Gene Dmel\fas

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General Information

Symbol

Dmel\fas

Species

D. melanogaster

Name

faint sausage

Annotation symbol

CG17716

Feature type

protein_coding_gene

FlyBase ID

FBgn0000633

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

50B6-50C3

Sequence location

2R:9,510,593..9,636,882 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene faint sausage is referred to in FlyBase by the symbol fas (CG17716, FBgn0000633). It has the cytological map location 50B6-50C3. Its sequence location is 2R:9510593..9636882. Its molecular function is unknown. It is involved in the biological processes: Malpighian tubule morphogenesis; dorsal closure; foregut morphogenesis; head involution; morphogenesis of an epithelium; salivary gland development; cardioblast cell fate determination; salivary gland morphogenesis; maintenance of polarity of embryonic epithelium. 18 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; embryonic nervous system; embryonic neuron; nervous system; anatomical structure; primordium; embryonic head; ectoderm derivative; spiracle; commissure; midgut constriction. It has one annotated transcript and one annotated polypeptide.

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

fas: faint sausage

Embryonic lethal; embryos have poorly developed cuticle with necrotic patches and an abnormal head. First visible in extended-germ-band stage.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50B6-50C3

Limits computationally determined from genome sequence between P{lacW}l(2)03105^k16702&P{lacW}fl(2)d^k16105 and P{lacW}shot^k03010

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

50C1-50C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

50B7-50B9

(Liu et al., 1999)

50C1-50C4

(determined by in situ hybridisation)

(Lekven et al., 1998)

50C1-50C2

(determined by in situ hybridisation)

(Preston et al., 1996)

50C1-50C2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-68

(Tearle and Nusslein-Volhard, 1987)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\fas for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

fas-RA

FBtr0087625

NM_079007

5944

822

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

fas-PA

FBpp0086751

91.6

822

7.04

NP_523731

AAF58341

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0000633

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Immunoglobulin subtype 2 (IPR003598)

Immunoglobulin subtype (IPR003599)

Immunoglobulin-like (IPR007110)

Immunoglobulin (IPR013151)

Immunoglobulin-like fold (IPR013783)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

HL03670

(Spradling et al., 1999)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

12606

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0000633

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0000633

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0000633

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

lethal | recessive

fas⁰⁵⁴⁸⁸

lethal | embryonic stage

fas¹

lethal | embryonic stage | recessive

Sterility

Allele

fertile

Phenotype manifest in

Allele

interface glial cell

fas⁰⁵⁴⁸⁸

aCC neuron

fas⁰⁵⁴⁸⁸

pCC neuron

fas⁰⁵⁴⁸⁸

MP1 neuron

fas⁰⁵⁴⁸⁸

dMP2 neuron

fas⁰⁵⁴⁸⁸

vMP2 neuron

fas⁰⁵⁴⁸⁸

adult salivary gland primordium

larval salivary gland & embryo

Malpighian tubule

larval hindgut & embryo

fas¹

embryonic/first instar larval cuticle

embryonic head

cardioblast

embryonic/larval pericardial cell

fas²

external sensory organ & embryo

fas²

trichogen cell & embryo

fas²

tormogen cell & embryo

fas²

eo neuron & embryo

fas²

ventral nerve cord

fas²

ventral nerve cord commissure

fas²

ventral midline

fas²

Malpighian tubule primordium

fas^k04221

embryonic digestive system

fas^k04221

larval foregut & embryo

fas^k04221

larval proventriculus & embryo

fas^k04221

midgut constriction

fas^k04221

dorsal closure embryo

fas^k04221

embryonic epidermis

fas^k04221

embryonic/larval posterior spiracle

fas^k04221

larval esophagus & embryo

fas^unspecified

keyhole structure

fas^unspecified

Classical Alleles ( 15 )

For All Classical Alleles Show

Allele of fas	Mutagen	Stocks	Known lesion
fas⁰⁵⁴⁸⁸	P-element activity	1	--
fas¹	ethyl methanesulfonate	1	--
fas²	ethyl methanesulfonate	0	--
fas^EY03881	P-element activity	1	--
fas^EY06334	P-element activity	1	--
fas^G5-29	γ ray	0	Yes
fas^KG06723	P-element activity	1	--
fas^MB00027		1	--
fas^PR95	Δ2-3	0	Yes
fas^TK	ethyl methanesulfonate	0	--
fas^f00157	piggyBac transposase	2	--
fas^f00890	piggyBac transposase	1	--
fas^f04326	piggyBac transposase	1	--
fas^k04221		0	Yes
fas^unspecified		0	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of fas	Mutagen	Stocks	Known lesion
fas^GD14405	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
fas^GD2565	in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
fas^GD69	in vitro construct \| RNAi in vitro construct \| regulatory fusion	3	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)CX1

Useful duplication

Dp(2;2)SMG45

Disrupted in

Df(2R)AA1

(Lekven et al., 1998)

Df(2R)CX1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)MK1

(Lekven et al., 1998)

Df(2R)MK2

(Lekven et al., 1998)

T(2;3)fas^G5-29

(Lekven et al., 1998)

Not disrupted in

Df(2R)50C-101

(Preston et al., 1996)

Df(2R)50C-102

(BDGP Project Members, 1994-1999, Preston et al., 1996)

Df(2R)50C-107

(Preston et al., 1996)

Df(2R)50C-111

(Preston et al., 1996)

Df(2R)50C-116

(Preston et al., 1996)

Df(2R)50C-128

(Preston et al., 1996)

Df(2R)50C-129

(Preston et al., 1996)

Df(2R)50C-131

(Preston et al., 1996)

Df(2R)50C-132

(Preston et al., 1996)

Df(2R)50C-133

(Preston et al., 1996)

Df(2R)50C-16

(Preston et al., 1996)

Df(2R)50C-21

(Preston et al., 1996)

Df(2R)50C-36

(Preston et al., 1996)

Df(2R)50C-38

(Preston et al., 1996)

Df(2R)50C-40

(Preston et al., 1996)

Df(2R)50C-43

(Preston et al., 1996)

Df(2R)50C-45

(BDGP Project Members, 1994-1999, Preston et al., 1996)

Df(2R)50C-49

(Preston et al., 1996)

Df(2R)50C-68

(Preston et al., 1996)

Df(2R)50C-69

(Preston et al., 1996)

Df(2R)50C-71

(Preston et al., 1996)

Df(2R)50C-81

(Preston et al., 1996)

Df(2R)50C-85

(Preston et al., 1996)

Df(2R)50C-89

(Preston et al., 1996)

Df(2R)Pu-D17

(Liu et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)cnn

(Heuer et al., 1995)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD14405}

P{GD2565}

P{GD69}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}fas^KG06723

P{UASp-YFP.Rab9Fb}38

insertion of enhancer trap binary system

Mi{ET1}fas^MB00027

insertion of enhancer trap

P{PZ}fas⁰⁵⁴⁸⁸

Yes

P{lacW}l(2)SH1767^SH1767

insertion of mobile activating element

P{EPgy2}fas^EY03881

P{EPgy2}fas^EY06334

Related Comments

Please look at the allele reports for the complete phenotype data

fas has been cloned and sequenced.

(Green, 1995.1.3)

fas mutants display disruption of the delamination of sensory neuronal precursors from the ectoderm. Sensory neurons appear in roughly normal numbers and position but are located in the epidermis.

(Lekven et al., 1992)

fas is required for the migration of mesodermal precursor cells from the germ layer, their survival and/or terminal differentiation of all mesodermal precursors.

(Michelson, 1995)

Internalisation of the salivary gland and salivary gland shape are altered in fas mutant embryos.

(Myat and Andrew, 2000)

Gene Ontology: Function, Process & Cellular Component ( 9 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References