Gene Dmel\Hsp83

General Information
Symbol	Dmel\Hsp83	Species	D. melanogaster
Name	Heat shock protein 83	Annotation symbol	CG1242
Feature type	protein_coding_gene	FlyBase ID	FBgn0001233
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3L	Recombination map	3-5
Cytogenetic map	63B11-63B11	Sequence location	3L:3,193,027..3,197,061 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Heat shock protein 83 is referred to in FlyBase by the symbol Hsp83 (CG1242, FBgn0001233). It has the cytological map location 63B11. Its sequence location is 3L:3193027..3197061. Its molecular function is described as: ATPase activity, coupled; ATP binding; unfolded protein binding. It is involved in the biological processes described with 11 unique terms, many of which group under: organelle organization and biogenesis; cell cycle; anatomical structure development; cell cycle process; cellular macromolecule metabolic process; response to stress; transmembrane receptor protein tyrosine kinase signaling pathway; sleep; actin filament-based process; gamete generation; anterior/posterior axis specification. 72 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; peripheral nervous system; adult segment; nervous system; adult mesothoracic segment; elongation stage spermatid; cytoplasmic part; germ cell; cell cycle; spermatocyte; spermatozoon; adult external prothorax. It has one annotated transcript and one annotated polypeptide.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Hsp83 The structural gene for the 83,000 dalton heat-shock protein (HSP83). During development, the gene is expressed at high levels in the absence of heat shock in many tissues, especially ovaries where it apparently originates in nurse cells (Zimmerman, Petri, and Meselson, 1983, Cell 32: 1161-70). During heat shock, however, the expression level is only raised several fold (Xiao and Lis, 1989, Mol. Cell Biol. 9: 1746-53). Deletion of sequences upstream from the coding region eliminates normal developmental expression and results in regulation of Hsp83 in a manner similar to that of Hsp70 which is activated only in response to heat shock.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63B11-63B11 Limits computationally determined from genome sequence between P{PZ}l(3)06803⁰⁶⁸⁰³ and P{PZ}kst⁰¹³¹⁸
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63B7-63B8 (determined by in situ hybridisation) (Spradling et al., 1999) 63B9-63B9 (determined by in situ hybridisation) (Cuenca et al., 1998) 63B5-63B11 (determined by in situ hybridisation) (van der Straten et al., 1997) 63B-63C (determined by in situ hybridisation) (Segarra et al., 1996) 88A-88A (determined by in situ hybridisation) (Carthew et al., 1994) 63A1-63B12 63B7--8 (BDGP Project Members, 1994-1999) 63A1-63B12 (determined by in situ hybridisation) (Castrillon et al., 1993) 63B-63C (determined by in situ hybridisation) (Papaceit and Juan, 1993) 63B-63C (determined by in situ hybridisation) (Lozovskaya et al., 1993) 63B-63C (determined by in situ hybridisation) (Blackman and Meselson, 1986) 63B-63B (determined by in situ hybridisation) (O'Connor and Lis, 1981) 63B-63C (determined by in situ hybridisation) (Holmgren et al., 1979)
Experimentally Determined Recombination Data
Location	3-5 (Simon et al., 1991) 3-13 +/- 4 (van der Straten et al., 1997) 3-55 (Carthew et al., 1994)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: Hsp83+ anon-63BC-T2? (O'Connor and Lis, 1981, van der Straten et al., 1997) Overall orientation not stated: CG14965- Hsp83+ anon-63BC-T2? (Blackman and Meselson, 1986)
Gene Model & Products
Please see the GBrowse view of Dmel\Hsp83 for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsp83-RA FBtr0073040 NM_079175 2904 717
Additional Transcript Data & Comments
Reported size (kB)	3.05 (northern blot) (Holmgren et al., 1979)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsp83-PA FBpp0072904 81.9 717 4.64 NP_523899 AAF47734
Additional Polypeptide Data & Comments
Reported size (kD)	83 (kD) (Holmgren et al., 1979)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001233
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Heat shock protein Hsp90 (IPR001404) ATP-binding region, ATPase-like (IPR003594) TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • R00773 R00774
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201714 AA201980 AA263921 AA263931 AA264203 AA264269 AA264791 AA390307 AA391363 AA536231 AA538922 AA539306 AA539732 AA539868 AA540960 AA694726 AA695036 AA695068 AA695216 AA695288 AA695400 AA695466 AA695575 AA695730 AA695990 AA696173 AA696178 AA696255 AA696261 AA696316 AA696535 AA696971 AA697637 AA698125 AA735741 AA735793 AA735993 AA801722 AA801822 AA801918 AA801970 AA802183 AA802322 AA802435 AA802561 AA802612 AA802823 AA802962 AA802992 AA803121 AA803149 AA803164 AA803214 AA803540 AA803990 AA804018 AA816434 AA816934 AA816987 AA821031 AA940625 AA941709 AA942154 AA949058 AA949750 AE003477 AAF47734 AF067904 AF067905 AI061745 AI061886 AI062176 AI062396 AI107504 AI108638 AI108864 AI109123 AI109402 AI109541 AI113662 AI113670 AI124331 AI133831 AI134620 AI135003 AI238974 AI239049 AI256956 AI257218 AI258754 AI258755 AI258788 AI258800 AI258881 AI258975 AI259122 AI259145 AI259323 AI259339 AI259440 AI259671 AI259799 AI260171 AI260593 AI293180 AI293207 AI293518 AI293603 AI293693 AI293836 AI294309 AI294672 AI294786 AI294858 AI295121 AI295657 AI295780 AI296317 AI296790 AI296831 AI296883 AI297177 AI297709 AI297881 AI297903 AI387952 AI388050 AI389815 AI389818 AI402120 AI402360 AI403487 AI403509 AI404689 AI404764 AI405627 AI512623 AI514457 AI514908 AI517542 AI517733 AI517856 AI518315 AI518542 AI519529 AI530751 AI530809 AI531473 AI531482 AI531984 AI532010 AI532115 AI532125 AI532131 AI532540 AI532803 AI532807 AI532933 AI532976 AI533318 AI533485 AI533504 AI533648 AI533843 AI533920 AI534306 AI534336 AI534380 AI534407 AI541667 AI542126 AI542340 AI542701 AI542839 AI542873 AI543376 AI543387 AI543488 AI543573 AI543652 AI543743 AI543753 AI544065 AI544399 AI544420 AI546555 AI546598 AI946294 AQ026323 AX047373 CAC18966 AX154860 AY122080 AAM52592 BE976946 BF486082 BF486286 BF489457 BF489995 BF493744 BF494602 BF495052 BF497612 BF497664 BF498055 BF498521 BF499762 BF501016 BF502380 BF502516 BF502690 BF504020 BF504368