A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\dre4

General Information
SymbolDmel\dre4SpeciesD. melanogaster
Namedre4Annotation symbolCG1828
Feature typeprotein_coding_geneFlyBase IDFBgn0002183
Created / Updated2004-12-03/2004-12-03
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map62B7-62B7Sequence location3L:1,871,573..1,876,336 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol dre4 (CG1828, FBgn0002183). It has the cytological map location 62B7. Its sequence location is 3L:1871573..1876336. Its molecular function is described as: DNA binding; metalloexopeptidase activity. It is involved in the biological processes: DNA unwinding during replication; regulation of chromatin assembly or disassembly; proteolysis. 80 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
l(3)62Bg
Locus displays ca 80 times the mutation rate of most of the other loci in the region, and it is relatively more sensitive to γ irradiation than to EMS mutagenesis than other loci (by a factor of six); in addition, none of the alleles is associated with a gross chromosome rearrangement. Hemizygotes are arrested in the first larval instar, where they remain robust and active. One allele temperature sensitive; developmental arrest takes place shortly after shift up in temperature at several stages.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
62B7-62B7  
Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\dre4 for information on other features
detailed view FBtr0300120 FBtr0072864 FBtr0072865 FBtr0072863 FBtr0072861 FBtr0072862 FBpp0289397 FBpp0072743 FBpp0072744 FBpp0072742 FBpp0072741 FBpp0072740 FBti0070228 FBti0056659 FBti0027088
Comments on Gene Model
Probable frameshift mutation in either the sequenced strain or strain used for O17045 and O17046
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
dre4-RA
FBtr0072864
 NM_057262
  3715
  1122
dre4-RB
FBtr0072865
 NM_167922
  3598
  1083
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
dre4-PA  
FBpp0072743  
127.8  
1122  
6.66  
  NP_476610
  AAF47587
dre4-PB  
FBpp0072744  
123.6  
1083  
6.21  
  NP_728686
  AAN11502
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Peptidase M24, catalytic core (IPR000994)
Region of unknown function DUF1747, eukaryote (IPR013719)
FACT complex subunit Spt16p/Cdc68p (IPR013953)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA263481
 
AA697111
 
AA978633
 
AB083008
BAC54898
 
AC004713
 
AE003473
AAF47587
 
AE003473
AAN11502
 
AF023269
AAB80935
 
AF023270
AAB80936
 
AI512751
 
AI530918
 
AI530947
 
AI531152
 
AI531475
 
BE976792
 
BF491003
 
BF492212
 
BF498918
 
BG635513
 
BT010116
AAQ22585
 
BT024965
 
CO287563
 
CO322570
 
CO332746
 
CO344999
 
CZ476816
 
EC052453
 
EC053933
 
EC057509
 
EC063095
 
EC067862
 
EC078154
 
EC226706
 
EC227395
 
EC241859
 
EC241935
 
EC242375
 
EC242376
 
EC255975
 
EC256396
 
EL875356
 
EL875357
 
EL884083
 
EL884084
 
EL884202
 
EL884203
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    (FlyBase, 1992-)
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
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        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        lethal | recessive | conditional - heat sensitive
        lethal | conditional - heat sensitive
        lethal | larval stage | recessive
        lethal | pupal stage | conditional - heat sensitive
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 77 )
        For All Classical Alleles Show

        Allele of dre4ClassMutagenStocksKnown lesion
        dre4100 --
        dre4110 --
        dre4120 --
        dre4130 --
        dre4140 --
        dre4150 --
        dre4160 --
        dre4170 --
        dre4180 --
        dre4190 --
        dre410 --
        dre4200 --
        dre4210 --
        dre4220 --
        dre4230 --
        dre4240 --
        dre4250 --
        dre4260 --
        dre4270 --
        dre4280 --
        dre4290 --
        dre420 --
        dre4300 --
        dre4310 --
        dre4320 --
        dre4330 --
        dre4340 --
        dre4350 --
        dre4360 --
        dre4370 --
        dre4380 --
        dre4390 --
        dre430 --
        dre4400 --
        dre4410 --
        dre4420 --
        dre4430 --
        dre4440 --
        dre4450 --
        dre4460 --
        dre4470 --
        dre4480 --
        dre4490 --
        dre440 --
        dre4500 --
        dre4510 --
        dre4520 --
        dre4530 --
        dre4540 --
        dre4550 --
        dre4560 --
        dre4570 --
        dre4580 --
        dre4590 --
        dre450 --
        dre4600 --
        dre4610 --
        dre4620 --
        dre4630 --
        dre4640 --
        dre4650 --
        dre4660 --
        dre4670 --
        dre4680 --
        dre4690 --
        dre460 --
        dre4700 --
        dre4710 --
        dre4720 --
        dre4730 --
        dre4740 --
        dre470 --
        dre480 --
        dre490 --
        dre4d095760 --
        dre4e55ts0 --
        dre4unspecified
          		0 --
          hide Alleles Carried on Transgenic Constructs ( 3 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of dre4ClassMutagenStocksKnown lesion
          dre4GD44461 Yes
          dre4Hsp83.PN0 Yes
          dre4Hsp83.T:Zzzz\His60 Yes
          hide Aneuploid Aberrations
          Useful deficiency
           
          Useful duplication
           
          Disrupted in
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