Gene Dmel\Fas3

General Information
Symbol	Dmel\Fas3	Species	D. melanogaster
Name	Fasciclin 3	Annotation symbol	CG5803
Feature type	protein_coding_gene	FlyBase ID	FBgn0000636
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36F2-36F4	Sequence location	2L:18,320,101..18,392,590 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Fasciclin 3 is referred to in FlyBase by the symbol Fas3 (CG5803, FBgn0000636). It has the cytological map location 36F2-36F4. Its sequence location is 2L:18320101..18392590. Its molecular function is unknown. It is involved in the biological processes: axon guidance; synaptic target recognition; ovarian follicle cell development; axonal fasciculation; homophilic cell adhesion; synaptic target attraction; axonogenesis; calcium-dependent cell-cell adhesion; learning and/or memory; olfactory learning. 30 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; abdominal ventral longitudinal muscle 3; nervous system; embryonic neuron; abdominal 7 longitudinal muscle; larval abdominal segment 5; larval abdominal segment; embryonic nervous system; hypodermal muscle of larval abdominal 2; abdominal 6 longitudinal muscle. It has 4 annotated transcripts and 4 annotated polypeptides.
External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Fas3: Fasciclin III Monoclonal-antibody staining reveals a complex sequence of temporal and spatial expression of Fas3. It is expressed on segmentally repeated patches of cells during neurogenesis and outside the developing CNS on segmentally repeated stripes in the epidermis at the segmental grooves, on patches of epithelial cells near the stomodeal and proctodeal invaginations, on the visceral but not the somatic mesoderm, and on the luminal surface of the salivary gland epithelium; expression is highest where fasciclin-III-positive cells contact one another. After germ-band extension transiently expressed on segmentally repeated patches of neuroepithelial cells and specific underlying neuronal lineages; by the end of germ band retraction fasciclin-III is expressed in repeated stripes across all body segments. At hour 12 fasciclin is detected on a subset of three axon bundles (fascicles) in the anterior commissure and two in the posterior commissure of each segment; generally, however it's not expressed on the axons of these neurons that exit CNS, specifically on the longitudinal fascicles. Expression of Fas3 in transfected cultured cells promotes their adhesion to each other, but not to nonexpressing cells (Snow, et al.). The monoclonal antibodies used in the isolation of fasciclin identify four closely related membrane glycoproteins of 80, 66, 59, and 46 kd molecular weight; all depend on the presence of Fas3+ for their presence.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36F2-36F4 Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36E1-36E1 (determined by in situ hybridisation) (Snow et al., 1989) 36E1-36E1 (determined by in situ hybridisation) (Patel et al., 1987)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Fas3 for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fas3-RA FBtr0081051 NM_165250 2486 508 Fas3-RB FBtr0081052 NM_165249 2102 401 Fas3-RC FBtr0112804 NM_001103703 2672 475 Fas3-RD FBtr0112805 NM_001103704 2429 577
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Fas3-PA FBpp0080604 55.9 508 4.92 NP_724107 AAF53665 Fas3-PB FBpp0080605 44.2 401 5.76 NP_724106 AAN11002 Fas3-PC FBpp0111716 51.7 475 4.67 NP_001097173 AAN11003 Fas3-PD FBpp0111717 63.4 577 5.95 NP_001097174 ABV53691
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0000636
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin-like (IPR007110) CD80-like, immunoglobulin C2-set (IPR013162)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141006 AA141590 AA440461 AA441631 AE003658 AAF53665 AE003658 AAN11002 AI133934 AI388031 AI532169 AY075516 AAL68324 BG632691 BI166245 BI170301 BI212765 BI214973 BI229670 BI231832 BI233224 BI234232 BI234390 BI240412 BI240577 BI240925 BI243349 BI356903 BI357859 BI361511 BI362295 BI363416 BI367090 BI368127 BI369014 BI369775 BI371063 BI375465 BI375793 BI375879 BI482059 BI483414 BI483937 BI484239 BI484447 BI485028 BI485920 BI486872 BI571403 BI577298 BI578235 BI578418 BI622303 BI624118 BI626194 BP540916 BP544838 BP547136 BP550331 BP550332 BP551235 BP551236 BP555279 BP557954 BP557955 BP558391 BT029964 BT030160 CK658161 CO177214 CO177646 CO177718 CO178238 CO178364 CO189480 CO189664 CO262395 CO262909 CO262914 CO264593 CO264668 CO265712 CO268091 CO269069 CO272736 CO275592 CO276855 CO278577 CO280624 CO280791 CO282188 CO285884 CO287210 CO289439 CO289616 CO290289 CO290607 CO291579 CO291939 CO296634 CO301129 CO301551 CO305020 CO305196 CO306879 CO307930 CO308138 CO316297 CO322377 CO322524 CO323153 CO323235 CO324312 CO325024 CO325697 CO326811 CO326831 CO330590 CO339172 CO340877 CO344803 CO345258 CZ468658 CZ470526 CZ477925 CZ480018 CZ480125 CZ480126 CZ480280 CZ482020 CZ482624 EC058171 EC058781 EC059013 EC059553 EC060917 EC063100 EC064287 EC070352 EC071440 EC071851 EC076363 EC077949 EC081306 EC082044 EC082059 EC082558 EC084806 EC085217 EC088773 EC089076 EC089627 EC194530 EC196182 EC197734 EC198529 EC200334 EC203287 EC204503 EC212236 EC212304 EC215012 EC215765 EC216326 EC223222 EC224669 EC224958 EC227546 EC229574 EC229857 EC230230 EC231549 EC233381 EC234989 EC238141 EC239543 EC242395 EC242609 EC242843 EC244484 EC245406 EC246884 EC246908 EC249113 EC251249 EC252956 EC253139 EC253937 EC254674 EC256444 EC256880 EL879772 EL879773 EL880042 EL886383 EL886429 EL886492 EL886591 EL886644 EL886711 EL886766 M27813 AAA28532

UniProtKB/Swiss-Prot	P15278
UniProtKB/TrEMBL

Maps to
Does NOT map to
Identified with	RE66907 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 7957
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression