Gene Dmel\ftz

General Information
Symbol	Dmel\ftz	Species	D. melanogaster
Name	fushi tarazu	Annotation symbol	CG2047
Feature type	protein_coding_gene	FlyBase ID	FBgn0001077
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map	3-47.5
Cytogenetic map	84A6-84A6	Sequence location	3R:2,690,046..2,691,950 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene fushi tarazu is referred to in FlyBase by the symbol ftz (CG2047, FBgn0001077). It has the cytological map location 84A6. Its sequence location is 3R:2690046..2691950. Its molecular function is described as: transcription factor activity; sequence-specific DNA binding. It is involved in the biological processes described with 11 unique terms, many of which group under: regionalization; embryonic pattern specification; embryonic development; multicellular organismal development; regulation of metabolic process; anatomical structure development; transcription, DNA-dependent; pattern specification process; regulation of biological process; head segmentation; periodic partitioning by pair rule gene; trunk segmentation; gonadal mesoderm development; cell fate commitment; cell motility. 192 alleles are reported. The phenotypes of these alleles are annotated with 81 unique terms, many of which group under: adult segment; blastoderm embryo; extended germ band embryo; abdominal ventral denticle belt; thoracic segment; embryonic segment; embryonic abdomen; organ system; gastrula embryo; larval abdominal segment. It has one annotated transcript and one annotated polypeptide.
External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ftz: fushi tarazu Null loss-of-function mutations result in embryonic lethality. Animals survive to the end of embryogenesis and exhibit a pair-rule mutant phenotype in the cuticle. This same phenotype is observable in animals at the beginning of segmentation of the germ band. Prior to deposition of cuticle, ftz- animals have two rather than three mouth (gnathocephalic) segments and five as compared to ten trunk metameres. The material deleted is derived from the even-numbered parasegments, ps2 through ps12. Similar metameric deletions/fusions are seen in the neuromeres of the ventral nerve cord of the CNS. The name of the locus derives from the phenotype and is Japanese for "segment" (fushi) "deficient" (tarazu) (N.B. - there is only one letter t in tarazu; it is at the start of the word i.e., there is no second t preceding the z). Temperature-sensitive alleles of the gene have shown that the temperature-critical period for viability and phenotype falls between 1 and 4 hours of embryogenesis with the mid point of 2.5 hours at the blastoderm stage. The recovery of clones of ftz- cells created by X-ray-induced somatic exchange after cellular blastoderm have demonstrated that ftz+ activity is not necessary for normal cuticular morphogenesis subsequent to this point in development. In addition to these recessive null and hypomorphic alleles there are two classes of dominant gain-of-function lesions at the ftz locus. The first, ftz- Regulator of postbithorax-like, causes a variable transformation of the posterior haltere into posterior wing. The second, ftz-Ultra-abdominal-like, is associated with a patchy transformation of the adult first abdominal segment toward third abdominal identity. The former (ftzRpl) lesion also shows a recessive loss-of-function phenotype while the latter class (ftzUal) has no discernable embryonic phenotype and is homozygous viable. The fact that these dominant alleles produce mutant phenotypes that mimic lesions in the BXC has been interpreted as demonstrating a regulatory link between the segment enumeration genes and the homeotics.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84A6-84A6 Limits computationally determined from genome sequence between P{PZ}pb⁰⁴⁴⁹⁸ and P{lacW}l(3)L2100^L2100
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84B1-84B1 (determined by in situ hybridisation) (Ranz et al., 2001) 84B1-84B2 (Tearle and Nusslein-Volhard, 1987) 84B1-84B2 (determined by in situ hybridisation) (Weiner et al., 1984) 84B1-84B2 (determined by in situ hybridisation) (Hafen et al., 1984) 84B1-84B2 (determined by in situ hybridisation) (Kuroiwa et al., 1984)
Experimentally Determined Recombination Data
Location	3-47.5 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: Dfd? anon-84Ba? anon-84Bb? Scr- anon-84Bc? Scr- ftz+ anon-84Bd- Antp- (Kuroiwa et al., 1985) In direction of increasing cytology: Scr- ftz+ anon-84Bd- Antp- (Riley et al., 1987) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\ftz for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ftz-RA FBtr0081625 NM_058150 1758 410
Additional Transcript Data & Comments
Reported size (kB)	1.8 (northern blot) (Weiner et al., 1984) 1.9 (northern blot) (Kuroiwa et al., 1984)
Comments	The transcription start site mapped is 50bp downstream of that reported previously. (Dearolf et al., 1989)
External Data
Crossreferences	Rfam - RNA families database of alignments and covariance models • RF00227
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein ftz-PA FBpp0081139 46.5 410 6.99 NP_477498 AAF54081
Additional Polypeptide Data & Comments
Reported size (kD)	68 (kD observed) (Kellerman et al., 1990) 413 (aa); 45 (kD predicted) (Laughon and Scott, 1984)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001077
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helix-turn-helix motif, lambda-like repressor (IPR000047) Homeobox (IPR001356) Fushi tarazu, N-terminal (IPR005567) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1FTZ TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • R00481 R00482 R00483 R00484 R00485 R02286 R02287 R02351 R02352 R02353 R02354 R02355 R02356 R02357 R02358 R02359 R02360 R02361 R02362 R02363 R02364 R02365 R02366 R02367 R02368 R02369 R02370 R02371 R02503 R02506 R02557 R02558 R02559 R02560 R02561 R02562 R02563 T00295
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE001572 AAD19794 AE003673 AAF54081 AY184094 AY184095 AY184096 AY184097 AY184098 AY184099 AY184100 AY184101 AY184102 AY184103 AY184104 AY184105 AY184106 BT022173 CO288301 EC057664 EC082788 K01947 AAA28372 K03136 AAA28374 X00854 CAA25408 X13402 X68047 X78905 CAA55518

UniProtKB/Swiss-Prot	P02835
UniProtKB/TrEMBL

Maps to	AE001572 (FlyBase, 1992-)
Does NOT map to
Identified with	IP01266 (Hoskins et al., 2005) D1316 Dm0074 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References aberration junction T(2;3)ftz[Rpl] 3R:2,691,195..2,691,195 comment=1st base of translocated segment evidence=experimental (Laughon and Scott, 1984, Weiner et al., 1984) point mutation ftz[Ual2] 3R:2,690,738..2,690,738 evidence=experimental na_change=C2690738T pr_change=P208L\|ftz-PA reported_pr_change=P211L (Kellerman et al., 1990) point mutation ftz[Ual3] 3R:2,690,749..2,690,749 evidence=experimental na_change=C2690749T pr_change=P212S\|ftz-PA reported_pr_change=P215S (Kellerman et al., 1990) point mutation ftz[Ual1] 3R:2,690,750..2,690,750 evidence=experimental na_change=C2690750T pr_change=P212L\|ftz-PA reported_pr_change=P215L (Kellerman et al., 1990) point mutation ftz[5] 3R:2,691,125..2,691,125 evidence=experimental na_change=C2691125T pr_change=A288V\|ftz-PA (Laughon and Scott, 1984) point mutation ftz[11.3] 3R:2,691,179..2,691,179 comment=Position of mutation on reference sequence inferred from Figure 5. evidence=experimental na_change=G2691179A pr_change=R306H\|ftz-PA reported_na_change=G?A reported_pr_change=R309H (Alonso et al., 2001) protein binding site ftz-protein_bind-1 3R:2,688,252..2,688,267 comment=site I; neuronal cis element bound by grh protein; TF:R00481 evidence=experimental bound_moiety=grh-XP (Dynlacht et al., 1989, Bergman et al., 2004) protein binding site ftz-protein_bind-2 3R:2,688,282..2,688,296 bound_moiety=grh-XP evidence=experimental comment=site II; neuronal cis element bound by grh protein; TF:R00482 (Dynlacht et al., 1989, Bergman et al., 2004) protein binding site ftz-protein_bind-5 3R:2,688,374..2,688,389 comment=site IV; neuronal cis element bound by grh protein (binds complement); TF:R00484 evidence=experimental bound_moiety=grh-XP (Dynlacht et al., 1989, Bergman et al., 2004) protein binding site ftz-protein_bind-10 3R:2,684,909..2,684,938 bound_moiety=ftz-XP evidence=experimental comment=high-affinity binding site; TF:R02355 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-11 3R:2,685,251..2,685,282 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-12 3R:2,685,853..2,685,871 bound_moiety=slp1-XP evidence=experimental (Bergman et al., 2004, Yu et al., 1999) protein binding site ftz-protein_bind-13 3R:2,689,753..2,689,772 evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-14 3R:2,686,028..2,686,048 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-15 3R:2,692,105..2,692,143 bound_moiety=en-XP evidence=experimental (Desplan et al., 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-16 3R:2,685,892..2,685,914 evidence=experimental (Han et al., 1993, Bergman et al., 2004) protein binding site ftz-protein_bind-17 3R:2,684,547..2,684,563 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02351 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-18 3R:2,686,042..2,686,065 evidence=experimental (Bergman et al., 2004, Han et al., 1993) protein binding site ftz-protein_bind-19 3R:2,684,593..2,684,613 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02352 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-20 3R:2,685,802..2,685,820 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02366 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-21 3R:2,685,310..2,685,340 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-22 3R:2,683,714..2,683,748 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-23 3R:2,685,720..2,685,735 bound_moiety=ftz-XP evidence=experimental comment=low-affinity binding site; TF:R02364 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-24 3R:2,686,177..2,686,193 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02371 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-25 3R:2,689,733..2,689,747 evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-26 3R:2,686,026..2,686,041 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02369 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-27 3R:2,685,374..2,685,494 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-28 3R:2,684,408..2,684,433 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-29 3R:2,683,910..2,683,923 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-30 3R:2,689,955..2,689,974 bound_moiety=ttk-XP evidence=experimental (Bergman et al., 2004, Fairall et al., 1992) protein binding site ftz-protein_bind-31 3R:2,684,880..2,684,899 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site: TF:R02354 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-32 3R:2,684,588..2,684,611 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-33 3R:2,689,783..2,689,812 evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-34 3R:2,686,020..2,686,030 evidence=experimental (Han et al., 1993, Bergman et al., 2004) protein binding site ftz-protein_bind-35 3R:2,689,959..2,689,972 evidence=experimental (Bergman et al., 2004, Topol et al., 1991) protein binding site ftz-protein_bind-36 3R:2,685,843..2,685,859 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-37 3R:2,685,823..2,685,839 bound_moiety=ftz-XP evidence=experimental comment=high-affinity binding site; TF:R02367 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-38 3R:2,685,337..2,685,354 evidence=experimental bound_moiety=ftz-XP comment=low-affinity binding site; TF:R02358 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-39 3R:2,685,247..2,685,265 bound_moiety=ttk-XP evidence=experimental (Bergman et al., 2004, Fairall et al., 1992) protein binding site ftz-protein_bind-40 3R:2,684,051..2,684,085 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-41 3R:2,685,371..2,685,390 bound_moiety=ftz-XP evidence=experimental comment=low-affinity binding site; TF:R02359 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-42 3R:2,684,448..2,684,538 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-43 3R:2,685,777..2,685,798 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02365 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-44 3R:2,689,755..2,689,768 bound_moiety=Hr39-XP evidence=experimental (Ohno et al., 1994, Bergman et al., 2004) protein binding site ftz-protein_bind-45 3R:2,685,929..2,685,947 evidence=experimental (Han et al., 1993, Bergman et al., 2004) protein binding site ftz-protein_bind-46 3R:2,684,903..2,684,956 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-47 3R:2,686,083..2,686,092 evidence=experimental (Bergman et al., 2004, Han et al., 1993) protein binding site ftz-protein_bind-48 3R:2,684,858..2,684,880 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-49 3R:2,689,678..2,689,717 evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-50 3R:2,689,992..2,690,012 evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-51 3R:2,685,838..2,685,853 evidence=experimental (Bergman et al., 2004, Han et al., 1993) protein binding site ftz-protein_bind-52 3R:2,685,625..2,685,637 bound_moiety=ftz-XP evidence=experimental comment=low-affinity binding site; TF:R02363 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-53 3R:2,684,103..2,684,208 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-54 3R:2,685,898..2,686,018 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-55 3R:2,684,810..2,684,828 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-56 3R:2,686,061..2,686,076 bound_moiety=ftz-XP evidence=experimental comment=low-affinity binding site; TF:R02370 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-57 3R:2,685,513..2,685,543 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-58 3R:2,685,038..2,685,068 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-59 3R:2,684,774..2,684,795 bound_moiety=ftz-XP evidence=experimental comment=low-affinity binding site; TF:R02353 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-60 3R:2,685,478..2,685,494 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02360 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-61 3R:2,685,678..2,685,728 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-62 3R:2,684,307..2,684,403 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-63 3R:2,689,754..2,689,769 evidence=experimental bound_moiety=ftz-f1-XP comment=TF:R0485 (Ueda et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-64 3R:2,686,050..2,686,080 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-65 3R:2,685,240..2,685,267 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site: TF:R02357 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-66 3R:2,685,823..2,685,836 evidence=experimental (Bergman et al., 2004, Han et al., 1993) protein binding site ftz-protein_bind-67 3R:2,684,955..2,685,010 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02356 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-68 3R:2,685,799..2,685,811 evidence=experimental (Han et al., 1993, Bergman et al., 2004) protein binding site ftz-protein_bind-69 3R:2,689,754..2,689,768 bound_moiety=ftz-f1-XP evidence=experimental (Ohno et al., 1994, Bergman et al., 2004) protein binding site ftz-protein_bind-70 3R:2,685,573..2,685,584 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02362 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-71 3R:2,685,888..2,685,902 bound_moiety=ftz-XP evidence=experimental comment=medium-affinity binding site; TF:R02368 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-72 3R:2,685,819..2,685,848 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-73 3R:2,685,535..2,685,549 evidence=experimental bound_moiety=ftz-XP comment=medium-affinity binding site; TF:R02361 (Pick et al., 1990, Bergman et al., 2004) protein binding site ftz-protein_bind-74 3R:2,685,568..2,685,650 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-75 3R:2,685,915..2,685,927 evidence=experimental (Han et al., 1993, Bergman et al., 2004) protein binding site ftz-protein_bind-76 3R:2,683,943..2,684,001 evidence=experimental (Bergman et al., 2004, Harrison and Travers, 1988) protein binding site ftz-protein_bind-77 3R:2,684,961..2,685,008 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-78 3R:2,684,655..2,684,697 evidence=experimental (Harrison and Travers, 1988, Bergman et al., 2004) protein binding site ftz-protein_bind-79 3R:2,689,851..2,689,887 bound_moiety=Unspecified-XP evidence=experimental (Bergman et al., 2004, Topol et al., 1991) protein binding site ftz-protein_bind-80 3R:2,689,894..2,689,904 evidence=experimental bound_moiety=Unspecified-XP (Brown et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-81 3R:2,689,897..2,689,915 bound_moiety=Unspecified-XP evidence=experimental (Topol et al., 1991, Bergman et al., 2004) protein binding site ftz-protein_bind-82 3R:2,685,250..2,685,268 bound_moiety=ttk-XP comment=TF:R02287 evidence=experimental (Harrison and Travers, 1990) protein binding site ftz-protein_bind-83 3R:2,685,254..2,685,274 bound_moiety=ttk-XP comment=TF:R02286 evidence=experimental (Harrison and Travers, 1990) protein binding site ftz-protein_bind-84 3R:2,688,329..2,688,344 bound_moiety=grh-XP comment=site IIIa; neuronal cis element bound by grh protein; TF:R00483 evidence=experimental (Dynlacht et al., 1989) protein binding site ftz-protein_bind-85 3R:2,688,348..2,688,363 bound_moiety=grh-XP comment=site IIIb; neuronal cis element bound by grh protein (binds complement); TF:R00483 evidence=experimental (Dynlacht et al., 1989) protein binding site ftz-protein_bind-86 3R:2,689,571..2,689,586 bound_moiety=cad-XP comment=CDRE, cad-protein DNA recognition element, TF:R02503; activating region; site consists of an inverted repeat of a 6 base motif with a 4 base spacer evidence=experimental (Dearolf et al., 1989) protein binding site ftz-protein_bind-89 3R:2,689,644..2,689,657 bound_moiety=cad-XP comment=CDRE, cad-protein DNA recognition element, TF:R2557, activating region; site consists of a direct repeat of a 6 base motif with a 2 base spacer evidence=experimental (Dearolf et al., 1989) protein binding site ftz-protein_bind-87 3R:2,689,864..2,689,882 bound_moiety=ttk-XP comment=ttk binding site I evidence=experimental (Brown et al., 1991) protein binding site ftz-protein_bind-88 3R:2,689,899..2,689,912 bound_moiety=ttk-XP comment=ttk binding site II evidence=experimental (Brown et al., 1991) regulatory region ftz\|reg_element\|2 3R:2,683,629..2,686,199 comment=ftz upstream enhancer element evidence=experimental linked_to=KpnI-XbaI_rfrag (Hiromi et al., 1985) regulatory region ftz\|reg_element\|5 3R:2,684,746..2,685,131 comment=distal enhancer of the ftz upstream enhancer element evidence=experimental (Pick et al., 1990) regulatory region ftz\|reg_element\|16 3R:2,685,409..2,685,988 comment=Prox A of the ftz upstream enhancer element; directs expression in seven mesodermal stripes. evidence=experimental (Pick et al., 1990) regulatory region ftz\|reg_element\|15 3R:2,685,409..2,686,199 comment=proximal enhancer of the ftz upstream enhancer element. evidence=experimental (Pick et al., 1990) regulatory region ftz\|reg_element\|26 3R:2,685,988..2,686,199 comment=Prox B of the ftz upstream enhancer element; directs expression in seven ectodermal stripes when in conjunction with Prox A. evidence=experimental (Pick et al., 1990) regulatory region ftz\|reg_element\|30 3R:2,687,126..2,689,378 comment=ftz neurogenic element evidence=experimental linked_to=XbaI-BalI_rfrag (Hiromi et al., 1985) regulatory region ftz\|reg_element\|36 3R:2,689,373..2,690,122 comment=ftz zebra element evidence=experimental linked_to=BalI-BalI_rfrag (Hiromi et al., 1985) regulatory region ftz\|reg_element\|39 3R:2,689,678..2,689,717 comment=fAE3, ftz Zebra element protein binding site, activating region; TF:R02558 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|40 3R:2,689,733..2,689,747 comment=fRE1, ftz Zebra element protein binding site, repressing element; TF:R02559 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|41 3R:2,689,753..2,689,772 comment=fDE1, ftz Zebra element protein binding site, has dual activating and repressing function; TF:R02560 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|43 3R:2,689,783..2,689,812 comment=fRE2, ftz Zebra element protein binding site, repressing element; TF:R02561 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|44 3R:2,689,851..2,689,887 comment=fRE3, ftz Zebra element protein binding site, repressing element; TF:R02562 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|46 3R:2,689,897..2,689,914 comment=fDE2, ftz Zebra element protein binding site, has dual activating and repressing function; TF:R02563 evidence=experimental (Topol et al., 1991) regulatory region ftz\|reg_element\|57 3R:2,691,714..2,691,915 comment=FIE3, ftz instability element 3', can autonomously destablize a heterologous mRNA evidence=experimental (Riedl and Jacobs-Lorena, 1996) regulatory region ftz\|reg_element\|58 3R:2,691,848..2,691,915 comment=core instability element evidence=experimental (Riedl and Jacobs-Lorena, 1996) rescue fragment ftz[+t10.8] 3R:2,683,629..2,694,040 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=KpnI-KpnI_rfrag (Hiromi et al., 1985)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 8480
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 11040
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference embryonic stage (Kuroiwa et al., 1984) embryonic stage \| stage 4-12 parasegment 12 (Kellerman et al., 1990) embryonic stage \| 0-12hr (Weiner et al., 1984) embryonic stage \| stage 10 ventral nerve cord (Kellerman et al., 1990) embryonic stage \| 2-4hr (Hafen et al., 1984) embryonic stage \| stage 3 (MacDonald et al., 1986) embryonic stage (Manoukian and Krause, 1992) embryonic stage \| stage 4-12 parasegment 14 (Kellerman et al., 1990) embryonic stage \| stage 4-12 parasegment 2 (Kellerman et al., 1990) embryonic stage \| early (Hafen et al., 1984) embryonic stage \| stage 4-12 parasegment 8 (Kellerman et al., 1990) embryonic stage \| cellular blastoderm (Hafen et al., 1984) embryonic stage \| stage 4-12 parasegment 4 (Kellerman et al., 1990) embryonic stage \| stage 4-14 parasegement 2,4,6,8,10,12,14 (MacDonald et al., 1986) embryonic stage \| stage 4-12 parasegment 10 (Kellerman et al., 1990) embryonic stage \| stage 4-12 parasegment 6 (Kellerman et al., 1990)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference embryonic stage \| cellular blastoderm (Karr and Kornberg, 1989) embryonic stage \| stage 10-12 MP1b neuron (Doe et al., 1988) embryonic stage \| stage 4-12 parasegment 4 (Kellerman et al., 1990) embryonic stage \| stage 4-12 parasegment 12 (Kellerman et al., 1990) embryonic stage \| stage 4 parasegment 4 (Frohnhofer and Nusslein-Volhard, 1987) embryonic stage \| 12-15hr embryonic/larval hindgut (Krause et al., 1988) embryonic stage \| stage 10-12 RP2 neuron (Doe et al., 1988) embryonic stage \| stage 4