A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\kl-1

General Information
SymbolDmel\kl-1SpeciesD. melanogaster
Namemale fertility factor kl1Annotation symbol
Feature typegeneFlyBase IDFBgn0001312
Created / Updated2006-08-22/2006-08-22
Genomic Location
Chromosome (arm)Recombination mapY-
Cytogenetic mapSequence location
hide Summary Information
Automatically generated summary

See sections below for more information
The gene male fertility factor kl1 is referred to in FlyBase by the symbol kl-1 (FBgn0001312). It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 19 alleles are reported. No phenotypic data is available. It has no annotated transcripts.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
kl-1
Males deficient or mutant at kl-1 are sterile. One allele of Brosseau's, probably kl-1B13, studied by Kiefer, produces motile sperm which are transferred to females but do not reach the female sperm-storage organs; substantial amounts of sperm degeneration observed [Kiefer, 1969, Genetics 61: 157-66 (fig.)]. The spermatogenic lesion resembles the late phenotypes of other sterile mutants suggesting that the primary departure from normality has been overlooked. Cross sections of sperm tails nonuniform within a cyst and the number of tails at various levels in a bundle varies. The minitubules, which fill the interstices among the individualized sperm tails of mature bundles, not formed. [Hardy, Tokuyasu, and Lindsley, 1981, Chromosoma 83: 593-617 (fig.)].
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
h14-h14  
Left limit from complementation mapping against T(Y;3)A23 (FBrf0039037) Right limit from complementation mapping against T(Y;2)J146 (FBrf0039037)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Y-
 
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Maps to
      Does NOT map to
      Identified with
      hide Mapped Features & Mutations
      Type
      Symbol & Location
      Additional Notes
      References
      hide External Data
      Linkouts
      Crossreferences
      hide Expression Data
      FlyBase-Curated Data
      Transcript and
      Protein data       		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
      hide Summary of Transcript Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Summary of Polypeptide Expression
        Stage
        Tissue/Position
        Reference
        Marker for
          Subcellular Localization
          CV Term
          hide External Data & Images
          Linkouts
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          hide Alleles & Phenotypes
          hide Summary of Allele Phenotypes
          Sterility
          Allele
          male sterile
          Phenotype manifest in
          Allele
          hide Classical Alleles ( 19 )
          For All Classical Alleles Show

          Allele of kl-1ClassMutagenStocksKnown lesion
          kl-1A50 --
          kl-1B130 --
          kl-1B10 --
          kl-1B250 --
          kl-1B290 --
          kl-1B300 --
          kl-1B330 --
          kl-1E30 --
          kl-1E40 --
          kl-1G160 --
          kl-1G170 --
          kl-1G60 --
          kl-1S150 --
          kl-1X10 --
          kl-1X20 --
          kl-1X30 --
          kl-1X40 --
          kl-1ts10 --
          kl-1ts20 --
          hide Alleles Carried on Transgenic Constructs ( 0 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of kl-1ClassMutagenStocksKnown lesion
          hide Aneuploid Aberrations
          Disrupted in
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
           
          (Gatti and Pimpinelli, 1983, Bonaccorsi and Lohe, 1991)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Zhang and Stankiewicz, 1998)
          (Bonaccorsi et al., 1990)
          (Bonaccorsi et al., 1990)
          (Bonaccorsi et al., 1990)
          (Bonaccorsi et al., 1990)
          (Hazelrigg et al., 1982)
          Not disrupted in
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Hazelrigg et al., 1982)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Gatti and Pimpinelli, 1983)
          (Zhang and Stankiewicz, 1998)
          (Zhang and Stankiewicz, 1998)
          (Zhang and Stankiewicz, 1998)
          (Zhang and Stankiewicz, 1998)
          (Zhang and Stankiewicz, 1998)
          (Hazelrigg et al., 1982)
          (Hazelrigg et al., 1982)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          Insertions
          Type of insertions
          Name
          Expression data
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          Males deficient or mutant at kl-1 are sterile. One allele of Brosseau's, probably kl-1B13, studied by Kiefer, produces motile sperm which are transferred to females but do not reach the female sperm-storage organs; substantial amounts of sperm degeneration observed (Kiefer, 1969). The spermatogenic lesion resembles the late phenotypes of other sterile mutants suggesting that the primary departure from normality has been overlooked. Cross sections of sperm tails nonuniform within a cyst and the number of tails at various levels in a bundle varies. The minitubules, which fill the interstices among the individualized sperm tails of mature bundles, not formed. (Hardy, Tokuyasu and Lindsley, 1981).
           
          hide Gene Ontology: Function, Process & Cellular Component ( 0 )
          hide Molecular Function
          CV term
          Evidence
          References
          hide Biological Process
          CV term
          Evidence
          References
          hide Cellular Component
          CV term
          Evidence
          References
          hide Sequence Ontology: Class of Gene
          gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          kl-1 allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
          Linkouts
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 0 )
          hide Genomic Clones ( 0 )
          hide cDNA Clones ( 0 )
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          hide Antibody Information
          hide Other Information
          hide Discoverer
          hide Etymology
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for database merge of
          Additional comments
          Williamson (1972) reported fifteen non-complementing and five complementing alleles, all induced by EMS.
           
          hide Comments About Role
          hide Comments About Molecular Function
          hide Other Comments
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          Other Crossreferences
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          hide Synonyms & Secondary IDs ( 3 )
          Reported As
          Symbol Synonym
          kl-1
           
          Lms1
          (Hazelrigg et al., 1982, )
          Name Synonym
          male fertility factor kl1
           
          Secondary FlyBase IDs
            hide References ( 30 )
            Generate a list of
            List References by type
            hide Recent research papers (0)
            All research papers listed in FlyBase were published before 2006
            Show research papers ...
            hide Recent reviews (0)
            All reviews listed in FlyBase were published before 2006
            Show reviews ...