Gene Dmel\Gli

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General Information

Symbol

Dmel\Gli

Species

D. melanogaster

Name

Gliotactin

Annotation symbol

CG3903

Feature type

protein_coding_gene

FlyBase ID

FBgn0001987

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

35D4-35D4

Sequence location

2L:15,756,001..15,762,755 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Gliotactin is referred to in FlyBase by the symbol Gli (CG3903, FBgn0001987). It has the cytological map location 35D4. Its sequence location is 2L:15756001..15762755. Its molecular function is described as carboxylesterase activity. It is involved in the biological processes: establishment of blood-nerve barrier; maintenance of imaginal disc-derived wing hair orientation; septate junction assembly; female meiosis chromosome segregation; regulation of tube size, open tracheal system. 37 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: embryonic nervous system; adult segment; peripheral nervous system; embryonic glial cell; adult mesothoracic segment; nervous system; plasma membrane part; embryonic peripheral nervous system; plasma membrane; organ system. It has 5 annotated transcripts and 5 annotated polypeptides.

External Summaries

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35D4-35D4

Limits computationally determined from genome sequence between P{lacW}CycE^k05007&P{lacW}CycE^k02602 and P{EP}crp^EP721&P{lacW}crp^k07829

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35D7-35D7

(determined by in situ hybridisation)

(Abdelilah-Seyfried et al., 2000)

35D6-35D7

(determined by in situ hybridisation)

(Ashburner et al., 1999)

35D6-35D7

(determined by in situ hybridisation)

(Spradling et al., 1999)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

l(2)35Di, l(2)35Df and Gli are definitely distal of wek.

(Roote, 2000.6.13)

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: l(2)35Df+ Gli- CG3793+

(Ashburner et al., 1999)

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Gli for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Gli-RA

FBtr0080765

NM_057254

4093

956

Gli-RB

FBtr0080766

NM_165130

3787

806

Gli-RC

FBtr0080767

NM_165127

4184

956

Gli-RD

FBtr0080768

NM_165128

3973

956

Gli-RE

FBtr0080769

NM_165129

4008

956

Additional Transcript Data & Comments

Reported size (kB)

6.0 (northern blot)

(Auld et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Gli-PA

FBpp0080324

109.2

956

8.79

NP_476602

AAF53482

Gli-PB

FBpp0080325

91.5

806

8.12

NP_723931

AAN10913

Gli-PC

FBpp0080326

109.2

956

8.79

NP_723928

AAN10910

Gli-PD

FBpp0080327

109.2

956

8.79

NP_723929

AAN10911

Gli-PE

FBpp0080328

109.2

956

8.79

NP_723930

AAN10912

Additional Polypeptide Data & Comments

Reported size (kD)

956 (aa); 109 (kD predicted)

(Auld et al., 1995)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0001987

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Carboxylesterase, type B (IPR002018)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

DS09217

(FlyBase, 1992-, Ashburner et al., 1999.10.12)

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

deletion

Gli[AE2Delta5]
2L:15,760,623..15,762,783

comment=deletion
evidence=experimental

(Auld et al., 1995)

point mutation

Gli[3]
2L:15,759,824..15,759,824

comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
evidence=experimental
na_change=C15759824T
pr_change=Q108|Gli-PA,Q108|Gli-PC,Q108|Gli-PD,Q108|G li-PE
reported_pr_change=Q108@

(Venema et al., 2004)

point mutation

Gli[dv3]
2L:15,759,539..15,759,539

(Venema et al., 2004)

point mutation

Gli[dv1]
2L:15,758,728..15,758,729

comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
evidence=experimental
pr_change=W454@|Gli-PA
reported_pr_change=W454@

(Venema et al., 2004)

point mutation

Gli[dv5]
2L:15,758,516..15,758,516

(Venema et al., 2004)

point mutation

Gli[RAR77]
2L:15,757,508..15,757,508

(Venema et al., 2004)

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•