Gene Dmel\Hsc70-4

General Information
Symbol	Dmel\Hsc70-4	Species	D. melanogaster
Name	Heat shock protein cognate 4	Annotation symbol	CG4264
Feature type	protein_coding_gene	FlyBase ID	FBgn0001219
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map	3-56.5
Cytogenetic map	88E4-88E4	Sequence location	3R:11,068,367..11,072,339 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Heat shock protein cognate 4 is referred to in FlyBase by the symbol Hsc70-4 (CG4264, FBgn0001219). It has the cytological map location 88E4. Its sequence location is 3R:11068367..11072339. Its molecular function is described as: ATPase activity; unfolded protein binding; chaperone binding; ATP binding. It is involved in the biological processes: embryonic development via the syncytial blastoderm; axon guidance; axonal fasciculation; nervous system development; neurotransmitter secretion; vesicle-mediated transport; protein folding; synaptic vesicle transport; RNA interference. 44 alleles are reported. The phenotypes of these alleles are annotated with 37 unique terms, many of which group under: anatomical structure; organ system; peripheral nervous system; nervous system; adult segment; adult; cytoplasmic part; imaginal precursor; intracellular membrane-bounded organelle; abdominal segment 7. It has 6 annotated transcripts and 6 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E4-88E4 Limits computationally determined from genome sequence between P{EP}CG33967^EP666 and P{lacW}Hsc70-4^L3929
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88E8-88E9 (determined by in situ hybridisation) (Spradling et al., 1999) 88E8-88E9 (determined by in situ hybridisation) (Perrimon et al., 1996) 88E3-88E4 (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-56.5 (Hing et al., 1999)
Left of (cM)	Sb (Hing et al., 1999, Mollaaghababa et al., 2001) sr (Mollaaghababa et al., 2001)
Right of (cM)	red (Hing et al., 1999) cu (Mollaaghababa et al., 2001)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: tefu- Hsc70-4+ (Hing et al., 1999) Gene Order (overall orientation not stated) References Overall orientation not stated: tefu? Hsc70-4+ CG6499+ (Bronk et al., 2001)
Gene Model & Products
Please see the GBrowse view of Dmel\Hsc70-4 for information on other features
Comments on Gene Model
	Multiple ESTs homologous to non-coding strand of this gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsc70-4-RA FBtr0083057 NM_079632 2413 651 Hsc70-4-RB FBtr0083060 NM_169625 2342 651 Hsc70-4-RC FBtr0083058 NM_169626 2283 651 Hsc70-4-RD FBtr0083059 NM_169627 2355 651 Hsc70-4-RE FBtr0083055 NM_176502 2287 651 Hsc70-4-RF FBtr0083056 NM_176503 2362 651
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsc70-4-PA FBpp0082516 71.1 651 5.16 NP_524356 AAF55150 Hsc70-4-PB FBpp0082519 71.1 651 5.16 NP_731987 AAN13637 Hsc70-4-PC FBpp0082517 71.1 651 5.16 NP_731988 AAN13638 Hsc70-4-PD FBpp0082518 71.1 651 5.16 NP_731989 AAN13639 Hsc70-4-PE FBpp0082514 71.1 651 5.16 NP_788679 AAO41567 Hsc70-4-PF FBpp0082515 71.1 651 5.16 NP_788680 AAO41568
Additional Polypeptide Data & Comments
Reported size (kD)	70 (kD) (Carbajal et al., 1993)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001219
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Heat shock protein Hsp70 (IPR001023) Heat shock protein 70 (IPR013126) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME04264
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201336 AA201373 AA201397 AA202015 AA202118 AA202137 AA202169 AA202233 AA202240 AA202335 AA202351 AA202376 AA202514 AA202533 AA202548 AA202770 AA202836 AA202876 AA203073 AA246360 AA246525 AA247017 AA247085 AA263245 AA263303 AA263410 AA263728 AA263745 AA263756 AA263770 AA264004 AA264135 AA264327 AA264386 AA264582 AA264606 AA264691 AA264806 AA390511 AA390637 AA390766 AA390907 AA390919 AA391000 AA391044 AA391121 AA391157 AA391235 AA391438 AA391463 AA391722 AA392397 AA392610 AA392680 AA392694 AA392825 AA392939 AA392949 AA392974 AA393002 AA438278 AA438465 AA438531 AA438828 AA439095 AA439221 AA439324 AA439459 AA440045 AA440051 AA440090 AA440152 AA440198 AA440445 AA440566 AA440613 AA440926 AA440993 AA441146 AA441332 AA441365 AA441480 AA441657 AA536327 AA538759 AA538761 AA538899 AA539004 AA539006 AA539114 AA539206 AA539482 AA539573 AA539650 AA539874 AA540054 AA540128 AA540170 AA540314 AA540349 AA540575 AA540785 AA540813 AA540981 AA541048 AA567231 AA567239 AA567266 AA694889 AA694927 AA695163 AA695205 AA695208 AA695251 AA695382 AA695515 AA695660 AA695702 AA695813 AA695949 AA696000 AA696007 AA696009 AA696095 AA696332 AA696401 AA696402 AA696570 AA696572 AA696573 AA696918 AA697157 AA697245 AA697677 AA697862 AA698080 AA698646 AA698962 AA699281 AA735114 AA735413 AA735417 AA735473 AA735486 AA735773 AA736020 AA736131 AA801648 AA801693 AA801840 AA801870 AA801878 AA802031 AA802205 AA802411 AA802450 AA802539 AA802540 AA802640 AA802708 AA802969 AA802996 AA803052 AA803078 AA803090 AA803167 AA803342 AA803536 AA803663 AA803745 AA803796 AA803822 AA803897 AA804016 AA804049 AA816401 AA816420 AA816820 AA817008 AA817042 AA817051 AA817072 AA817138 AA817236 AA817305 AA817346 AA817434 AA817506 AA817650 AA820246 AA820270 AA820280 AA820366 AA820511 AA820659 AA820732 AA820834 AA820866 AA820877 AA821125 AA821132