HomeGene Dmel\klar
| General Information | ||||
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| Symbol | Dmel\klar | Species | D. melanogaster | |
| Name | klarsicht | Annotation symbol | CG17046 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0001316 | |
| Created / Updated | 2003-12-01/2003-12-01 | |||
| Genomic Location | ||||
| Chromosome (arm) | 3L | Recombination map | 3-0.0 | |
| Cytogenetic map | 61C1-61C3 | Sequence location | 3L:434,258..540,589 [-] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene klarsicht is referred to in FlyBase by the symbol klar (CG17046, FBgn0001316). It has the cytological map location 61C1-61C3. Its sequence location is 3L:434258..540589. Its molecular function is described as: ATPase activity, coupled; protein binding; actin binding. It is involved in the biological processes: microtubule-based movement; nuclear migration; lumen formation, open tracheal system; lipid particle transport along microtubule; compound eye morphogenesis; tube morphogenesis; membrane organization and biogenesis; compound eye photoreceptor development; lipid transport. 77 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult; rhabdomere; egg; imaginal precursor; cytoplasmic part; cell part; yolk; tracheal system; cell projection; cone cell; lipid particle; embryonic foregut. It has 4 annotated transcripts and 4 annotated polypeptides. | |||
| External Summaries | ||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | kls: klarsicht
Maternal effect mutant; without effect on viability
or fertility of homozygotes. Homozygous females produce eggs
with clear distinction between yolk and germ layers. Facilitates in vivo observation of developmental processes.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 61C1-61C3
Limits computationally determined from genome sequence between P{PZ}trh10512 and P{EP}EP3104EP3104
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 61C-61C 61C-61C Location based on deficiency mapping.
61C4-61C7 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 3-0.0 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\klar
for information on other features
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| Comments on Gene Model | ||||
DGC clones appear problematic : incomplete CDS; GM08528 5' only, GH05536 3' only, LD08331 internal. | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0110818
7665
2045 FBtr0112807
3035
567 FBtr0112808
6842
1823 | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 8.5, 8.0 (northern blot) | |||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0110115
221.3
2045
5.75
FBpp0111719
62.1
567
5.44
FBpp0111720
197.4
1823
6.27
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | ||||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Klarsicht/ANC-1/syne-1 homology (IPR012315)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | |||
| UniProtKB/Swiss-Prot | ||||
| UniProtKB/TrEMBL | ||||
| Maps to | ||||
| Does NOT map to | ||||
| Identified with | ||||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation klar[marb-FQ19] 3L:435,664..435,664 evidence=experimental na_change=T419196A pr_change=C2081@|klar-PA reported_na_change=T6234A reported_pr_change=?2081@ point mutation klar[marb-CD4] 3L:435,300..435,300 evidence=experimental na_change=C418832T pr_change=Q2203@|klar-PA reported_na_change=C6607T reported_pr_change=?2203@ sequence variant klar[marb-BX5] 3L:508,265..508,274 comment=Deletion of 10bp resulting in a frameshift in the open reading frame after amino acid 79 evidence=experimental sequence variant klar[marb-BX14] 3L:451,302..451,303 comment=Mutation is deletion of 2bp (GG) leading to frameshift. Position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental sequence variant klar[marb-BX6] 3L:435,845..435,852 comment=8bp deletion leading to truncation after D2018 (author statement) evidence=experimental sequence variant klar[marb-BX15] 3L:435,255..435,258 comment=Mutation is a 4bp deletion leading to a frameshift. Position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental | ||||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
• | |||
| Crossreferences | ||||
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Expression Data
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| FlyBase-Curated Data | ||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | |||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
larval stage | third instar
eye disc
embryonic stage | late
adult salivary gland primordium
larval stage | third instar
morphogenetic furrow | posterior to | ||||
| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
larval stage | third instar
photoreceptor | ||||
| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | perinuclear space | |||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele
Sterility Allele Phenotype manifest in Allele | ||||
