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Gene Dmel\egh

General Information
Symbol	Dmel\egh	Species	D. melanogaster
Name	egghead	Annotation symbol	CG9659
Feature type	protein_coding_gene	FlyBase ID	FBgn0001404
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.2
Cytogenetic map	3A6-3A6	Sequence location	X:2,482,534..2,492,638 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene egghead is referred to in FlyBase by the symbol egh (CG9659, FBgn0001404). It has the cytological map location 3A6. Its sequence location is X:2482534..2492638. Its molecular function is described as beta-1,4-mannosyltransferase activity. It is involved in the biological processes described with 15 unique terms, many of which group under: anatomical structure development; gamete generation; sexual reproduction; ovarian follicle cell development; reproductive process in a multicellular organism; cell motility; regulation of response to stimulus; establishment and/or maintenance of cytoskeleton polarity; oogenesis; morphogenesis of follicular epithelium; cell fate commitment. 54 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; nervous system; adult segment; adult; peripheral nervous system; larval head segment; tergite; egg; embryonic nervous system; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(1)3Ae Alleles tested [l(1)Ae2, l(1)Ae3, l(1)Ae6, l(1)Ae8, l(1)Ae10, l(1)Ae11] die in post puparial stage, but growth slowing starts at various earlier stages; tested alleles survive in hemizygous condition in gynandromorphs; hemizygous eyes rough. Pharate adults dissected from l(1)3Ae1 and l(1)Ae5 pupae show rough eyes, sparse microchaetae, and incomplete dorsal midline; XY but not XO males of both rescued by Dp(1;4)wm65g, exhibiting phenotype of dissected pharate adults described above (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38).
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A6-3A6   Limits computationally determined from genome sequence between P{EP}CG32796EP1385&P{EP}EP1160 and P{EP}eghEP804
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3A8-3A8   (Hollmann, 2000.2.9) 3A5-3A8 (determined by in situ hybridisation)   (Endow and Hatsumi, 1991)
Experimentally Determined Recombination Data
Location	1-1.2
Left of (cM)
Right of (cM)	wds (Judd et al., 1972)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: egh+ Klp3A- mit(1)15+ (Williams et al., 1995) In direction of increasing cytology: egh+ Klp3A- (Goode et al., 1996) In direction of increasing cytology: trol- CG13758+ CG8310- CG13759+ CG13760- wds+ egh+ Klp3A- mit(1)15+ (Benos, 2000.2.6) Gene Order (overall orientation not stated) References Overall orientation not stated: wds+ egh+ (Hollmann, 2000.2.9)
Gene Model & Products
Please see the GBrowse view of Dmel\egh for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) egh-RB FBtr0070440  NM_166946   2795   457 egh-RC FBtr0070439  NM_080313   3575   457
Additional Transcript Data & Comments
Reported size (kB)	3.7 (northern blot) (Goode et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein egh-PB   FBpp0070424   52.0   457   8.09     NP_726818   AAF45792 egh-PC   FBpp0070423   52.0   457   8.09     NP_525052   AAN09081
Additional Polypeptide Data & Comments
Reported size (kD)	457 (aa); 52 (kD predicted) (Goode et al., 1996)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001404
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003424 AAF45792   AE003424 AAN09081   AF233288 AAF43419   AI062041   AI106667   AI258743   AL138972 CAB72293   AW940094   AY060595 AAL28143   BI166219   BI171240   BI215246   BI216224   BI230402   BI234058   BI240830   BI362817   BI615382   BI626989   BP546181   CO156728   CO178826   CO337119   CZ473504   DN154421   EC071918   EC081834   EC089319   EC198882   EC241703   EC248845   EC263290   EC263338   U15602 AAB49734   U21218 AAB49735
UniProtKB/Swiss-Prot	O01346
UniProtKB/TrEMBL	Q95ST6 A4V3W0
Maps to
Does NOT map to
Identified with	GH01085 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation egh[7] X:2,491,481..2,491,481 comment=Site of nucleic acid difference inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=T2491481A pr_change=M308K|egh-PC,M308K|egh-PB reported_pr_change=M308K (Wandall et al., 2005) rescue fragment egh[+t7] X:2,487,796..2,495,012 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=SalI-XhoI_rfrag (Williams et al., 1995)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 315
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  oogenesis stage,adult stage  germarium region 2a <&> germ cell (Goode et al., 1996)  embryonic stage | 0-2 hr   (Goode et al., 1996)  oogenesis stage,adult stage | stage S10  nurse cell (Goode et al., 1996)  oogenesis stage,adult stage  germarium region 2b <&> germ cell (Goode et al., 1996)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI062041
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0001404 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0001404
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable eghcm eghmedley lethal egh7 egh9pp4 lethal | maternal effect | pupal stage egh27 lethal | recessive egh10 egh11 egh12 egh13 egh14 egh15 egh17 egh18 egh19 egh1 egh22 egh24 egh25 egh2 egh3 egh4 egh5 egh62d18 egh6 egh7 egh8 egh9 egh9pp4 eghM15 eghM19 eghM36 eghM54 eghT4 lethal | germ-line clone | maternal effect | recessive egh27 lethal | germ-line clone | neurogenic egh27 lethal | pupal stage | recessive egh10 egh11 egh1 egh25 egh27 egh2 egh3 egh5 egh6 egh7 egh8 egh9pp4 lethal | pharate adult stage | recessive egh27 egh62d18 semi-lethal egh16 egh21 egh23 egh6 Other Phenotypes Allele wild-type egh+t7 eghhs.PG visible eghmedley behavior defective eghcm2 eghcm behavior defective (with egh7) eghcm behavior defective (with eghcm) egh7 neuroanatomy defective egh3 egh7 egh9pp4 Sterility Allele female sterile egh25 egh3 egh62d18 egh7 egh9pp4 eghcm eghmedley female sterile | germ-line clone | recessive egh27 Phenotype manifest in Allele eye egh1 egh5 eghcm eghmedley macrochaeta egh1 egh5 eghBG01635 abdominal tergite 1 egh1 egh5 abdominal tergite 2 egh1 egh5 abdominal tergite 3 egh1 egh5 abdominal tergite 4 egh1 egh5 abdominal tergite 5 egh1 egh5 abdominal tergite 6 egh1 egh5 abdominal tergite 7 egh1 egh5 egg | germ-line clone egh11 female reproductive system egh11 dorsal appendage | germ-line clone egh25 egh27 egh3 egh62d18 egh7 egh9pp4 embryonic nervous system | germ-line clone egh25 egh27 egh3 egh62d18 egh7 egh9pp4 oocyte egh25 eghcm eghmedley nurse cell egh25 eghcm follicle cell egh25 eghmedley basal stalk egh25 denticle belt egh25 procephalic segment egh25 oocyte | germ-line clone egh27 egh3 egh62d18 egh7 egh9pp4 nurse cell | germ-line clone egh27 egh3 egh62d18 egh7 egh9pp4 follicle cell | germ-line clone egh27 egh3 egh7 egh9pp4 basal stalk | germ-line clone egh27 egh3 egh62d18 egh7 egh9pp4 larval midgut & embryo egh27 nervous system | germ-line clone egh27 egg chamber | germ-line clone | maternal effect egh27 photoreceptor cell R1 & axon egh3 egh7 egh9pp4 photoreceptor cell R2 & axon egh3 egh7 egh9pp4 photoreceptor cell R3 & axon egh3 egh7 egh9pp4 photoreceptor cell R4 & axon egh3 egh7 egh9pp4 photoreceptor cell R5 & axon egh3 egh7 egh9pp4 photoreceptor cell R6 & axon egh3 egh7 egh9pp4 larval optic neuropil egh3 egh7 lamina plexus egh3 egh7 egh9pp4 lamina anlage egh7 lobula egh7 lamina anlage glial cell egh7 lobula & neuron egh7 ventral nerve cord | somatic clone egh7 ventral nerve cord (with eghcm) egh7 germ cell egh8 eghcm ovary eghcm oocyte | precursor eghcm first optic chiasma eghcm photoreceptor cell eghcm ventral nerve cord (with egh7) eghcm egg eghmedley wing vein eghmedley
Classical Alleles ( 45 )
For All Classical Alleles Show
Allele of egh Class Mutagen Stocks Known lesion egh10 X ray ethylenimine 0 -- egh11 ethylenimine 0 -- egh12 ethylenimine 0 -- egh13 ethyl methanesulfonate 0 -- egh14 ethyl methanesulfonate 0 -- egh15 ethyl methanesulfonate 0 -- egh16 ethyl methanesulfonate 0 -- egh17 ethyl methanesulfonate 0 -- egh18 methyl methanesulfonate 0 -- egh19 methyl methanesulfonate 0 -- egh1 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- egh21 methyl methanesulfonate 0 -- egh22 methyl methanesulfonate 0 -- egh23 methyl methanesulfonate 0 -- egh24 methyl methanesulfonate 0 -- egh25 X ray 0 -- egh26 X ray 0 -- egh27 ethyl methanesulfonate 0 -- egh28 ethyl methanesulfonate 0 -- egh29 ethyl methanesulfonate 0 -- egh2 X ray 0 -- egh30 ethyl methanesulfonate 0 -- egh3 X ray ethyl methanesulfonate 0 Yes egh4 X ray ethylenimine 0 -- egh5 spontaneous 0 -- egh62d18 ethyl methanesulfonate 0 Yes egh6 X ray 0 -- egh7 hypomorph X ray ethylenimine ethyl methanesulfonate 2 Yes egh8 X ray ethylenimine 0 -- egh9 ethylenimine 0 -- egh9pp4 ethyl methanesulfonate 0 Yes eghBG01635 P-element activity 0 Yes eghEP804 P-element activity 2 Yes eghM15 methyl methanesulfonate 0 -- eghM19 methyl methanesulfonate 0 -- eghM36 methyl methanesulfonate 0 -- eghM54 methyl methanesulfonate 0 -- eghNKu1 urethane 0 -- eghNKu2 urethane 0 -- eghNKx1 X ray 0 -- eghT4 methyl methanesulfonate 0 -- eghcm2 0 Yes eghcm hypomorph 0 Yes eghd03687 P-element activity 1 -- eghmedley 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of egh Class Mutagen Stocks Known lesion egh+t7 in vitro construct | genomic fragment 0 Yes egh+tP2 in vitro construct | genomic fragment 0 Yes eghGD3206 in vitro construct | RNAi in vitro construct | regulatory fusion 3 Yes eghP1 in vitro construct | genomic fragment 0 Yes eghScer\UAS.T:Ivir\HA1 in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes eghScer\UAS.cFa in vitro construct | regulatory fusion 0 Yes eghScer\UAS.cWa in vitro construct | regulatory fusion 0 Yes eghhs.PG in vitro construct | regulatory fusion 0 Yes eght9 in vitro construct | genomic fragment 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(1)TEM7
Useful duplication	Dp(1;Y)w+303
Disrupted in	Df(1)63e4 (Williams et al., 1995, Goode et al., 1996) Df(1)64c4 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)7 (Nomura and Kurokawa, 1997) Df(1)HM3 (Kramers et al., 1983) Df(1)HM406 (Kramers et al., 1983) Df(1)K95 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)L126 (Nomura and Kurokawa, 1997) Df(1)NKx2 (Nomura and Kurokawa, 1997) Df(1)TEM1 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM501 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM7 (Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM75 (Lim and Snyder, 1974) Df(1)X12 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w-N71a (Judd et al., 1972) Df(1)w-rJ1 (Judd et al., 1972, Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Nomura and Kurokawa, 1997) Df(1)w258-11 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-42 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-48 (Kramers et al., 1983, Kramers et al., 1991) Df(1)z-EM41 (Montgomery et al., 1991) Df(1)z-EM42 (Montgomery et al., 1991) Df(1)z-EM43 (Montgomery et al., 1991) Df(1)z-EM44 (Montgomery et al., 1991) Df(1)z-EM45 (Montgomery et al., 1991) Df(1)z-EM46 (Montgomery et al., 1991) Df(1)z-deb311 (Goldberg et al., 1989) Df(1)z-deb511 (Goldberg et al., 1989) Df(1)z-deb54 (Goldberg et al., 1989) Df(1)z-deb62 (Goldberg et al., 1989) Df(1)z-deb65 (Goldberg et al., 1989) Df(1)z-deb72 (Goldberg et al., 1989) Df(1)z-deb81 </