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Gene Dmel\if

General Information
Symbol	Dmel\if	Species	D. melanogaster
Name	inflated	Annotation symbol	CG9623
Feature type	protein_coding_gene	FlyBase ID	FBgn0001250
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map	1-55
Cytogenetic map	15A5-15A7	Sequence location	X:16,646,222..16,677,467 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene inflated is referred to in FlyBase by the symbol if (CG9623, FBgn0001250). It has the cytological map location 15A5-15A7. Its sequence location is X:16646222..16677467. Its molecular function is described as: cell adhesion molecule binding; receptor activity; protein binding. It is involved in the biological processes described with 17 unique terms, many of which group under: anatomical structure development; cell adhesion; open tracheal system development; cell motility; organ development; cell-cell adhesion; organ morphogenesis; maintenance of protein localization; cell-substrate adhesion; heterophilic cell adhesion; imaginal disc-derived wing margin morphogenesis; macromolecule localization; muscle cell differentiation; gut development; regulation of cell morphogenesis. 77 alleles are reported. The phenotypes of these alleles are annotated with 43 unique terms, many of which group under: organ system; hypodermal muscle of larval abdomen; primordium; adult segment; embryonic nervous system; larval abdominal segment 5; adult mesothoracic segment; larval abdominal segment; nervous system; abdominal 7 longitudinal muscle. It has 2 annotated transcripts and 2 annotated polypeptides.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	if: inflated Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert et al., 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox, Brown, Piovant, Smith, and White, 1984, EMBO J. 3: 2307-13). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert et al., 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio, and Leptin). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered. if3 Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. if3/if3 flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands, and most other tissues seem to be normal (Brower and Jaffe, 1989). Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if3/ifk27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles); penetrance is reduced in if3/ifk27e flies by low temperature and crowding (Brower and Jaffe, 1989). ifN
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15A5-15A7   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References 15A1-15A5 (determined by in situ hybridisation)   (Bogaert et al., 1987)
Experimentally Determined Recombination Data
Location	1-55 (Curry, 1939)
Left of (cM)	f (Curry, 1939)
Right of (cM)	r (Wilcox et al., 1989, Green, 1997.8.18) un (Curry, 1939)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\if for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) if-RA FBtr0074358  NM_167544   4757   1146 if-RB FBtr0074357  NM_078654   5724   1396
Additional Transcript Data & Comments
Reported size (kB)	5.7 (northern blot) (Bogaert et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein if-PA   FBpp0074132   126.6   1146   5.25     NP_728021   AAN09423 if-PB   FBpp0074131   154.3   1396   6.10     NP_523378   AAF48661
Additional Polypeptide Data & Comments
Reported size (kD)	1394 (aa); 140 (kD observed) (Bogaert et al., 1987)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001250
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Integrins alpha chain (IPR000413) Integrin alpha chain, C-terminal cytoplasmic region (IPR013513) FG-GAP (IPR013517) Integrin alpha beta-propellor (IPR013519) Integrin alpha-2 (IPR013649)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141822   AA141823   AA803975   AE003503 AAF48661   AE003503 AAN09423   AY118840 AAM50700   BF494222   BT025044   CK02516   CO186660   CO264090   CO265925   CO270351   CO285448   CO291655   CO292632   CO294770   CO295924   CO298379   CO305426   CO340643   CO341448   EC051283   EC051778   EC051786   EC055462   EC055912   EC056118   EC061061   EC065918   EC073636   EC074966   EC077350   EC083073   EC083790   EC084359   EC085560   EC194667   EC194872   EC198420   EC209666   EC222648   EC224126   EC243314   EC247472   EC255869   EL885330   EL885331   EL885370   EL885371   EL885406   EL885407   M19059 AAC12788
UniProtKB/Swiss-Prot	P12080
UniProtKB/TrEMBL	Q8IR07 Q8MSG3
Maps to
Does NOT map to
Identified with	GM12416 (BDGP Project Members, 2000-) D1050 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References aberration junction T(1;2)if[B6].bk1 X:16,665,729..16,673,883 comment=Breakpoint one of T(1;2)if[B6] maps to the second intron of if. evidence=experimental (Brown, 1994) deletion if[B4] X:16,650,572..16,652,184 comment=Reported as a deletion in the if gene encompassing 1036 bases of intron 8 and 577 bases of exon 9. evidence=experimental (Brown, 1994) rescue fragment if[+t39] X:16,644,099..16,683,112 comment=The position of the rescue fragment on the reference sequence was inferred by a FlyBase curator. evidence=experimental linked_to=SpeI-XhoI_rfrag (Brown, 1994) rescue fragment if[+tBa] X:16,645,935..16,679,861 comment=Position of rescue fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=NotI-SpeI_rfrag (Bloor and Brown, 1998)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 3099
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  larval stage | third instar  peripodial epithelium (Bogaert et al., 1987)  embryonic stage | stage 4-13  mesoderm (Bogaert et al., 1987)  larval stage | third instar  dorsal mesothoracic disc (Bogaert et al., 1987)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage  gonadal sheath muscle (Bogaert et al., 1987)  embryonic stage  pharyngeal muscle (Bogaert et al., 1987)  embryonic stage  gonad | restricted (Bogaert et al., 1987)  embryonic stage  muscle attachment site (Bogaert et al., 1987)  larval stage | third instar  dorsal mesothoracic disc (Bogaert et al., 1987)  embryonic stage | stage >=10  mesoderm (Bogaert et al., 1987)  embryonic stage  visceral mesoderm (Bogaert et al., 1987)
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001250 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0001250 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0001250
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable if1 if3 ifN viable | poor if1 lethal | recessive if2B1 ifB2 ifC2B ifH18 ifK13 ifk27e lethal | embryonic stage ifB2 ifB4 ifk27e lethal | embryonic stage | recessive if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if648 if64 if6 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifSEF ifk27e lethal, with Scer\GAL4elav.PLu ifGD1175 lethal, with Scer\GAL4Mef2.PR ifGD1175 Other Phenotypes Allele wild-type if+t39 if+tBa ifminigene visible if1 if3 ifN ifm8.αTub84B visible | recessive if3 visible | recessive | conditional cs if3 visible | dominant if26 if2B1 if648 if64 if6 if8 ifB4 ifC2B ifK13 ifK23 ifL10 ifL326 ifL6 visible | conditional ts, with Scer\GAL4337Y ifGOF.m8.Scer\UAS ifLOF.m8.Scer\UAS ifm8.Scer\UAS neuroanatomy defective ifk27e Sterility Allele fertile if3 ifN fertile | poor if1 Phenotype manifest in Allele wing if1 if26 if2B1 if3 if6 if64 if648 if8 ifB4 ifC2B ifK13 ifK23 ifL10 ifL326 ifL6 ifN ifk27e ifm8.αTub84B wing vein if1 if3 ifN embryonic/larval somatic muscle if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e sarcomere & somatic muscle if13ts if17 if21 if35 ifSEF anterior midgut proper primordium if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e gastric caecum primordium if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e gastric caecum if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e ventral nerve cord if13ts if16 if17 if21 if26 if2B1 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifSEF ifk27e embryonic/larval visceral muscle if17 ifB4 ifC2B larval midgut & embryo if2B1 ifA7 ifB2 ifB4 ifC2B ifk27e somatic muscle & larva if2B1 wing | conditional cs if3 crossvein if3 ifN anterior crossvein if3 wing | somatic clone ifA7 stage S14 oocyte ifB2 embryonic peripheral nervous system ifB2 ifk27e embryonic central nervous system ifB2 ifk27e embryonic/larval visceral branch ifB4 abdominal 2 segment border muscle ifB4 abdominal 3 segment border muscle ifB4 abdominal 4 segment border muscle ifB4 abdominal 5 segment border muscle ifB4 abdominal 6 segment border muscle ifB4 abdominal 7 segment border muscle ifB4 abdominal 2 lateral longitudinal muscle 1 ifB4 abdominal 3 lateral longitudinal muscle 1 ifB4 abdominal 4 lateral longitudinal muscle 1 ifB4 abdominal 5 lateral longitudinal muscle 1 ifB4 abdominal 6 lateral longitudinal muscle 1 ifB4 abdominal 7 lateral longitudinal muscle 1 ifB4 abdominal 2 ventral longitudinal muscle 1 ifB4 abdominal 3 ventral longitudinal muscle 1 ifB4 abdominal 4 ventral longitudinal muscle 1 ifB4 abdominal 5 ventral longitudinal muscle 1 ifB4 abdominal 6 ventral longitudinal muscle 1 ifB4 abdominal 7 ventral longitudinal muscle 1 ifB4 visceral mesoderm ifB4 ifk27e embryonic/first instar larval cuticle | dorsal ifB4 ifk27e embryonic digestive system ifB4 muscle attachment site & connecting hemi-adherens junction ifB4 muscle attachment site & muscle tendon junction ifB4 muscle attachment site & basal lamina ifB4 extended germ band embryo ifB4 ifk27e posterior midgut proper primordium ifB4 ifk27e midgut constriction ifB4 ifk27e somatic muscle ifB4 ifSEF ifk27e larval proventriculus & embryo ifB4 proventriculus inner layer ifB4 eye, with Scer\GAL4how-24B ifC.Scer\UAS embryonic gastric caecum ifC2B wing | conditional ts, with Scer\GAL4337Y ifGOF.m8.Scer\UAS ifLOF.m8.Scer\UAS ifm8.Scer\UAS germ layer & embryo ifk27e embryonic salivary gland ifk27e
Classical Alleles ( 51 )
For All Classical Alleles Show
Allele of if Class Mutagen Stocks Known lesion if13ts hypomorph ethyl methanesulfonate 0 -- if16 amorph ethyl methanesulfonate 0 -- if17 hypomorph ethyl methanesulfonate 0 -- if1 spontaneous 0 -- if21 hypomorph ethyl methanesulfonate 0 -- if26 amorph X ray 0 -- if2 0 -- if2B1 ethyl methanesulfonate 0 -- if2B2 amorph ethyl methanesulfonate 0 -- if2B3 amorph ethyl methanesulfonate 0 -- if35 hypomorph ethyl methanesulfonate 0 -- if38 amorph ethyl methanesulfonate 0 -- if3 hypomorph spontaneous 2 -- if4.5 amorph ethyl methanesulfonate 0 -- if648 amorph ethyl methanesulfonate 0 -- if64 amorph X ray 0 -- if6 amorph X ray 0 -- if815-17 X ray 0 -- if8 amorph X ray 0 -- if9 amorph ethyl methanesulfonate 0 -- ifA2 amorph ethyl methanesulfonate 0 -- ifA7 amorph, loss of function ethyl methanesulfonate 0 -- ifB2.1 γ r