

wing margin bristle, with Scer\GAL4^69B

mα^Scer\UAS.cLa

central nervous system

mα^dsRNA.cNa

peripheral nervous system

mα^dsRNA.cNa

hide

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of mα	Class	Mutagen	Stocks	Known lesion

hide

Alleles Carried on Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mα	Class	Mutagen	Stocks	Known lesion
mα^GD13895		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
mα^Scer\UAS.cAa		in vitro construct \| regulatory fusion	0	Yes
mα^Scer\UAS.cLa		in vitro construct \| regulatory fusion	0	Yes
mα^dsRNA.cNa		in vitro construct \| RNAi	0	Yes
mα^{mα.T:Avic\GFP}		in vitro construct \| regulatory fusion in vitro construct \| coding region fusion	0	Yes

hide

Aneuploid Aberrations

Useful deficiency

Df(3R)Espl9

Useful duplication

Dp(3;3)M95A⁺13

Disrupted in

Df(3R)Exel6204

(Ryder, 2004.4.26)

Df(3R)P11

(Nagel et al., 2000)

hide

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct