HomeGene Dmel\ltd
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| Symbol | Dmel\ltd | Species | D. melanogaster | ||||||||||||||||||||
| Name | lightoid | Annotation symbol | CG8024 | ||||||||||||||||||||
| Feature type | protein_coding_gene | FlyBase ID | FBgn0002567 | ||||||||||||||||||||
| Created / Updated | 2003-12-22/2003-12-22 | ||||||||||||||||||||||
| Genomic Location | |||||||||||||||||||||||
| Chromosome (arm) | 2R | Recombination map | 2-[59] | ||||||||||||||||||||
| Cytogenetic map | 45B2-45B3 | Sequence location | 2R:5,065,369..5,073,866 [-] | ||||||||||||||||||||
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene lightoid is referred to in FlyBase by the symbol ltd (CG8024, FBgn0002567). It has the cytological map location 45B2-45B3. Its sequence location is 2R:5065369..5073866. Its molecular function is described as: GTP binding; GTPase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; ATP binding; protein kinase activity. It is involved in the biological processes: ommochrome biosynthetic process; learning and/or memory; olfactory learning; eye pigment granule organization and biogenesis; eye pigment precursor transport; small GTPase mediated signal transduction; protein amino acid phosphorylation; protein transport. 16 alleles are reported. The phenotypes of these alleles are annotated with: pigment cell; Malpighian tubule; ocellus pigment granule; primary pigment cell pigment granule; secondary pigment cell pigment granule; tertiary pigment cell pigment granule. It has 5 annotated transcripts and 5 annotated polypeptides. | ||||||||||||||||||||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | ltd: lightoid
Eye color clear, light, translucent yellowish pink.
Resembles lt but is lighter, darkens with age. Ocelli colorless; larval Malpighian tubes colorless. Deficient in ommochrome synthesis. Lack detectable levels of 3OH kynurenine
despite normal levels of kynurenine hydroxylase activity;
administration of 3 hydroxykynurenine without effect (Phillips, Simmons, and Dowman, 1970, Biochem. Genet. 4: 481-87;
Sullivan, Kitos, and Sullivan, 1973, Genetics 75: 651-61).
Exhibits reduced levels of phenoazinone synthetase, an enzyme
involved in the condensation of 3OH kynurenine molecules to
xanthommatin, as do other mutants deficient in ommochrome synthesis (Phillips, Forrest, and Kulkarni, 1973, Genetics
73: 45-56). Uptake of kynurenine, which is produced in the
fat body, by the Malpighian tubes, where it is converted to
3-hydrokynurenine, is defective; similar defect seen in eye
discs (Sullivan and Sullivan, 1975, Biochem. Genet. 13: 603-13). Sullivan and Sullivan postulate that ltd is a transport
mutant that prevents the substrate kynurenine from reaching
the sites of its conversion to ommochrome. Phenotypic
interaction with other eye-color mutants examined by Rudy and
Carvalier (1971, J. Hered. 62: 131-34) and by Silva and
Mensua, 1985, DIS 61: 156); produces nearly white eyes when
combined with either rb or g.
ltd37b
Eye color of newly hatched adult bright red like v,
darkens to a color like pr in old flies. Ocelli colorless;
larval Malpighian tubes colorless. Viability excellent. RK1.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||||||||||||||||||||||
Cytogenetic map Evidence for location 45B2-45B3
Limits computationally determined from genome sequence between P{lacW}CG8788k04512&P{lacW}l(2)k13412k13412 and P{PZ}Pkn06736
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| Experimentally Determined Cytological Location | |||||||||||||||||||||||
Cytogenetic map Notes References 45A8-45B5 | |||||||||||||||||||||||
| Experimentally Determined Recombination Data | |||||||||||||||||||||||
| Location | 2-[59] | ||||||||||||||||||||||
| Left of (cM) | |||||||||||||||||||||||
| Right of (cM) | |||||||||||||||||||||||
| Notes | |||||||||||||||||||||||
| Molecular Map Data | |||||||||||||||||||||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||||||||||||||||||||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\ltd
for information on other features
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| Comments on Gene Model | |||||||||||||||||||||||
EST data support existence of multiple transcripts | |||||||||||||||||||||||
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Transcript Data
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| Annotated Transcripts | |||||||||||||||||||||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||||||||||||||||||||||
| Additional Transcript Data & Comments | |||||||||||||||||||||||
| Reported size (kB) | |||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| External Data | |||||||||||||||||||||||
| Crossreferences | |||||||||||||||||||||||
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Polypeptide Data
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| Annotated Polypeptides | |||||||||||||||||||||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||||||||||||||||||||||
| Reported size (kD) | |||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| External Data | |||||||||||||||||||||||
| Linkouts | |||||||||||||||||||||||
| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Ras GTPase (IPR001806)
Ras small GTPase, Rab type (IPR003579)
Small GTP-binding protein (IPR005225)
Ras (IPR013753)
Protein kinase ATP binding, conserved site (IPR017441)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||||||||||||||||||||||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation ltd[1] 2R:5,066,689..5,066,689 comment=Mutation is in the common exon of the predicted ltd transcripts and eliminates the C-terminal 203 amino acid region. Position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental na_change=C5066689G pr_change=Y183|ltd-PA,Y484|ltd-PB,Y186|ltd-PE,Y20|lt d-PD,Y186@|ltd-PC reported_na_change=C?G reported_pr_change=??@ | |||||||||||||||||||||||
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External Data
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Expression Data
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| FlyBase-Curated Data | |||||||||||||||||||||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||||||||||||||||||||||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Subcellular Localization | |||||||||||||||||||||||
| CV Term | |||||||||||||||||||||||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Subcellular Localization | |||||||||||||||||||||||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele Sterility Allele Phenotype manifest in Allele eye photoreceptor cell & pigment granule | |||||||||||||||||||||||
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Classical Alleles
( 11 ) | |||||||||||||||||||||||
| For All Classical Alleles Show | |||||||||||||||||||||||
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